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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Market Orientation and Performance: Modelling a Neural Network 显示文摘 | Silva M Moutinho L Coelho A Marques A | 2009 | European Journal of Marketing2009，43，3： | 1 |
| 3 | Consumer behavior in tourism显示文摘 | Moutinho L | 1997 | European Jour- nal of Marketing1997，21，0： | 1 |
| 4 | Ethnopharmacological notes about ancient uses of medicinal plants in Trás-os-Montes (northern of Portugal)显示文摘 | José Manuel Neves Carla Matos Carla Moutinho Glória Queiroz Lígia Rebelo Gomes | 2009 | Journal of Ethnopharmacology2009，，2： | 1 |
| 5 | Consumer behavior in tourism显示文摘 | Moutinho L | 1987 | European Journal of Marketing1987，21，10： | 1 |
| 6 | Abnormal uterine bleeding as a presenting symptom is related to multiple uterine leiomyoma : an ultrasound - based study 显示文摘 | FONSECA MOUTINHO J A BARBOSA L S TORRES D G | 2013 | Int J Womens Health2013，18，5： | 1 |
| 7 | Brand relationships through brand reputation and brand tribalism显示文摘 | Veloutsou C Moutinho L | 2009 | Journal of Business Research2009，62，3： | 1 |
| 8 | The role of brand image,product involvement,and knowledge in explaining consumer purchase behaviour of counterfeits:Direct and indirect effects显示文摘 | Bian X Moutinho L | 2011 | European Journal of Marketing2011，45，12： | 1 |
| 9 | Consumer behavior in tourism显示文摘 | Moutinho L | 1987 | European Journal of Marketing1987，21，10： | 1 |
| 10 | Growth and characterization of radio frequency magnetron sputter-deposited zinc stannate, Zn2SnO4, thin films显示文摘 | Moutinho H Yan Y | 2002 | J Appl Phys2002，92，： | 1 |
| 11 | Signalling pathways in pollen tube growth and reorientation显示文摘 | Malho R Camacho L Moutinho A | 2000 | Ann Bot2000，85，： | 1 |
| 12 | Forecasting Tourism Demand by Fuzzy Time Series Models 显示文摘 | Huarng K H Yu T H K Moutinho L | 2012 | International Journal of Culture Tourism and Hospitality2012，6，4： | 1 |
| 13 | BRAF,KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in eolorectal carcinogenesis 显示文摘 | Velho S Moutinho C Cirnes L | 2008 | BMC Cancer2008，8，： | 1 |
| 14 | Brand relationships through brand reputation and brand tribalism 显示文摘 | Veloutsou C and Moutinho L | 2009 | Journal of Business Research2009，62，3： | 1 |
| 15 | Consumer behavior in tourism 显示文摘 | Moutinho L | 1987 | European Journal of Marketing1987，21，10： | 1 |
| 16 | Consumer behavior in tourism显示文摘 | Moutinho L | 1987 | European Journal of Marketing1987，21，10： | 1 |
| 17 | Consumer behavior in tourism显示文摘 | Moutinho L | 1987 | European journal of marketing1987，，21： | 1 |
| 18 | Consumer behavior in tourism 显示文摘 | Moutinho L | 1987 | European Journal of Marketing1987，21，10： | 1 |
| 19 | Modeling Bank Customer Satisfaction Through Mediation of Attitudes Towards Human and Automated Banking显示文摘 | MOUTINHO L SMITH A | 2000 | International Journal of Bank Marketing2000，18，3： | 1 |
| 20 | Using Neural Networks to Understand Service Risk in the Holiday Product 显示文摘 | Mitchell V Davies F Moutinho L | 1999 | Journal of Business Research1999，46，： | 1 |
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