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| 1 | Correlation of matrix metalloproteinase-2, -9, tissue inhibitor-1 of matrix metalloproteinase and CD44 variant 6 in head and neck cancer metastasis显示文摘This study aimed to explore the molecular mechanism in tumor invasion and metastasis. The ex-pression of matrix metalloproteinase-2,-9 (MMP-2,MMP-9), tissue inhibitor-1 of matrix metalloprote inase(TIMP-1) , cell adhesion molecule 44 variant 6 (CD44v6) , HER2/neu and p53 was investigated in 154 pa-tients with head and neck squamous cell carcinoma (SCC) by ABC and ImmunoMax immunohistochemical method. Their clinical relevance and correlation were analysed. The expression of MMP-2, MMP-9, TIMP-1,CD44v6, HER2/neu and p53 was found in cancer cells in 87.01%, 85.71%, 68. 18%, 98.05%,55.19% and 50.65% cases respectively. Linear regression and correlation analysis revealed that there wasclose positive relationship ( P < 0.05) between the expression of MMP-2 and MMP-9, TIMP-1 and CD44v6,HER2/neu and MMP-9, MMP-2 and p53. Up-regulation of MMP-2 was accompanied by advanced T stage( P < 0.01 ) . There was also a trend of MMP-2 expression being related with tumor metastasis. Increased ex-pression of HER2/neu was found in patients with tumor recurrence( P < 0.05 ) . The expression of TIMP-1 washigher in laryngeal cancer than that in pharyngeal cancer, and higher in keratinizing and non-keratlnizing SCC than that in basaloid SCC ( P < 0.05 ) . These findings suggested that MMP-2 and MMP-9, HER2/neu andMMP-9, MMP-2 and p53 had a coordinate function in aggression of tumor; that MMP-2 had a more important function than MMP-9 in tumor invasion and metastasis; and that HER2/neu might serve as a biomarker forpoor prognosis in HNSCC. | 徐娅苹 赵学群 SOMMER,K. MOUBAYED,P. | 2003 | Journal of Zhejiang University Science2003，4，4： | 8 |
| 2 | 基质金属蛋白酶和细胞黏附因子与头颈部鳞癌转移的相关性研究显示文摘 | 徐娅苹 Konard Sommer Pierre Moubayed Staphan Remmert | 2002 | 中华耳鼻咽喉科杂志2002，37，4： | 4 |
| 3 | Research on Hybrid Renewable Energy Systems with Fault Detection Technology显示文摘 | Hiba Al-Sheikh Nazih Moubayed | 2013 | Journal of Energy and Power Engineering2013，7，12： | 3 |
| 4 | Psoriasin (S100A7) is significantly up-regu- lated in human epithelial skin tumours显示文摘 | MOUBAYED N WEICHENTHAL M HARDER J | 2007 | J Cancer Res Clin Oncol2007，133，： | 1 |
| 5 | An unusual finding of corneal edema complicatin selective laser trabeculoplasly显示文摘 | Moubayed SP Hamid M Choremis J | 2009 | J Ophthalmol2009，44，3： | 1 |
| 6 | Osteoeutaneous free flaps for mandibular reconstruction: sys- tematic review of their frequency of use and a preliminary quali- ty of life comparison 显示文摘 | Moubayed SP L'Heureux-Lebeau B Christopoulos A | 2014 | J Laryngol Otol2014，128，12： | 1 |
| 7 | An unusual finding of corneal edema complicating selective laser trabeculoplasty 显示文摘 | Moubayed SP Hamid M Choremis J | 2009 | Can J Ophthalmo12009，44，3： | 1 |
| 8 | Psoriasin (S100A7) is significantly up-regulated in human epithelial skin tumours显示文摘 | MOUBAYED N WEICHENTHAL M HARDER J | | 0，，： | 1 |
| 9 | Periorbital cellulitis in the pediatric population:clinical features and management of 117cases显示文摘 | MOUBAYED S P VU T T QUACH C | 2011 | J Otolaryngol Head Neck Surg2011，40，： | 1 |
| 10 | Carcinoma in situ in a lateral cervical cyst显示文摘 | Zimmermann CE Von Domarus H Moubayed P | 2002 | Head -Neck2002，24，10： | 1 |
| 11 | Experimental hepa-titis A virus infection in guinea pigs 显示文摘 | Hornei B Kmmerer R Moubayed P | 2001 | J Med Virol2001，64，4： | 1 |
| 12 | High frequency of human papillomavirus 6/11,16,and 18 infections in precancerous lesions and squamous cell carcinoma of the conjunctiva in subtropical Tanzania显示文摘 | Moubayed P Mwakyoma H Schneider DT | | 0，，06： | 1 |
| 13 | The submental island flap for soft-tissue head and neck reconstruction:step-bystep video description and long-term results显示文摘 | Moubayed SP Rahal A Ayad T | 2014 | Plast Reconstr Surg2014，133，3： | 1 |
| 14 | The submental island flap for soft-tissue head and neck reconstruction:step-by- step video description and long-term results显示文摘 | Moubayed SP Rahal A Ayad T | 2014 | Hast Re-constr Surg2014，133，3： | 1 |
| 15 | Psoriasin (S100A7) is significantly up-regulated in human epithelial skin tumours显示文摘 | Moubayed N Weichenthal M Harder J | 2007 | J Cancer Res Clin Oncol2007，133，4： | 1 |
| 16 | Vertebrobasilar insufficiency presenting as isolated positional vertigo or dizziness: a double blind retrospective cohort study 显示文摘 | Moubayed S P Saliba I | 2009 | Laryngo- scope2009，119，10： | 1 |
| 17 | Carcinoma in situ in a lateral cervical cyst显示文摘 | Zimmemann C E Von Domarus H Moubayed P | 2002 | Head Neck2002，24，10： | 1 |
| 18 | An unusual finding of corneal edema complicating selective laser trabeculoplasty 显示文摘 | Moubayed SP Hamid M Choremis J | 2009 | Can J Ophthalmol2009，44，3： | 1 |
| 19 | Drug treatment of inborn errors of metabolism: a systematic review 显示文摘 | Alfadhel M A1-Thihli K Moubayed | 2013 | Arch Dis Child2013，98，6： | 1 |
| 20 | Analysis and imple-mentation of an adaptative PV based battery floating charger 显示文摘 | KARAMI N MOUBAYED N OUTB1B R | 2012 | Solar Energy2012，86，： | 1 |
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