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| 1 | Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin显示文摘AIM: To assess the aetiological role of Helicobacter pylori (H. pylori) infection in adult patients with ironrefractory or iron-dependent anaemia of previously unknown origin. METHODS: Consecutive patients with chronic irondeficient anaemia (IDA) with H. pylori infection and a negative standard work-up were prospectively evaluated. All of them had either iron refractoriness or iron dependency. Response to H. pylori eradication was assessed at 6 and 12 mo from follow-up. H. pylori infection was considered to be the cause of the anaemia when a complete anaemia resolution without iron supplements was observed after eradication. RESULTS: H. pylori was eradicated in 88 of the 89 patients. In the non-eradicated patient the four eradicating regimens failed. There were violations of protocol in 4 patients, for whom it was not possible to ascertain the cause of the anaemia. Thus, 84 H. pylori eradicated patients (10 men; 74 women) were available to assess the effect of eradication on IDA. H. pylori infection was considered to be the aetiology of IDA in 32 patients (38.1%; 95%CI: 28.4%-48.8%). This was more frequent in men/postmenopausal women than in premenopausal women (75% vs 23.3%; P < 0.0001) with an OR of 9.8 (95%CI: 3.3-29.6). In these patients, anaemia resolution occurred in the first follow-up visit at 6 mo, and no anaemia or iron deficiency relapse was observed after a mean follow-up of 21 ± 2 mo. CONCLUSION: Gastric H. pylori infection is a frequent cause of iron-refractory or iron-dependent anaemia of previously unknown origin in adult patients. | Helena Monzón Montserrat Forné Maria Esteve Mercé Rosinach Carme Loras Jorge C Espinós Josep M Viver Antonio Salas Fernando Fernández-Baares | 2013 | World Journal of Gastroenterology2013，19，26： | 13 |
| 2 | Outcome in obscure gastrointestinal bleeding after capsule endoscopy显示文摘AIM: To investigate the clinical impact of capsule endoscopy(CE) after an obscure gastrointestinal bleeding(OGIB) episode, focusing on diagnostic work-up, followup and predictive factors of rebleeding. METHODS: Patients who were referred to Hospital del Mar(Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid antiinflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings(significant or non-significant), work-up and patient out-comes were analyzed from electronic charts. Variables were compared by χ 2 analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model. RESULTS: There were 105 patients [45.7% women, median age of 72 years old(interquartile range 56-79)] and a median follow-up of 326 d(interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1%(55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients(69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios(HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above(HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE(HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding. CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions. | Alex Caas-Ventura Lucia Márque Xavier Bessa Josep Maria DedeuDepartment of Gastroenterology Hospital del Mar Research Institute Pompeu Fabra University Marc Puigvehí Sílvia Delgado-Aros Ines Ana Ibáez Agustin Seoane Luis Barranco Felipe Bory Montserrat Andreu Begoa González-Suárez | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 4 |
| 3 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 4 | Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non small cell lung cancer patients显示文摘 | ESTELLWR M MONTSERRAT SC ROSELL R | 1999 | Cancer Res1999，59，： | 1 |
| 5 | Are island plant communi- ties more invaded than their mainland counterparts显示文摘 | Montserrat V Joan P Ana M | 2010 | Journal of Vegetation Science2010，21，3： | 1 |
| 6 | Changes in Bacteriophlankton Composition under Different Phytoplankton Regimens显示文摘 | PINHASSI J MONTSERRAT M S HAVSKUM H | 2004 | Applied and Environmental Microbiology2004，70，11： | 1 |
| 7 | N-nitrosodimethylamine (NDMA) removal by reverse osmosis and UV treatment and analysis via LC-MS/MS显示文摘 | Plummee M H Montserrat L M | 2008 | Water Research2008，42，12： | 1 |
| 8 | Authentication of atlantic salmon(Salmo salar)using real-time PCR显示文摘 | Beatriz Herrero Juan M Vieites Montserrat Espieira | 2011 | Food Chemistry2011，127，3： | 1 |
| 9 | Assessment of Copy Number Variation Using the Illumina Infinium 1M SNP-array:A Comparison of Methodological Approaches in the Spanish Bladder Cancer/EPICURO Study显示文摘 | Gaellla M Benjanim R S Montserrat G C | | 0，，02： | 1 |
| 10 | Application of an experimental design for the optim-zation and validation of a new HPLC method for the determination of vancomycin in an extemporaneous ophthalmic solution 显示文摘 | Montse E Encarna GM Montserrat M | 2008 | Journal of Chromatographic Science2008，46，10： | 1 |
| 11 | Comparative antioxidant and cytotoxic effects of lignins from different sources 显示文摘 | Vanessa U Montserrat M Maria P V | 2008 | Bioresource Technology2008，99，14： | 1 |
| 12 | Reproduction of the deep-water shrimpAristeus antennatus(Decapoda:Dendrobranchiata)显示文摘 | Montserrat D Jose M F | 1992 | Mar EcolProg Ser1992，84，： | 1 |
| 13 | Sleep-related breath ing disorders: impact on mortality of cerebrovascular disease显示文摘 | Parra O Arboix A Montserrat J M | 2004 | EurRespirJ2004，24，26： | 1 |
| 14 | Identification of Candida albicans exposed surface proteins in vivo by a rapid proteomic approach 显示文摘 | Maria L H Pilar X E Montserrat M G | 2010 | Proteomics2010，73，7： | 1 |
| 15 | Solid-phase mieroex trac- tion and gas chromatography olfactometry analysis of succes- sively diluted samples: A new approach of the aroma extract di- lution analysis applied to the char acterization of wine aroma 显示文摘 | Maria P M Montserrat M Cristina S | 2003 | J Agric Food Chem2003，51，： | 1 |
| 16 | Correlation between the ultraviolet protection factor and the weight and thickness of undyed cellulosic woven fabrics 显示文摘 | INES M Algaba MONTSERRAT Pepio | 2008 | Fibres&Textiles in Eastern Europe2008，16，1： | 1 |
| 17 | Proteomic analysis of cytoplasmic and surface proteins from yeast cells, hyphae, and biofilms of Candida albicans 显示文摘 | Montserrat M G Perumal P Mekala S | 2009 | Proteomics2009，9，8： | 1 |
| 18 | Risk of Liver Decompensation Among HIV/Hepatitis C Virus–Coinfected Individuals With Advanced Fibrosis: Implications for the Timing of Therapy显示文摘 | Juan Macías Manuel Márquez Francisco Téllez Dolores Merino Patricia Jiménez-Aguilar Luis F. López-Cortés Enrique Ortega Miguel A. von Wichmann Antonio Rivero María Mancebo Jesús Santos Montserrat Pérez-Pérez Ignacio Suárez-Lozano Alberto Romero-Palacios A | 2013 | Clinical Infectious Diseases2013，，10： | 1 |
| 19 | Bacterial lipopolysaccharide induces apoptosis in the trout ova- ry 显示文摘 | MacKenzie S Montserrat N Mas M | 2006 | Reprod Biol Endocrinol2006，4，： | 1 |
| 20 | Evaluation of a simplified oscillation technique for assessing airway obstruction in sleep apneea显示文摘 | Farre R Rigau J Montserrat J M | | 0，，： | 1 |
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