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| 1 | Burden of onchocerciasis-associated epilepsy:first estimates and research priorities显示文摘Background:Since the 1990s,evidence has accumulated of an increased prevalence of epilepsy in onchocerciasisendemic areas in Africa as compared to onchocerciasis-free areas.Although the causal relationship between onchocerciasis and epilepsy has yet to be proven,there is likely an association.Here we discuss the need for disease burden estimates of onchocerciasis-associated epilepsy(OAE),provide them,detail how such estimates should be refined,and discuss the socioeconomic impact of OAE,including a cost-estimate for anti-epileptic drugs.Main body:Providing OAE burden estimates may aid prevention of epilepsy in onchocerciasis-endemic areas by inciting and informing collaboration between onchocerciasis control programmes and mental health services.Epilepsy not only massively impacts the health of those affected,but it also carries a high socioeconomic burden for the households and communities involved.We used previously published geospatial estimates of onchocerciasis in Africa and a separately published logistic regression model quantifying the association between onchocerciasis and epilepsy to estimate the number of OAE cases.We then applied disability weights for epilepsy to quantify the burden in terms of years of life lived with disability(YLD)and estimate the cost of treatment.We estimate that in 2015 roughly 117000 people were affected by OAE across onchocerciasis-endemic areas previously under the African Programme for Onchocerciases control(APOC)mandate where OAE has ever been reported or suspected,and another 264000 persons in onchocerciasis-endemic areas where OAE has never been investigated before.The total number of YLDs due to OAE was 39300 and 88700 in these areas respectively,based on a weighted mean disability weight of 0.336.The burden of OAE is approximately 13%of the total YLDs attributable to onchocerciasis and 10%of total YLDs attributable to epilepsy.We estimated that by 2015 the total costs of treatment with antiepileptic drug for OAE cases would have been a minimum of 12.4 million US$.Conclusions:These estimates suggest a considerable health,social and economic burden of OAE in Africa.The treatment and care for people with epilepsy,especially in hyperendemic onchocerciasis areas with high epilepsy prevalence thus requires more financial and human resources. | Natalie V.S.Vinkeles Melchers Sarah Mollenkopf Robert Colebunders Michael Edlinger Luc E.Coffeng Julia Irani Tresor Zola Joseph N.Siewe Sake Jde Vlas Andrea S.Winkler Wilma A.Stolk | 2018 | Infectious Diseases of Poverty2018，7，1： | 3 |
| 2 | Identification of immunogenic antigens of Helicobacter pylori via the Escherichia coli hemolysin secretion system (1) 显示文摘 | Gentschev I Goebel W Mollenkopf H Eck M Muller-Hermelink HK Schmausser B | 2000 | FEMS Microbiol Lett2000，186，2： | 1 |
| 3 | Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma显示文摘 | Schaefer A Jung M Mollenkopf HJ | 2010 | Int J Cancer2010，126，5： | 1 |
| 4 | MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy显示文摘 | Jung M Mollenkopf HJ Grimm C | 2009 | J Cell Mol Med2009，13，9： | 1 |
| 5 | Differential T cell responses to Mycobacterium tuberculosis ESAT6 in tuberculosis patients and healthy donors显示文摘 | Ulrichs T Munk ME Mollenkopf H | 1998 | Eur J Immunol1998，28，： | 1 |
| 6 | MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy显示文摘 | Jung M Mollenkopf H J Grimm C | 2009 | J Cell Mol Med2009，13，9： | 1 |
| 7 | Comparative proteome analysis of Mycobacterium tuberculosis and Mycobacterium bovis BCC strains; towards functional genomics of microbial pathogens显示文摘 | Jungblut P R Schaible U E Mollenkopf H J | 1999 | Mol Microbiol1999，33，6： | 1 |
| 8 | MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy显示文摘 | Jung M Mollenkopf HJ Grimm C | 2009 | J Cell Mol Med2009，13，9： | 1 |
| 9 | Application of Mycobacterial Proteomics to Vaccine Design:Improved Protectionby Mycobacterium bovis BCG Prime-Rv3407 DNA Boost Vaccination against Tuberculosis显示文摘 | Mollenkopf HJ Grode L Mattow J | 2004 | Infect immun2004，72，11： | 1 |
| 10 | Continuity and change in older adults’ perceptions of out-of-home mobility over ten years: a qualitative???quantitative approach显示文摘 | HEIDRUN MOLLENKOPF ANNETTE HIEBER HANS-WERNER WAHL | 2011 | Ageing and Society2011，，5： | 1 |
| 11 | Natural killer T-cell characterization through gene expression profiling : an account of versatility bridging T helper type 1 ( Thl ) , Th2 and Th17 immune responses显示文摘 | Niemeyer M Darmoise A Mollenkopf H J | 2007 | Immunology2007，123，1： | 1 |
| 12 | MicroRNA pro- filing of clear cell renal cell cancer identifies a robust sig- nature to define renal malignancy 显示文摘 | Jung M Mollenkopf HJ Grimm C | 2009 | J Cell Mol Med2009，13，9： | 1 |
| 13 | Development of antigen-delivery systems based on the Escherichia coli hemolysin secretion pathway显示文摘 | Mollenkopf H Sokolovic Z | 1996 | Gene1996，179，： | 1 |
| 14 | Comparative proteome analysis of Mycobacterium tuberculosis and Mycobacterium bovis BCG stains: towards functional genomics of microbial pathogens显示文摘 | Jungblut P R Schaible U E Mollenkopf H J | 1999 | Molecular Microbiology1999，33，： | 1 |
| 15 | Diagnostic and prognos- tic implications of microRNA profiling in prostate carcinoma显示文摘 | Schaefer A Jung M Mollenkopf H J | 2010 | Int J Cancer2010，126，5： | 1 |
| 16 | MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy显示文摘 | Jung M Mollenkopf HJ Grimm C | 2009 | J Cell Mol Med2009，13，9： | 1 |
| 17 | Application of Mycobacterial proteomics to vaccine desine:improved protection by Mycobacterium bovis BCG pfime-Rv3407 DNA boost vaccination against tuberculosis 显示文摘 | Mollenkopf HJ Grode L Mattow J | 2004 | Infect lmmun2004，72，： | 1 |
| 18 | CTX-M-type extended-spectrum fl -Lactamases present in Escherichia coli from the feces of cattle in Ohio, United States 显示文摘 | WITFUM T E MOLLENKOPF D F DANIELS J B | 2010 | Foodborne Pathogens and Disease2010，7，12： | 1 |
| 19 | MicroRNA profihng of clear cell renal cell cancer identifies a robust signature to define renal malignancy显示文摘 | Jurtg M Mollenkopf ILl Grimm C | 2009 | J Cell Mol Med2009，13，9： | 1 |
| 20 | Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma显示文摘 | Schaefer A Jung M Mollenkopf H J | 2010 | Int J Cancer2010，126，5： | 1 |
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