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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Gastric cancer in young people under 30 years of age: worse prognosis, or delay in diagnosis?显示文摘 | Horacio N López-Basave Diaz Romero C Alejandro Padilla Rosciano Melchor Ruan J Silvio A. ?amendys-Silva Vela Sarmiento I Ruiz Molina JM Calderillo Ruiz G Flavia Morales-Vásquez Abelardo Meneses Garcia Angel Herrera-Gomez | 2013 | Cancer Management and Research (default)2013，，： | 2 |
| 3 | Analysis of products, mechanisms of reaction, and some functional properties of soy protein hydrolysates 显示文摘 | MOLINA ORTIZ S E ANON M C | 2000 | JAOCS2000，77，： | 1 |
| 4 | Ignition and devolatilization of pulverized bituminous coal particles during oxygen/carbon dioxide coal combustion显示文摘 | Molina A Shaddix C R | 2007 | Proceedings of the Combus- tion Institute2007，21，2： | 1 |
| 5 | Major hemorrhage and tolerabiIity of warfarin in the first year of therapy among elderly patients with atrial fibrillation 显示文摘 | HYLEK EM EVANS MOLINA C SHEA C | 2007 | Circulation2007，115，21： | 1 |
| 6 | Matrix metalloproteinase-9 pretreament level predicts intracranial hemorrhagic complications after thrombolysis in human stroke显示文摘 | Montaner J Molina C Monasterio J | 2003 | Circulation2003，107，： | 1 |
| 7 | Nitrogen leaching and denitrification in continuous corn as related to residue management and nitrogen fertilization显示文摘 | GOLLANY H T MOLINA J A CLAPP C E | 2004 | Environmental Management2004，33，： | 1 |
| 8 | A comparative study using two methods to produce zeolites from fly ash显示文摘 | A Molina C Poole | 2003 | Minerals Engineering2003，，2： | 1 |
| 9 | Enhanced emission from Eu(Ⅲ) β-diketone complex combined with ether-type oxygen atoms of di-ureasil organic-inorganic hybrids显示文摘 | Molina C Dahmouche K Messaddeq Y | 2003 | Journal of Luminescence2003，104，： | 1 |
| 10 | Microbubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator显示文摘 | Molina C Ribo M Rubiera M | 2006 | Stroke2006，37，： | 1 |
| 11 | Determination of the third generation oral cephalosporin cefpodoxime in biological fluids by high-speed high-performance liquid chromatography 显示文摘 | Molina F Jehl F Gallion C | 1991 | J Chromatogr1991，563，1： | 1 |
| 12 | Particle imaging of ignition and devolatilization of pulverized coal during oxy-fuel combus- tion显示文摘 | Shaddix C R Molina A | 2009 | Proceedings of the Combustion Institute2009，32，2： | 1 |
| 13 | A comparative study using two meth- ods to produce zeolites from fly ash 显示文摘 | Molina A Poole C | 2004 | Minerals Engi- neering2004，17，： | 1 |
| 14 | Particle imaging of ignition and devolatilization of pulverized coal during oxy-fuel com- bustion显示文摘 | Shaddix C R Molina A | 2009 | Proceedings of the Combustion Institute2009，32，2： | 1 |
| 15 | The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus显示文摘 | Molina S Castet V Fournier-Wirth C | 2007 | J Hepatol2007，46，3： | 1 |
| 16 | 显示文摘 | Almansa C Molina S M Rodriguez R F | 2004 | Microporous and Mesoporous Materials2004，76，3： | 1 |
| 17 | A characterization of Quasi-copulas显示文摘 | Genest C Quesada Molina J J Rodriguez-Lallena J A | 1999 | J Multivariate Analysis1999，69，2： | 1 |
| 18 | First genotyping of Giardia lamblia from human and animal feces in Argentina, South America 显示文摘 | Minvielle M C Molina N B Polverino D | 2008 | Mem Inst Oswaldo Cruz2008，103，1： | 1 |
| 19 | Framework for global virtual business 显示文摘 | MOLINA A PONGTA S BREMER C F | 1998 | Agility and Global Competition1998，2，3： | 1 |
| 20 | Determination oforganophosphorous pesticides in water by SPE followed by LC/ high flow pneumatically assisted electrospray MS显示文摘 | Molina C Honing M Barcelo D | 1994 | Anal Chem1994，66，24： | 1 |
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