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| 1 | Long-term results of Ahmed glaucoma valve implantation in Egyptian population显示文摘AIM: To evaluate the long-term results and complications of Ahmed glaucoma valve(AGV) implantation in a cohort of Egyptian patients.METHODS: A retrospective study of 124 eyes of 99 patients with refractory glaucoma who underwent AGV implantation and had a minimum follow-up of 5 y was performed. All patients underwent complete ophthalmic examination and intraocular pressure(IOP) measurement before surgery and at 1 d, weekly for the 1 st month, 3, 6 mo,and 1 y after surgery and yearly afterward for 5 y. IOP was measured by Goldmann applanation tonometry and/or Tono-Pen. Complications and the number of anti-glaucoma medications needed were recorded. Success was defined as IOP less than 21 mm Hg with or without anti-glaucoma medication and without additional glaucoma surgery. RESULTS: Mean age was 23.1±19.9 y. All eyes had at least one prior glaucoma surgery. IOP was reduced from a mean of 37.2±6.8 to 19.2±5.2 mm Hg after 5 y follow-up with a reduced number of medications from 2.64±0.59 to 1.81±0.4.Complete and qualified success rates were 31.5% and 46.0%respectively at the end of follow-up. The most common complications were encapsulated cyst formation in 51 eyes(41.1%), complicated cataract in 9 eyes(7.25%), recessed tube in 8 eyes(6.45%), tube exposure in 6 eyes(4.8%) and corneal touch in 6 eyes(4.8%). Other complications included extruded AGV, endophthalmitis and persistent hypotony.Each of them was recorded in only 2 eyes(1.6%). CONCLUSION: Although refractory glaucoma is a difficult problem to manage, AGV is effective and relatively safe procedure in treating refractory glaucoma in Egyptian patients with long-term follow-up. Encapsulated cyst formation was the most common complication, which limits successful IOP control after AGV implantation.However, effective complications management can improve the rate of success. | Eman Elhefney Tharwat Mokbel Waleed Abou Samra Hanem Kishk Tarek Mohsen Amr El-Kannishy | 2018 | International Journal of Ophthalmology(English edition)2018，11，3： | 4 |
| 2 | mRNA expression of DOK1-6 in human breast cancer显示文摘AIM:To examine the expression of downstream of tyrosine kinase(DOK)1-6 genes in normal and breast cancer tissue and correlated this with several clinicopathological and prognostic factors.METHODS:DOK1-6 m RNA extraction and reverse transcription were performed on fresh frozen breast cancer tissue samples(n = 112) and normal background breast tissue(n = 31). Tissues were collected between 1991 and 1996 at two centres and all patients underwent mastectomy and ipsilateral axillary node dissection. All tissues were randomly numbered and the details were only made known after all analyses were completed. Transcript levels of expression were determined using real-time polymerase chain reaction and analyzed against TNM stage, tumour grade and clinical outcome over a 10-year follow-up period.RESULTS:DOK-2 and DOK-6 expression decreased with increasing TNM stage. DOK-6 expression decreased with increasing Nottingham Prognostic Index(NPI) [NPI-1 vs NPI-3(mean copy number 15.4 vs 0.22, 95%CI:2.7-27.6, P = 0.018) and NPI-2 vs NPI-3(mean copy number 7.6 vs 0.22, 95%CI:0.1-14.6, P = 0.048)]. After a median follow up period of 10 years, higherlevels of DOK-2 expression were found among patients who remained disease-free compared to those who developed local or distant recurrence(mean copy number 3.94 vs 0.0000096, 95%CI:1.0-6.85, P = 0.0091), and distant recurrence(mean copy number 3.94 vs 0.0025, 95%CI:1.0-6.84, P = 0.0092). Patients who remained disease-free had higher levels of DOK-6 expression compared to those who died from breast cancer.CONCLUSION:Decreasing expression levels of DOK-2 and DOK-6 with increased breast tumour progression supports the notion that DOK-2 and DOK-6 behave as tumour suppressors in human breast cancer. | Tamara Ghanem James Bracken Abdul Kasem Wen G Jiang Kefah Mokbel | 2014 | World Journal of Clinical Oncology2014，5，2： | 3 |
| 3 | Functional and anatomical evaluation of the effect of nepafenac in prevention of macular edema after phacoemulsification in diabetic patients显示文摘AIM: To evaluate the effect of prophylactic administration of nepafenac in prevention of macular edema occurring in diabetic patients after phacoemulsification and to investigate the correlation between optical coherence tomography(OCT) foveal thickness and multifocal electroretinogram(MF-ERG) parameters.METHODS: The study included two groups. Group 1 included 50 diabetic patients with senile cataract(50 eyes, 30 females, 20 males, aged 55±7 y) received nepafenac 0.1% eye drop. Group 2 included another 50 diabetic patients with senile cataract(50 eyes, 22 female, 28 males, aged 53.8±8 y) did not receive nepafenac. All patients were followed up for 3 mo postoperatively. OCT and MF-ERG were done preoperative and at 1 wk, 1, 2 and 3 mo.RESULTS: The mean foveal thickness was statistically significantly lower in Group 1. Five eyes in Group 2 developed clinical cystoid macular oedema(CMO)(10%), and no patients in Group 1 developed central macular thickening more than 50 μm. There were insignificant differences in MF-ERG amplitudes and latencies between the two groups except in the five eyes that developed CMO, there statistically significant reduction of MF-ERG amplitude with increase in foveal thickness. CONCLUSION: Perioperative nepafenac reduces the incidence of CMO following uncomplicated phacoemulsification significantly. Nepafenac has no side effects. | Tharwat Mokbel Sameh Saleh Mona Abdelkader Sherief E.El-khouly Waleed Abou Samra Mohamed Mamdouh | 2019 | International Journal of Ophthalmology(English edition)2019，12，3： | 3 |
| 4 | Mammary ductoscopy:current status and future prospects显示文摘 | Mokbel K Escobar PF Matsunaga T | 2005 | Eur J Surg Oncol2005，31，1： | 1 |
| 5 | The role of telomerase in breast cancer显示文摘 | Mokbel K | 2000 | Eur J Surg Oncol2000，26，： | 1 |
| 6 | In vitro fertilization and breast cancer risk:a review显示文摘 | SALHAB M ai SARAKBI W MOKBEL K | 2005 | Int J Fertil Womens Med2005，50，6： | 1 |
| 7 | Evidence for a tumour suppressor function of SETD2 in human breast cancer: a new hypothesis 显示文摘 | NEWBOLD R F MOKBEL K | 2010 | Anticancer Res2010，30，9： | 1 |
| 8 | Privacy in Location-based Services:A System Architecture Perspective显示文摘 | Chow C Y Mokbel M F | | 0，，02： | 1 |
| 9 | Casper*:query processing for location services without compromising privacy显示文摘 | Chow C Y Mokbel M F Aref W G | 2009 | Acm Transactions on Database Systems2009，34，4： | 1 |
| 10 | Management of gynaecomastia: an update 显示文摘 | Gikas P Mokbel K | 2007 | Int J Clin Pratt2007，61，7： | 1 |
| 11 | Antioxidant and antimicrobial activities of the methanol extracts from pummelo ( Citrus grandis Osbeck) fruit albedo tissues显示文摘 | MOKBEL MS SUGAMUMA T | 2006 | Eur Food Res Technol2006，224，1： | 1 |
| 12 | Could women with systemic lu- pus erythematosus ( SLE ) have successful pregnancy outcomes? Pro- spective observational study 显示文摘 | Mokbel A Geilan AM AboElgheit S | 2013 | The Egyptian Rheumatologist2013，35，2： | 1 |
| 13 | Skin-sparing mastectomy显示文摘 | Cunnick GH Mokbel K | 2004 | Am J Surg2004，188，1： | 1 |
| 14 | Analysis of Multi-Dimensional Space-Filling Curves显示文摘 | Mohamed F. Mokbel Walid G. Aref Ibrahim Kamel | 2003 | GeoInformatica2003，，3： | 1 |
| 15 | The role of cyclooxygenase-2 (COX-2) in breast cancer,and implications of COX-2 inhibition显示文摘 | SinglyRanger G Mokbel K | 2002 | Eur J Surg Onco12002，28，： | 1 |
| 16 | The significance of human telomerase reverse transcriptase(hTERT) in cancer显示文摘 | Kirkpatrick KL Mokbel K | 2001 | Eur J Surg Oncol2001，27，8： | 1 |
| 17 | Management of gynaecomastia:an update显示文摘 | Gikas P Mokbel K | | 0，，07： | 1 |
| 18 | Evaluation of the antioxidant activity of extracts from buntan (Citrus grandis Osbeck) fruit tissues显示文摘 | Mokbel M S Hashinaga F | | 0，，04： | 1 |
| 19 | Spatial cloaking for anonymous location-based services in mobile peer-to-peer environments显示文摘 | Chow C Y Mokbel M F Liu X | 2011 | Geoinformatica2011，15，2： | 1 |
| 20 | Casper* :query proces- sing for location services without compromising privacy 显示文摘 | CHOW C Y MOKBEL M F AREF W G | 2009 | ACM Trans on Database Systems2009，34，4： | 1 |
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