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| 1 | Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response显示文摘AIM: To investigate the co-incidence of apoptosis, autophagy, and unfolded protein response(UPR) in hepatitis B(HBV) and C(HCV) infected hepatocytes.METHODS: We performed immunofluorescence confocal microscopy on 10 liver biopsies from HBV and HCV patients and tissue microarrays of HBV positive liver samples. We used specific antibodies for LC3β, cleaved caspase-3, BIP(GRP78), and XBP1 to detect autophagy, apoptosis and UPR, respectively. AntiHCV NS3 and anti-HBs antibodies were also used to confirm infection. We performed triple blind counting of events to determine the co-incidence of autophagy(LC3β punctuate), apoptosis(cleaved caspase-3), and unfolded protein response(GRP78) with HBV and HCV infection in hepatocytes. All statistical analyses were performed using SPSS software for Windows(Version 16 SPSS Inc, Chicago, IL, United States). P-values < 0.05 were considered statistically significant. Statistical analyses were performed with Mann-Whitney test to compare incidence rates for autophagy, apoptosis, and UPR in HBV- and HCV-infected cells and adjacent noninfected cells.RESULTS: Our results showed that infection of hepatocytes with either HBV and HCV induces significant increase(P < 0.001) in apoptosis(cleavage of caspase-3), autophagy(LC3β punctate), and UPR(increase in GRP78 expression) in the HCV- and HBVinfected cells, as compared to non-infected cells of the same biopsy sections. Our tissue microarray immunohistochemical expression analysis of LC3β in HBV^(Neg) and HBV^(Pos) revealed that majority of HBVinfected hepatocytes display strong positive stainingfor LC3β. Interestingly, although XBP splicing in HBVinfected cells was significantly higher(P < 0.05), our analyses show a slight increase of XBP splicing was in HCV-infected cells(P > 0.05). Furthermore, our evaluation of patients with HBV and HCV infection based on stage and grade of the liver diseases revealed no correlation between these pathological findings and induction of apoptosis, autophagy, and UPR.CONCLUSION: The results of this study indicate that HCV and HBV infection activates apoptosis, autophagy and UPR, but slightly differently by each virus. Further studies are warranted to elucidate the interconnections between these pathways in relation to pathology of HCV and HBV in the liver tissue. | Behzad Yeganeh Adel Rezaei Moghadam Javad Alizadeh Emilia Wiechec Seyed Moayed Alavian Mohammad Hashemi Bita Geramizadeh Afshin Samali Kamran Bagheri Lankarani Martin Post Payam Peymani Kevin M Coombs Saeid Ghavami | 2015 | World Journal of Gastroenterology2015，21，47： | 13 |
| 2 | Fluid Flow and Heat Transfer Modeling of AC Arc in Ferrosilicon Submerged Arc Furnace显示文摘A two-dimensional mathematical model was developed to describe the heat transfer and fluid flow in an AC arc zone of a ferrosilicon submerged arc furnace.In this model,the time-dependent conservation equations of mass,momentum,and energy in the specified domain of plasma zone were numerically solved by coupling with the Maxwell and Laplace equations for magnetic filed and electric potential,respectively.A control volume-based finite difference method was used to solve the governing equations in cylindrical coordinates.The reliability of the developed model was checked by experimental data from the previous available literature.The results of present model were in good agreement with the given data comparing with other models,because of solving the Maxwell and Laplace equations simultaneously in order to calculate current density.In addition,parametric studies were carried out to evaluate the effects of electrical current and arc length on flow field and temperature distribution within the arc.According to the computed results,a lower power input led to a higher arc efficiency. | M Mohebi Moghadam S H Seyedein M Reza Aboutalebi | 2010 | Journal of Iron and Steel Research(International)2010，17，9： | 5 |
| 3 | Comparison of Shear Bond Strength of RMGI and Composite Resin for Orthodontic Bracket Bonding显示文摘 | Yassaei S Davari A Goldani Moghadam M | 2014 | J Dent(Tehran)2014，11，3： | 1 |
| 4 | Optimization of cardiac resynchronization guided by Doppler echocardiography :haemodynamic improvement and intraindividual variability different pacing configurations and atrioventricular delays显示文摘 | STOCKBURGER M FATEH MOGHADAM S NITARDY A | 2006 | Europace2006，8，： | 1 |
| 5 | Simplified forecasting of tight/shale-gas production in line ar flow显示文摘 | NOBAKHT M MATTAR L MOGHADAM S | 2012 | Journal of Canadian Petroleum Technology2012，11，： | 1 |
| 6 | Infinitely many solutions for perturbed difference equations显示文摘 | Moghadam M K Heidarkhani S Henderson J | 2014 | J Differ Equ Appl2014，20，7： | 1 |
| 7 | Catalytic epoxi- dation of olefins with hydrogen peroxide by hybrid complex containing nickel(Ⅲ) Schiff base complex covalently linked to pelyoxometalate 显示文摘 | Mirkhani V Moghadam M Tangestaninejad S | 2008 | Applied Catalysis A:Genera1l2008，334，12： | 1 |
| 8 | Investigation of membrane fouling显示文摘 | Mohammadi T Madaeni S S Moghadam M K | 2003 | Desalination2003，153，3： | 1 |
| 9 | Investigation of membrane fouling显示文摘 | Mohammadi T Sadaeni S S Moghadam M K | 2002 | Desalination2002，153，2： | 1 |
| 10 | Ultrastructure of follicles after vitrification of mouse ovarian tissue显示文摘 | SALEHNIA M ABBASIAN MOGHADAM E REZAZADEH VELOJERDI M | 2002 | Fertil Steril2002，78，3： | 1 |
| 11 | Harmo- ny search based algorithms for the optimum cost design of reinforced concrete cantilever retaining walls 显示文摘 | Poursha M Khoshnoudian F Moghadam A S | 2011 | In- ternational Journal of Civil Engineering2011，9，1： | 1 |
| 12 | Sacroiliitis as an initial presentation of acute lymphoblastic leukaemia显示文摘 | Moghadam A Talebi-Taher M Dehghan A | 2010 | Acta Clin Belg2010，65，3： | 1 |
| 13 | Investigation of membrane fouling显示文摘 | T Mohammadi S S Madaeni M K Moghadam | 2003 | Esalination2003，153，13： | 1 |
| 14 | Determination of CO2 minimum miscibility pressure from measured and predicted equilibrium interfacial tensions显示文摘 | Nobakht M Moghadam S Gu Yongan | 2008 | Industrial & Engineering Chemistry Research2008，47，22： | 1 |
| 15 | 显示文摘 | Montazer M Pakdel E Moghadam M B | 2010 | Fibers and Poly- mers2010，11，7： | 1 |
| 16 | Chemi- cal cleaning of reverse osmosis membranes 显示文摘 | Madaeni S S Mohammadi T Moghadam M K | 2001 | Desalination2001，134，： | 1 |
| 17 | The effect of TiO2 nanoparticles on gas transport properties of Matrimid5218-based mixed matrix membranes显示文摘 | Moghadam F Omidkhah M R Vasheghani-Farahani E | 2011 | Separation and Purification Technology2011，77，1： | 1 |
| 18 | Nano-rod Catalysts: Building MOF Bottles(MIL-101 Family as Heterogeneous Single-site Catalysts) Around Vanadium Oxide Ships显示文摘 | Fazaeli R Aliyan H Moghadam M | 2013 | J Mol Catal A:Chem2013，37，： | 1 |
| 19 | Mild and efficient oxidation of alcohols with sodium periodate catalyzed by polystyrene-bound Mn ( Ⅲ ) porphyrin 显示文摘 | Moghadam M Tangestaninejad S Mirkhani V | 2005 | Bioorg Med Chem2005，13，： | 1 |
| 20 | Application of isogeometric analysis in structural shape optimization显示文摘 | HASSANI B TAVAKKOLI S M MOGHADAM N Z | 2011 | Scientia Iranica2011，18，4： | 1 |
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