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| 1 | NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene-induced colitis through down-regulation of NFκ-B and iNOS显示文摘AIM: To evaluate the efficacy and mechanism of action of NCB-02, a standardized Curcumin preparation, against 2, 4-dinitrochlorobenzene (DNCB)-induced ulcerative colitis in rats. METHODS: Ulcerative colitis was induced in male rats by sensitizing with topical application of DNCB in acetone for 14 d and intra-colonol challenge with DNCB on day 15. A separate group of animals with vehicle treatment in similar fashion served as control group. Colitis rats were divided into different groups and treated with NCB-02 at doses of 25, 50 and 100 mg/kg b.wt p.o. for 10 d. Sulfasalazine at a dose of 100 mg/kg b.wt for 10 d served as a reference group. On day 10 after respective assigned treatment, all the animals were euthanized and the length of the colon, weight of entire colon and distal 8 cm of the colon were recorded. The distal part of the colon was immediately observed under a stereomicroscope and the degree of damage was scored. Further distal 8 cm of the colon was subject to the determination of colonic myeloperoxidase (MPO), lipid peroxidation (LPO) and alkaline phosphatase (ALP) activities. A small piece of the sample from distal colon of each animal was fixed in 10% neutral buffered formalin and embedded in paraffin wax and sectioned for immunohistochemical examination of NFκ-B and iNOS expression. RESULTS: NCB-02 showed a dose dependent protection against DNCB-induced alteration in colon length and weight. NCB-02 treatment also showed a dose dependent protection against the elevated levels of MPO, LPO and ALP, induced by DNCB. NCB-02 demonstrated a significant effect at a dose of 100 mg/kg b.wt., which was almost equipotent to 100 mg/kg b.wt. of sulfasalazine. Treatment with sulfasalazine and curcuminat a dose of 100 mg/kg b.wt. inhibited the DNCB-induced overexpression of NFκ-B and iNOS in the colon. CONCLUSION: Curcumin treatment ameliorates colonic damage in DNCB-induced colitic rats, an effect associated with an improvement in intestinal oxidative stress and downregulation of colonic NFκ-B and iNOS expression. | MV Venkataranganna Md Rafiq S Gopumadhavan Ghouse Peer UV Babu SK Mitra | 2007 | World Journal of Gastroenterology2007，13，7： | 12 |
| 2 | A high yielding mutant of mycobacteriophage L1 and its application as a diagnostic tool显示文摘 | Chatterjee S Mitra M Das Gupta SK | 2000 | FEMS Microbiol Lett2000，188，： | 1 |
| 3 | Integrin-regulated FAK-Src signaling in normal and cancer cells 显示文摘 | Mitra SK Schlaepfer DD | 2006 | Curt Opin Cell Biol2006，18，5： | 1 |
| 4 | IL-22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade 显示文摘 | Mitra A Raychaudhuri SK Raychaudhuri SP | 2012 | Cytokine2012，60，1： | 1 |
| 5 | Staging of cervical cancer with soft computing显示文摘 | Mitra S Pal SK | 2000 | IEEE Trans Biomed Eng2000，47，7： | 1 |
| 6 | Focal adhesion kinase: in eommand and control of cell motility显示文摘 | Mitra SK Hanson DA Schlaepfer DD | 2005 | Nat Rev Mol Cell Biol2005，6，1： | 1 |
| 7 | Differential regulation of cell motility and invasion by FAK显示文摘 | Hsia DA Mitra SK Hauck CR | 2003 | J Cell Biol2003，160，5： | 1 |
| 8 | Control of motile andinvasive cell phenotypes by focal adhesion kinase 显示文摘 | Schlaepfer DD Mitra SK Ilic D | 2004 | Biochim Biophys Acta2004，1692，23： | 1 |
| 9 | Side-to-side lienorenalshunt without splenectomy in noncirrhotic portal hypertension inchildren显示文摘 | Mitra SK Rao KL Narasimhan KL | 1993 | J Pediatr Surg1993，28，3： | 1 |
| 10 | Integrin-regulated FAK-Src signaling in normal and cancer cells显示文摘 | Mitra SK Schlaepfer DD | 2006 | Curr Opin Cell Biol2006，18，5： | 1 |
| 11 | Differential regulation of cell motility and invasion by FAK显示文摘 | Hsia DA Mitra SK Hauck CR | 2003 | J Cell Biol2003，160，5： | 1 |
| 12 | Differential regulation of cell motility and invasion by FAK显示文摘 | Hsia DA Mitra SK Hauck CR | 2003 | J Cell Biol2003，160，5： | 1 |
| 13 | Jointly analyzing gene expr- ession and copy number data in breast cancer using data reduction mo- dels 显示文摘 | Berger JA Hautaniemi S Mitra SK | 2006 | 1EEE/ACM transactions on computational biology and bioin-formatics //IEEE ACM2006，3，1： | 1 |
| 14 | Delay of intracellular calcium transients using a calcium chelator: application to high-throughput screening of the capsaicin receptor ion channel and G-protein-coupled receptors显示文摘 | Grant SK Bansal A Mitra A | 2001 | Anal Biochem2001，294，： | 1 |
| 15 | Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors显示文摘 | Mitra SK Mikolon D Molina JE | | 0，，44： | 1 |
| 16 | Differential regulation of cell motility and invasion by FAK显示文摘 | Hsia DA Mitra SK Hauck CR | 2003 | J Cell Biol2003，160，5： | 1 |
| 17 | Control of motile and invasive cell phenotypes by focal adhesion kinase 显示文摘 | Schlaepfer DD Mitra SK Ilic D | 2004 | Biochim Biophys Acta2004，1692，23： | 1 |
| 18 | Focal adhesion kinase: in command and control of cell motility显示文摘 | Mitra SK Hanson DA Schlaepfer DD | 2005 | Nat Rev Mol Cell Biol2005，6，： | 1 |
| 19 | Fluorinated Diamond Like Carbon as an Electron Field Emission Materi- al 显示文摘 | Ahmed Sk F Mitra M K Chattopadhyay K K | 2009 | J Nanosci Nanotechn2009，9，： | 1 |
| 20 | Intrinsic focal adhesion kinase ac- tivity controls orthotopic breast carcinoma metastasis via the regu- lation of urokinase plasminogen activator expression in a syngeneic tumor model 显示文摘 | Mitra SK Lim ST Chi A | 2006 | Oncogene2006，25，： | 1 |
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