|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Natural orifice transluminal endoscopic surgeryvs laparoscopic ovariectomy:Complications and inflammatory response显示文摘AIM:To compare natural orifice transluminal endoscopic surgery (NOTES) vs standard laparoscopic ovariectomy in mini pigs with respect to technical aspects,complications and parameters of systemic inflammatory response.METHODS:This was a randomized,experimental,survival study.Ten female mini pigs underwent NOTES transgastric ovariectomy (NOTES group) and ten female mini pigs underwent laparoscopic ovariectomy (LAP group).A 'percutaneous endoscopic gastrostomy' approach with guidewire and sphincterotome was used for gastrotomy creation.The ovary was resected using standard biopsy forceps and a snare.The access site was closed using a 'KING' closure with a single endoloop and several clips.In the laparoscopic group,a three-port laparoscopy and an ovariectomy were performed with the use of standard laparoscopic devices.C-reactive protein (CRP),white blood count and interleukin (IL)-6 plasma levels were used as indicators of systemic inflammatory response.All animals were euthanized 28 d after surgery.RESULTS:All animals survived without complications.The mean procedure time was 41.3 min ± 17.6 min (NOTES group) and 25.7 min ± 5.25 min (LAP group,P < 0.02).Postmortem examinations demonstrated that 50% and 70% of animals were free of any complications in the NOTES and LAP groups,respectively.The remaining animals developed minor complications (adhesions) in a comparable frequency between the two groups.In the NOTES group,one animal developed a small intramural gastric abscess close to the gastrotomy site.A minor serous exudate that was present in 50% and 40% of the animals in the NOTES and laparoscopy groups,respectively,was not considered a complication.In both groups CRP levels increased significantly on the 2nd and 7th postoperative days (POD) and returned to normal after 28 d.On POD 2,an increase of CRP level was significantly higher in the NOTES group compared to the LAP group.Values of IL-6 did not differ from baseline values in either of the groups postoperatively.Interestingly,the platelet count decreased significantly on POD 2,but returned close to baseline values on POD 7 and PODs 28-30.CONCLUSION:Both NOTES and laparoscopic ovariectomies had a similar frequency of minor complications.However,the NOTES technique produced an increased systemic inflammatory response on POD 2. | Jan Martínek Ondej Ryska Tereza Filípková Radek Dolezel Stefan Juhas Jan Motlík Monika Holubová Vladimír Nosek Barbora Rotnáglová Miroslav Zavoral Miroslav Ryska | 2012 | World Journal of Gastroenterology2012，18，27： | 4 |
| 2 | Molecular modulation of autophagy: New venture to target resistant cancer stem cells显示文摘Autophagy is a highly regulated catabolic process in which superfluous,damaged organelles and other cytoplasmic constituents are delivered to the lysosome for clearance and the generation of macromolecule substrates during basal or stressed conditions.Autophagy is a bimodal process with a context dependent role in the initiation and the development of cancers.For instance,autophagy provides an adaptive response to cancer stem cells to survive metabolic stresses,by influencing disease propagation via modulation of essential signaling pathways or by promoting resistance to chemotherapeutics.Autophagy has been implicated in a cross talk with apoptosis.Understanding the complex interactions provides an opportunity to improve cancer therapy and the clinical outcome for the cancer patients.In this review,we provide a comprehensive view on the current knowledge on autophagy and its role in cancer cells with a particular focus on cancer stem cell homeostasis. | Harpreet K Mandhair Miroslav Arambasic Urban Novak Ramin Radpour | 2020 | World Journal of Stem Cells2020，12，5： | 2 |
| 3 | Derivatives of (Pheylsulfanyl)benzoic Acids with MultipleAntileukotrienic Activity 显示文摘 | MIROSLAV K VOJT CHCH K VLADIMfRA P | 2004 | Collect Czech Chem Commun2004，69，： | 1 |
| 4 | Learning in the Presence of Con-cept Drift and Hidden Contexts 显示文摘 | Gerhard W Miroslav K | 1996 | Machine Learning1996，23，1： | 1 |
| 5 | Impact of ozonation on the genotoxic activity of tertiary treated municipal wastewater显示文摘 | Miroslav Misika S K F F | 2011 | Water Research2011，45，12： | 1 |
| 6 | Methyl jasmonate and echinothrips americanus regulate coumarin accumulation in leaves of Matricaria chamomilla显示文摘 | Miroslav Rep?ák Martin Suvák | 2013 | Biochem Syst Ecol2013，47，8： | 1 |
| 7 | Potent protection of gallic acid against DNA oxidation: Results of human and animal experiments显示文摘 | Franziska Ferk Asima Chakraborty Walter J?ger Michael Kundi Julia Bichler Miroslav Mi?ík Karl-Heinz Wagner Bettina Grasl-Kraupp Sandra Sagmeister Gerald Haidinger Christine Hoelzl Armen Nersesyan Maria Du?inská Tatjana Simi? Siegfried Knasmüller | 2011 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2011，，1： | 1 |
| 8 | The influence of Cr and Ce additions on the mechanical properties of Fe3Al based alloys 显示文摘 | Miroslav C Miroslav K Martin B | 2002 | Material Science and Engineering2002，324，： | 1 |
| 9 | Standardised uptake value of 18F-FDG on staging PET/ CT in newly diagnosed patients with different subtypes of non- Hodgkin' s lymphoma显示文摘 | Toma' sv Papajl'k Miroslav Myslivec v ek Zuzana Sv edova' | 2011 | Eur J Haematol2011，86，1： | 1 |
| 10 | Exact reliability formula and bounds for general k-out-of-n systems 显示文摘 | Miroslav K | 2003 | Reliability Engineering and Safety2003，82，2： | 1 |
| 11 | The interaction of natural ageing with straining in a twin-roll cast AlMgSi automotive sheet 显示文摘 | Yucel B Miroslav K | 2006 | Scripta Materialia2006，55，7： | 1 |
| 12 | Experimental tests of selected constituents of movement resistance of the belt conveyors used in the underground mining显示文摘 | MIROSLAV B ROBERT K | 2015 | Procedia Earth and Planetary Science2015，15，： | 1 |
| 13 | Control Lyapunov functions for adaptive nonlinear stabilization显示文摘 | MIROSLAV K PETAR V K | 1995 | Systems & Control Letters1995，26，1： | 1 |
| 14 | Models for glycosidic juvenogens: Enzymic formation of selected alkyl-β-D-glucopyranosides and alkyl-β-D-galactopyranosides under microwave irradiation显示文摘 | Marie Zarevúcka Miroslav Vacek Zdeněk Wimmer Christine Brunet Marie-Dominique Legoy | 1999 | Biotechnology Letters1999，，9： | 1 |
| 15 | The influence of Cr and Ce additions on the mechanical properties of Fe3Al based alloys 显示文摘 | Miroslav C Miroslav K Martin B | 2002 | Materials Science and Engineering2002，324，： | 1 |
| 16 | Nonlinear design of adaptive controllers for linear systems显示文摘 | MIROSLAV K IOANNIS K P PETAR V K | 1994 | IEEE Transactions on Automatic Control1994，39，4： | 1 |
| 17 | Selective enzymic esterification of free fatty acids with n-butanol under microwave irradiation and under classical heating显示文摘 | Miroslav Vacek Marie Zarevúcka Zdeněk Wimmer Karel Stránsky Kate?ina Demnerová Marie-Dominique Legoy | 2000 | Biotechnology Letters2000，，19： | 1 |
| 18 | Compensation of state-dependent input delay for nonlinear systems显示文摘 | NIKOLAOS B L MIROSLAV K | 2013 | IEEE Transactions on Automatic Control2013，58，2： | 1 |
| 19 | Use of local measurements to estimate voltage-stability margin显示文摘 | MIROSLAV K V BEGOVIC M NOVOSEL D | 1999 | IEEE Transactions on Power Systems1999，14，3： | 1 |
| 20 | Diversity of foliar endophytes in wind-fallen Picea abies trees显示文摘The unmanaged Norway spruce montane forests in the Bohemian Forest National Park(Czech Republic)suffered from repeated large-scale bark beetle outbreaks in last decade.In this study,the diversity of culturable foliar endophyte microfungi in needles originating from eleven recently wind-fallen trees in this area was surveyed.Our aims were to describe their diversity and to determine the relative host and organ specificities of isolated endophyte species to estimate the species pool and abundance of foliar endophytes before the forest degradation.Microfungi were isolated from surface-sterilized needles,and the outgrowing strains were identified based on morphological and molecular characteristics(analyses of ITS1,ITS2 and partial 28S rDNA).Fungal communities in the needles were diverse,with ascomycetes(mostly anamorphs of Helotiales)dominating basidiomycetes.The most frequent species(Phacidiopycnis sp.,Cistella acuum,Sirococcus sp.and two species of Chalara)did not correspond with those recorded in previous studies of Picea spp.For example,the widely distributed Lophodermium piceae was rarely recorded in this study.This pattern may be caused by different methods of sterilization and cultivation or by physiological characteristics of the needles,or it may reflect the species distribution in the studied area.Members of the Helotiales,along with sequences from GenBank,showed substantial overlap in host affinities,most prominently between Pinus and Picea,and also among species from distant plant lineages. | Ondřej Koukol Miroslav Kolařík Zuzana Kolářová Petr Baldrian | 2012 | Fungal Diversity2012，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员