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| 1 | Ferroptosis is an autophagic cell death process显示文摘Ferroptosis 是调整坏死的一种铁依赖者形式。它在各种各样的人的疾病被含有,包括 ischemic 机关损坏和癌症。这里,我们报导 autophagy 的关键角色,特别地细胞的铁存储蛋白质(作为 ferritinophagy 知道的一个过程) 的 autophagic 降级,在 ferroptosis。用 RNAi,屏蔽结合了随后的基因分析,我们作为 ferroptosis 的积极管理者识别了多重 autophagy 相关的基因。Ferroptosis 正式就职导致了 autophagy 激活和 ferritin 和 ferritinophagy 货物受体 NCOA4 的作为结果的降级。一致地,由 autophagy 的阻塞的 ferritinophagy 的抑制或废除的 NCOA4 击倒联系 ferroptosis 的细胞的易变的铁的累积和反应的氧种类,以及最终的 ferroptotic 细胞死亡。因此, ferroptosis 是一个 autophagic 房间死亡过程,并且调停 NCOA4 的 ferritinophagy 由控制细胞的铁动态平衡支持 ferroptosis。 | Minghui Gao Prashant Monian Qiuhui Pan Wei Zhang Jenny Xiang Xuejun Jiang | 2016 | Cell Research2016，26，9： | 138 |
| 2 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 3 | MEKK1, MKK1/MKK2 and MPK4 function together in a mitogen-activated protein kinase cascade to regulate innate immunity in plants显示文摘激活 Mitogen 的蛋白质 kinase (MAPK ) 串联在调整植物起重要作用天生的有免疫力的回答。在到为有组成的防卫回答的异种的搜索的一幅基因屏幕,我们识别了展出房间死亡和组成的防卫回答的 mpk4 和 mekk1 的多重等位基因。双分子的荧光互补(BiFC ) 分析证明 MPK4 和 MEKK1 与 MKK1 和 MKK2 交往,二密切相关的 MAPK kinases。mkk1 和 mkk2 单身者异种植物没有明显的变异的显型。测试 MKK1 和 MKK2 是否冗余地工作, mkk1 mkk2 两倍异种被产生。mkk1 mkk2 两倍变异的植物在幼苗舞台和幼苗致命性显型死是温度依赖者。类似于 mpk4 和 mekk1 异种,两倍变异的幼苗积累的 mkk1 mkk2 H2O2 高级,显示自发的房间死亡,联系的组成地快速的致病(PR ) 基因和展览病原体抵抗。另外,由 flg22 的 MPK4 的激活在 mkk1 mkk2 被损害两倍异种,在地图 kinase 串联和 MPK4 和 MEKK1 建议那 MKK1 和 MKK2 功能否定地在植物调整天生的有免疫力的回答。 | Minghui Gao Jinman Liu Dongling Bi Zhibin Zhang Fang Cheng2, Sanfeng Chen Yuelin Zhang | 2008 | Cell Research2008，18，12： | 37 |
| 4 | Crustal velocity structure in the Emeishan large igneous province and evidence of the Permian mantle plume activity显示文摘The Emeishan large igneous province(ELIP) in SW China is interpreted to be associated with an ancient mantle plume. Most of the constraints on the role of mantle plume in the generation of the Emeishan flood basalts were provided by geological and geochemical methods, but the geophysical investigation is very limited. In order to better understand the deep structure and features of ELIP, we have studied the crustal velocity structure using the data acquired from the Lijiang-Panzhihua-Qingzhen wide-angle seismic profile. This profile crosses the three sub-zones of the ELIP(the inner, intermediate, and outer zones), divided based on the differential erosion and uplift of the Maokou limestone. The results provided by the active source seismic experiment demonstrate:(1) The average depth of the crystalline basement along the profile is about 2 km.(2) The middle crust in the Inner Zone is characterized by high-velocity anomalies, with the average velocity of 6.2-6.6 km/s, which is about 0.1– 0.2 km/s higher than the normal one. The velocity of the lower crust in the inner zone is 6.9-7.2 km/s, higher than those observed in the intermediate and outer zones(6.7-7.0 km/s). Relatively low velocity anomalies appear in the upper, middle and lower crusts near the junction of the inner zone and intermediate zone, probably due to the effect of the Xiaojiang fault(XJF).(3) The average velocity of the crust is comparatively low on both sides of XJF, especially on the east side, and the average velocity of the consolidated continental crust is also low there. This may suggest that the XJF extends at least down to 40 km deep, even beyond through the crust.(4) The depth to the Moho discontinuity decrease gradually from 47-53 km in the inner zone, via 42-50 km in the intermediate zone to 38-42 km in the outer zone. In the inner zone, the Moho uplifts locally and the(consolidated) crust is characterized by high-velocity anomalies, which are likely related to intensive magma intrusion and underplating associated with melting of plume head. Overall the crustal velocity structure in the study area recorded the imprint left by the Permian Emeishan mantle plume. | XU Tao ZHANG ZhongJie LIU BaoFeng CHEN Yun ZHANG MingHui TIAN XiaoBo XU YiGang TENG JiWen | 2015 | Science China Earth Sciences2015，58，7： | 36 |
| 5 | Component analysis of Chinese medicine and advances in fuming-washing therapy for knee osteoarthritis via unsupervised data mining methods显示文摘OBJECTIVE: To analyze the component law of Chinese medicines in fuming-washing therapy for knee osteoarthritis(KOA), and develop new fuming-washing prescriptions for KOA through unsupervised data mining methods.METHODS: Chinese medicine recipes for fuming-washing therapy for KOA were collected and recorded in a database. The correlation coefficient among herbs, core combinations of herbs, andnew prescriptions were analyzed using modified mutual information, complex system entropy cluster, and unsupervised hierarchical clustering, respectively.RESULTS: Based on analysis of 345 Chinese medicine recipes for fuming-washing therapy, 68 herbs occurred frequently, 33 herb pairs occurred frequently, and 12 core combinations were found.Five new fuming-washing recipes for KOA were developed.CONCLUSION: Chinese medicines for fuming-washing therapy of KOA mainly consist of wind-dampness-dispelling and cold-dispersing herbs, blood-activating and stasis-resolving herbs,and wind-dampness-dispelling and heat-clearing herbs. The treatment of fuming-washing therapy for KOA also includes dispelling wind-dampness and dispersing cold, activating blood and resolving stasis, and dispelling wind-dampness and clearing heat. Zhenzhutougucao(Herba Speranskiae Tuberculatae), Honghua(Flos Carthami), Niuxi(Radix Achyranthis Bidentatae), Shenjincao(Herba Lycopodii Japonici), Weilingxian(Radix et Rhizoma Clematidis Chinensis), Chuanwu(Radix Aconiti), Haitongpi(Cortex Erythrinae Variegatae), Ruxiang(Olibanum),Danggui(Radix Angelicae Sinensis), Caowu(Radix Aconiti Kusnezoffii), Moyao(Myrrha), and Aiye(Folium Artemisiae Argyi) are the main herbs used in the fuming-washing treatment for KOA. | Jun Liu Jianke Pan Yanping Wang Dingkun Lin Dan Shen Hongjun Yang Xiang Li Minghui Luo Xuewei Cao | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 32 |
| 6 | Statistics-based Optimization of the Polarimetric Radar Hydrometeor Classification Algorithm and Its Application for a Squall Line in South China显示文摘A modified hydrometeor classification algorithm(HCA) is developed in this study for Chinese polarimetric radars. This algorithm is based on the U.S. operational HCA. Meanwhile, the methodology of statistics-based optimization is proposed including calibration checking, datasets selection, membership functions modification, computation thresholds modification,and effect verification. Zhuhai radar, the first operational polarimetric radar in South China, applies these procedures. The systematic bias of calibration is corrected, the reliability of radar measurements deteriorates when the signal-to-noise ratio is low, and correlation coefficient within the melting layer is usually lower than that of the U.S. WSR-88D radar. Through modification based on statistical analysis of polarimetric variables, the localized HCA especially for Zhuhai is obtained,and it performs well over a one-month test through comparison with sounding and surface observations. The algorithm is then utilized for analysis of a squall line process on 11 May 2014 and is found to provide reasonable details with respect to horizontal and vertical structures, and the HCA results—especially in the mixed rain–hail region—can reflect the life cycle of the squall line. In addition, the kinematic and microphysical processes of cloud evolution and the differences between radardetected hail and surface observations are also analyzed. The results of this study provide evidence for the improvement of this HCA developed specifically for China. | Chong WU Liping LIU Ming WEI Baozhu XI Minghui YU | 2018 | Advances in Atmospheric Sciences2018，35，3： | 32 |
| 7 | The application of large volume airgun sources to the onshore-offshore seismic surveys: implication of the experimental results in northern South China Sea显示文摘Onshore-offshore seismic experiments were carried out for the first time in northern South China Sea using large volume airgun sources at sea and seismic stations on land. The experimental results indicate that seismic signals from the new airgun array of R/V Shiyan 2 can be detected as far as 255 km. The signal effective area reaches nearly 50000 km2, which covers Hong Kong and Pearl River Delta. Compared with the old airgun array, the signal amplitude, propagation distance and effective area of the new airgun array have been increased notably, which demonstrates that the upgrade of the airgun source was successful. Comparisons with previous experimental results in other regions show that the shooting effect of the new airgun array is similar to those best airgun sources in the world. Especially, it is a new breakthrough in using the permanent seismic stations onshore to record long distance airgun signals offshore, which has great significance to the realization of the 'seismic radar' concept and the 3D seismic surveys of crustal structure in coastal areas. | QIU XueLin CHEN Yong ZHU RiXiang XU HuiLong SHI XiaoBin YE ChunMing ZHAO MingHui XIA ShaoHong | 2007 | Chinese Science Bulletin2007，52，4： | 27 |
| 8 | Distribution of polycyclic aromatic hydrocarbons in sediments from Yellow River Estuary and Yangtze River Estuary,China显示文摘Surface sediment samples collected from twenty-one sites of Yellow River Estuary and Yangtze River Estuary were determined for sixteen priority polycyclic aromatic hydrocarbons (PAHs) by isotope dilution GC-MS method. The total PAH contents varied from 10.8 to 252 ng/g in Yellow River Estuary sediment, and from 84.6 to 620 ng/g in Yangtze River Estuary sediment. The mean total PAH content of Yangtze River Estuary was approximately twofold higher than that of Yellow River Estuary. The main reasons for the difference may be the rapid industrial development and high population along Yangtze River and high silt content of Yellow River Estuary. The evaluation of PAH sources suggested that PAHs in two estuaries sediments estuaries were derived primarily from combustion sources, but minor amounts of PAHs were derived from petroleum source in Yellow River Estuary. PAHs may be primary introduced to Yellow River Estuary via dry/wet deposition, wastewater effuents, and accidental oil spills, and Yangtze River Estuary is more prone to be affected by wastewater discharge. | HUI Yamei ZHENG Minghui LIU Zhengtao GAO Lirong | 2009 | Journal of Environmental Sciences2009，21，12： | 24 |
| 9 | Laser cleaning of steel structure surface for paint removal and repaint adhesion显示文摘Paint removal from steel structure is executed for shipyards of marine and offshore engineering.Due to environmental unfriendliness and unhealthy drawbacks of sand blasting technique, laser ablation technique is proposed as a substituting method.By absorbing high energy of the 1064 nm pulsed laser, the paint is vaporized quickly.The ablated debris is then collected by using a suction pump.Initial metal surface of the steel is exposed when laser beam irradiates perpendicularly and scans over it.The cleaned surface fulfills the requirements of surface preparation standards ISO 8501 of SA2.The adhesion is further characterized with pull-off test after carrying out painting with Jotamastic 87 aluminum paint.The repainting can be embedded onto the laser cleaned surface to bond much more tightly.The excellent adhesion strength of 20 MPa between repainted coating and the substrate is achieved, which is higher than what is required by shipyards applications. | Xiaoguang Li Tingting Huang Ang Wei Chong Rui Zhou Yoo Sang Choo Minghui Hong | 2017 | 光电工程2017，44，3： | 24 |
| 10 | The South China Sea is not a mini-Atlantic: plate-edge rifting vs intra-plate rifting显示文摘The South China Sea,as‘a non-volcanic passive margin basin’in the Pacific,has often been considered as a small-scale analogue of the Atlantic.The recent ocean drilling in the northern South China Sea margin found,however,that the Iberian model of non-volcanic rifted margin from the Atlantic does not apply to the South China Sea.In this paper,we review a variety of rifted basins and propose to discriminate two types of rifting basins:plate-edge type such as the South China Sea and intra-plate type like the Atlantic.They not only differ from each other in structure,formation process,lifespan and geographic size,but also occur at different stages of the Wilson cycle.The intra-plate rifting occurred in the Mesozoic and gave rise to large oceans,whereas the plate-edge rifting took place mainly in the mid-Cenozoic,with three-quarters of the basins concentrated in the Western Pacific.As a member of the Western Pacific system of marginal seas,the South China Sea should be studied not in isolation on its origin and evolution,but in a systematic context to include also its neighboring counterparts. | Pinxian Wang Chi-Yue Huang Jian Lin Zhimin Jian Zhen Sun Minghui Zhao | 2019 | National Science Review2019，6，5： | 24 |
| 11 | Exosomes containing miR-21 transfer the characteristic of cisplatin resistance by targeting PTEN and PDCD4 in oral squamous cell carcinoma显示文摘 | Tao Liu Gang Chen Dawei Sun Minghui Lei Yongqiang Li Changming Zhou Xiaodong Li Wei Xue Hong Wang Chunjun Liu Jiang Xu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，9： | 22 |
| 12 | The implementation of an improved NPML absorbing boundary condition in elastic wave modeling显示文摘在向前当模特儿的有弹性的波浪,吸收边界条件(ABC ) 被用来从模型截断边界减轻不希望得到的思考。完美地匹配的层(PML ) 证明了是最好的可得到的 ABC。然而,传统的切开 PML (SPML ) ABC 有一些严肃的劣势:例如,全球 SPML ABC 要求更多计算记忆,尽管实现是容易的。本地 SPML ABC 的实现也有一些困难,自从边和角落必须被考虑。因为卷绕旋转,传统的非切开的完美地匹配的层(NPML ) ABC 有复杂计算。在这篇论文,基于 ABC 与复杂转移频率的拉长函数(CFS ) 相结合的非切开的完美地匹配的层(NPML ) ,我们为与简单计算方程,小存储器要求,和容易的编程吸收边界条件的 PML 介绍一个新奇数字实现方法。 | Qin Zhen Lu Minghui Zheng Xiaodong Yao Yao Zhang Cai Song Jianyong | 2009 | Applied Geophysics2009，6，2： | 21 |
| 13 | COMPARISONS OF LOW CARBON POLICIES IN SUPPLY CHAIN COORDINATION显示文摘This paper investigates the influence of low-carbon policies on channel coordination for a two-echelon supply chain consisting of one supplier and one retailer.Four different models are considered:the basic model,the carbon emission model,the carbon emission trading model and the carbon tax model.We find that the government policy on all carbon emission models is not universal among the firms as well as the customers.The carbon emission trading policy is always better than the carbon emission policy and the carbon tax policy when the allocated carbon emission quotas are greater than the carbon emissions.The carbon emission trading policy is proved to be an effective mechanism which can motivate the supply chain to reduce carbon emissions.Under certain conditions,the supply chain prefers the carbon emission trading policy with higher carbon price to other policies.In the framework of Stackelberg game with the supplier as the leader,for each carbon policy,the paper presents coordination mechanism with the all-unit wholesale quantity discount contract(AWQD).We analyze and compare the influence of low-carbon policies on channel coordination for the four low-carbon policies.Numerical experiments are conducted to examine our findings. | Lei YANG Chenshi ZHENG Minghui XU | 2014 | Journal of Systems Science and Systems Engineering2014，23，3： | 20 |
| 14 | Temporo-spatial Coordinates of Evolution of the Ordos Basin and Its Mineralization Responses显示文摘摘要:Ordos 盆被开发从中间迟了对早白垩纪三叠纪,然后自从迟了的白垩纪,进入了它的以后的改革时期。它的主要身体忍受 intra-cratonic 盆的特征。盆也属于在大规模盆上重叠了的多迭加的盆早并且晚古生代。当前, Ordos 盆成为了剩余盆各种各样的式样的富有经验的改革自从迟了的白垩纪。它建议了有在盆的进化期间存在的构造变丑的至少四个明显的阶段,把进化和沉积划分成四个阶段。优先二个阶段具有最繁荣,在哪个期间湖盆是宽广的,免职范围多于比当前的剩余盆两次大,导致主要含有石油、忍受煤的阶层。二个阶段被分开由地区性高举在区域的变化。在 Yan'an 阶段的结束, depositional 打断和侵蚀正在持续时间的一个短时期。第三是中间 -- 侏罗记并且 Zhiluo 舞台,沉积程度仍然在是宽广的但是湖区域显然被减少。在迟了的侏罗记构造变丑是集中的。当不同厚度的集团企业在东方方面的 foredeep 以内被积累时,一条戳越过水坝落下的水带在盆的西方的边缘上被形成。盆的中央、东方的部分服从于侵蚀和改革。一个地区性的框架与在西方在东方和消沉高举黄河向西在区域形成了。在早白垩纪,沉积广泛地被散布, unconformably 重叠北、南部的边阶上的以前的西方的边缘戳带和山脉。象在 Ordos 盆形成的油,天然气,煤和铀存款那样有丰富的精力资源。产生的主要阶段,矿化作用并且资源有明显的反应的多重精力放在 Ordos 中生代和新生代进化和改革与那些联合关系的连接和结束盆。 | LIU Chiyang ZHAO Hongge ZHAO Junfeng WANG Jianqiang ZHANG Dongdong YANG Minghui | 2008 | Acta Geologica Sinica(English Edition)2008，82，6： | 20 |
| 15 | Alkaline modification of ZSM-5 catalysts for methanol aromatization: The effect of the alkaline concentration显示文摘ZSM-5 催化剂的物理性质上并且在他们为到 aromatics 变换的甲醇的活动的碱的处理的效果被调查了。一个温和碱的处理(0.2 和 0.3 mol/L NaOH ) 在酸味上没有明显的效果在父母沸石创造了 mesopores。mesopores 的存在为 aromatics 给催化剂更长的一生和更高的选择。有 0.4 mol/L NaOH 的处理减少了 Br 的数字 ? nsted 酸地点由于 dealumination 和 desilication,它导致了更低的释放率。另外,更多的 mesopores 比与温和碱的处理被生产。作为结果,与 0.4 mol/L NaOH 对待的样品的一生是乘父母 ZSM-5 的的几乎五。有更高碱的集中(0.5 mol/L ) 的处理极大地减少了 Br 的数字 ? nsted 酸地点和导致不完全的甲醇变换的 micropores 的数字。当碱对待的催化剂与酸被洗时,一些孔被恢复,为 aromatics 的选择的细微增加被获得。 | Zhenhao Wei Tengfei Xia Minghui Liu Qingsheng Cao Yarong Xu Kake Zhu Xuedong Zhu | 2015 | Frontiers of Chemical Science and Engineering2015，9，4： | 18 |
| 16 | Characteristics of the crustal structure and hypocentral tectonics in the epicentral area of Nan'ao earthquake (M7.5), the northeastern South China Sea显示文摘1918 Nan’ao earthquake (M7.5) occurred in the northeast coastal areas of Guangdong Province. With the seismogeological survey of the epicentral area and history materials analyses, the earthquake epicenter was estimated to locate in the intersection part of the Binhai fault zone (Littoral) and Huanggangshui fault, which strikes NEE and NW, respectively. The activities of the NEE-striking thrust fault and NW-striking extensional fault that were attributed to 1918 Nan’ao earthquake occurred in the Dongshan Island of the epicentral area; they reflected the focal stress field with compression in NW-SE direction and extension in NE-SW direction. The isoseismal contour of seismic intensity X shows a shape of ‘X’ composed of two mutually overlapping ellipses with two axes striking NEE and NW, respectively, and such shape implies that the occurrence of this earthquake is controlled by a pair of conjugate seismotectonic faults constituted by the NEE-striking Binhai fault zone and the NW-striking Huanggangshui fault. The Binhai fault zone is a dominant seismogenic structure, and the NW-striking Huanggangshui fault is the subdominant one. The onshoreoffshore deep seismic profile that crossed the epicentral area and was perpendicular to the strike of the Binhai fault zone was obtained. According to the analyses of the seismic data, the Binhai fault zone is defined as a low velocity zone with SE dip-slip in thecrustal structure section. The Binhai fault zone is a boundary fault between the South China subplate and South China Sea subplate. The crust structure on the northwest side of Binhai fault zone is a normal continental crust with a thickness of 30 km, and the one on the southeast side of the fault zone is a thinning continental crust with a thickness of 25―28 km. The Binhai fault zone is an important seismogenic fault and also is an earthquake-controlling fault. The intersection part between the Binhai fault zone and the low velocity zone of upper crust is advantageous to stress concentration and strain energy accumulation, and presents the deep dynamic conditions for the earthquake’s pregnancy and occurrence. | XU Huilong QIU Xuelin ZHAO Minghui SUN Jinlong ZHU Junjiang | 2006 | Chinese Science Bulletin2006，51，B12： | 17 |
| 17 | Design and fabrication of broadband ultralow reflectivity black Si surfaces by laser micro/nanoprocessing显示文摘Light collection efficiency is an important factor that affects the performance of many optical and optoelectronic devices.In these devices,the high reflectivity of interfaces can hinder efficient light collection.To minimize unwanted reflection,anti-reflection surfaces can be fabricated by micro/nanopatterning.In this paper,we investigate the fabrication of broadband anti-reflection Si surfaces by laser micro/nanoprocessing.Laser direct writing is applied to create microstructures on Si surfaces that reduce light reflection by light trapping.In addition,laser interference lithography and metal assisted chemical etching are adopted to fabricate the Si nanowire arrays.The anti-reflection performance is greatly improved by the high aspect ratio subwavelength structures,which create gradients of refractive index from the ambient air to the substrate.Furthermore,by decoration of the Si nanowires with metallic nanoparticles,surface plasmon resonance can be used to further control the broadband reflections,reducing the reflection to below 1.0%across from 300 to 1200 nm.An average reflection of 0.8%is achieved. | Jing Yang Fangfang Luo Tsung Sheng Kao Xiong Li Ghim Wei Ho Jinghua Teng Xiangang Luo Minghui Hong | 2014 | Light(Science & Applications)2014，3，1： | 17 |
| 18 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 19 | Early Serum HBsAg Kinetics as Predictor of HBsAg Loss in Patients with HBeAg-Negative Chronic Hepatitis B after Treatment with Pegylated Interferonα-2a显示文摘Hepatitis B surface antigen(HBsAg)loss is an ideal treatment endpoint for patients with chronic hepatitis B(CHB).We investigated the predictive value of on-treatment HBsAg levels for HBsAg loss in hepatitis B e antigen(HBe Ag)-negative CHB patients who received 120-week PEG-IFNα-2a treatment.Serum HBV DNA,HBsAg,and anti-HBs levels were assayed at baseline and every 3 months during the treatment.Of 81 patients,12 achieved HBsAg loss,20 achieved HBsAg\100 IU/mL,and 49 maintained HBs Ag C 100 IU/mL.HBsAg loss rate was only 3.7%at 48 weeks,while it reached to 11.1%and 14.8%after treatment of 96 weeks and 120 weeks.The cutoff HBs Ag levels at 12 weeks predicting HBsAg loss at 96 weeks and 120 weeks of treatment were 400 IU/mL and 750 IU/mL,with AUC 0.725 and 0.722,positive predictive value(PPV)29.41%and 30.56%,and negative predictive value(NPV)93.75%and 97.78%,respectively.The cutoff HBsAg levels at 24 weeks predicting HBsAg loss at 96 weeks and 120 weeks of treatment were 174 IU/m L and 236 IU/mL respectively,with AUC 0.925 and 0.922,PPV 40.0%and 46.15%,and both NPV 100%.The predictive ability of the cutoff HBsAg levels at 24 weeks was better than that at 12 weeks for HBs Ag loss at either 96 or 120 weeks(χ~2=3.880,P=0.049 andχ~2=4.412,P=0.036).These results indicate that extended therapy is critical to HBsAg loss in HBe Ag-negative CHB patients during PEG-IFN treatment,and the HBsAg level at 24 weeks can be used to predict HBsAg loss during tailoring PEG-IFN therapy. | Minghui Li Lu Zhang Yao Lu Qiqi Chen Huihui Lu Fangfang Sun Zhan Zeng Gang Wan Linqing Zhao Yao Xie | 2021 | Virologica Sinica2021，36，2： | 15 |
| 20 | f-heredity knowledge and f-heredity mining显示文摘Using S-rough sets, this paper gives the concepts of f-heredity knowledge and its heredity coefficient, and f-variation coefficient of knowledge; presents the theorem of f-attribute dependence of variation coefficient and the relation theorem of heredity-variation. The attribute dependence of f-variation coefficient and the relation of heredity-variation are important characteristics of S-rough sets. From such discussion, this paper puts forward the heredity mining of f-knowledge and the algorithm of heredity mining, also gives its relative application. | Cui Minghui Shi Kaiquan | 2006 | Journal of Systems Engineering and Electronics2006，17，4： | 14 |
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