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| 1 | 日本东北9.0级地震的同震与震后滑动显示文摘大部分强震都发生在海沟,那里是海洋板块向大陆板块俯冲的地方。大量矩震级MW9.0以上的地震发生在若干区域,包括智利,阿拉斯加,堪察加半岛和苏门答腊岛等。位于太平洋板块俯冲鄂霍茨克板块的日本海沟,历史记载上没有发生过MW9.0地震,除了至今震级还有争议的公元869年Jogan大地震[1](可能超过MW9.0)。然而,根据最新的大地测量资料估算的应变积累速率比已发生的板块间地震的平均释放速率要高[2~6]。这一发现又引发了这样的疑问:这些区域如何释放积累的应变。2011年3月11日发生的逆冲型MW9.0强震(下文中均称为日本东北大地震),撕裂了日本东北部的太平洋海岸板块边界。我们报道根据GPS网络监测到的地表位移确定的同震与震后滑动特征。同震滑移区域沿日本海沟方向长约400 km,与震前闭锁区域基本吻合[4]。震后滑动不仅覆盖了同震滑移区域,而且扩展到了其邻区,甚至其影响已经达到100 km深度区域,引起2011年3月25日的MW8.3地震。由于东北地震释放了积累数百年的应变,之前提到的应变积累与释放不平衡的问题可能得到部分解释。这次东北地震同时也提醒我们,即使在过去没有发生过强震的其它海沟地区,也有发生MW9.0强震的潜在危险。因此,利用空间对地形变观测技术监测应变积累,以确定强震潜在危险区是非常重要的。 | Shinzaburo Ozawa Takuya Nishimura Hisashi Suito Tomokazu Kobayashi Mikio Tobita Tetsuro Imakiire 张慧(译) 焦明若(校) | 2011 | 华南地震2011，31，3： | 30 |
| 2 | Clinical significance of serum procalcitonin in patients with ulcerative colitis显示文摘AIM:To investigate the association of procalcitonin(PCT)with ulcerative colitis(UC)activity.METHODS:Serum PCT levels,C-reactive protein(CRP)levels,the erythrocyte sedimentation rate,and the white blood cell count were analyzed in 18 patients with UC and 11 healthy volunteers.Serum PCT levels were analyzed by an electrochemiluminescence immunoassay.Severity assessments were based on Truelove and Witts’severity index.Correlation of serum PCT and CRP levels with UC activity was examined.Moreover,we assessed serum PCT and CRP levels in patients with a Mayo endoscopic subscore.RESULTS:Serum PCT levels in severe UC patients(n=7)(0.096±0.034 ng/mL)were significantly higher than in mild-to-moderate UC patients(n=11)(0.033±0.012 ng/mL)and healthy volunteers(n=11)(0.035±0.005 ng/mL)(P=0.0005 and P<0.0001,respectively).In addition,there was no difference in serum PCT levels between mild-to-moderate UC patients and healthy volunteers.Interestingly,patients with a Mayo endoscopic subscore of 3 points displayed significantly increased levels of serum PCT(0.075±0.043 ng/mL)compared with patients with a subscore of 2 points(0.03±0.011 ng/mL)(P=0.0302).Moreover,CRP levels in patients with severe UC or a Mayo endoscopic subscore of 3 points were not significantly higher than in patients with mild-to-moderate UC or a Mayo endoscopic subscore of 3 points.CONCLUSION:Serum PCT levels were significantly correlated with UC activity. | Shigeo Koido Toshifumi Ohkusa Kazuki Takakura Shunichi Odahara Shintaro Tsukinaga Toyokazu Yukawa Jimi Mitobe Mikio Kajihara Kan Uchiyama Hiroshi Arakawa Hisao Tajiri | 2013 | World Journal of Gastroenterology2013，19，45： | 15 |
| 3 | Herbal cardiotonic pills prevent gut ischemia/reperfusion-induced hepatic microvascular dysfunction in rats fed ethanol chronically显示文摘AIM: Cardiotonic Pill (CP), an oral herbal medicine that includes Danshen (Salviae Miltiorrhizae), Panax notoginseny and Dyroblanops aromatica gaertn, has been clinically used for vascular diseases such as occlusive vasculitis, coronary diseases, atherosclerosis, and cerebral infarction. The main component, SaMae Miltiorrhizae, has been reported to prevent cerebral and intestinal reperfusion injury. However, little is known about the effect of CP on hepatic microcirculation.Thus, this study aimed to determine whether CP could affect hepatic microvascular dysfunction elicited by gut ischemia/reperfusion (I/R) in rats fed ethanol chronically.METHODS: Male Wistar rats were pair-fed with a liquid diet containing ethanol or isocaloric control diet for 6 wk. After laparotomy, one lobe of the liver was examined through an inverted intravital microscope. The rats were exposed to 30 rain of gut ischemia followed by 60 rain of reperfusion.Rhodamine-6G-labeled leukocytes in the sinusoids were observed 90 rain after the onset of superior mesenteric artery ocdusion. Plasma tumor necrosis factor (TNF)-α and endotoxin levels were measured 1 h after the onset of reperfusion.Plasma alanine aminotransferase (ALT) activities were measured 6 h after the onset of reperfusion. In another set of experiments, CP (0.8 g/kg, intragastrically) was administered 1 and 24 h before the onset of ischemia.RESULTS: In control rats, gut I/R elicited increases in the number of stationary leukocytes, and plasma TNF-α and endotoxin levels and plasma ALT activities. These changes were mitigated by pretreatment with CP. In ethanol-fed rats,the gut I/R-induced increases in the number of stationary leukooltes, plasma endotoxin levels and ALT activities were enhanced. Pretreat^nent with CP attenuated the enhancement of gut I/R-induced responses by chronic ethanol consumption.CONCLUSION: These results suggest that CP prevents the gut I/R-induced hepatic microvascular dysfunction and hepatocellular injury. A reduction of inflammatory responses such as TNF-α production via reduction of blood endotoxin levels appears to be involved in the mechanisms. Chronic ethanol consumption enhances gut I/R-induced hepatic microvascular and hepatocellular injury. CP also attenuates an enhancement of gut I/R-induced responses by chronic ethanol consumption via the reduction of blood endotoxin levels. | Yoshinori Horie Shuka Mori Masahiro Konishi Mikio Kajihara Takehiko Kaneko Yoshiyuki Yamagishi Shinzo Kato Hiromasa Ishii Toshifumi Hibi | 2005 | World Journal of Gastroenterology2005，11，4： | 13 |
| 4 | Serrated polyps of the colon and rectum:Remove or not?显示文摘In recent years,the serrated neoplasia pathway where serrated polyps arise as a colorectal cancer has gained considerable attention as a new carcinogenic pathway.Colorectal serrated polyps are histopathologically classified into hyperplastic polyps(HPs),sessile serrated lesions,and traditional serrated adenomas;in the serrated neoplasia pathway,the latter two are considered to be premalignant.In western countries,all colorectal polyps,including serrated polyps,apart from diminutive rectosigmoid HPs are removed.However,in Asian countries,the treatment strategy for colorectal serrated polyps has remained unestablished.Therefore,in this review,we described the clinicopathological features of colorectal serrated polyps and proposed to remove HPs and sessile serrated lesions≥6 mm in size,and traditional serrated adenomas of any size. | Wataru Sano Daizen Hirata Akira Teramoto Mineo Iwatate Santa Hattori Mikio Fujita Yasushi Sano | 2020 | World Journal of Gastroenterology2020，26，19： | 12 |
| 5 | Antibody markers in the diagnosis of inflammatory boweldisease显示文摘Inflammatory bowel disease(IBD), including Crohn's disease and ulcerative colitis, is a chronic intestinal inflammation of unknown etiology. The diagnosis of IBD is based on endoscopic, radiologic and histopathologic criteria. Recently, the search for a noninvasive marker that could augment or replace part of this diagnostic process has become a focus of IBD research. In this review, antibody markers, including microbial antibodies, autoantibodies and peptide antibodies, will be described, focusing on their common features. At present, no single marker with qualities that are satisfactory for the diagnosis and treatment of IBD has been identified, although panels of some antibodies are being evaluated with keen interest. The discovery of novel IBD-specific and sensitive markers is anticipated. Such markers could minimize the use of endoscopic and radiologic examinations and could enable clinicians to implement individualized treatment plans designed to improve the long-term prognosis of patients with IBD. | Keiichi Mitsuyama Mikio Niwa Hidetoshi Takedatsu Hiroshi Yamasaki Kotaro Kuwaki Shinichiro Yoshioka Ryosuke Yamauchi Shuhei Fukunaga Takuji Torimura | 2016 | World Journal of Gastroenterology2016，22，3： | 12 |
| 6 | Immunotherapy for colorectal cancer显示文摘The incidence of colorectal cancer(CRC)is on the rise,and the prognosis for patients with recurrent or metastatic disease is extremely poor.Although chemotherapy and radiation therapy can improve survival rates,it is imperative to integrate alternative strategies such as immunotherapy to improve outcomes for patients with advanced CRC.In this review,we will discuss the effect of immunotherapy for inducing cytotoxic T lymphocytes and the major immunotherapeutic approaches for CRC that are currently in clinical trials,including peptide vaccines,dendritic cell-based cancer vaccines,whole tumor cell vaccines,viral vector-based cancer vaccines,adoptive cell transfer therapy,antibody-based cancer immunotherapy,and cytokine therapy.The possibility of combination therapies will also be discussed along with the challenges presented by tumor escape mechanisms. | Shigeo Koido Toshifumi Ohkusa Sadamu Homma Yoshihisa Namiki Kazuki Takakura Keisuke Saito Zensho Ito Hiroko Kobayashi Mikio Kajihara Kan Uchiyama Seiji Arihiro Hiroshi Arakawa Masato Okamoto Jianlin Gong Hisao Tajiri | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 7 | Vitamin D and calcium are required at the time of denosumab administration during osteoporosis treatment显示文摘To evaluate the differences in outcomes of treatment with denosumab alone or denosumab combined with vitamin D and calcium supplementation in patients with primary osteoporosis. Patients were split into a denosumab monotherapy group(18 cases) or a denosumab plus vitamin D supplementation group(combination group; 23 cases). We measured serum bone alkaline phosphatase(BAP), tartrate-resistant acid phosphatase(TRACP)-5 b and urinary N-terminal telopeptide of type-I collagen(NTX) at baseline, 1 week, as well as at 1 month and 2, 4, 8 and 12 months. We also measured bone mineral density(BMD) of L1–4 lumbar vertebrae(L)-BMD and bilateral hips(H)-BMD at baseline and at 4, 8 and 12 months. There was no significant difference in patient background. TRACP-5 b and urinary NTX were significantly suppressed in both groups from 1 week to 12 months(except at 12 months for NTX). In the combination group, TRACP-5 b was significantly decreased compared with the denosumab monotherapy group at 2 and 4 months(P < 0.05).BAP was significantly suppressed in both groups at 2–12 months. L-BMD significantly increased at 8 and12 months(8.9%) in the combination group and at 4, 8 and 12 months(6.0%) in the denosumab monotherapy group, compared with those before treatment. H-BMD was significantly increased in the combination group(3.6%) compared with the denosumab group(1.2%) at 12 months(P < 0.05). Compared with denosumab monotherapy, combination therapy of denosumab with vitamin D and calcium stopped the decrease in calcium caused by denosumab, inhibited bone metabolism to a greater extent, and increased BMD(especially at the hips). | Yukio Nakamura Takako Suzuki Mikio Kamimura Kohei Murakami Shota Ikegami Shigeharu Uchiyama Hiroyuki Kato | 2017 | Bone Research2017，5，4： | 11 |
| 8 | Adsorption of Ce(Ⅳ) Anionic Nitrato Complexes onto Anion Exchangers and Its Application for Ce(Ⅳ) Separation from Rare Earths(Ⅲ)显示文摘Ce(Ⅳ) nitrato complexes were adsorbed on two anion exchangers based on polyvinyl pyridine (PVP) and quaternized PVP incorporated into porous silica matrix. The effect of nitric acid concentration (0.5~6 mol·L -1 ) and temperature (278~318 K) on Ce(Ⅳ) sorption efficiency was investigated. Sorption increased with increasing nitric acid concentration, indicating that Ce(NO3)6 2- complex is the main adsorbed Ce(Ⅳ) species. Oxidation of sorbents by adsorbed Ce(Ⅳ) species resulting in Ce(Ⅲ) release to the solution was observed. Pyridine based anion exchangers exhibited higher oxidation stability compared to the commercial strong base anion exchanger. Ce(Ⅳ) reduction was temperature dependent and obeyed pseudo-first-order reaction kinetics. Column separation of Ce(Ⅳ) from La(Ⅲ) and Y(Ⅲ) was carried out from 6 mol·L -1 nitric acid with PVP based anion exchanger. Reasonable Ce(Ⅳ) breakthrough capacity (0.7 mol·kg -1 PVP) was achieved. No remarkable decrease of capacity was observed within 3 consequent runs. In contrast, Ce(Ⅲ) leakage due to reduction decreased and breakthrough capacity slightly increased. This effect was more pronounced with increasing temperature. Regeneration with 0.1 mol·L -1 nitric acid was successful (recovery 100%±4%) and Ce solution of high purity (>99.97%) with respect to La and Y content was gained. | Ludek Jelinek Mikio Kumagai | 2006 | Journal of Rare Earths2006，24，4： | 9 |
| 9 | Prostate-specific antigen-based population screening for prostatecancer: current status in Japan and future perspective in Asia显示文摘在西方的国家,屏蔽的前列腺癌症上的临床的试用为耐心的幸存表明了一个有限好处。在亚太区域,包括日本,测试与西方的国家相比很低的遗体的前列腺特定的抗原(PSA ) 的率,和基于人口的屏蔽的好处仍然保持不清楚。这评论描述人口在日本为前列腺癌症屏蔽和诊断的当前的地位并且讨论人口为亚洲人口屏蔽的功效。自从 1990 年代,屏蔽系统被各市政的管理在日本管理了,并且处于前列腺癌症死亡率减少在到屏蔽的 PSA 的暴露率显著地增加了的一些区域被期望。在人口屏蔽被开始以后,一个基于人口的屏蔽队表明在逐渐地屏蔽检测的癌症的变形疾病的比例与高浆液 PSA 层次在癌症的比例根据增加的暴露率,和一个减少的趋势减少了。人口屏蔽检测的前列腺癌症的预后被表明比在屏蔽的人口外面诊断的那些更有利。在屏蔽队的最近的结果表明了 PSA 的功效。关于在日本的基于人口的屏蔽的这些最近的证据可以贡献建立在亚洲个人屏蔽系统的最佳的前列腺癌症。 | Yasuhide Kitagawa Mikio Namiki | 2015 | Asian Journal of Andrology2015，17，3： | 7 |
| 10 | Prospective postsurgical capsule endoscopy in patients with Crohn's disease显示文摘AIM: To clarify the usefulness of postsurgical capsule endoscopy(CE) in the diagnosis of recurrent small bowel lesions of Crohn's disease(CD). METHODS: This prospective study included 19 patients who underwent ileocolectomy or partial ileal resection for CD. CE was performed 2-3 wk after surgery to check for the presence/absence and severity of lesions remaining in the small bowel, and for any recurrence at the anastomosed area. CE was repeated 6-8 mo after surgery and the findings were compared with those obtained shortly after surgery. The Lewis score (LS) was used to evaluate any inflammatory changes of the small bowel. RESULTS: One patient was excluded from analysis because of insufficient endoscopy data at the initial CE. The total LS shortly after surgery was 428.3 on average(median, 174; range, 8-4264), and was ≥ 135(active stage) in 78%(14 of 18) of the patients. When the remaining unresected small bowel was divided into 3 equal portions according to the transition time(proximal, middle, and distal tertiles), the mean LS was 286.6, 83.0, and 146.7, respectively, without any significant difference. Ulcerous lesions in the anastomosed area were observed in 83% of all patients. In 38% of the 13 patients who could undergo CE again after 6-8 mo, the total LS was higher by ≥ 100 than that recorded shortly after surgery, thus indicating a diagnosis of endoscopic progressive recurrence. CONCLUSION: Our pilot study suggests that CE can be used to objectively evaluate the postoperative recurrence of small bowel lesions after surgery for CD. | Tomoaki Kono Nobuyuki Hida Koji Nogami Masaki Iimuro Yoshio Ohda Yoko Yokoyama Koji Kamikozuru Katsuyuki Tozawa Mikio Kawai Tomohiro Ogawa Kazutoshi Hori Hiroki Ikeuchi Hiroto Miwa Shiro Nakamura Takayuki Matsumoto | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，3： | 7 |
| 11 | Parallel computing of discrete element method on multi-core processors显示文摘This paper describes parallel simulation techniques for the discrete element method (DEM) on multi-core processors. Recently, multicore CPU and GPU processors have attracted much attention in accelerating computer simulations in various flelds. We propose a new algorithm for multi-thread parallel computation of DEM, which makes effective use of the available memory and accelerates the computation. This study shows that memory usage is drastically reduced by using this algorithm. To show the practical use of DEM in industry, a large-scale powder system is simulated with a complicated drive unit. We compared the performance of the simulation between the latest GPU and CPU processors with optimized programs for each processor. The results show that the difference in performance is not substantial when using either GPUs or CPUs with a multithread parallel algorithm. In addition, DEM algorithm is shown to have high scalability in a multi-thread parallel computation on a CPU. | Yusuke Shigeto Mikio Sakai | 2011 | Particuology2011，9，4： | 6 |
| 12 | Dermatomyositis associated with hepatocellular carcinoma in an elderly female patient with hepatitis C virus-related liver cirrhosis显示文摘有丙肝的一个 79 岁的女病人病毒相关的肝肝硬化作为与 2.0 厘米的一条直径有肝细胞癌(HCC ) 被诊断。她为 HCC 拒绝了治疗。在诊断以后的九个月,当 HCC 扩大了到 6.0 厘米的一条直径时,她开发了皮肤肌炎。她为皮肤肌炎,然后 transcatheter 经历了治疗为 HCC 的动脉的 chemoembolization。尽管皮肤肌炎的表明改善了,全部肿瘤坏死被完成,她在 HCC 的治疗以后死于肺病 2 瞬间。HCC 或长期的丙肝病毒感染可能涉及皮肤肌炎的致病。 | Nobuyuki Toshikuni Rikako Torigoe Mikio Mitsunaga Akiyoshi Omoto Koji Nakashima | 2006 | World Journal of Gastroenterology2006，12，10： | 6 |
| 13 | Electro-Oxidation of Concentrated Ce(Ⅲ) at Carbon Felt Anode in Nitric Acid Media显示文摘Electro-oxidation of Ce(Ⅲ) to Ce(Ⅳ) in parallel plate flow type electrolyzer divided with cation exchange membrane was carried out in nitric acid media at carbon felt anode under galvanostatic conditions. Carbon felt was used as an anode for its high specific surface area and high oxygen evolution overpotential. Pt coated Ti plates were used as cathode and anode current feeder. The oxidation of 1 mol·L -1 Ce(Ⅲ) solution in 2 mol·L -1 HNO3 was proceeding with a high current efficiency (92%) until about 80% of Ce(Ⅲ) was oxidized. Then, oxygen evolution, accompanied by terminal voltage jump, took place, lowering current efficiency. Ce(Ⅲ) was oxidized up to 90% with current efficiency of 62%. In this mode, strong carbon felt anode oxidation was observed. The wear out of carbon felt was 46% in six consequent runs (6 h of operation). After each run, carbon felt surface had to be renewed with slightly alkaline solution to remove carbon oxidation products and ensure regular operational conditions. When anode surface was blocked, oxygen evolution took place from the beginning of electrolysis due to higher actual current density. The wear out of carbon felt anode could be minimized by means of oxygen evolution prevention. In the case when electrolysis had been stopped before oxygen evolution started (at Ce(Ⅳ) conversion of about 80%), the wear out of anode was less than 2% during 6 consequent runs (4 h of operation). | Jelinek Ludek Mikio Kumagai | 2006 | Journal of Rare Earths2006，24，3： | 6 |
| 14 | Understanding prostate-specific antigen dynamics in monitoring metastatic castration-resistant prostate cancer: implications for clinical practice显示文摘象为变形阉割抵抗的前列腺癌症(CRPC ) 的 docetaxel 和 cabazitaxel 治疗一样的新奇神经质的治疗的可获得性在没有前进的幸存和全面幸存与改进为这组病人改变了眼界。医生们经常用浆液诊断前列腺癌症的前进前列腺特定的抗原(PSA ) 。然而,浆液 PSA 总是没在 CRPC 与临床的地位被相关。与更大的精确评估 PSA 动力学, PSA 并且 CRPC 的开发的机制的控制的理解被需要。而且,与最佳地改进预后和病人的 QOL 的适当预定使用新神经质的治疗是必要的。在现在的评论,我们查明 PSA 动力学和 CRPC 的发展的机制为 mCRPC 在新治疗的最佳的利用帮助。 | Atsushi Mizokami Kouji Izumi Hiroyuki Konaka Yasuhide Kitagawa Yoshifumi Kadono Kazutaka Narimoto Takahiro Nohara Amit K Bahl Mikio Namiki | 2017 | Asian Journal of Andrology2017，19，2： | 5 |
| 15 | Advances in inducing adaptive immunity using cell-based cancer vaccines: clinical applications in pancreatic cancer显示文摘The incidence of pancreatic ductal adenocarcinoma(PDA) is on the rise, and the prognosis is extremely poor because PDA is highly aggressive and notoriously difficult to treat. Although gemcitabine- or 5-fluorouracil-based chemotherapy is typically offered as a standard of care, most patients do not survive longer than 1 year. Therefore, the development of alternative therapeutic approaches for patients with PDA is imperative. As PDA cells express numerous tumor-associated antigens that are suitable vaccine targets, one promising treatment approach is cancer vaccines. During the last few decades, cell-based cancer vaccines have offered encouraging results in preclinical studies. Cell-based cancer vaccines are mainly generated by presenting whole tumor cells or dendritic cells to cells of the immune system. In particular, several clinical trials have explored cell-based cancer vaccines as a promising therapeutic approach for patients with PDA. Moreover, chemotherapy and cancer vaccines can synergize to result in increased efficacies in patients with PDA. In this review, we will discuss both the effect of cell-based cancer vaccines and advances in terms of future strategies of cancer vaccines for the treatment of PDA patients. | Mikio Kajihara Kazuki Takakura Tomoya Kanai Zensho Ito Yoshihiro Matsumoto Shigetaka Shimodaira Masato Okamoto Toshifumi Ohkusa Shigeo Koido | 2016 | World Journal of Gastroenterology2016，22，18： | 4 |
| 16 | 南海海槽等海域天然气水合物资源评价显示文摘介绍了南海海槽、富山海槽、日本海东部边缘、Choshi陆架山和种子岛东—日向—纳达等海域的天然气水合物和水合物气的估算值;用体积法计算的这些海域天然气水合物资源量为(4~20)×1012m3,水合物气(天然气水合物中的甲烷)的总量为(20.56~142.3)×1012m3。 | Mikio Satoh 宋海斌 | 2003 | 天然气地球科学2003，14，6： | 4 |
| 17 | Clinical usefulness of ursodeoxycholic acid for Japanese patients with autoimmune hepatitis显示文摘AIM To evaluate the therapeutic effects of ursodeoxycholic acid(UDCA) on autoimmune hepatitis(AIH).METHODS A total 136 patients who were diagnosed with AIH were included in our study. All of the patients underwent a liver biopsy, and had at least a probable diagnosis on the basis of either the revised scoring system or the simplified scores. Initial treatment included UDCA monotherapy(Group U, n = 48) and prednisolone(PSL) monotherapy(Group P, n = 88). Group U was further classified into two subgroups according to the effect of UDCA: Patients who had achieved remission induction with UDCA monotherapy and showed no sign of relapse(Subgroup U1, n = 34) and patients who additionally received PSL during follow-up(Subgroup U2, n = 14). We compared the clinical and histological findings between each groups, and investigated factorscontributing to the response to UDCA monotherapy.RESULTS In Group U, 34 patients(71%) achieved and maintained remission over 49(range: 8-90) mo(Subgroup U1) and 14 patients(29%) additionally received PSL(Subgroup U2) during follow-up. Two patients in Subgroup U2 achieved remission induction once but additionally required PSL administration because of relapse(15 and 35 mo after the start of treatment). The remaining 12 patients in Subgroup U2 failed to achieve remission induction during follow-up, and PSL was added during 7(range: 2-18) mo. Compared with Subgroup U2, Subgroup U1 had significantly lower alanine aminotransferase(ALT) levels at onset(124 IU/L vs 262 IU/L, P = 0.023) and a significantly higher proportion of patients with mild inflammation(A1) on histological examination(70.6% vs 35.7%, P = 0.025). When multivariate analysis was performed to identify factors contributing to the response to UDCA monotherapy, only a serum ALT level of 200 IU/L or lower was found to be associated with a significant difference(P = 0.013).CONCLUSION To prevent adverse events related to corticosteroids, UDCA monotherapy for AIH needs to be considered in patients with a serum ALT level of 200 IU/L or lower. | Yuichi Torisu Masanori Nakano Keiko Takano Ryo Nakagawa Chisato Saeki Atsushi Hokari Tomohisa Ishikawa Masayuki Saruta Mikio Zeniya | 2017 | World Journal of Hepatology2017，9，1： | 3 |
| 18 | A comparison of electromigration failure of metal lines with fracture mechanics显示文摘Atoms constructing an interconnecting metal linein a semiconductor device are transported by electron flowin high density.This phenomenon is called electromigration,which may cause the line failure.In order to characterize theelectromigration failure,a comparison study is carried outwith some typical phenomena treated by fracture mechanicsfor thin and large structures.An example of thin structures,which have been treated by fracture mechanics,is silica optical fibers for communication systems.The damage growth ina metal line by electromigration is characterized in comparison with the crack growth in a silica optical fiber subjectedto static fatigue.Also a brief comparison is made betweenthe electromigration failure and some fracture phenomena inlarge structures. | Hiroyuki Abé Mikio Muraoka Kazuhiko Sasagawa Masumi Saka | 2012 | Acta Mechanica Sinica2012，28，3： | 3 |
| 19 | Fusions between dendritic cells and whole tumor cells as anticancer vaccines显示文摘 | Shigeo Koido Sadamu Homma Masato Okamoto Yoshihisa Namiki Kazuki Takakura Kan Uchiyama Mikio Kajihara Seiji Arihiro Hiroo Imazu Hiroshi Arakawa Shin Kan Hideo Komita Masaki Ito Toshifumi Ohkusa Jianlin Gong Hisao Tajiri | 2013 | OncoImmunology2013，，： | 3 |
| 20 | Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients显示文摘基因机制作为一些男不孕的一个原因被含有,还糟糕被理解。成熟分裂为复制对细菌房间和必需品唯一。synaptonemal 建筑群是为染色体配对,分离和再结合的一个批评部件。因为猛烈雄的老鼠是不肥沃的, Hormad1 为哺乳动物的 gametogenesis 是必要的。在早 pachytene 阶段和 synaptonemal 建筑群的 Hormad1 缺乏的睾丸展览 meiotic 拘捕不能被设想。为了分析人的 HORMAD1 基因缺点与人的精子缺乏被联系的假设,由 meiotic 拘捕引起了, mutational 分析被诊断,精子缺乏源于 meiotic 的 30 个日本人的直接顺序分析在所有编码区域执行拘捕。由顺序分析,三个多型性地点,单个核苷酸多型性 1 (c。163A > G ) , SNP2 (c。501T > G ) 并且 SNP3 (c。918C > T ) ,在 exons 被发现 3, 8 和 10。有精子缺乏和 80 个正常的证明怀孕的、肥沃的人的 30 个病人为 HORMAD1 多型性被分析。SNP1 和 SNP2 与人的精子缺乏由完全的早 meiotic 拘捕引起了被联系(P< 0.05 ) 。我们建议 HORMAD1 让必要 meiotic 在人的精子发生工作。 | Toshinobu Miyamoto Aldra Tsujimura Yasushi Miyagawa Eitetsu Koh Mikio Namiki Michiharu Horikawa Yasuaki Saijo Kazuo Sengoku | 2012 | Asian Journal of Andrology2012，14，4： | 3 |
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