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| 1 | 某轨道客车制造企业作业人员多部位工作相关肌肉骨骼疾患影响因素分析显示文摘目的分析某轨道客车制造企业作业人员多部位工作相关肌肉骨骼疾患(WMSDs)的患病情况及其影响因素。方法采用整群抽样方法,选择某轨道客车制造企业装配和铆焊车间366名男性作业人员为研究对象,采用《中国肌肉骨骼问卷》调查其多部位WMSDs患病情况,采用多因素Logistic回归分析分析其影响因素。结果研究对象WMSDs总患病率为56.3%(206/366);各部位WMSDs患病率由高到低依次为:下背部、手/腕、颈部、肩部、膝部、上背部、臀腿部、踝/足部、肘部,患病率依次为35.5%、27.6%、23.2%、21.0%、19.9%、18.6%、18.0%、15.8%、12.3%(P<0.01)。研究对象多部位WMSDs总患病率为38.0%(139/366);不同数量部位WMSDs患病率由高到低依次为:6个及以上部位、2个部位、3个部位、5个部位、4个部位,患病率依次为12.0%、10.7%、6.6%、5.5%、3.3%(P<0.01)。多因素Logistic回归分析结果显示,超重和肥胖的作业工人罹患多部位WMSDs的风险高于体质量正常者(P<0.05);长时间保持低头、频繁弯腰、长时间弯曲肘部、工作要求做事很快的频率越高者、与领导沟通职业卫生问题的频率越少者,罹患多部位WMSDs的风险越高(P<0.05)。结论轨道客车制造企业作业人员多部位WMSDs的患病率较高;其影响因素包括个体因素、不良工效学因素和社会心理因素。 | 金宪宁 娜扎开提.买买提 王世娟 王富江 董一丹 王莹 申梓安 盛立刚 Mikael Forsman 杨丽云 张忠彬 何丽华 | 2019 | 中国职业医学2019，46，2： | 28 |
| 2 | 质性内容分析方法与质量控制显示文摘质性研究方法已经成为护理研究的重要方法之一并占据重要地位。本文旨在介绍质性内容分析方法与质量控制,为我国护理研究者的科学研究增加新思路与新工具。在方法方面,主要介绍Mayring内容分析法和Graneheim&Lundman内容分析法。在质量控制方面,质性研究需从研究的可信性、可靠性、可确定性以及可转换性来考量。研究者应根据研究目的和问题,选择最适合的质性内容分析方法,并进行质量控制,从而提高护理质性研究水平。 | 葛莉 黄萍萍 王冠东 Mikael Rask | 2021 | 护士进修杂志2021，36，9： | 20 |
| 3 | Laparoscopic vs open approach to resection of hepatocellular carcinoma in patients with known cirrhosis:Systematic review and meta-analysis显示文摘AIM: To review the currently available literature comparing laparoscopic to open resection of hepatocellular carcinoma(HCC) in patients with known liver cirrhosis.METHODS: A literature search of MEDLINE, EMBASE, and Cochrane databases was conducted. The search terms used included(laparoscopic OR laparoscopy) AND(hepatic or liver) AND(surgery or resection) AND 'hepatocellular carcinoma' AND(cirrhosis or cirrhotic). Furthermore, to widen the search, we also used the 'related articles' section. Studies reporting a comparison of outcomes and methods of open vs laparoscopic hepatic resection for HCC in patients with liver cirrhosis were included. Meta-analysis of results was performed using a random effects model to compute relative risk(RR) and for dichotomous variablesand standard mean differences(SMD) for continuous variables.RESULTS: A total of 420 patients from 4 cohort studies were included in final analysis. Patients undergoing laparoscopic procedures had statistically less blood loss compared to the open cohort, SMD of-1.01(95%CI:-1.23-0.79), P < 0.001, with a reduced risk of transfusion, RR = 0.19(95%CI: 0.09-0.38), P < 0.001. A wider clearance at tumour resection margins was achieved following a laparoscopic approach, SMD of 0.34(95%CI: 0.08-0.60), P = 0.011. No significant difference was noted between laparoscopic and open resection operative times, SMD of-0.15(95%CI: 0.35-0.05), P = 0.142. The overall RR of suffering from postoperative morbidity is 0.25 in favour of the open surgery cohort(95%CI: 0.17-0.37), P < 0.001. Patients under-going laparoscopic surgery had significantly shorter length of stays in hospital compared to the open cohort, SMD of-0.53(95%CI:-0.73 to-0.32), P < 0.001.CONCLUSION: This review suggests that laparoscopic resection of hepatocellular carcinoma in patients with cirrhosis is safe and may provide improved patient outcomes when compared to the open technique. | Ahmed Twaij Philip H Pucher Mikael H Sodergren Tamara Gall Ara Darzi Long R Jiao | 2014 | World Journal of Gastroenterology2014，20，25： | 16 |
| 4 | 某轨道客车制造企业工人心理负荷对其工作相关肌肉骨骼疾患的影响显示文摘目的分析某轨道客车制造企业工人心理负荷水平和工作相关肌肉骨骼疾患(WMSDs)患病情况,探讨两者的关系。方法采用整群抽样方法,选取某轨道客车制造企业装配和铆焊车间362名男性工人为研究对象,以中文版《主观负荷评价技术量表》和《中国肌肉骨骼问卷》调查其心理负荷水平和WMSDs患病情况。结果 362名研究对象心理负荷水平中位数为67分,WMSDs患病率为56.9%。多因素Logistic回归分析结果显示,在排除混杂因素的影响后,轨道客车制造工人心理负荷越严重者罹患WMSDs的风险越高(P<0.05),从事铆焊工种者罹患WMSDs的风险高于从事装配工种者(P<0.01),工作节奏快者罹患WMSDs的风险高于工作节奏正常者(P<0.01),工作环境温度舒适者罹患WMSDs的风险低于工作环境温度不舒适者(P<0.01)。结论轨道客车制造工人心理负荷可增加其罹患WMSDs的风险,呈剂量-效应关系;工种、工作节奏和工作环境温度等也是WMSDs的影响因素。 | 秦东亮 王菁菁 金宪宁 王世娟 王莹 申梓安 盛立刚 Mikael Forsman 杨丽云 王生 张忠彬 何丽华 | 2018 | 中国职业医学2018，45，3： | 15 |
| 5 | 八段锦对脑卒中患者肢体功能康复影响的Meta分析显示文摘目的系统评价八段锦对脑卒中患者肢体功能康复的影响。方法计算机检索Pubmed、Cochrane图书馆、中国生物医学数据库、万方数据库等,纳入符合标准的随机对照试验,检索时间为建库至2016年11月。纳入文献的方法学质量采用Cochrane偏倚风险评估工具进行评价。应用RevMan 5.3统计软件进行Meta分析。结果最终纳入6篇文献,共涉及443名研究对象。Meta分析结果显示,八段锦组与对照组相比能改善脑卒中患者的平衡功能;八段锦联合平衡功能训练可改善下肢运动功能;八段锦联合常规健康指导或康复治疗,可改善脑卒中患者的日常生活活动能力和神经功能缺损状况。结论八段锦在一定程度上能够促进脑卒中患者肢体功能的康复,但需进一步在大样本中验证其有效性。 | 郑清香 葛莉 谭景予 廖燕锬 谢秋林 Mikael Rask | 2017 | 解放军护理杂志2017，34，12： | 13 |
| 6 | The Role of ABA Recycling and Transporter Proteins in Rapid Stomatal Responses to Reduced Air Humidity, Elevated CO2, and Exogenous ABA显示文摘减少的空气湿度 -- ,提高的公司 2-, 和骆驼毛的织物的导致骆驼毛的织物的有气孔的回答搬运并且再循环异种。 | Ebe Merilo Pirko Jalakas Hannes Kollist Mikael Brosch | 2015 | Molecular Plant2015，8，4： | 11 |
| 7 | 医院Ⅱ型暴力影响因素定性研究的系统评价显示文摘目的系统评价医院Ⅱ型暴力的影响因素。方法计算机检索PubMed、EMbase、The Cochrane Library、Web of Science、CINAHL、PsycoINFO、中国知网、维普和万方数据库等,搜集有关医院Ⅱ型暴力影响因素的定性研究文献,采用质性研究质量评价量表进行研究目的、方法学、研究设计、结果和研究贡献的评估;并利用定性系统评价证据分级量表对主题综合结果进行信度分级。结果共纳入24篇定性研究,包括1 124名研究对象。主题综合结果显示,医院Ⅱ型暴力主要受患方、医方、医患双方、社会环境和自然环境的影响。主题信度分级结果显示5个为高信度,8个为中信度,22个为低信度。结论医院Ⅱ型暴力受多维因素的影响。为降低医院Ⅱ型暴力,医疗机构需建立应对医院Ⅱ型暴力的长效机制,社会应形成医院Ⅱ型暴力防御体系,采取措施提高患者信任度和满意度,以降低医疗工作场所暴力的发生。 | 谢秋林 葛莉 金浪 郑清香 Mikael Rask | 2018 | 护理学杂志2018，33，10： | 11 |
| 8 | Childhood achalasia: A comprehensive review of disease, diagnosis and therapeutic management显示文摘Achalasia is an esophageal motility disorder character-ized by failure of lower esophageal sphincter(LES) relaxation and is rare in children. The most common symptoms are vomiting, dysphagia, regurgitation, and weight loss. Definitive diagnosis is made with barium swallow study and esophageal manometry. In adults, endoscopic biopsy is recommended to exclude malig-nancy however; it is not as often indicated in children. Medical management often fails resulting in recurrent symptoms and the ultimate definitive treatment is sur-gical. Laparoscopic Heller myotomy with or without an anti-reflux procedure is the treatment of choice and has become standard of care for children with achala-sia. Peroral endoscopic myotomy is a novel therapy uti-lized with increasing frequency for achalasia treatment in adults. More experience is needed to determine the safety, efficacy, and feasibility of peroral endoscopic myotomy in children. | Ashanti L Franklin Mikael Petrosyan Timothy D Kane | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 9 |
| 9 | 华北晚中新世羚羊的食性与古环境——稳定碳同位素的证据显示文摘通过分析华北晚中新世保德期三个经典地点的羚羊牙齿釉质之稳定碳同位素,结合相同地点的单纯食叶者(鹿科)与食草者(三趾马)的数据,推断其食性取向。结果显示这些晚中新世生态系统中C_3植物占据主导地位,但也含有一小部分的C_4植物(可能小于30%)。高冠羚羊(Gazella dorcadoides类型)取食约20%的C_4植物,而中冠羚羊(G.paotehensis类型)与低冠羚羊(G.gaudryi类型)为纯C_3植物消费者。鹿科动物单纯取食C_3植物,而三趾马与G.dorcadoides类型的羚羊取食C_4植物的比例在统计上难以区分。碳同位素数据与G.gaud- ryi类型的食叶性以及G.dorcadoides类型以草食为主的观点相一致。参照这些类群的地理分布,当前的数据支持晚中新世黄土高原东南部处于相对于西北部更为封闭环境的观点。这种环境梯度的分布方向与模式可能是该地区东亚季风体系的早期信号。 | Benjamin H.PASSEY Jussi T.ERONEN Mikael FORTELIUS 张兆群 | 2007 | 古脊椎动物学报2007，45，2： | 8 |
| 10 | 作业人员姿势负荷评价信效度分析及与肌肉骨骼疾患关系显示文摘目的:建立作业人员工作过程中的动态、静态姿势负荷综合分析评价方法并进行信效度分析,探索作业人员动态静态姿势负荷水平与肌肉骨骼疾患患病情况的关系。方法:选择电子配件组装、轨道客车制造等装配作业人员共844人作为研究对象,依据《中国肌肉骨骼问卷》中的工作姿势相关条目建立作业人员工作过程动态、静态姿势负荷综合分析评价方法,并采用Cronbach系数、聚类分析、因子分析等方法对姿势负荷综合分析评价方法的信效度进行分析,采用非条件Logistic回归模型探索姿势负荷与肌肉骨骼疾患患病情况之间的关系。结果:该评价方法的信效度分析显示:(1)内在一致性评价总体Cronbach系数达0.934,分半信度Spearman-Brown系数0.881,前后相关系数0.787;(2)聚类分析结果提示同一身体部位动态、静态工作姿势距离最短;因子分析共提取2个公因子,累计方差贡献率达65.604%;协方差分析显示负荷得分在不同工种之间差异存在统计学意义(P<0.05)。多因素Logistic回归模型显示,饮酒(OR=2.141,95%CI 1.337~3.428)和肥胖(OR=3.408,95%CI 1.629~7.130)是肌肉骨骼疾患的危险因素,作业人员动静态姿势负荷水平越高肌肉骨骼疾患患病风险也越高(OR=1.035,95%CI 1.022~1.048),不同工种、性别、年龄人群的患病风险也存在差异,女性更易患病(OR=2.626,95%CI 1.414~4.879),30~40岁职业人群患病风险高于30岁以下者(OR=1.909,95%CI 1.237~2.946)。结论:作业人员动态、静态姿势负荷综合分析评价方法在装配作业人群中应用可靠有效,姿势负荷与肌肉骨骼疾患之间存在关联。 | 秦东亮 金宪宁 王世娟 王菁菁 娜扎开提·买买提 王富江 王莹 申梓安 盛立刚 Mikael Forsman 杨丽云 王生 张忠彬 何丽华 | 2018 | 北京大学学报(医学版)2018，50，3： | 8 |
| 11 | Progastrin-releasing peptide and gastrin-releasing peptide receptor mRNA expression in non-tumor tissues of the human gastrointestinal tract显示文摘瞄准:用分子的生物学技术在人的食管,胃肠道,胰和胆囊的非肿瘤纸巾调查释放 gastrin 肽(GRP ) 和 GRP 受体 mRNA 的表示。方法:多形核白细胞,(+) mRNA 用一个自动化 nucleic 抽出者从全部的 RNA 摘录被孤立并且随后,变换成搁浅单人赛的 cDNA (ss-cDNA ) 。PCR 扩大用基因特定的 GRP 和 GRP 受体教材被执行。PCR amplicons 的特性被南部的污点分析进一步用基因特定的 GRP 和 GRP 受体杂交探针证实。结果:GRP 和 GRP 受体 mRNA 的表示在将近非肿瘤标本的片断分析了的所有在各种各样的层次被检测,除了胆囊。在大多数活体检视标本, GRP 和 GRP 受体 mRNA 的合作表示看起来发生。然而, GRP mRNA 的表示比是 GRP 受体 mRNA 是更突出的。结论:GRP 和 GRP 受体 mRNAs 在整个胃肠道被表示并且在正常和肿瘤房间为印射的未来和它的生理的重要性的决心提供信息。 | Hans-Jürg Monstein Niclas Grahn Mikael Truedsson Bodil Ohisson | 2006 | World Journal of Gastroenterology2006，12，16： | 7 |
| 12 | 护患语言与社会交往问卷的中文修订及信效度检验显示文摘目的构建具有良好信效度的中文版《护患语言与社会交往问卷》,用于评估普通科室护士对患者的语言和社会交往能力。方法在原英文版《精神科护患语言和社会交往问卷》基础上,通过与问卷原作者和护理专家一起讨论、修订,经过翻译、回译、预实验检测,形成初步问卷。正式调查424名临床护士,行探索性因子分析及信效度检验。结果中文版《护患语言与社会交往问卷》为4个维度31个条目,内容效度为0.943,4个维度共解释63.267%的总变异;问卷的内在一致性信度Cronbach′sα系数为0.948,重测信度r为0.859。结论中文版《护患语言与社会交往问卷》具有良好的信效度,可以用于评估普通科室护士对患者的语言和社会交往能力。 | 葛莉 王冠东 张敏 郑婉玲 谢秋林 Mikael Rask | 2018 | 护理学杂志2018，33，11： | 7 |
| 13 | 美国Haynesville页岩气井产量递减规律显示文摘Haynesville区块是美国含气量最丰富的页岩区块之一,地位重要,且数据相对完善,对其进行产量递减规律研究,既有现实意义,又有理论价值。同时运用传统Arps双曲递减模型和现代扩展指数递减模型对该区块2008—2014年812口页岩气单井产量进行拟合,分析递减模型的参数、峰值产量、不同时期递减率和最终可采储量,进而总结页岩气井的产量递减规律。结果表明:(1)该地区大部分页岩气井显示出典型的'钟型曲线'产量变化模式,即产量在短时期内从低到高达到峰值,然后迅速下降,并长期保持低产;(2)在递减阶段,两个模型对页岩气井组均值和单井产量数据序列都有很好的拟合效果,尽管传统的双曲递减模型的参数β有26%的取值大于l,但合理选取页岩气井的产气生命周期长度(比如20年)可有效降低最终可采储量预测误差,因此仍可用于页岩气产量分析;(3)约有70%的页岩气井峰值产量达到9.3万~27.9万m3/d,且从整体趋势看,'新井'往往比'老井'具有更高的峰值产量,递减期第1年时的产量递减率为72%,第2年时为86%。 | 郭克强 张宝生 Mikael HK Kjell ALEKLETT | 2016 | 石油科学通报2016，1，2： | 6 |
| 14 | 非均布荷载作用下煤岩力学强度特性试验研究显示文摘考虑不同初始垂向应力、不同初始水平应力及不同应力转移速度条件,借助于自主研发的采动应力试验系统,研究了非均布荷载作用下煤岩体的力学强度特性。研究结果表明:煤岩外部损伤残余块体对煤岩内部力学承载能力具有强化作用,当初始垂向应力、初始水平应力、应力转移速度一定时,煤岩内部力学承载能力近似为煤岩外部力学承载能力的2倍;伴随初始垂向应力的增加,煤岩整体后期力学承载能力不断降低,且处于不同初始垂向应力范围,煤岩内、外部后期力学强度递减特征不同,当处于较小初始垂向应力范围时,煤岩外部后期力学强度递减量大于煤岩内部,当处于较大初始垂向应力范围时,煤岩外部后期力学强度递减量小于煤岩内部;初始水平应力越大,煤岩体的力学承载能力越高,且无论较小还是较大初始水平应力范围,煤岩内部后期力学强度增量总大于煤岩外部;伴随应力转移速度的增加,煤岩峰值强度不断升高,应力转移速度对煤岩内部区域力学性质的影响相对较大。 | 王晓 文志杰 MIKAEL Rinne 沈宝堂 谢军 | 2017 | 岩土力学2017，38，3： | 6 |
| 15 | Modelling fracture propagation and failure in a rock pillar under mechanical and thermal loadings显示文摘The spPillar Stability Experiment (APSE) was conducted to study the rock mass response in a heated rock pillar between two large boreholes. This paper summarizes the back calculations of the APSE using a two-dimensional (2D) fracture propagation code FRACOD. To be able to model all the loading phases of the APSE, including the thermal loading, the code was improved in several ways. A sequential excavation function was developed to model promptly the stepwise changing loading geometry. Prior to the mod-elling, short-term compressive strength test models were set up aiming to reproduce the stress-strain behaviour observed for the sp diorite in laboratory. These models simulate both the axial and lateral strains of radial-controlled laboratory tests. The volumetric strain was calculated from the simulations and compared with the laboratory results. The pillar models include vertical and horizontal 2D models from where the stress in the pillar wall was investigated. The vertical model assesses the stability of the experimental rock volume and suggests the resultant stress below the tunnel floor in the pillar area. The horizontal model considers cross-sections of the pillar between the two large boreholes. The horizontal model is used to simulate the evolution of the stress in the rock mass during the excavation of the boreholes and during and the heating phase to give an estimation of the spalling strength. The modelling results suggest that the excavation-induced stresses will cause slight fracturing in the pillar walls, if the strength of the APSE pillar is set to about 123 MPa. Fracture propagation driven by thermal loading leads to minor spalling. The thermal evolution, elastic behaviour and brittle failure observed in the experiment are well reflected by the models. | Mikael Rinne Baotang Shen Tobias Backers | 2013 | Journal of Rock Mechanics and Geotechnical Engineering2013，5，1： | 6 |
| 16 | No difference in mortality among ALPPS,two-staged hepatectomy,and portal vein embolization/ligation:A systematic review by updated traditional and network meta-analyses显示文摘Background:There is an ongoing debate on the feasibility,safety,and oncological efficacy of the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique.The aim of this study was to compare ALPPS,two-staged hepatectomy(TSH),and portal vein embolization(PVE)/ligation(PVL)using updated traditional meta-analysis and network meta-analysis(NMA).Data sources:Electronic databases were used in a systematic literature search.Updated traditional metaanalysis and NMA were performed and compared.Mortality and major morbidity were selected as primary outcomes.Results:Nineteen studies including 1200 patients were selected from the pool of 436 studies.Of these patients,315(31%)and 702(69%)underwent ALPPS and portal vein occlusion(PVO),respectively.Ninetyday mortality based on updated traditional meta-analysis,subgroup analysis of the randomized controlled trials(RCTs),and both Bayesian and frequentist NMA did not demonstrate significant differences between the ALPPS cohort and the PVE,PVL,and TSH cohorts.Moreover,analysis of RCTs did not demonstrate significant differences of major morbidity between the ALPPS and PVO cohorts.The ALPPS cohort demonstrated significantly more favorable outcomes in hypertrophy parameters,time to operation,definitive hepatectomy,and R0 margins rates compared with the PVO cohort.In contrast,1-year disease-free survival was significantly higher in the PVO cohort compared to the ALPPS cohort.Conclusions:This study is the first to use updated traditional meta-analysis and both Bayesian and frequentist NMA and demonstrated no significant differences in 90-day mortality between the ALPPS and other hepatic hypertrophy approaches.Furthermore,two high quality RCTs including 147 patients demonstrated no significant differences in major morbidity between the ALPPS and PVO cohorts. | Paschalis Gavriilidis Robert P Sutcliffe Keith J Roberts Madhava Pai Duncan Spalding Nagy Habib Long R Jiao Mikael H Sodergren | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 6 |
| 17 | 中国大油田的发展历程与展望(英文)显示文摘中国国内超过70%的原油产量来自于9个大油田。掌握这些油田的动态对于了解中国国内原油产量和未来中国原油进口需求是必要的。该研究利用递减曲线和采油速度分析,得出中国大油田未来产量的走势。研究表明,中国国内未来原油产量将会面临一个巨大的挑战,而这正是由大油田的成熟和递减引起的。证据也表明,水驱和提高采收率方法的大规模运用将会掩盖日益严重的资源缺乏,并可能会导致油田未来递减率比目前所见到的递减率更大。中国石油工业已经设法使其国内大油田的产量在几十年内保持稳定,但任何措施都无法阻止这些油田最终走向递减,且中国许多大油田已经过了峰值产量期进入递减。笔者认为,在未来几十年里,中国大油田的原油产量将大幅降低。 | Mikael Hk 唐旭 庞雄奇 Kjell Aleklett | 2010 | 石油勘探与开发2010，37，2： | 5 |
| 18 | Diabetes:特殊免疫细胞亚群或促进1型糖尿病发展显示文摘发表在国际杂志Diabetes上的一项最新研究中,来自东芬兰大学的研究人员通过研究发现,最近描述的一种T细胞亚群或许在1型糖尿病的发生上扮演着关键性的中枢角色;这种名为滤泡T辅助细胞的T细胞亚群在1型糖尿病开始阶段时水平处于增加之中,而且这种现象和疾病相关的常见自身抗体的存在直接相关。 | Tyyne Viisanen Emmi-Leena Ihantola Kirsti Näntö-Salonen Heikki Hyöty Noora Nurminen Jenni Selvenius Auni Juutilainen Leena Moilanen Jussi Pihlajamäki Riitta Veijola Jorma Toppari Mikael Knip Jorma Ilonen Tuure Kinnunen | 2017 | 现代生物医学进展2017，17，4： | 5 |
| 19 | Fluorescent SiC and its application to white light-emitting diodes显示文摘Fluorescent-SiC(f-SiC),which contains donor and acceptor impurities with optimum concentrations, has high conversion efficiency from NUV to visible light caused by donor-acceptor-pair(DAP) recombination. This material can be used as a substrate for a near UV light-emitting diode(LED) stack,and leads to monolithic white LED device with suitable spectral property for general lighting applications.In this paper,we describe basic technologies of the white LED,such as optical properties of f-SiC substrate,and epitaxial growth of NUV stack on the f-SiC substrate. | Satoshi Kamiyama Motoaki Iwaya Tetsuya Takeuchi Isamu Akasaki Mikael Syvjrvi Rositza Yakimova | 2011 | Journal of Semiconductors2011，32，1： | 5 |
| 20 | Radiofrequency combined with immunomodulation for hepatocellular carcinoma: State of the art and innovations显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver tumor and has been considered a very immunogenic tumor.The treatment with radiofrequency ablation(RFA)has been established as the standard ablative therapy for early HCC,and is currently recognized as the main ablative tool for HCC tumors<5 cm in size;however,progression and local recurrence remain the main disadvantages of this approach.To solve this clinical problem,recent efforts were concentrated on multimodal treatment,combining different strategies,including the combination of RFA and immunotherapy.This article reviewed the combination treatment of RFA with immunotherapy and found that this treatment strategy leads to an increased response of anti-tumor T cells,significantly reduces the risk of recurrence and improves survival rates compared to RFA alone.This review highlighted scientific evidence that supports the current recommendations for pre-clinical studies,and discuss the need for further research on this topic. | Adriano Carneiro da Costa Mikael Sodergren Kumar Jayant Fernando Santa Cruz Duncan Spalding Madhava Pai Nagy Habib | 2020 | World Journal of Gastroenterology2020，26，17： | 5 |
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