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| 1 | 同种主动脉瓣临床应用的初步报告显示文摘本文报告5例应用同种主动脉瓣手术治疗的初步经验,并将同种瓣的收集、保存、修剪和缝合方法以及同种瓣的优缺点作了简要的介绍。 | 萧明第 O'Brien MF 朱晓东 郭加强 刘迎龙 漆志涛 李晓东 | 1989 | 中国循环杂志1989，4，1： | 5 |
| 2 | 体质量状态变化与高血压发生的相关性显示文摘在美国近1/3的儿童和青少年是肥胖或超重的。虽然最近该比值保持稳定,但在过去40年中则呈快速上升的趋势。儿童肥胖与高血压显著相关。主要在初中和高中学生中进行的流行病学调查研究报道,高血压的发病率在0.8%~3.2%,而在肥胖学生中高血压发病率则〉10%。在大型的医疗保健系统门诊和小学儿童中进行的一项研究报道显示,正常体质量的儿童高血压总发病率为0.3%~0.9%,肥胖儿童为1.0%~9.2%。 | Parker ED Sinaiko AR Kharbanda EO Margolis KL Daley MF Trower NK Sherwood NE Greenspan LC Lo JC Magid DJ o'connor pj | 2016 | 中华高血压杂志2016，24，6： | 3 |
| 3 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 4 | Comparison of dopamine receptor antagonists on hyperlocomotion induced by cocaine, amphetamine, MK-801 and the dopamine D1 agonist C-APB in mice显示文摘 | O'Neill MF Shaw G | 1999 | Psyehopharmacology (Berl)1999，145，3： | 1 |
| 5 | ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvasta- tin 显示文摘 | Keskitalo JE Zolk O Fromm MF | 2009 | Clin Pharmacol Ther2009，86，： | 1 |
| 6 | Daily interrupt-ion of sedative infusions in critically ill patients undergoing mechanical ventilation显示文摘 | Kress JP Pohlman AS O'Connor MF | 2000 | N Engl J Med2000，342，20： | 1 |
| 7 | 3% follow-up of 1 022 valve replacement显示文摘 | O'Brien MF Harrocks S Stafford EG The homograft aortic valve:A 29-year 99 | 2001 | J Heart Valve Dis2001，10，3： | 1 |
| 8 | Benefit of glycery| trinitrate on arterial stiffness is directly due to effects on peripheral arteries显示文摘 | Pauca AL Kon ND O'Rourke MF | 2005 | J Heart2005，9，： | 1 |
| 9 | Spinal tuberculous arach-noiditis with intradural extremedullary tuberculomas显示文摘 | Belahsen MF Maaroufi M Messouak O | | 0，，： | 1 |
| 10 | Artifacts in 3-T MRI:physical background and reduction strategies显示文摘 | Dietrich O Reiser MF Schoenberg SO | 2008 | Euro J Radiol2008，65，1： | 1 |
| 11 | Clinical applications of arterial stiffness;defi- nitions And reference Values 显示文摘 | O'Rouker MF | 2002 | Hypertens2002，26，7： | 1 |
| 12 | Craving love? Enduring grief activates brainrs reward center 显示文摘 | O'Connor MF Wellisch DK Stanton AL | 2008 | Neuroimage2008，42，2： | 1 |
| 13 | Comparison of the lowest instrumented,stable,and lower end vertebrae in 'single overhang' thoracic adolescent idiopathic scoliosis: anterior versus posterior spinal fusion 显示文摘 | Kuklo TR O Brien MF Lenke LG | 2006 | Spine2006，19，： | 1 |
| 14 | Heptic artery stenosis after livertransplantation-incidence presentation,treatment and long term outcome显示文摘 | Abbasoglu O Levy MF Vodapally MS | 1997 | Transplantation1997，63，： | 1 |
| 15 | Carotid -artery intima and media thickness as a risk factor for myocardial infarction and stroke 显示文摘 | Nichols WW Pepine CJ O'Rourke MF | 1999 | New Eng J Med1999，340，22： | 1 |
| 16 | Relationship between aortic stiffening and microvascular disease in brain and kidney:cause and logic of therapy显示文摘 | O'Rourke MF Safar ME | | 0，，： | 1 |
| 17 | Implementation of a closed- loop reporting system for critical values and clinical communica- tion in compliance with goals of the joint commission 显示文摘 | Parl FF O'Leary MF Kaiser AB | 2010 | Clin Chem2010，56，3： | 1 |
| 18 | Prospective evaluation of a method for estimating ascending aortic pressure from the radial artery pressure waveform 显示文摘 | Pauca AL O Rourke MF Kon ND | 2001 | Hypertension2001，38，： | 1 |
| 19 | Effect of methylphenidate on auditory event related potential in boys with attention deficit hyperactivity disorder显示文摘 | Ozdag MF Yorbik O Ulas UH | 2004 | Int J Pediatr Otorhinolaryngol2004，68，10： | 1 |
| 20 | Treatment of open apex teeth using two types of white mineral trioxide aggregate after initial dressing with calcium hydroxide in children显示文摘 | Moore A Howley MF O′Connell AC | | 0，，03： | 1 |
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