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| 1 | Endoglin in liver fibrogenesis: Bridging basic science and clinical practice显示文摘Endoglin, also known as cluster of differentiation CD105, was originally identified 25 years ago as a novel marker of endothelial cells. Later it was shown that endoglin is also expressed in pro-fibrogenic cells including mesangial cells, cardiac and scleroderma fibroblasts, and hepatic stellate cells. It is an integral membranebound disulfide-linked 180 kDa homodimeric receptor that acts as a transforming growth factor-β(TGF-β) auxiliary co-receptor. In humans, several hundreds of mutations of the endoglin gene are known that give rise to an autosomal dominant bleeding disorder that is characterized by localized angiodysplasia and arteriovenous malformation. This disease is termed hereditary hemorrhagic telangiectasia type Ⅰ and induces various vascular lesions, mainly on the face, lips, hands and gastrointestinal mucosa. Two variants of endoglin(i.e., S- and L-endoglin) are formed by alternative splicing that distinguishes from each other in the length of their cytoplasmic tails. Moreover, a soluble form of endoglin, i.e.,sol-Eng, is shedded by the matrix metalloprotease-14 that cleaves within the extracellular juxtamembrane region. Endoglin interacts with the TGF-β signaling receptors and influences Smad-dependent and-independent effects. Recent work has demonstrated that endoglin is a crucial mediator during liver fibrogenesis that critically controls the activity of the different Smad branches. In the present review, we summarize the present knowledge of endoglin expression and function, its involvement in fibrogenic Smad signaling, current models to investigate endoglin function, and the diagnostic value of endoglin in liver disease. | Steffen K Meurer Muhammad Alsamman David Scholten Ralf Weiskirchen | 2014 | World Journal of Biological Chemistry2014，5，2： | 3 |
| 2 | Variable expression of cystatin C in cultured trans-differentiating rat hepatic stellate cells显示文摘瞄准:学习 C (CysC ) ,它由转变生长 factor-beta1 (TGF-beta1 ) 的规定和导出血小板的生长因素(PDGF ) 和有在这个特殊房间发信号的 TGF-beta1 的 CysC 的潜在的干扰打的 cystatin 的表示。方法:我们计算了 CysC 表达式在有教养, profibrogenic 肝的星形细胞和区分 trans 的 myofibroblasts 由北、西方弄污并且共焦的激光扫描显微镜学。结果:CysC 在 trans 区别期间显著地被增加。TGF-beta1 和 PDGF-BB 压制了 CysC 表示。而且, CysC 分泌物被处理与 TGF-beta1 导致。尽管 CysC 导致了 TGF 贝它的一种增加的有约束力的亲密关系,受体是由化学 cross-linking 估计了与打 III (beta-glycan )[125I ] 它没调制的 -TGF-beta1, 由评估 Smad2/3 磷酸化地位出现的 TGF-beta1 信号转导变异并且[CAGA ]-MLP-luciferase 记者基因试金。有趣地,流类型 III TGF 贝它受体 beta-glycan 在对待 CysC 的房间被减少。我们的数据显示那 CysC 表情起来在 trans 区别期间调整了。结论:在患肝疾病的病人的浆液的增加的 CysC 层次是至少部分由于在激活的肝的星形细胞的更高的表情。而且, TGF-beta1 影响 CysC 的分泌物,加亮在肝的纤维发生的前进的半胱氨酸朊酶的一个潜在地重要的角色。 | Axel M Gressner Birgit Lahme Steffen K Meurer Olav Gressner Raif Weiskirchen | 2006 | World Journal of Gastroenterology2006，12，5： | 2 |
| 3 | Inhibition of cox-1 attenuates the formation of thromboxane a2 and ameliorates the acute decrease in glomerular filtration rate in endotoxemic mice显示文摘 | Mederle K Meurer M Castrop H | 2015 | Am J Physiol Renal Physiol2015，309，4： | 1 |
| 4 | A study of iterative type Ⅱ polyketide synthases using bacterial genes cloned from soil DNA:A means to access and use genes from uncultured microorganisms显示文摘 | Seow K T Meurer G Gerlitz M | 1997 | J Bacteriol1997，179，21： | 1 |
| 5 | Value of MRI in diagnosis of occult fractures显示文摘 | Meurer A Kreitner KF Tsironis K | 1999 | Unfallchirurg1999，102，1： | 1 |
| 6 | Endoglin differentially modulates antagonistic transforming growth factor-beta 1 and BMP-7 signaling显示文摘 | Scherner O Meurer S K Tihaa L | 2007 | J Biol Chem2007，282，13： | 1 |
| 7 | New and bioactivecompounds from Streptomyces strains residing in thewood of Celastraceae显示文摘 | Pullen C Schmitz P Meurer K | 2002 | Planta2002，216，1： | 1 |
| 8 | Long-term treatment of atopic dermatitis with pimecrolimus cream 1% in infants does not interfere with the development of protective antibodies after vaccination显示文摘 | Papp KA Breuer K Meurer M | 2005 | J Am Acad Dermatol2005，52，2： | 1 |
| 9 | Isolation of high-chlorophyll-fluorescence mutants of Arabidopsis thaliana and their characterization by spectroscopy, immunoblotting and Northern hybridization显示文摘 | Meurer J Meierhoff K Westhoff P | 1996 | Planta1996，198，： | 1 |
| 10 | Conversion of vitamin D3 to hormonally active 1 alpha, 25- dihydroxyvitamin D3 in cultured keratinocytes : relevance to cell growth and differentiation 显示文摘 | Lehmann B1 Schattiger K Meurer M | 2010 | J Steroid Biochem Mol Biol2010，121，12： | 1 |
| 11 | New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae显示文摘 | PULLEN C SCHMITZ P MEURER K | 2002 | Planta2002，216，1： | 1 |
| 12 | BMP-7 counteracting TGF-betal activities in organ fibrosis 显示文摘 | Weiskirchen R Meurer S K | 2013 | Front Biosci (Landmark Ed)2013，18，： | 1 |
| 13 | New and Bioactive Compounds from Streptomyces Strains Residing in the Wood of Celastraceae显示文摘 | PULLEN C SCHMITZ P MEURER K | 2002 | Planta2002，216，1： | 1 |
| 14 | A study of iterative type II polyketide synthases, using bacterial genes cloned from soil DNA: A means to access and use genes from uncultured microorganisms 显示文摘 | Seow K T Meurer G Gerlitz M | 1997 | J Bacterlol1997，179，23： | 1 |
| 15 | PDGF-D signaling in portal myofibroblasts and hepatic stellate cells proves identical to PDGF-B via both PDGF receptor typeαandβ显示文摘 | BORKHAM-KAMPHORST E MEURER S K VAN DE LEUR E | 2015 | Cell Signal2015，27，： | 1 |
| 16 | Stroke awareness among inpatient nursing staff at an academic medical center显示文摘 | Adelman E E Meurer W J Nance D K | 2014 | Stroke:A Journal of Cerebral Circulation2014，45，1： | 1 |
| 17 | Moderate and vigorous exercise programs in children with asthma: safety, parental satisfaction, and asthma outcomes显示文摘 | WEISGERBER M WEBBER K MEURER J | 2008 | Pediatr Pulmonol2008，43，12： | 1 |
| 18 | Minimizing dioxin andfuran emissions during zinc dust recycle by the Waelz process 显示文摘 | MAGER K MEURER U WIRLING J | 2003 | JOM-Journal of the Minerals Metals & Materials Society2003，，： | 1 |
| 19 | A study of iterative typeⅡpolyketide synthases,using bacterial genes cloned from soil DNA:a means to access and use genes from uncultured microorganisms显示文摘 | SEOW K T MEURER G GERLITZ M | 1997 | Bacteriol1997，179，23： | 1 |
| 20 | A study of iterative type Ⅱ polyketide synthases, using bacterial genes cloned from soil DNA: a means to access and use genes from uncultured microorganisms 显示文摘 | Seow K T Meurer G Gerlitz M | 1997 | J Bacte-riol1997，179，23： | 1 |
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