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| 1 | 面向21世纪的卒中新定义:美国心脏病学会和美国卒中学会声明显示文摘尽管脑血管病有着全球性影响且对其病理生理学的认识有了很多进步,但是'卒中'这一术语在临床实践、临床研究或公共卫生评估中的定义却不一致。传统的定义依据于临床,却没有考虑到科学技术的进步。美国心脏协会(AHA)和美国卒中协会(ASA)卒中分会组织了写作小组,为21世纪卒中新定义撰写专家共识性声明。中枢神经系统(CNS)梗死,指由缺血所导致的脑、脊髓或视网膜的细胞死亡,是基于持续性损害的神经病理学、神经影像学和(或)临床证据。CNS梗死表现为一个临床谱:缺血性卒中特指伴有明显症状的CNS梗死,而静息性梗死根据定义指未引起已知的症状的梗死。卒中也还包括脑出血和蛛网膜下腔出血。新定义的卒中结合了临床和组织学标准,可被用于实践、研究和公共卫生评估。 | 俞羚 董荃 宋叶平 江静雯 李卉 刘亮贤 苏爱萍 李焰生 Sacco RL Kasner SE Broderick JP Caplan LR Connors JJ Culebras A Elkind MS George MG Hamdan AD Higashida RT Hoh BL Janis LS Kase CS Kleindorfer DO Lee JM Moseley ME Peterson ED Turan TN Valderrama AL Vinters HV | 2013 | 神经病学与神经康复学杂志2013，10，2： | 188 |
| 2 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 3 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005，11，39： | 26 |
| 4 | The microbiome and autoimmunity: a paradigm from the gut–liver axis显示文摘Microbial cells significantly outnumber human cells in the body,and the microbial flora at mucosal sites are shaped by environmental factors and,less intuitively,act on host immune responses,as demonstrated by experimental data in germ-free and gnotobiotic studies.Our understanding of this link stems from the established connection between infectious bacteria and immune tolerance breakdown,as observed in rheumatic fever triggered by Streptococci via molecular mimicry,epitope spread and bystander effects.The availability of high-throughput techniques has significantly advanced our capacity to sequence the microbiome and demonstrated variable degrees of dysbiosis in numerous autoimmune diseases,including rheumatoid arthritis,type 1 diabetes,multiple sclerosis and autoimmune liver disease.It remains unknown whether the observed differences are related to the disease pathogenesis or follow the therapeutic and inflammatory changes and are thus mere epiphenomena.In fact,there are only limited data on the molecular mechanisms linking the microbiota to autoimmunity,and microbial therapeutics is being investigated to prevent or halt autoimmune diseases.As a putative mechanism,it is of particular interest that the apoptosis of intestinal epithelial cells in response to microbial stimuli enables the presentation of self-antigens,giving rise to the differentiation of autoreactive Th17 cells and other T helper cells.This comprehensive review will illustrate the data demonstrating the crosstalk between intestinal microbiome and host innate and adaptive immunity,with an emphasis on how dysbiosis may influence systemic autoimmunity.In particular,a gut–liver axis involving the intestinal microbiome and hepatic autoimmunity is elucidated as a paradigm,considering its anatomic and physiological connections. | Bo Li Carlo Selmi Ruqi Tang ME Gershwin Xiong Ma | 2018 | Cellular & Molecular Immunology2018，15，6： | 15 |
| 5 | Incidence and mortality of primary liver cancer in England and Wales: Changing patterns and ethnic variations显示文摘AIM: To explore recent trends, modes of diagnosis, ethnic distribution and the mortality to incidence ratio of primary liver cancer by subtypes in England and Wales. METHODS: We obtained incidence(1979-2008) and mortality(1968-2008) data for primary liver cancer for England and Wales and calculated age-standardised incidence and mortality rates. Trends in age-standardised mortality(ASMR) and incidence(ASIR) rates and basis of diagnosis of primary liver cancer and subcategories: hepatocellular carcinoma, intrahepatic bile duct and unspecified liver tumours, were analysed over the study period. Changes in guidelines for the diagnosis of primary liver cancer(PLC) may impact changing trends in the rates that may be obtained. We thus explored changes in the mode of diagnosis as reported to cancer registries. Furthermore, we examined the distribution of these tumours by ethnicity. Most of the statistical manipulations of these data was carried out in Microsoft excel(Seattle, Washington, United Sttaes). Additional epidemiological statistics were done in Epi Info software(Atlanta, GA, United Sttaes). To define patterns of change over time, we evaluated trends in ASMR and ASIR of PLC and intrahepatic bile duct carcinoma(IHBD) using a least squares regression line fitted to the natural logarithm of the mortality and incidence rates. We estimated the patterns of survival over subsequent 5 and 10 years using complement of mortality to incidence ratio(1-MIR). RESULTS: Age-standardised mortality rate of primary liver cancer increased in both sexes: from 2.56 and 1.29/100000 in 1968 to 5.10 and 2.63/100000 in 2008 for men and women respectively. The use of histology for diagnostic confirmation of primary liver cancer increased from 35.7% of registered cases in 1993 to plateau at about 50% during 2005 to 2008. Reliance on cytology as a basis of diagnosis has maintained a downward trend throughout the study period. Although approximately 30% of the PLC registrations had information on ethnicity, there was a relatively higher registration of the major tumour subtypes in patients whose ethnic backgrounds were from high incident regions of the world. Survival from PLC is estimated to get poorer in 10 years(2018) relative to 2008, particularly as a result of IHBD. CONCLUSION: Incidence and mortality of PLC, and particularly IHBD, have continued to rise in England and Wales. Changes in the modes of diagnosis may be contributing. | Nimzing G Ladep Shahid A Khan Mary ME Crossey Andrew V Thillainayagam Simon D Taylor-Robinson Mireille B Toledano | 2014 | World Journal of Gastroenterology2014，20，6： | 15 |
| 6 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 7 | 抗菌药物策略性更换对医院耐药模式的影响显示文摘目的肯塔基大学医院为减少第三代头孢菌素头孢噻肟和头孢他啶的应用以第四代头孢菌素头孢吡肟进行策略性换药,并对其进行了评价。方法对换药前及换药后各6个月的抗生素应用及细菌耐药性进行回顾性研究。研究包括所有住院患者发生的耐万古霉素肠球菌(VRE)、耐头孢他啶肺炎克雷伯菌(CRKP)、耐甲氧西林金黄色葡萄球菌(MRSA)、耐哌拉西林铜绿假单胞菌(PRPA)及耐头孢他啶铜绿假单胞菌(CRPA)感染。结果头孢他啶用量自其9600g减少至99g,头孢噻肟用量自6314g减少至732g,两者总用量共减少89%。头孢吡肟用量自0g增加至5396g。耐头孢他啶肺炎克雷伯菌感染自13%降低至3%,耐哌拉西林铜绿假单胞菌感染自22%降低至14%,耐头孢他啶铜绿假单胞菌感染自25%降低至15%(p值均小于0.05)。MRSA感染降低不明显,而VRE感染显著增多。结论以头孢吡肟替代头孢他啶或头孢噻肟,在减少头孢菌素用量的同时似可降低耐头孢他啶肺炎克雷伯菌、耐哌拉西林铜绿假单胞菌和耐头孢他啶铜绿假单胞菌感染的发生率。 | Kerry ME 李光辉 张秀珍 | 2003 | 临床药物治疗杂志2003，1，2： | 13 |
| 8 | A380结构的先进材料和技术——未来发展的技术平台显示文摘A380超大型客机是目前仅有的采用全机身长度双层客舱的4通道客机、能容纳555名乘客。本文简要介绍了A380机体结构所采用的先进材料和制造技术。 | Jéróme Pora | 2003 | 航空维修与工程2003，，6： | 13 |
| 9 | CYP2D6的多态性与文拉法辛的临床效应显示文摘 | Shams ME Arneth B Hiemke C 王小艳 | 2006 | 中国处方药2006，5，10： | 12 |
| 10 | 干扰素调节因子5通过损伤胞葬作用控制动脉粥样硬化病变中的坏死核心形成显示文摘髓系细胞是动脉粥样硬化病变发展和易损斑块形成的核心。动脉吞噬细胞吸收凋亡细胞(胞葬作用)的能力受损,可促进病变生长并建立坏死核心。干扰素调节因子(interferon regulatory factor,IRF)5是髓系细胞功能的重要调节因子。该研究试图确定IRF5是否影响动脉粥样硬化病变的形成和表型。方法:通过两种互补模型,研究IRF5在动脉粥样硬化中的作用: | Seneviratne AN Edsfeldt AO Cole JE Kassiteridi C Swart M Park I Green P Khoyratty TE Saliba DG Goddard ME Sansom SN Goncalves I Krams R Udalova IA Monaco C 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 9 |
| 11 | 硫酸参与喀斯特流域(北盘江)风化过程的碳同位素证据显示文摘在碳酸盐岩地区,流域侵蚀过程中硫酸是否参与,对于我们正确理解流域化学风化速率,以及流域侵蚀对大气CO2的消耗和全球碳循环等都有重要的意义。本工作在前期工作(乌江)的基础上,对贵州喀斯特地区的河流(北盘江)和支流的水化学特征以及水体溶解无机碳同位素组成进行了初步研究,研究结果证实硫酸参与了该喀斯特流域岩石/土壤化学风化过程。 | 李思亮 韩贵琳 张鸿翔 刘丛强 Jérme Gaillardet Calmels Damien | 2006 | 地球与环境2006，34，2： | 8 |
| 12 | 小胶质细胞可能通过选择性吞噬丘脑底核谷氨酸能突触来代偿多巴胺能神经元丢失造成的帕金森模型鼠的功能缺失显示文摘当帕金森患者出现临床症状时,其黑质致密部的绝大部分多巴胺神经元已发生退行性改变。这提示可能存在某些代偿机制,延缓了临床症状的出现。本研究制作6-羟多巴胺诱导的偏侧帕金森大鼠模型,观察位于黑质下网状部和苍白球的激活的小胶质细胞在代偿机制中的作用。研究发现,在偏侧帕金森大鼠中,黑质下网状部聚集的激活的小胶质细胞远多于苍白球中。激活的小胶质细胞胞体增大并表达吞噬物标志物CD68和NG2蛋白多糖。激活的小胶质细胞聚集在黑质下网状部的特定部位,该部位的突触蛋白I和突触后密集蛋白95的表达降低。活化的小胶质细胞吞噬突触前、后膜上的各种蛋白,包括NMDA受体。将红色荧光标记物Di I作为顺行示踪剂注入丘脑底核,可见黑质下网状部和苍白球内的细胞吞噬了Di I。在谷氨酸刺激下,原代培养的小胶质细胞吞噬活动增强,编码吞噬相关因子的m RNA转录水平也增加。人工合成的糖皮质激素地塞米松可以减弱这种改变。给PD大鼠皮下注射地塞米松,可以抑制黑质下网状部小胶质细胞的活化,运动功能障碍进一步加重,谷氨酸能突触转录m RNA增加,GABA能突触转录m RNA水平未增加。这些发现提示,当谷氨酸能神经元活动增强时,黑质下网状部和苍白球的小胶质细胞活化,选择性吞噬丘脑底核的谷氨酸能突触。因此,在基底核区可能存在一个负反馈环路,间接地代偿了由于多巴胺能神经元丢失而导致的功能障碍。小胶质细胞在这个负反馈环路中扮演了重要的角色。 | Aono H Choudhury ME Higaki H Miyanishi K Kigami Y Fujita K Akiyama JI Takahashi H Yano H Kubo M Nishikawa N Nomoto M Tanaka J 唐颖馨 | 2017 | 神经损伤与功能重建2017，12，5： | 7 |
| 13 | 2001年1月26日高纬磁层顶通量管事件的观测研究显示文摘20 0 1年 1月 2 6日 11:10~ 11:4 0UT ,ClusterⅡ卫星簇位于午后高纬磁鞘边界层和磁鞘区 ,此时行星际磁场Bz 为南向 .本文对在此期间观测到的多次磁通量管事件作了详细的研究 ,获得一系列的新发现 :(1)高纬磁鞘边界层磁通量管的出现具有准周期性 ,周期约为 78s,比目前已知的磁层顶向阳面FTE的平均周期 (8~ 11min)小得多 .(2 )这些通量管都具有强的核心磁场 ;其主轴多数在磁场最小变化方向 ,少数在中间变化方向 ,有些无法用PAA判定其方向 (需要用电流管PAA确定 ) ,这与卫星穿越通量管的相对路径有关 .(3)每个事件都存在很好的HT参考系 ,在HT参考系中这些通量管是准定常态结构 ;所有通量管都沿磁层顶表面运动 ,速度方向大体相同 ,都来自晨侧下方 .通量管的径向尺度为 1~ 2RE,与通常的FTE通量管相当 .(4 )起源于磁层的强能离子大体上沿着管轴方向由磁层向磁鞘运动 ;起源于太阳风的热等离子体沿管轴向磁层传输 .通量管为太阳风等离子体向磁层输运和磁层粒子向行星际空间逃逸提供了通道 .(5 )每个通量管事件都伴随有晨昏电场的反转 ,该电场为对流电场 . | 黄宗英 濮祖荫 肖池阶 宗秋刚 傅绥燕 谢伦 史全岐 曹晋滨 刘振兴 沈超 史建魁 路立 王迺权 陈涛 T Fritz K-H Glassmeier P Daly H Rème | 2004 | 地球物理学报2004，47，2： | 7 |
| 14 | 纳米粒疗法:一种新兴的癌症治疗方法显示文摘纳米粒具有在肿瘤细胞靶向定位和促进细胞吸收的功能,可在增强疗效的同时减少副作用,纳米粒疗法作为一种新型的癌症治疗方法正逐渐应用于临床。本文主要介绍纳米粒的主要结构及其区别于其他类型抗癌药物的特性,讨论目前第1代纳米粒疗法的临床应用以及处于临床前研究的最新纳米粒治疗系统,并总结纳米粒治疗系统目前已取得的成果和今后发展的趋势及挑战。 | 梁尔光 王玉丽 高春生 Davis ME Chen Z Shin DM | 2009 | 国际药学研究杂志2009，36，1： | 7 |
| 15 | Near-infrared reflectance spectroscopy reveals wide variation in major components of sesame seeds from Africa and Asia显示文摘Sesame is an important oilseed crop in Africa and Asia, owing to its high nutritional quality seed and market value. Variation in sesame seed components including oil, oleic acid,linoleic acid, and protein was investigated by near-infrared reflectance spectrometry in 139 samples collected from different countries. Oil and protein contents were between 40.8%and 60.3%(mean 53.0%) and 15.5% to 25.5%(mean 20.4%), respectively. Linoleic acid,ranging from 31.8% to 52.4%(mean 46%) was more abundant than oleic acid(31.8%–50.6%,mean 38.1%). Light-seeded samples displayed higher nutritional quality, as they were richer in oil, protein, and linoleic acid than dark seeds. Samples from Africa had higher oil and linoleic acid contents, while Asian samples had higher oleic content. The analysis revealed West African sesame cultivars containing especially high levels of seed components, which may command high market values. Two clusters of sesame samples grouped by seed composition were obtained, including one cluster with high oil and oleic acid content and the other with high protein and linoleic acid content. This study revealed that sesame samples from Africa and Asia harbor high variation for major seed components and also provided background information for breeding high-nutrition varieties according to the demands of sesame seed markets. | Komivi Dossa Xin Wei Marème Niang Pan Liu Yanxin Zhang Linhai Wang Boshou Liao Ndiaga Cissé Xiurong Zhang Diaga Diouf | 2018 | The Crop Journal2018，6，2： | 7 |
| 16 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 17 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 18 | pTC-1 observation of ion high-speed flow reversal in the near-Earth plasma sheet during substorm显示文摘Based on measurements of FGM and HIA on board TC-1 at its apogee on Septem-ber 14, 2004, we analyzed the ion high-speed flows in the near-Earth plasma sheet observed during the substorm expansion phase. Strong tailward high-speed flows (Vx ~ -350 km/s) were first seen at about X ~ -13.2 RE in near-Earth magnetotail, one minute later the flows reversed from tailward to earthward. The reversal process occurred quickly after the substorm expansion onset. The near-Earth magnetotail plasma sheet was one of key regions for substorm onset. Our analysis showed that the ion flow reversal from tailward to earthward was likely to be in close relation with the substorm expansion initiation and might play an important role in trigger-ing the substorm expansion onset. | H. RME I. DANDOURAS C. M. CARR | 2008 | Science China(Technological Sciences)2008，51，10： | 6 |
| 19 | 日本血吸虫Mf1和胞质氨基肽酶基因的亚克隆表达与免疫保护效果测定显示文摘目的 在大肠杆菌中高效表达日本血吸虫 (Schistosomajaponicum ,Sj)Mf1蛋白和胞质氨基肽酶 (cytosolaminopeptidase ,CA) ,并对表达产物进行免疫保护效果测定。 方法 将SjMf1基因和SjCA基因亚克隆至 pGEX - 5X - 3载体 ,转化入感受态大肠杆菌ER2 688,在IPTG诱导下进行表达 ,表达产物免疫小鼠 ,免疫用抗原剂量为 50 μg/次 /鼠 ,免疫 3次后进行攻击感染 ,观察诱导产生的减虫效果。结果 在IPTG诱导下 ,表达载体中的SjGST基因与重组的SjMf1基因和SjCA基因在大肠杆菌中获得了高效表达 ,形成SjGST -Mf1和SjGST -CA融虫蛋白 ,用这两种融合蛋白免疫小鼠 ,分别诱导产生了 39 1 5 %和 2 6 57%的减虫率。结论 SjMf1和SjCA基因亚克隆至pGEX - 5X - 3载体后可在大肠杆菌中高效表达 。 | 王庆林 易新元 曾宪芳 罗新松 何永康 彭兴华 Larry Me Reynolds | 2003 | 中国人兽共患病杂志2003，19，2： | 6 |
| 20 | High-resolution multimodal flexible coherent Raman endoscope显示文摘Coherent Raman scattering microscopy is a fast,label-free,and chemically specific imaging technique that shows high potential for future in vivo optical histology.However,the imaging depth in tissues is limited to the sub-millimeter range because of absorption and scattering.Realization of coherent Raman imaging using a fiber endoscope system is a crucial step towards imaging deep inside living tissues and providing information that is inaccessible with current microscopy tools.Until now,the development of coherent Raman endoscopy has been hampered by several issues,mainly related to the fiber delivery of the excitation pulses and signal collection.Here,we present a flexible,compact,coherent Raman,and multimodal nonlinear endoscope(4.2mm outer diameter,71mm rigid length)based on a resonantly scanned hollow-core Kagomé-lattice double-clad fiber.The fiber design enables distortion-less,background-free delivery of femtosecond excitation pulses and back-collection of nonlinear signals through the same fiber.Sub-micrometer spatial resolution over a large field of view is obtained by combination of a miniature objective lens with a silica microsphere lens inserted into the fiber core.We demonstrate high-resolution,high-contrast coherent anti-Stokes Raman scattering,and second harmonic generation endoscopic imaging of biological tissues over a field of view of 320μm at a rate of 0.8 frames per second.These results pave the way for intraoperative label-free imaging applied to real-time histopathology diagnosis and surgery guidance. | Alberto Lombardini Vasyl Mytskaniuk Siddharth Sivankutty Esben Ravn Andresen Xueqin Chen Jérôme Wenger Marc Fabert Nicolas Joly Frédéric Louradour Alexandre Kudlinski Hervé Rigneault | 2018 | Light(Science & Applications)2018，7，1： | 6 |
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