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| 1 | A review of the roles of forest canopy gaps显示文摘Treefall gap, canopy opening caused by the death of one or more trees, is the dominant form of disturbance in many forest systems worldwide. Gaps play an important role in forest ecology helping to preserve bio- and pedo-diversity, influencing nutrient cycles, and maintaining the complex structure of the late-successional forests. Over the last 30 years, numerous reviews have been written describing gap dynamics. Here we synthesize current understanding on gap dynamics relating to tree regeneration with particular emphasis on gap characteristics considered critical to develop ecologically sustainable forest management systems and to conserve native biodiversity. Specifically, we addressed the question: how do gaps influence forest structure? From the literature reviewed, the size of gaps induces important changes in factors such as light intensity, soil humidity and soil biological properties that influence tree species regeneration and differ in gaps of different sizes. Shadetolerant species can colonize small gaps; shade-intolerant species need large gaps for successful regeneration. Additionally, gap dynamics differ between temperate, boreal, and tropical forests, showing the importance of climate differences in driving forest regeneration. This review summarizes information of use to forest managers who design cutting regimes that mimic natural disturbances and who must consider forest structure, forest climate, and the role of natural disturbance in their designs. | Adele Muscolo Silvio Bagnato Maria Sidari Roberto Mercurio | 2014 | Journal of Forestry Research2014，25，4： | 22 |
| 2 | Cardiovascular and metabolic effects of Berberine显示文摘Berberine(BBR) is a natural alkaloid isolated from the Coptis Chinensis.While this plant has been used in Ay-urvedic and Chinese medicine for more than 2500 years,interest in its effects in metabolic and cardiovascular disease has been growing in the Western world in the last decade.Many papers have been published in these years reporting beneficial effects in carbohydrate and lip-id metabolism,endothelial function and the cardiovascu-lar system.In this review,we report a detailed analysis of the scientific literature regarding this topic,describing the effects and the underlying mechanisms of BBR on carbohydrate and lipid metabolism,endothelial function and the cardiovascular system. | Flora Affuso Valentina Mercurio Valeria Fazio Serafino Fazio | 2010 | World Journal of Cardiology2010，2，4： | 10 |
| 3 | A nutraceutical combination improves insulin sensitivity in patients with metabolic syndrome显示文摘AIM:To test the efficacy of a proprietary nutraceutical combination in reducing insulin resistance associated with the metabolic syndrome(MetS).METHODS:Sixty-four patients with MetS followed at a tertiary outpatient clinic were randomly assigned to receive either placebo or a proprietary nutraceutical combination(AP)consisting of berberine,policosanol and red yeast rice,in a prospective,double-blind,placebo-controlled study.Evaluations were performed at baseline and after 18 wk of treatment.The homeostasis model assessment of insulin resistance(HOMAIR)index was the primary outcome measure.Secondary endpoints included lipid panel,blood glucose and insulin fasting,after a standard mixed meal and after an oral glucose tolerance test(OGTT),ow-mediated dilation(FMD),and waist circumference.RESULTS:Fifty nine patients completed the study,2 withdrew because of adverse effects.After 18 wk there was a signif icant reduction in the HOMA-IR index in the AP group compared with placebo(ΔHOMA respectively-0.6 ± 1.2 vs 0.4 ± 1.9;P < 0.05).Total and low density lipoprotein cholesterol also significantly decreased in the treatment arm compared with placebo(Δlow density lipoprotein cholesterol-0.82 ± 0.68 vs-0.13 ± 0.55 mmol/L;P < 0.001),while triglycerides,high density lipoprotein cholesterol,and the OGTT were not affected.In addition,there were significant reductions in blood glucose and insulin after the standard mixed meal,as well as an increase in FMD(ΔFMD 1.9 ± 4.2 vs 0 ± 1.9 %;P < 0.05)and a significant reduction in arterial systolic blood pressure in the AP arm.CONCLUSION:This short-term study shows that AP has relevant beneficial effects on insulin resistance and many other components of MetS. | Flora Affuso Valentina Mercurio Antonio Ruvolo Concetta Pirozzi Filomena Micillo Guido Carlomagno Fabrizia Grieco Serafino Fazio | 2012 | World Journal of Cardiology2012，4，3： | 7 |
| 4 | 胰岛素抵抗: 现在是主要预防的时间?显示文摘 Insulin resistance is a clinical condition characterized by a decrease in sensitivity and responsiveness to the metabolic actions of insulin, so that a given concentration of insulin produces a less-than-expected biological effect. As a result, higher levels of insulin are needed to maintain normal glucose tolerance. Hyperinsulinemia, indeed, is one of the principal characteristics of insulin resistance states. This feature is common in several pathologic conditions, such as type 2 diabetes, obesity, and dyslipidemia, and it is also a prominent component of hypertension, coronary heart disease, and atherosclerosis. The presence of endothelial dysfunction, related to insulin resistance, plays a key role in the development and progression of atherosclerosis in all of these disorders. Insulin resistance represents the earliest detectable abnormality in type 2 diabetes, and is one of the major underlying mechanisms of hypertension and cardiovascular diseases. Its early detection could be of great importance, in order to set a therapeutic attack and to counteract the higher risk of diabetes and cardiovascular diseases. | Valentina Mercurio Guido Carlomagno Valeria Fazio Serafino Fazio | 2012 | World Journal of Cardiology2012，4，1： | 5 |
| 5 | Efficacy and safety of valsartan plus hydroclorothiazide for high blood pressure显示文摘AIM:To evaluate efficacy and tolerability of the combination valsartan plus hydrochlorothiazide(160 mg and 25 mg daily,respectively) in young-middle aged males with high-normal blood pressure(BP) or firstdegree arterial hypertension with evidence of target organ damage.METHODS:Twenty males with high-normal BP or first-degree hypertension associated with left ventricular concentric remodeling and/or increased aortic stiffness were enrolled.BP at rest and during exercise,and echocardiographic parameters of the left ventricle(LV),were evaluated at baseline and after 3 mo of treatment.The effects of treatment on aortic stiffness,metabolic parameters,renal and erectile function were also assessed.RESULTS:BP was significantly reduced by treatment both at rest(P < 0.001) and during exercise(P < 0.001),and 85% of patients achieved BP normalization(< 130/85 mmHg).Doppler echocardiography showed a significant reduction of LV mass(P < 0.005).LV hypertrophy was identified in 70% of subjects at baseline and in 5% after 3 mo of treatment.The ratio of early(E) to late(A) trans-mitral diastolic flow velocity increased,(P < 0.05),the relative wall thickness decreased(P < 0.05) and the left ventricular relaxation time shortened(P < 0.005).The left atrial diameter(P < 0.05) and the aortic diameter(P < 0.05) and stiffness(P < 0.005) also decreased.CONCLUSION:The full-dose combination of valsartan plus hydrochlorothiazide produced optimal BP control with regression of target organ damage,already after 3 mo,without relevant side effects. | Antonio Ruvolo Valentina Mercurio Valeria Fazio Guido Carlomagno Teresa Russo Flora Affuso Serafino Fazio | 2010 | World Journal of Cardiology2010，2，5： | 4 |
| 6 | Berberine behind the thriller of marked symptomatic bradycardia显示文摘Berberine is used in traditional Chinese medicine for the treatment of congestive heart failure, hypertension, diabetes, and dyslipidaemia and has a good safety profile. We report a case of a 53-year-old sportsman referred to our hospital for the onset of fatigue and dyspnoea upon exertion after he started berberine to treat hypercholesterolaemia. An electrocardiogram showed sinus bradycardia (45 bpm), first-degree atrioventricular block, and competitive junctional rhythm. An ergometric stress test showed slightly reduced chronotropic competence and the presence of runs of competitive junctional rhythm, atrial tachycardia, and sinus pauses in the recovery. After 10 d of wash-out from berberine, the patient experienced a complete resolution of symptoms, and an ergometric stress test showed good chronotropic competence. An electrocardiogram Holtershowed a latent hypervagotonic state. This is the first case report that shows that berberine could present certain side effects in hypervagotonic people, even in the absence of a situation that could cause drug accumulation. Therefore, berberine's use should be carefully weighed in hypervagotonic people due to the drug's bradycardic and antiarrhythmic properties, which could became proarrhythmic, exposing patients to potential health risks. | Margherita Cannillo Simone Frea Cristina Fornengo Elisabetta Toso Giancarlo Mercurio Stefania Battista Fiorenzo Gaita | 2013 | World Journal of Cardiology2013，5，7： | 3 |
| 7 | Multiple signals converging on NF-kappaB.显示文摘 | Mercurio F | | 0，，： | 3 |
| 8 | Proteases,Extracellular Matrix,and Cancer显示文摘 | DeClerck YA Mercurio AM Stack MS | 2004 | American Journal of Pathology2004，164，7： | 1 |
| 9 | Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex显示文摘 | Mercurio S Latinkic B Itasaki N | 2004 | Development2004，131，9： | 1 |
| 10 | Proteases, extra cellular matrix, and cancer: a workshop of the path B study显示文摘 | Declerck YA Mercurio AM Stack MS | 2004 | Am J Pathol2004，154，4： | 1 |
| 11 | High Throughput Analysis of Red Wine and Grape Phenolicss Adaptation and Validation of Methyl Cellulose Precipitable Tannin Assay and Modified Somers Color Assay to a Rapid 96 Well Plate Forma显示文摘 | Mercurio M D Dambergs R G Herderich M J | 2007 | J Agric Food Chem2007，，55： | 1 |
| 12 | Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4显示文摘 | Wendt MA Mercurio AM | 2002 | Cancer Res2002，62，24： | 1 |
| 13 | Vascular endothelial growth factor promotes carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4显示文摘 | Bachelder RE Wendt MA Mercurio Am | 2002 | Cancer Res2002，62，24： | 1 |
| 14 | Multiple signals converging on NFκappa B显示文摘 | Mercurio F Manning AM | 1999 | Curr Opin Cell Biol1999，11，2： | 1 |
| 15 | Tracheostomal stenosis following total laryngectomy显示文摘 | YONKERS A MERCURIO G | 1983 | Otolaryngol Clin North Am1983，16，： | 1 |
| 16 | Proteases, extra cellular matrix, and cancer: aworkshop of the path B study section 显示文摘 | De Clerck YA Mercurio AM Stack MS | 2004 | Am J Pathol2004，164，4： | 1 |
| 17 | The crystal chemistry and dielectric properties of the Aurivillius family of complex bismuth oxides with perovskite-like layered structures 显示文摘 | FRIT B MERCURIO J P | 1992 | J Alloy Compd1992，188，19： | 1 |
| 18 | Depression after minor stroke:prevalence and predictors显示文摘 | Altieri M Maestrini I Mercurio A | | 0，，： | 1 |
| 19 | NF-kappa B and the Link between inflammation and Cancer显示文摘 | Didonato JA Mercurio F Karin M | | 0，，01： | 1 |
| 20 | IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation 显示文摘 | MERCURIO F ZHU H MUTTAY B W | 1997 | Science1997，278，5339： | 1 |
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