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| 1 | The complex genetics in autism spectrum disorders显示文摘Autism spectrum disorders(ASD) are a pervasive neurodevelopmental disease characterized by deficits in social interaction and nonverbal communication, as well as restricted interests and stereotypical behavior. Genetic changes/heritability is one of the major contributing factors, and hundreds to thousands of causative and susceptible genes, copy number variants(CNVs), linkage regions, and micro RNAs have been associated with ASD which clearly indicates that ASD is a complex genetic disorder. Here, we will briefly summarize some of the high-confidence genetic changes in ASD and their possible roles in their pathogenesis. | HUA Rui WEI MengPing ZHANG Chen | 2015 | Science China(Life Sciences)2015，58，10： | 10 |
| 2 | Identification and characterization of rice blast resistance gene Pid4 by a combination of transcriptomic profiling and genome analysis显示文摘Map-based cloning of plant disease resistance (R) genes is time-consuming. Here, we reported the isolation of blast R gene Pid4 using comparative transcriptomic profiling and genome-wide sequence analysis. Pid4 encodes a coiled-coil nucleotide-binding site leucine-rich repeat(CC-NBS-LRR) protein and is constitutively expressed at diverse developmental stages in the rice variety Digu. The Pid4 protein is localized in both the nucleus and cytoplasm. Introduction of Pid4 into susceptible rice cultivars confers race-specific resistance to leaf and neck blast. Amino acid sequence comparison and blast resistance spectrum tests showed that Pid4 is a novel R gene, different from the previously reported R genes located in the same gene cluster. A Pid4 Indel marker was developed to facilitate the identification of Pid4 in different rice varieties. We demonstrated that a plant R gene can be quickly isolated using transcriptomic profiling coupled with genome-wide sequence analysis. | Zhixiong Chen Wen Zhao Xiaobo Zhu Chengdong Zou Junjie Yin Mawsheng Chern Xiaogang Zhou Heng Ying Xin Jiang Yongzhen Li Haicheng Liao Mengping Cheng Weitao Li Min He Jing Wang Jichun Wang Bingtian Ma Jirui Wang Shigui Li Lihuang Zhu Xuewei Chen | 2018 | Journal of Genetics and Genomics2018，45，12： | 7 |
| 3 | Embedding hollow Co3O4 nanoboxes into a three- dimensional macroporous graphene framework for high-performance energy storage devices显示文摘 | Mengping Li Maher F. EI-Kady Jee Y. Hwang Matthew D. Kowal Kristofer Marsh Haosen Wang Zhijuan Zhao Richard B. Kaner | 2018 | Nano Research2018，11，5： | 3 |
| 4 | A REACTIVE DYNAMIC CONTINUUM USER EQUILIBRIUM MODEL FOR BI-DIRECTIONAL PEDESTRIAN FLOWS显示文摘In this paper, a reactive dynamic user equilibrium model is extended to simu-late two groups of pedestrians traveling on crossing paths in a continuous walking facility. Each group makes path choices to minimize the travel cost to its destination in a reactive manner based on instantaneous information. The model consists of a conservation law equation coupled with an Eikonal-type equation for each group. The velocity-density relationship of pedestrian movement is obtained via an experimental method. The model is solved using a finite volume method for the conservation law equation and a fast-marching method for the Eikonal-type equation on unstructured grids. The numerical results verify the rationality of the model and the validity of the numerical method. Based on this continuum model, a number of results, e.g., the formation of strips or moving clusters composed of pedestrians walking to the same destination, are also observed. | Yanqun Jiang Tao Xiong S.C. Wong Chi-Wang Shu Mengping Zhang Peng Zhang William H.K. Lam | 2009 | Acta Mathematica Scientia2009，29，6： | 3 |
| 5 | NUMERICAL BOUNDARY CONDITIONS FOR THE FAST SWEEPING HIGH ORDER WENO METHODS FOR SOLVING THE EIKONAL EQUATION显示文摘快打扫方法的高顺序最近在文学被开发了高效地解决静态的 Hamilton-Jacobi 方程。与快打扫方法的第一份订单作比较,快大规模的高顺序方法是更精确的,但是因为精确地在流入边界附近对待点是特别地重要的更宽的数字模板,他们经常在边界附近为几个格子点要求另外的数字边界处理,当信息将流进计算领域并且将影响全球精确性。在文学,在这些边界点的数字答案也与准确答案被修理,它不总是是可行的,或与第一顺序 discretization 计算了,它能减少全球精确性。在这篇论文,我们讨论二策略处理流入边界条件。一个人基于快在边界和理查森推测附近与几种不同网孔尺寸打扫方法的第一份订单的数字答案,其它基于一个 Lax-Wendroff 类型过程到反复利用 PDE 以正切的衍生物给正常写空间衍生物到流入边界,从而在格子获得高顺序解决方案值指在流入边界附近。我们用快大规模高度探索这二条途径顺序 WENO 计划在[18 ] 为作为一个代表性的例子解决静态的 Eikonal 方程。数字例子被给表明这二条途径的表演。 | Ling Huang Chi-Wang Shu Mengping Zhang | 2008 | Journal of Computational Mathematics2008，26，3： | 2 |
| 6 | The genetic equidistance result:misreading by the molecular clock and neutral theory and reinterpretation nearly half of a century later显示文摘In 1963,Margoliash discovered the unexpected genetic equidistance result after comparing cytochrome c sequences from different species.This finding,together with the hemoglobin analyses of Zuckerkandl and Pauling in 1962,directly inspired the ad hoc molecular clock hypothesis.Unfortunately,however,many biologists have since mistakenly viewed the molecular clock as a genuine reality,which in turn inspired Kimura,King,and Jukes to propose the neutral theory of molecular evolution.Many years of studies have found numerous contradictions to the theory,and few today believe in a universal constant clock.What is being neglected,however,is that the failure of the molecular clock hypothesis has left the original equidistance result an unsolved mystery.In recent years,we fortuitously rediscovered the equidistance result,which remains unknown to nearly all researchers.Incorporating the proven virtues of existing evolutionary theories and introducing the novel concept of maximum genetic diversity,we proposed a more complete hypothesis of evolutionary genetics and reinterpreted the equidistance result and other major evolutionary phenomena.The hypothesis may rewrite molecular phylogeny and population genetics and solve major biomedical problems that challenge the existing framework of evolutionary biology. | HU TaoBo LONG MengPing YUAN DeJian ZHU ZhuBing HUANG YiMin HUANG Shi | 2013 | Science China(Life Sciences)2013，56，3： | 2 |
| 7 | Endophilin A1 regulates dendritic spine morphogenesis and stability through interaction with p140Cap显示文摘树枝状的脊骨是是在哺乳动物的大脑的有刺激性的 synaptic 输入的主要地点的充满肌动朊的膜伸出,并且他们的词法粘性为学习和记忆提供结构的基础。这里,我们报导与在在 presynaptic 终端的调停 clathrin 的 synaptic 泡 endocytosis 的一个生长得很好的角色, endophilin A1 也本地化到树枝状的脊骨并且为脊骨形态发生,触处形成和 synaptic 功能被要求。我们识别 p140Cap,细胞骨架重组的一个管理者, endophilin A1 的一个下游的受动器并且证明他们的相互作用的那混乱损害脊骨形成和成熟。而且,我们表明那 endophilin A1 或 p140Cap 击倒损害脊骨稳定和 synaptic 功能。我们进一步证明 endophilin A1 调整 p140Cap 和它的下游的受动器的分发,在树枝状的脊骨的 F-actin-binding 蛋白质 cortactin 以及 F 肌动朊丰富。一起,这些结果通过 p140Cap 的规定在脊骨形态发生,稳定和 synaptic 功能揭示 postsynaptic endophilin A1 的新奇功能。 | Yanrui Yang Mengping Wei Ying Xiong Xiangyang Du Shaoxia Zhu Lin Yang Chen Zhang Jia-Jia Liu | 2015 | Cell Research2015，25，4： | 2 |
| 8 | Synthesis of self-crosslinking sodium polyacrylate hydrogel and water-absorbing mechanism显示文摘 | Hua Fengjun Qian Mengping | 2001 | Journal of Materials Science2001，36，3： | 1 |
| 9 | Synthesis of self - crosslinking sodium polyacrylate hydrogel and water - absorbing mechanism 显示文摘 | Fengjun Hua Mengping Qian | 2001 | Journal of Materials Science2001，36，3： | 1 |
| 10 | Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia显示文摘T-cell acute lymphoblastic leukemia(T-ALL)is one of the most dangerous hematological malignancies,with high tumor heterogeneity and poor prognosis.More than 60%of T-ALL patients carry NOTCH1 gene mutations,leading to abnormal expression of downstream target genes and aberrant activation of various signaling pathways.We found that chidamide,an HDAC inhibitor,exerts an antitumor effect on T-ALL cell lines and primary cells including an anti-NOTCH1 activity.In particular,chidamide inhibits the NOTCH1-MYC signaling axis by down-regulating the level of the intracellular form of NOTCH1(NICD1)as well as MYC,partly through their ubiquitination and degradation by the proteasome pathway.We also report here the preliminary results of our clinical trial supporting that a treatment by chidamide reduces minimal residual disease(MRD)in patients and is well tolerated.Our results highlight the effectiveness and safety of chidamide in the treatment of T-ALL patients,including those with NOTCH1 mutations and open the way to a new therapeutic strategy for these patients. | Mengping Xi Shanshan Guo Caicike Bayin Lijun peng Florent Chuffart Ekaterina Bourova-Flin Sophie Rousseaux Saadi Khochbin Jian-Qing Mi Jin Wang | 2022 | Frontiers of Medicine2022，16，3： | 1 |
| 11 | Superconvergence of Energy-Conserving Discontinuous Galerkin Methods for Linear Hyperbolic Equations显示文摘In this paper,we study the superconvergence properties of the energy-conserving discontinuous Galerkin(DG)method in[18]for one-dimensional linear hyperbolic equations.We prove the approximate solution superconverges to a particular projection of the exact solution.The order of this superconvergence is proved to be k+2 when piecewise Pk polynomials with K≥1 are used.The proof is valid for arbitrary non-uniform regular meshes and for piecewise polynomials with arbitrary K≥1.Furthermore,we find that the derivative and function value approxi?mations of the DG solution are superconvergent at a class of special points,with an order of k+1 and R+2,respectively.We also prove,under suitable choice of initial discretization,a(2k+l)-th order superconvergence rate of the DG solution for the numerical fluxes and the cell averages.Numerical experiments are given to demonstrate these theoretical results. | Yong Liu Chi-Wang Shu Mengping Zhang | 2019 | Communications on Applied Mathematics and Computation2019，1，1： | 1 |
| 12 | Molecular cytogenetic characterization of a new wheat Secale africanum 2R a (2D) substitution line for resistance to stripe rust显示文摘 | MENGPING LEI GUANGRONG LI SUFEN ZHANG CHENG LIU ZUJUN YANG | 2011 | Journal of Genetics2011，，2： | 1 |
| 13 | Numerical simulation of a complex moving rigid body under the impingement of a shock wave in 3D显示文摘In this paper,we take a numerical simulation of a complex moving rigid body under the impingement of a shock wave in three-dimensional space.Both compressible inviscid fluid and viscous fluid are considered with suitable boundary conditions.We develop a high order numerical boundary treatment for the complex moving geometries based on finite difference methods on fixed Cartesian meshes.The method is an extension of the inverse Lax-Wendroff(ILW)procedure in our works(Cheng et al.,Appl Math Mech(Engl Ed)42:841-854,2021;Liu et al.)for 2D problems.Different from the 2D case,the local coordinate rotation in 3D required in the ILW procedure is not unique.We give a theoretical analysis to show that the boundary treatment is independent of the choice of the rotation,ensuring the method is feasible and valid.Both translation and rotation of the body are taken into account in this paper.In particular,we reformulate the material derivative for inviscid fluid on the moving boundary with no-penetration condition,which plays a key role in the proposed algorithm.Numerical simulations on the cylinder and sphere are given,demonstrating the good performance of our numerical boundary treatments. | Shihao Liu Ziqiang Cheng Yan Jiang Jianfang Lu Mengping Zhang Shuhai Zhang | 2022 | Advances in Aerodynamics2022，4，1： | 1 |
| 14 | 显示文摘 | QIAN MengPing | 2001 | J Material Science2001，36，： | 1 |
| 15 | Synthesis of self- crosslinking sodium polyacrylate hydrogel and water - absorbing mechanism 显示文摘 | FENG Junhua QIAN Mengping | 2001 | Journal of MaterialScience2001，，36： | 1 |
| 16 | WENO scheme with subcell resolution for computing nonconservative Euler equations with applications to one-dimensional compressible two-medium flows显示文摘 | XIONG Tao SHU Chiwang ZHANG Mengping | 2012 | Journal of Scientific Computing2012，53，1： | 1 |
| 17 | A 16-element multiplexed heterodyning fiber grating laser sensor array 显示文摘 | Jin Long Liang Yizhi Li Mengping eta/ | 2014 | Journal of Lightwave Technology2014，32，22： | 1 |
| 18 | 显示文摘 | Hua Fengjun Qian Mengping | 2001 | Journal of Materials Sci- ence2001，36，3： | 1 |
| 19 | The effectiveness of a self- management program on quality of life for knee osteoarthritis patient显示文摘 | Mujung Kao Mengping Wu Meiwun Tsm | 2012 | Arch Gerontol Greiat2012，54，： | 1 |
| 20 | A high order boundary scheme to simulate complex moving rigid body under impingement of shock wave显示文摘In the paper, we study a high order numerical boundary scheme for solving the complex moving boundary problem on a fixed Cartesian mesh, and numerically investigate the moving rigid body with the complex boundary under the impingement of an inviscid shock wave. Based on the high order inverse Lax-Wendroff(ILW) procedure developed in the previous work(TAN, S. and SHU, C. W. A high order moving boundary treatment for compressible inviscid flows. Journal of Computational Physics, 230(15),6023–6036(2011)), in which the authors only considered the translation of the rigid body,we consider both translation and rotation of the body in this paper. In particular, we reformulate the material derivative on the moving boundary with no-penetration condition, and the newly obtained formula plays a key role in the proposed algorithm. Several numerical examples, including cylinder, elliptic cylinder, and NACA0012 airfoil, are given to indicate the effectiveness and robustness of the present method. | Ziqiang CHENG Shibao LIU Yan JIANG Jianfang LU Mengping ZHANG Shuhai ZHANG | 2021 | Applied Mathematics and Mechanics(English Edition)2021，42，6： | 1 |
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