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| 1 | The complex genetics in autism spectrum disorders显示文摘Autism spectrum disorders(ASD) are a pervasive neurodevelopmental disease characterized by deficits in social interaction and nonverbal communication, as well as restricted interests and stereotypical behavior. Genetic changes/heritability is one of the major contributing factors, and hundreds to thousands of causative and susceptible genes, copy number variants(CNVs), linkage regions, and micro RNAs have been associated with ASD which clearly indicates that ASD is a complex genetic disorder. Here, we will briefly summarize some of the high-confidence genetic changes in ASD and their possible roles in their pathogenesis. | HUA Rui WEI MengPing ZHANG Chen | 2015 | Science China(Life Sciences)2015，58，10： | 10 |
| 2 | Endophilin A1 regulates dendritic spine morphogenesis and stability through interaction with p140Cap显示文摘树枝状的脊骨是是在哺乳动物的大脑的有刺激性的 synaptic 输入的主要地点的充满肌动朊的膜伸出,并且他们的词法粘性为学习和记忆提供结构的基础。这里,我们报导与在在 presynaptic 终端的调停 clathrin 的 synaptic 泡 endocytosis 的一个生长得很好的角色, endophilin A1 也本地化到树枝状的脊骨并且为脊骨形态发生,触处形成和 synaptic 功能被要求。我们识别 p140Cap,细胞骨架重组的一个管理者, endophilin A1 的一个下游的受动器并且证明他们的相互作用的那混乱损害脊骨形成和成熟。而且,我们表明那 endophilin A1 或 p140Cap 击倒损害脊骨稳定和 synaptic 功能。我们进一步证明 endophilin A1 调整 p140Cap 和它的下游的受动器的分发,在树枝状的脊骨的 F-actin-binding 蛋白质 cortactin 以及 F 肌动朊丰富。一起,这些结果通过 p140Cap 的规定在脊骨形态发生,稳定和 synaptic 功能揭示 postsynaptic endophilin A1 的新奇功能。 | Yanrui Yang Mengping Wei Ying Xiong Xiangyang Du Shaoxia Zhu Lin Yang Chen Zhang Jia-Jia Liu | 2015 | Cell Research2015，25，4： | 2 |
| 3 | Mechanism and effect of stress granule formation in cancer and its potential roles in breast cancer therapy显示文摘Stress granules are non-membranous cytoplasmic foci induced by various stress conditions.It is a protective strategy used by cells to suppress overall translation during stress.In cancer cells,it was thought that the formation of stress granules could protect them from apoptosis and induces resistance towards anti-cancer drugs or radiation treatment which makes the stress granules a potential target for cancer treatment.However,most of our understanding of stress granules are still in the stage of molecular and cell biology,and a transitional gap for its actual effect on clinical settings remains.In this review,we summarize the mechanism and effect of stress granules formation in cancer and try to illuminate its potential applications in cancer therapy,using breast cancer as an example. | Taobo Hu Wei Hou Enhua Xiao Mengping Long | 2022 | Genes & Diseases2022，9，3： | 1 |
| 4 | Microfluidics-assisted optimization of highly adhesive haemostatic hydrogel coating for arterial puncture显示文摘Although common in clinical practice,bleeding after tissue puncture may cause serious outcomes,especially in arterial puncture.Herein,gelatin-tannic acid composite hydrogels with varying compositions are prepared,and their adhesive properties are further optimized in microfluidic channel-based simulated vessels for haemostasis in arterial puncture.It is revealed that the composite hydrogels on the syringe needles used for arterial puncture should possess underwater adhesion higher than 4.9 kPa and mechanical strength higher than 86.0 kPa.The needles coated with the gelatin-tannic acid composite hydrogel completely prevent blood loss after both vein and arterial puncture in different animal models.This study holds great significance for the preparation of haemostatic needles for vessel puncture,and gelatin-tannic acid hydrogel coated needles may help to prevent complications associated with arterial puncture. | Xingjie Yin Jingli Ren Wei Lan Yu Chen Mengping Ouyang Hua Su Lianbin Zhang Jintao Zhu Chun Zhang | 2022 | Bioactive Materials2022，7，6： | 0 |
| 5 | Noninvasive Tracking of Every Individual in Unmarked Mouse Groups Using Multi-Camera Fusion and Deep Learning显示文摘Accurate and efficient methods for identifying and tracking each animal in a group are needed to study complex behaviors and social interactions.Traditional tracking methods(e.g.,marking each animal with dye or surgically implanting microchips)can be invasive and may have an impact on the social behavior being measured.To overcome these shortcomings,video-based methods for tracking unmarked animals,such as fruit flies and zebrafish,have been developed.However,tracking individual mice in a group remains a challenging problem because of their flexible body and complicated interaction patterns.In this study,we report the development of a multi-object tracker for mice that uses the Faster region-based convolutional neural network(R-CNN)deep learning algorithm with geometric transformations in combination with multi-camera/multi-image fusion technology.The system successfully tracked every individual in groups of unmarked mice and was applied to investigate chasing behavior.The proposed system constitutes a step forward in the noninvasive tracking of individual mice engaged in social behavior. | Feng Su Yangzhen Wang Mengping Wei Chong Wang Shaoli Wang Lei Yang Jianmin Li Peijiang Yuan Dong-Gen Luo Chen Zhang | 2023 | Neuroscience Bulletin2023，39，6： | 0 |
| 6 | Sedimentological Characteristics of Sandy Gravel Beach in Kongtong Island显示文摘Hydrological characteristics such as waves, tides, currents, and meteorological features such as weather and wind, as well as geological structure were collected. Through the field trips of Kongtong Island, observations of its base rock coast, measurement of beach slope and beach gravel particle size, gravel and sandy samples was collected in the intertidal zone of west beach, east beach, and north beach of Kongtong. Particle size analysis and roundness calculation were carried out to verify whether they were consistent with the oceanographic data collected from Kongtong Island. The results showed that the north beach was mainly gravel, the west beach was a mixture of sand and gravel, and east beach was a sandy sediment. The particle sizes and roundness of different samples showed that north beach had the strongest hydrodynamic conditions, followed by the west beach, and the east beach had the weakest hydrodynamic conditions. This had a direct relationship with perennial wave direction and wind direction. Full understanding of the oceanographic characteristics of Kongtong Island is of great practical significance for the better development and utilization of Kongtong Island and the rational use of its geographic location for tourism and recreation. | ZHANG Wei LIN Mengping CHEN Yang FAN Shuimiao | 2019 | Journal of Landscape Research2019，11，6： | 0 |
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