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| 1 | Personalizing therapies for gastric cancer: Molecular mechanisms and novel targeted therapies显示文摘Globally,gastric cancer is the 4thmost frequently diagnosed cancer and the 2ndleading cause of death from cancer,with an estimated 990000 new cases and738000 deaths registered in 2008.In the advanced setting,standard chemotherapies protocols acquired an important role since last decades in prolong survival.Moreover,recent advances in molecular therapies provided a new interesting weapon to treat advanced gastric cancer through anti-human epidermal growth factor receptor 2(HER2)therapies.Trastuzumab,an anti-HER2 monoclonal antibody,was the first target drug in the metastatic setting that showed benefit in overall survival when in association with platinum-5-fluorouracil based chemotherapy.Further,HER2 overexpression analysis acquired a main role in predict response for trastuzumab in this field.Thus,we conducted a review that will discuss the main points concerning trastuzumab and HER2 in gastric cancer,providing a comprehensive overview of molecular mechanisms and novel trials involved. | Michael Luis Ana Tavares Liliana S Carvalho Lúcio Lara-Santos António Araújo Ramon Andrade de Mello | 2013 | World Journal of Gastroenterology2013，19，38： | 6 |
| 2 | Methane production and small intestinal bacterial overgrowth in children living in a slum显示文摘AIM:To analyze small intestinal bacterial overgrowth in school-aged children and the relationship between hydrogen and methane production in breath tests.METHODS:This transversal study included 85 children residing in a slum and 43 children from a private school,all aged between 6 and 10 years,in Osasco,Brazil.For characterization of the groups,data regarding the socioeconomic status and basic housing sanitary conditions were collected.Anthropometric data was obtained in children from both groups.All children completed the hydrogen(H 2) and methane(CH 4) breath test in order to assess small intestinal bacterial overgrowth(SIBO).SIBO was diagnosed when there was an increase in H 2 ≥ 20 ppm or CH 4 ≥ 10 ppm with regard to the fasting value until 60 min after lactulose ingestion.RESULTS:Children from the slum group had worse living conditions and lower nutritional indices than children from the private school.SIBO was found in 30.9%(26/84) of the children from the slum group and in 2.4%(1/41) from the private school group(P = 0.0007).Greater hydrogen production in the small intestine was observed in children from the slum group when compared to children from the private school(P = 0.007).A higher concentration of hydrogen in the small intestine(P < 0.001) and in the colon(P < 0.001) was observed among the children from the slum group with SIBO when compared to children from the slum group without SIBO.Methane production was observed in 63.1%(53/84) of the children from the slum group and in 19.5%(8/41) of the children from the private school group(P < 0.0001).Methane production was observed in 38/58(65.5%) of the children without SIBO and in 15/26(57.7%) of the children with SIBO from the slum.Colonic production of hydrogen was lower in methaneproducing children(P = 0.017).CONCLUSION:Children who live in inadequate environmental conditions are at risk of bacterial overgrowth and methane production.Hydrogen is a substrate for methane production in the colon. | Carolina Santos Mello Soraia Tahan Lígia Cristina FL Melli Mirian Silva do Carmo Rodrigues Ricardo Martin Pereira de Mello Isabel Cristina Affonso Scaletsky Mauro Batista de Morais | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 3 | A correct and complete algorithm for the generation of mechanical assembly sequences显示文摘 | Homem de Mello L S Sanderson A C | 1991 | IEEE Journal of Robotics and Automation1991，7，2： | 2 |
| 4 | Feulgen - DNA absorption spectrum of euchromatin and Constitutive heterochromatin 显示文摘 | Mello M L | 1978 | J Histochem cytochem1978，26，12： | 1 |
| 5 | Unified Method for the Prediction of Rain Attenuation in Satellite and Terrestrial Links显示文摘 | DA SILVA MELLO L PONTES M S | 2012 | Journal of Microwaves Optoelectronics and Electromagnetic Applications2012，11，1： | 1 |
| 6 | A technical and economical evaluation of CO2 capture from FCC units 显示文摘 | DE MELLO L F PIMENTA R D M MOURE G T | 2009 | Energy Procedia2009，1，1： | 1 |
| 7 | Prediction of rain attenuation in terrestrial links using full rainfall rate distribution显示文摘 | SILLVA MELLO DA L A R PONTES M S SOUZA DE R M | 2007 | Electronics Letters2007，43，25： | 1 |
| 8 | A correct and complete algorithm for the generation of mechanical assembly sequences显示文摘 | SandersonAC | 1991 | IEEE Transation on Robotics and Automation1991，7，2： | 1 |
| 9 | Application of microwave induced combustion in closed vessels for carbon black-containing elastomers decomposition 显示文摘 | Moraes D P Mesko M F Mello P A Paniz J N G Dressler V L Knapp G Flores E M M | 2007 | Spectrochim Acta : Part B2007，62，： | 1 |
| 10 | A correct and complete algorithmfor the generation of mechanical assembly sequences显示文摘 | Homen de Mello L S Sanderson A | 1991 | IEEE Trans-action on Robotics and Automation1991，7，2： | 1 |
| 11 | Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity显示文摘 | Verneulen L Todaro M de Sousa Mello F | | 0，，： | 1 |
| 12 | Downregulation of genes involved in NF kappaB activation in peripheral blood mononuclear cells after weight loss is associated with the improvement of insulin sensitivity in individuals with the metabolic syndrome:the GENOBIN study显示文摘 | de Mello V D Kolehmainen M Pulkkinen L | 2008 | Diabetologia2008，51，11： | 1 |
| 13 | inducible systemic RNA silencing in Caenorhabditis elegans 显示文摘 | TIMMONS L Tabara H Mello C C | 2003 | Mol Biol Cell2003，14，7： | 1 |
| 14 | Thrombophilia is significant- ly associated with severe preeclampsia: results of a large-scale, case-controlled study 显示文摘 | Mello G Parretti E Marozio L | 2005 | Hypertension2005，46，6： | 1 |
| 15 | Foreign direct investment -led growth: evidence from time series and panel data 显示文摘 | De Mello L R | 1999 | 51(1) : 133 -1511999，51，1： | 1 |
| 16 | Hypoxia- inducible myoglobin expression in nonmuscle tissues 显示文摘 | Fraser J de Mello L V Ward D | 2006 | Proceedings of the National Academy of Sciences of the United States of American2006，103，8： | 1 |
| 17 | First report of Cowpea aphid-borne mosaic virus on sesame in Paraguay显示文摘 | Segnana L G de Lopez M R Mello A P O A | 2011 | Plant Disease2011，95，5： | 1 |
| 18 | RNAi in C elegans: soaking in the genome sequence显示文摘 | TABARA H GRISHOK A MELLO C L | 1998 | Science1998，282，： | 1 |
| 19 | Bifurcation analysis of the Watt governor system 显示文摘 | Sotomayor J Mello L F Braga D C | 2007 | Comp Appl Math2007，26，： | 1 |
| 20 | Ab- sorption of CO2 into aqueous solutions of MEA and AMP in a wetted wall column with film promoter Chemical 显示文摘 | MELLO L C SALVAGNINI W M DE PAIVA J L | 2013 | Engineering and Processing: Process Intensifica- tion2013，73，12： | 1 |
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