|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Requirement for cyclin D3 in germinal center formation and function显示文摘第二等的淋巴的纸巾的幼芽的中心(GC ) 对装高亲密关系的体液的有免疫力的回答批评。当多样化他们的抗体基因时,在 GC 以内的 B 房间经历快速的同种细胞的扩大和选择。尽管 GC B 房间采用一个唯一的 proliferative 程序提供这些进程,这通常被相信,很少联系 GC 的房间周期怎么被安排被知道。D 类型 cyclins 组成使房间能对生理的变化作出回应的房间周期引擎的一个重要部件。房间类型 -- 并且 D 类型 cyclins 的发展阶段特定的角色被描述了,但是 cyclin D 要求没在 GC 反应期间被探讨。在这研究,我们报导 cyclin D3 为切换的增长和 Ig 班大部分是非必需的在 vitro 激活的 B 房间。相反,在 Ccnd3 的 GC 开发 ?/ ?老鼠显著地被损害,作为是 T 房间依赖者抗体反应。在 GC 以内,尽管切换, unswitched B 房间被 cyclin D3 inactivation 影响, IgM?水池更严重地被减少。有趣地尽管有 cyclin D2 表示的补偿增加, Ccnd3 的一个重要数字 ?/ ?GC B 房间处于静止 G0 状态积累。最后,尽管 cyclin D3 inactivation 没在 GC B 房间破坏 BCL6 表示,支持 BCL6 overexpression 的效果完全堵住了 GC,建议 cyclin D3 调整 GC 形成的 BCL6 下游地行动。这是 cyclin D3 玩的第一示范在 B 房间开发的 GC 阶段的一个重要、唯一的角色。 | Jonathan U Peled J Jessica Yu Jeganathan Venkatesh Enguang Bi B Belinda Ding Melissa Krupski-Downs Rita Shaknovich Piotr Sicinski Betty Diamond Matthew D Scharff B Hilda Ye | 2010 | Cell Research2010，20，6： | 3 |
| 3 | Global cancer statistics显示文摘 | Ahmedin J Freddie B Melissa M | 2011 | CA Cancer J Clin2011，61，2： | 1 |
| 4 | Reproductive toxicity evaluation of dietary butyl benzyl phthalate(BBP)in rats显示文摘 | Rochelle W T Christina B M Melissa C M | 2004 | Reproductive Toxicology2004，18，： | 1 |
| 5 | Global cancerstatistics显示文摘 | Ahmedin J Freddie B Melissa M | 2011 | Ca Cancer J Clin2011，61，2： | 1 |
| 6 | Synthe- sis, antifungal activity, and structure-activity relation- ships of coruscanone A analogues显示文摘 | BABU K B LI X C MELISSA R J | 2006 | J Med Chem2006，49，26： | 1 |
| 7 | Global cancer statistics 显示文摘 | Ahmedin J Freddie B Melissa MC | 2011 | CA Cancer J Clin2011，61，： | 1 |
| 8 | Global cancer statistics显示文摘 | Ahmedin J Freddil B Melissa M | 2011 | CA Cancer J Clin2011，61，2： | 1 |
| 9 | Characterization of the last deglacial transition in tropical East Afri显示文摘 | Melissa A B Thomas C J Josef P W | 2014 | Palaeogeography Palaeoclimatology Palaeoecology2014，409，： | 1 |
| 10 | la, 25(OH)2-vitamin D3 membrane-initiated calcium signaling modulates exocytosis and cell survival显示文摘 | Zhang XY Payal B Melissa O | 2007 | J Sterold Blochem Mol Biol2007，103，： | 1 |
| 11 | Structure of hybrid (organic/inorganic) TiO2 SiO2 xerogels II:thermai behavior as monitored by temperature-programmed techniques and spectroscopy显示文摘 | LARSEN G MELISSA B S NGUYEN C | 2001 | J Non Cryst Solids2001，279，： | 1 |
| 12 | Global cancer statistics 显示文摘 | Ahmedin J Freddie B Melissa M | 2011 | CA Cancer J Clin2011，61，2： | 1 |
| 13 | Equity--based compensation for employees: firm performance and determinants 显示文摘 | MELISSA B FRYE | 2004 | The Journal of Financial Research2004，，1： | 1 |
| 14 | Maternal milk reduces severity of necrotizing enterocolitis and increases intestinal IL-10 in a neonatal rat model显示文摘 | DVORAK B MELISSA D HALPERN H | 2003 | Pediatr Res War2003，53，： | 1 |
| 15 | Global Cancer Statistics显示文摘 | AhmedinJ Freddil B Melissa M et a1 | | 0，，2： | 1 |
| 16 | Secondhand smoke drift: Examining the influence of indoor smoking bans on indoor and outdoor air quality at pubs and bars 显示文摘 | Emily B Melissa C Charles W | 2010 | Nicotine & Tobacco Research2010，12，： | 1 |
| 17 | Modeled earthquake losses and social vulnerability in Charleston, South Carolina 显示文摘 | MATHEW C S JOHN M S MELISSA B | 2011 | Applied Geography2011，31，1： | 1 |
| 18 | Global cancer statistics显示文摘 | Ahmedin J Freddie B Melissa M | 2011 | CA Cancer J Clin2011，61，： | 1 |
| 19 | Global cancer statistics显示文摘 | Ahmedin J Freddie B Melissa M | 2011 | CA Cancer J Clin2011，61，2： | 1 |
| 20 | Global cancer statistics 显示文摘 | AHMEDIN J FREDDIE B MELISSA M | 2011 | CA Cancer J Clin2011，61，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员