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2396篇 您的检索式:作者名="MEHDI"
    题名 作者 年代 出处 被引量
1Phase 1 human trial of autologous bone marrow-hematopoietic stem cell transplantation in patients with decompensated cirrhosis显示文摘AIM: To evaluate safety and feasibility of autologous bone marrow-enriched CD34+ hematopoietic stem cell Tx through the hepatic artery in patients with decompensated cirrhosis.METHODS: Four patients with decompensated cirrhosis were included. Approximately 200 mL of the bone marrow of the patients was aspirated, and CD34+ stem cells were selected. Between 3 to 10 million CD34+ cells were isolated. The cells were slowly infused through the hepatic artery of the patients.RESULTS: Patient 1 showed marginal improvement in serum albumin and no significant changes in other test results. In patient 2 prothrombin time was decreased; however, her total bilirubin, serum creatinine, and Model of End-Stage Liver Disease (MELD) score worsened at the end of follow up. In patient 3 there was improvement in serum albumin, porthrombin time (PT), and MELD score. Patient 4 developed radiocontrast nephropathy after the procedure, and progressed to type 1 hepatorenal syndrome and died of liver failure a few days later. Because of the major side effects seen in the last patient, the trial was prematurely stopped.CONCLUSION: Infusion of CD34+ stem cells through the hepatic artery is not safe in decompensated cirrhosis. Radiocontrast nephropathy and hepatorenal syndrome could be major side effects. However, this study doesnot preclude infusion of CD34+ stem cells through other routes.Mehdi Mohamadnejad Mehrnaz Namiri Mohamad Bagheri Seyed Masiha Hashemi Hossein Ghanaati Narges Zare Mehrjardi Saeed Kazemi Ashtiani Reza Malekzadeh Hossein Baharvand 2007World Journal of Gastroenterology2007,13,24:74
2TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization显示文摘皮肤的神经原的发炎(CNI ) 是被导致的发炎(或提高) 在由从感觉神经末端的 neuropeptides 的版本的皮肤。临床的表明主要是象瘙痒和红斑那样的感觉、脉管的混乱。短暂受体潜力 vanilloid 1 并且 ankyrin 1 (TRPV1 和 TRPA1,分别地) 是知道明确地参予疼痛和 CNI 的非选择的阳离子隧道。TRPV1 和 TRPA1 在感觉神经的一个大子集被共同表示,在他们集成众多的有害刺激的地方。两条隧道的表示也在皮肤在感觉神经以外远延长,现在是清楚的,在 keratinocytes,桅杆房间,树枝状的房间,和 endothelial 房间也发生。在这些 non-neuronal 房间, TRPV1 和 TRPA1 也充当 nociceptive 传感器并且加强煽动性的过程。这评论在在感觉神经原和 non-neuronal 皮肤房间导致或维持 CNI 的煽动性的基因的调整讨论 TRPV1 和 TRPA1 的角色。另外,这评论由支持 CNI 的自我维护的另外的内长的煽动性的调停人提供关于两条 TRP 隧道的细胞内部的促进感受性小径的当前的研究的一篇摘要。Olivier Gouin Killian L'Herondelle Nicolas Lebonvallet Christelle Le Gall-lanotto Mehdi Sakka Virginie Buhe Emmanuelle PIee-Gautier Jean-Luc Carre Luc Lefeuvre Laurent Misery~,Raphaele Le Garrec 2017Protein & Cell2017,8,9:45
3Amelioration of Saline-Sodic Soils with Tillage Implements and Sulfuric Acid Application显示文摘Amelioration of saline-sodic soils through land preparation with three tillage implements (disc plow, rotavator and cultivator) each followed by application of sulfuric acid at 20% of gypsum (CaSO4·2H2O) requirement or no sulfuric acid application during crop growth period was evaluated in a field study for 2.5 years at three sites, i.e., Jhottianwala, Gabrika (Thabal), and Thatta Langar, in Tehsil Pindi Bhattian, Hafizabad District, Pakistan. Within 2.5 years, there was a decrease in the salinity parameters measured (electrical conductivity, pH, and sodium adsorption ratio), with a gradual increase in rice and wheat grain yields. It was observed that the disc plow, which not only ensured favorable yields but also helped improve soil health at all the three sites, was the most effective tillage implement. Also, application of sulfuric acid resulted in higher yields and promoted rapid amelioration of the saline-sodic soils.M.SADIQ G.HASSAN S. M. MEHDI N. HUSSAIN M. JAMIL 2007Pedosphere2007,17,2:28
4Use of antibiotics in broiler production:Global impacts and alternatives显示文摘Antibiotics are used to fight bacterial infections.However, a selective pressure gave rise to bacteria resistant to antibiotics.This leaves scientists worried about the danger to human and animal health.Some strategies can be borrowed to reduce the use of antibiotics in chicken farms.Much research has been carried out to look for natural agents with similar beneficial effects of growth promoters.The aim of these alternatives is to maintain a low mortality rate, a good level of animal yield while preserving environment and consumer health.Among these, the most popular are probiotics, prebiotics, enzymes,organic acids, immunostimulants, bacteriocins, bacteriophages, phytogenic feed additives, phytoncides,nanoparticles and essential oils.Youcef Mehdi Marie-Pierre Létourneau-Montminy Marie-Lou Gaucher Younes Chorfi Gayatri Suresh Tarek Rouissi Satinder Kaur Brar Caroline Cté Antonio Avalos Ramirez Stéphane Godbout 2018Animal Nutrition2018,,2:19
5冲击载荷作用下磁流变阻尼器的建模与分析显示文摘以某12.7 mm机枪的磁流变(MR)后坐阻尼器为研究对象,基于Herschel-Bulkley本构模型,建立了该MR后坐阻尼器的轴对称一维层流模型。运用ANSYS软件,对该阻尼器的MR阀进行了磁场有限元分析,求得了环状间隙间MR流体的磁通密度。将MR流体流动模型和MR阀有限元结果相结合,建立了不同磁场作用下阻尼力随活塞速度的变化规律,利用这些规律对该阻尼器的落锤撞击试验和实弹射击试验进行了数值仿真。理论与试验结果的对比指出,在低磁场作用的情况下,理论与试验结果具有较好的一致性。侯保林 MEHDI Ahmadian 2006机械工程学报2006,42,4:17
6Stool-based DNA testing,a new noninvasive method for colorectal cancer screening,the first report from Iran显示文摘AIM:To detect tumor-associated DNA changes in stool samples among Iranian patients with colorectal cancer(CRC)compared to healthy individuals using BAT-26,p16 hypermethylation and long DNA markers.METHODS:Stool DNA was isolated from 45 subjects including 25 CRC patients and 20 healthy individuals using a new,fast and easy extraction method.Long DNA associated with tumor was detected using polymerase chain reaction method.Microsatellite studies were performed utilizing denaturating polyacrylamide gel to determine the instability of BAT-26.Methylation status of p16 promoter was analyzed using methylation-specific PCR(MSP).RESULTS:The results showed a significant difference in existence of long DNA(16 in patients vs 1 in controls,P < 0.001)and p16(5 in patients vs none in controls,P = 0.043)in the stool samples of two groups.Long DNA was detected in 64% of CRC patients;whereas just one of the healthy individuals was positive for Long DNA.p16 methylation was found in 20% of patients and in none of healthy individuals.Instability of BAT-26 was not detected in any of stool samples.CONCLUSION:We could detect colorectal cancer related genetic alterations by analyzing stool DNA witha sensitivity of 64% and 20% and a specificity of 95% and 100% for Long DNA and p16 respectively.A non-invasive molecular stool-based DNA testing can provide a screening strategy in high-risk individuals.However,additional testing on more samples is necessary from Iranian subjects to determine the exact specificity and sensitivity of these markers.Mohammad Reza Abbaszadegan Alireza Tavasoli Arash Velayati Hamid Reza Sima Hassan Vosooghinia Mehdi Farzadnia Hamid Asadzedeh Mehran Gholamin Ezzat Dadkhah Azadeh Aarabi 2007World Journal of Gastroenterology2007,13,10:14
7Accuracy and responses of genomic selection on key traits in apple breeding显示文摘The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation interval.The objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key traits.The training population comprised 977 individuals derived from 20 pedigreed fllsib families.Historic phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP array.From these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib families.The application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by imputation.These five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding values.Accuracy of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of 0.19.The accuracies were strongly affected by the phenotypic distribution and heritability of traits.In the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic distribution.Traits that showed non-significant response often had reduced and skewed phenotypic variation or low heritability.Among the five application families the accuracies were uncorrelated to the degree of relatedness to the training population.The results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs.Hélène Muranty Michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar François Laurens Marco C.A.M.Bink 2015Horticulture Research2015,2,1:14
8S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3显示文摘建筑群由 S100 钙绑定蛋白质家庭,的二个成员形成了 S100A8/A9,在不同起源的各种各样的房间施加导致 apoptosis 活动。这里,我们内在的分子的机制包含的现在的证据两个都规划了房间死亡我(PCD 我, apoptosis ) 并且象死亡一样的 PCD II (autophagy ) 。有 S100A8/A9 的房间的处理引起了 Beclin-1 表示以及 Atg12-Atg5 形成的增加。S100A8/A9-induced 房间死亡被特定的 PI3-kinase 班 III 禁止者部分禁止, 3-methyladenine (3 麻省) ,并且由液泡 H+-ATPase 禁止者, bafilomycin-A1 (Baf-A1 ) 。S100A8/A9 挑起了 BNIP3 的 translocation, BH3 仅仅 pro-apoptotic Bcl2 家庭成员,到线粒体。与这发现一致,螖 T M-BNIP3 overexpression 部分禁止了 S100A8/A9-induced 细胞死亡,减少的反应的氧种(ROS ) 产生,并且部分在 S100A8/A9-treated 细胞在 mitochondrial transmembrane 潜力免于减少。另外,任何一个螖 T M-BNIP3 overexpression 或 N-acetyl-L-cysteine 合作处理减少了在与 S100A8/A9 对待的房间的 lysosomal 激活。我们的数据显示 S100A8/A9-promoted 房间死亡通过线粒体的串音发生,经由 ROS 和这个过程的 lysosomes 包含 BNIP3。Saeid Ghavami Mehdi Eshragi Sudharsana R Ande Walter J Chazin Thomas Klonisch Andrew J Halayko Karol D Mcneill Mohammad Hashemi Claus Kerkhoff Marek Los 2010Cell Research2010,20,3:13
9Computational fluid dynamics(CFD) simulation of effect of baffles on separation in mixer settler显示文摘The main ideas in the development of the solvent extraction mixer settler focused on achieving clean phase separation,minimizing the loss of the reagents and decreasing the surface area of the settlers.The role of baffles in a mechanically agitated vessel is to ensure even distribution,reduce settler turbulence,promote the stability of power drawn by the impeller and to prevent swirling and vortexing of liquid,thus,greatly improving the mixing of liquid.The insertion of the appropriate number of baffles clearly improves the extent of liquid mixing.However,excessive baffling would interrupt liquid mixing and lengthen the mixing time.Computational fluid dynamics(CFD) provides a tool for determining detailed information on fluid flow(hydrodynamics) which is necessary for modeling subprocesses in mixer settler.A total of 54 final CFD runs were carried out representing different combinations of variables like number of baffles,density and impeller speed.CFD data shows that amount of separation increases with increasing baffles number and decreasing impeller speed.Mohsen Ostad Shabani Ali Mazahery Mehdi Alizadeh Ali Asghar Tofigh Mohammad Reza Rahimipour Mansour Razavi Alireza Kolahi 2012International Journal of Mining Science and Technology2012,22,5:12
10Abrasive Wear Behavior of High Chromium Cast Iron and Hadfield Steel-A Comparison显示文摘Wear properties of two different crushers used for grinding raw materials of cement industry are compared using pin-on-disk wear test.The wear test was carried out with different loads on a pin.Abrasive wear behavior of two alloys was evaluated by comparing mass loss,wear resistance,microhardness and friction coefficient.The microstructure of the specimens was detected using optical microscope.The results showed that abrasive wear of high chromium cast iron is lower than that of Hadfield steel.Due to the presence of M7C3 carbides on the high chromium cast iron matrix,impact crushers exhibited higher friction coefficient.Mehdi Mazar Atabaki Sajjad Jafari Hassan Abdollah-pour 2012Journal of Iron and Steel Research(International)2012,19,4:10
11表面溶解对从不同脉石矿物中浮选分离钛铁矿的动力学参数的影响(英文)显示文摘研究表面酸溶解对钛铁矿(IL)及其常见伴生脉石矿物(包括橄榄石-辉石(Ol-Px)、透闪石-斜绿泥石(Tr-Cch)和石英)浮选动力学的影响。结果表明,通过表面溶解,钛铁矿的吸附速率常数从5.272增大到8.441 mol/(g·min),而Ol-Px、Tr-Cch和石英的吸附速率常数分别从6.332、7.309和7.774mol/(g·min)减小为5.034、6.223和7.371mol/(g·min)。二元混合矿物的浮选实验结果表明,经表面溶解后,从Ol-Px、Tr-Cch和石英中浮选钛铁矿的修正速率常数值分别从36.15、36.52和47.86min^-1增大到41.72、45.78和56.24min^-1,导致从脉石矿物中分离预处理过的钛铁矿过程的动力学选择性指数(SI)增大。ICP-MS分析证实,脉石矿物动力学参数的降低可能是由于其表面Fe^2+、Ca^2+和Mg^2+的去除,导致矿物表面缺乏足够的活性位点与捕集剂组分发生作用。接触角测量结果证实,表面溶解可防止矿物表面形成稳定的疏水层,从而可在矿物和气泡之间发生稳定的附着。一般来说,钛铁矿浮选动力学参数的提高与伴生脉石矿物中的铁含量呈负相关关系。Omid SALMANI NURI Mehdi IRANNAJAD Akbar MEHDILO 2019Transactions of Nonferrous Metals Society of China2019,29,12:10
12SO3H-Functionalized Ionic Liquids: Green, Efficient and Reusable Catalysts for the Facile Dehydration of Aldoximes into Nitriles显示文摘容易综合的 aldoximes 被简单反应用二没有卤素的 SO3H-functionalized 离子的液体在很温和的条件下面变换成相应 nitriles ,3-methyl-1-( 4-sulfonic 酸)butylimi- dazolium 氢硫酸盐[ MIM ( CH2 ) 4SO3H ][ HSO4 ]并且1-( 4-sulfonic 酸) butylpyridinium 氢硫酸盐[ PY ( CH2 ) 4SO3H ][ HSO4 ],没有任何另外的器官的溶剂的催化剂和反应媒介。方法为忍受捐赠电子、撤退电子的取代者的芳香的 aldoximes 是同等地有效的。考虑环境、节俭的考虑,这里介绍的协议有环境地友好的、简单操作,容易的病情的检查和很好的收益的优点。催化剂能被再循环并且再使用为若干次没有显著地在他们的催化活动减少。Davoodnia Abolghasem Khojastehnezhad Amir Bakavoli Mehdi Tavakoli-Hoseini Niloofar 2011Chinese Journal of Chemistry2011,29,5:10
13Forecasting the number of zoonotic cutaneous leishmaniasis cases in south of Fars province, Iran using seasonal ARIMA time series method显示文摘Objective: To predict the trend of cutaneous leishmaniasis and assess the relationship between the disease trend and weather variables in south of Fars province using Seasonal Autoregressive Integrated Moving Average(SARIMA) model,Methods: The trend of cutaneous leishmaniasis was predicted using Mini tab software and SARIMA model,Besides,information about the disease and weather conditions was collected monthly based on time series design during January 2010 to March 2016,Moreover,various SARIMA models were assessed and the best one was selected,Then,the model's fitness was evaluated based on normality of the residuals' distribution,correspondence between the fitted and real amounts,and calculation of Akaike Information Criteria(AIC) and Bayesian Information Criteria(BIC),Results: The study results indicated that SARIMA model(4,1,4)(0,1,0)(12) in general and SARIMA model(4,1,4)(0,1,1)(12) in below and above 15 years age groups could appropriately predict the disease trend in the study area,Moreover,temperature with a three-month delay(lag3) increased the disease trend,rainfall with a four-month delay(lag4) decreased the disease trend,and rainfall with a nine-month delay(lag9) increased the disease trend,Conclusions: Based on the results,leishmaniasis follows a descending trend in the study area in case drought condition continues,SARIMA models can suitably measure the disease trend,and the disease follows a seasonal trend.Mehdi Sharafi Haleh Ghaem Hamid Reza Tabatabaee Hossein Faramarzi 2017Asian Pacific Journal of Tropical Medicine2017,10,1:9
14CFD-DEM simulation of the hole cleaning process in a deviated well drilling: The effects of particle shape显示文摘Siamak Akhshik Mehdi Behzad Majid Rajabi 2016Particuology2016,14,2:8
15Influence of the roughness and shape of quartz particles on their flotation kinetics显示文摘Surface roughness and shape play an important role on the behavior of particles in various processes such as flotation. In this re-search, the influence of different grinding methods on the surface roughness and shape characteristics of quartz particles as well as the effect of these parameters on the flotation of the particles was investigated. The surface roughness of the particles was determined by measuring their specific surface area via the gas adsorption method. The shape characteristics of the particles were measured and calculated by images obtained by scanning electron microscopy via an image analysis system. The flotation kinetics was determined using a laboratory flotation cell. The results showed that the particles of rod mill products have higher roughness and elongation ratio and lower roundness than the parti-cles of ball mill products. The flotation kinetics constant of the particles increased with their surface roughness increasing. Particles with higher elongation and lower roundness indicated higher floatability. In addition, the influence of the surface roughness on the flotation kinet-ics was greater than that of shape parameters.Mehdi Rahimi Fahimeh Dehghani Bahram Rezai Mohammad Reza Aslani 2012International Journal of Minerals,Metallurgy and Materials2012,19,4:8
16Application of GA, PSO, and ACO Algorithms to Path Planning of Autonomous Underwater Vehicles显示文摘在这份报纸,一在水下车辆与运动的六个维的非线性的方程被建模,在自由的所有度由 DC 马达控制了。在精力充沛的环境为的在最佳附近的轨道在水下车辆用一个非线性的最佳的控制问题(NOCP ) 的一个数字答案被计算。一个费用函数,应该被最小化,被定义的一个精力性能索引。产生问题是一个二点的边界价值问题(TPBVP ) 。一个基因算法(GA ) ,粒子群优化(PSO ) ,和蚂蚁殖民地优化(ACO ) 算法被使用解决产生 TPBVP。把一个 Euler-Lagrange 方程用于 NOCP,一个 conjugate 坡度惩罚方法也被采用解决 TPBVP。精力充沛的环境的问题,包含一些精力采购原料,被讨论。一些在最佳附近的路径用 GA, PSO,和 ACO 算法被发现。最后,在精力充沛的环境的碰撞回避的问题也被考虑。Mohammad Pourmahmood Aghababa Mohammad Hossein Amrollahi Mehdi Borjkhani 2012Journal of Marine Science and Application2012,11,3:8
17Multi-objective short-term scheduling of active distribution networks for benefit maximization of DisCos and DG owners considering demand response programs and energy storage system显示文摘This paper proposes a multi-objective benefit function for operation of active distribution systems considering demand response program(DRP)and energy storage system(ESS).In the active distribution system,active network management(ANM)is applied so that the distribution system equipment is controlled in real-time status based on the real-time measurements of system parameters(voltages and currents).The multi-objective optimization problem is solved using e-constraint method,and a fuzzy satisfying approach has been employed to select the best compromise solution.Two different objective functions are considered as follows:benefit maximization of distribution company(DisCo);benefit maximization of distributed generation owner(DGO).To increase the benefits and efficient implementation of distributed generation(DG),DGO has installed battery as energy storage system(ESS)in parallel with DG unit.Consequently,DGO decides for the battery charging/discharging.DisCo has the ability to exchange energy with the upstream network and DGO.Also,DisCo focuses to study the effect of demand response program(DRP)on total benefit function and consequently its influence on the load profile has been discussed.This model is successfully applied to a 33-bus radial distribution network.Saeed ABAPOUR Sayyad NOJAVAN Mehdi ABAPOUR 2018Journal of Modern Power Systems and Clean Energy2018,6,1:8
18Silica Gel-Supported Polyphosphoric Acid (PPA/SiO2): An Efficient and Reusable Heterogeneous Catalyst for Facile Synthesis of 14-Aryl-14H-dibenzo[aj]xanthenes under Solvent-free Conditions显示文摘为 14-aryl-14H-dibenzo 的合成的一个简单、有效、绿的方法[一, j ] 由萘粉和芳基醛使用硅石的一个壶冷凝作用反应的氧杂蒽支持胶化的 polyphosphoric 酸(PPA/SiO2 ) ,有效、可重用的催化剂,在没有溶剂的条件下面被描述。现在的方法论提供几个优点,例如有任何不稳定、危险的器官的溶剂的容易的病情的检查,短反应时间,高收益,和缺席的一个简单过程。Khojastehnezhad Amir Davoodnia Abolghasem Bakavoli Mehdi Tavakoli-Hoseini Niloofar Zeinali-Dastmalbaf Mohsen 2011Chinese Journal of Chemistry2011,29,2:8
19Multiple linear regression, artificial neural network, and fuzzy logic prediction of 28 days compressive strength of concrete显示文摘评估在里面然而,借助于核心的压缩力量从变硬的水泥割了的 situ 水泥作为最平常的方法被承认自从它被象不同混合图案那样的许多因素影响,预言水泥的压缩力量是很困难的,混合的方法,治好条件,压缩,等等。在这份报纸,就试验性的结果而言,多重线性回归模型( MLR )的三个不同模型,人工的神经网络( ANN ),和适应neuro模糊的推理系统( ANFIS )被建立,训练,并且为与 173 个不同混合图案预言水泥的 28 天压缩的力量在 Matlab 编程环境以内测试了。最后,这三个模型与对方相比并且导致 ANN 和 ANFIS 模型使我们能然而,可靠地与不同混合图案评估水泥的压缩力量的事实因为在具体混合参数之间的非线性的关系,多重线性回归模型不在这个区域是足够可行的。最后,为具体压缩力量预言上的参数的二个不同集合的敏感分析(SA ) 被执行。Faezehossadat KHADEMI Mahmoud AKBARI Sayed Mohammadmehdi JAMAL Mehdi NIKOO 2017Frontiers of Structural and Civil Engineering2017,11,1:8
20Electrochemical measurements used for assessment of corrosion and protection of metallic materials in the field:A critical review显示文摘Corrosion degradation is detrimental to metal structures as it shortens their lifetime and leads to huge economic losses and unexpected disasters.Therefore,the detection and monitoring of corrosion degradation is of great importance.Herein,we briefly review the state-of-the-art electrochemical methods,instrumentation(based on virtual instrumentation),and advanced sensor/probes that are used in the field for the assessment of corrosion damage.Typical corrosion monitoring results,some of which have been obtained at Tianjin University in the past 30 years,for metallic materials and organic coating/metal systems in atmospheric,marine,and soil conditions in the field are presented.Detection methods,data analysis,and theoretical and mathematical models regarding each corrosion system are discussed,and the challenges,problems and possible solutions for each case are suggested.Lastly,future developments,such as wireless,intelligent,and automatic electrochemical measurement,that will augment the present electrochemical methods of evaluating corrosion degradation are summarized.Da-Hai Xia Cheng-Man Deng Digby Macdonald Sina Jamali Douglas Mills Jing-Li Luo Michael G.Strebl Mehdi Amiri Weixian Jin Shizhe Song Wenbin Hu 2022Journal of Materials Science & Technology2022,,17:8
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