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| 1 | 干扰素调节因子5通过损伤胞葬作用控制动脉粥样硬化病变中的坏死核心形成显示文摘髓系细胞是动脉粥样硬化病变发展和易损斑块形成的核心。动脉吞噬细胞吸收凋亡细胞(胞葬作用)的能力受损,可促进病变生长并建立坏死核心。干扰素调节因子(interferon regulatory factor,IRF)5是髓系细胞功能的重要调节因子。该研究试图确定IRF5是否影响动脉粥样硬化病变的形成和表型。方法:通过两种互补模型,研究IRF5在动脉粥样硬化中的作用: | Seneviratne AN Edsfeldt AO Cole JE Kassiteridi C Swart M Park I Green P Khoyratty TE Saliba DG Goddard ME Sansom SN Goncalves I Krams R Udalova IA Monaco C 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 9 |
| 2 | 2001年1月26日高纬磁层顶通量管事件的观测研究显示文摘20 0 1年 1月 2 6日 11:10~ 11:4 0UT ,ClusterⅡ卫星簇位于午后高纬磁鞘边界层和磁鞘区 ,此时行星际磁场Bz 为南向 .本文对在此期间观测到的多次磁通量管事件作了详细的研究 ,获得一系列的新发现 :(1)高纬磁鞘边界层磁通量管的出现具有准周期性 ,周期约为 78s,比目前已知的磁层顶向阳面FTE的平均周期 (8~ 11min)小得多 .(2 )这些通量管都具有强的核心磁场 ;其主轴多数在磁场最小变化方向 ,少数在中间变化方向 ,有些无法用PAA判定其方向 (需要用电流管PAA确定 ) ,这与卫星穿越通量管的相对路径有关 .(3)每个事件都存在很好的HT参考系 ,在HT参考系中这些通量管是准定常态结构 ;所有通量管都沿磁层顶表面运动 ,速度方向大体相同 ,都来自晨侧下方 .通量管的径向尺度为 1~ 2RE,与通常的FTE通量管相当 .(4 )起源于磁层的强能离子大体上沿着管轴方向由磁层向磁鞘运动 ;起源于太阳风的热等离子体沿管轴向磁层传输 .通量管为太阳风等离子体向磁层输运和磁层粒子向行星际空间逃逸提供了通道 .(5 )每个通量管事件都伴随有晨昏电场的反转 ,该电场为对流电场 . | 黄宗英 濮祖荫 肖池阶 宗秋刚 傅绥燕 谢伦 史全岐 曹晋滨 刘振兴 沈超 史建魁 路立 王迺权 陈涛 T Fritz K-H Glassmeier P Daly H Rème | 2004 | 地球物理学报2004，47，2： | 7 |
| 3 | 2型糖尿病患者采用血管紧张素转换酶抑制剂治疗后血清肌酐急性升高及其继续治疗对主要临床结局的影响显示文摘血管紧张素转换酶抑制剂开始治疗后血清肌酐急性升高≥30%时推荐停药。但血清肌酐升高后继续服药或停药对主要临床结局的长期影响仍不明确。在ADVANCE(糖尿病与血管疾病行动:培哚普利-吲达帕胺与达美康缓释片对照评估)试验中,11 140例糖尿病患者在6周活性导入期后随机采用培哚普利-吲达帕胺或安慰剂治疗。 | Ohkuma T Jun M Rodgers A Cooper ME Glasziou P Hamet P Harrap S Mancia G Marre M Neal B Perkovic V Poulter N Williams B Zoungas S Chalmers J Woodward M 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，1： | 6 |
| 4 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 5 | 前蛋白转化酶枯草溶菌素9变异、低密度脂蛋白胆固醇与神经认知功能损害的关系显示文摘尽管之前的研究引发了对抑制前蛋白转化酶枯草溶菌素9(proprotein convertase subtilisin/kexintype9,PCSK9)造成神经认知功能损害事件的关注,但近期一个第3期随机试验并没有发现药物性PCSK9抑制与神经认知损害有关。 | 黄洁 叶鹏 Mefford MT Rosenson RS Cushman M Farkouh ME McClure LA Wadley VG Irvin MR Bittner VA Safford MM Somaratne R Monda KL Muntner P Levitan EB | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 6 | Homocysteinein uremia-a puzzling and conflicting story 显示文摘 | Suliman ME Barany P Kalantar-Eadeh K | 2005 | Nephro Dial Transplant2005，20，1： | 1 |
| 7 | Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting : the clopidogrel aspirin stent international cooperative study (CLASSICS) 显示文摘 | RUPPRECHT HJ URBAN P | 2000 | Circulation2000，102，6： | 1 |
| 8 | Herbal supplement sales experience slight increase in 2008 显示文摘 | Cavaliere C Rea P Lynch ME | 2009 | Herbal Gram2009，82，： | 1 |
| 9 | A novel CDK9-associated C-type cyclin in- teracts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA 显示文摘 | Wei P Garber ME Fang SM | 1998 | Cell1998，92，4： | 1 |
| 10 | A systematic study on spatial and seasonal patterns of eight taste and odor compounds with relation to various biotic and abiotic parameters in Gonghu Bay of Lake Taihu,China显示文摘 | CHEN J ME P MA Z | 2010 | Sci Total Environ2010，409，2： | 1 |
| 11 | Chemical aspects of clustered DNA damage induction by ionising radiation显示文摘 | Lomax ME Gulston MK and O'Neill P | 2002 | Radiat Prot Dosim2002，99，14： | 1 |
| 12 | Conceptual Model of Web Service Reputation显示文摘 | MICHAEL ME SINGH MUNINDAR P | 2002 | SIGMOD Record2002，，： | 1 |
| 13 | Clinical impact of (18) F-FDG PET in thyroid carcinoma patients with elevated thyroglobulin levels and negative (131)I scanning results after therapy显示文摘 | Helal BO Merlet P Toubert ME | 2001 | J Nucl Med2001，42，： | 1 |
| 14 | Statins for sepsis: a critical and updated review显示文摘 | Kopterides P Falagas ME | 2009 | Clin Microbiol Infect2009，15，4： | 1 |
| 15 | Isolation of polymorphic microsatellite loci from Eurasian woodcock ( Scolopax rusticola) and their cross-utility in related species 显示文摘 | Cardla P Ferrero ME Gon:alves D | 2007 | Mol Ecol Notes2007，7，1： | 1 |
| 16 | A shared chemical basis of avian hostparasite egg colour mimicry显示文摘 | Igic B Cassey P Grim T Greenwood DR Moskát C Rutila J Hauber ME | | 0，，： | 1 |
| 17 | Risk factors for the isolation of multi-drug-resistant Acinetobacter baumannii and Pseudomonas aerugi-nosa :a systematic review of the literature 显示文摘 | Falagas ME Kopterides P | 2006 | Journal of HospitalInfection2006，，： | 1 |
| 18 | Effects on growth,tolerability and biochemical parameters of two different human milk for tifiers in very low birth-weight new borns显示文摘 | Zuppa AA Girlando P Scapillati ME | 2004 | Pediatr Med Chir2004，26，1： | 1 |
| 19 | A new method ofclassifying prognostic comorbidity in longitudinal studies : developmentand validation 显示文摘 | Charlson ME Pompei P Ales KL | 1987 | Journal of Chronic Diseases1987，40，5： | 1 |
| 20 | Release of chromatin protein HMGB1 by necrotic cells triggers inflammation显示文摘 | Scaffidi P Misteli T Bianchi ME | 2002 | Nature2002，418，6894： | 1 |
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