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| 1 | Peripheral T-lymphocyte subpopulations in different clinical stages of chronic HBV infection correlate with HBV load显示文摘AIM: To characterize the peripheral T-cell subpopulation profiles and their correlation with hepatitis B virus (HBV) replication in different clinical stages of chronic HBV infection.METHODS: A total of 422 patients with chronic HBV infection were enrolled in this study. The patients were divided into three stages: immune-tolerant stage, immune active stage, and immune-inactive carrier stage. Composition of peripheral T-cell subpopulations was determined by flow cytometry. HBV markers were detected by enzyme-linked immunosorbent assay. SerumHBV DNA load was assessed by quantitative real-time polymerase chain reaction.RESULTS: CD8+ T-cells were significantly higher in patients at the immune-tolerant stage than in patients at the immune-active and -inactive carrier stages (36.87 ± 7.58 vs 34.37 ± 9.07, 36.87 ± 7.58 vs 28.09 ± 5.64, P < 0.001). The peripheral blood in patients at the immune-tolerant and immune active stages contained more CD8+ T-cells than CD4+ T-cells (36.87 ± 7.58 vs 30.23 ± 6.35, 34.37 ± 9.07 vs 30.92 ± 7.40, P < 0.01), whereas the peripheral blood in patients at the immune-inactive carrier stage and in normal controls contained less CD8+ T-cells than CD4+ T-cells (28.09 ± 5.64 vs 36.85 ± 6.06, 24.02 ± 4.35 vs 38.94 ± 3.39, P < 0.01). ANOVA linear trend test showed that CD8+ T-cells were signif icantly increased in patients with a high viral load (39.41 ± 7.36, 33.83 ± 7.50, 31.81 ± 5.95 and 26.89 ± 5.71, P < 0.001), while CD4+ T-cells were signif icantly increased in patients with a low HBV DNA load (37.45 ± 6.14, 33.33 ± 5.61, 31.58 ± 6.99 and 27.56 ± 5.49, P < 0.001). Multiple regression analysis displayed that log copies of HBV DNA still maintained its highly signif icant coefficients for T-cell subpopulations, and was the strongest predictors for variations in CD3+, CD4+ and CD8+ cells and CD4+/CD8+ ratio after adjustment for age at HBV-infection, maternal HBV-infection status, presence of hepatitis B e antigen and HBV mutation.CONCLUSION: Differences in peripheral T-cell subpopulation profi les can be found in different clinical stages of chronic HBV infection. T-cell impairment is signifi cantly associated with HBV load. | Jing You Lin Zhuang Yi-Feng Zhang Hong-Ying Chen Hutcha Sriplung Alan Geater Virasakdi Chongsuvivatwong Teerha Piratvisuth Edward McNeil Lan Yu Bao-Zhang Tang .lun-Hua Huang | 2009 | World Journal of Gastroenterology2009，15，27： | 39 |
| 2 | Peripheral mechanisms of itch显示文摘Detection of environmental stimuli that provoke an aversive response has been shown to involve many receptors in the periphery. Probably the least-studied of these stimuli are those that induce the perception of itch (pruritus), an often-experienced unpleasant stimulus. This review covers the ligands and their receptors which are known to cause primary sensory neuron activation and initiate itch sensation. Also covered are several itch-inducing substances which may act indirectly by activating other cell types in the periphery which then signal to primary neurons. Finally, progress in identifying candidate neurotransmitters that sensory neurons use to propagate the itch signal is discussed. | Benjamin McNeil Xinzhong Dong | 2012 | Neuroscience Bulletin2012，28，2： | 8 |
| 3 | Loss of heterozygosity for loci on chromosome arms 1p and 10q in oligoden-droglial tumors: relationship to outcome and chemosensitivity显示文摘Oligodendroglial tumors frequently have deletions ofchromosomal loci on lp and l9q.Loas of heterozygosity(LOH)of chromosome 10 may be a negative prognostic factor.We reviewed 23 patients with oligodendroglial tumors,toevaluate the frequency of lp and 10q LOH and correlate with clinical outcome.Three loci(DlS402,DlSl 172,MCT118)on lp and 2 loci(Dl0S520 and D10S521)on 10q were analyzed for LOH using PCR techniques. | Thiessen B Maguire JA McNeil K Huntsman D Martin MA Horsman D | 2003 | 中国神经肿瘤杂志2003，1，4： | 3 |
| 4 | Estimation of tail-related risk measures for heteroscedastic financial time series: an extreme value approach显示文摘 | Alexander J. McNeil Rüdiger Frey | 2000 | Journal of Empirical Finance2000，，3： | 3 |
| 5 | 加拿大PICU和NICU临床医生的道德困境显示文摘目的量化NICU和PICU临床医生的道德困境,并确认相关因素。设计对在NICU或PICU中工作的临床医生进行全国性横断面调查。采用道德困境量表修订版(Moral Distress Scale-Revised,MDS-R)和自我评定法评价道德困境程度。采用Maslach职业倦怠问卷子量表评定去人格化。受访者报告参加6项可能有助于缓解一线员工道德困境的医院支持活动中每一项的具体情况。通过分析受试者特征比较预后,通过分层线性回归评估个体、ICU、医院和地区的影响。场所入组ICUs为加拿大的PICUs和三级NICUs。对象入组受访者已在参与研究的ICUs内工作3个月以上。干预措施无测量方法和主要结果从31家医院中确定了54个符合纳入标准的ICUs。49个(91%)加拿大NICUs和PICUs提供了2852份完整回复,应答率为45.2%。多数受访者为护士(64.9%)或来自NICU(66.5%)。中位MDS-R评分为79(52,113)分,997例(34.2%)的受访者MDS-R得分≥100分,234例(8.3%)受访者强烈认同工作引起的严重道德困境。护士的中位MDS-R评分为85(57,121)分,比内科医生高19分,比呼吸治疗师高8分(P<0.001)。ICU工作年限<1年者MDS-R评分为53(35,79)分,工作30年以上者MDS-R评分升至83(54,120)分(P<0.001);22.5%的受访者报告高度去人格化,这与道德困境有关(P<0.001)。MDS-R评分的变异性个体因素占92%,医院因素占5%,ICU影响占1%。参与可能有缓解作用的医院支持活动的频率对MDS-R平均值影响很小(<10分)。结论道德困境常见于儿童ICUs临床医生。解决道德困境需要针对高危群体的个体化干预措施。 | Dryden-Palmer K Moore G McNeil C 方伯梁(译) 钱素云(校) | 2021 | 中国小儿急救医学2021，28，2： | 2 |
| 6 | Activation of peroxisome proliferator-activated receptor gamma and retinoid X receptor results in net depletion of cellular cholesteryl esters in macrophages exposed to oxidized lipoproteins显示文摘 | Argmann CA Sawyez CG McNeil CJ | | Arterioscler Thromb Vasc0，，： | 2 |
| 7 | The meaning and the use of the area under a receiver operating characteristic ( ROC ) curve 显示文摘 | Hanley J McNeil B | 1982 | Radiology1982，143，： | 1 |
| 8 | Risk factors for lacunar infarction syndromes显示文摘 | You R McNeil JJ OM' alley HM | 1995 | Neurology1995，45，： | 1 |
| 9 | Behavior of Phenolics in Coal Liquefaction:Adduction Tendency and Coal Conversion Capability显示文摘 | McNeil R I Cronauer D C | 1984 | Fuel Processing Technology1984，9，1： | 1 |
| 10 | Recommendations for lipid testing and reporting by australian pathology laboratories显示文摘 | Caldwell G McNeil AR | 2007 | Clin Biocbem Rev2007，28，： | 1 |
| 11 | A comparison between highfinx and plain robes,boiling pentane in a Horizontal Kettle Reboiler显示文摘 | Burnside B M Miller K M Tarrad A H | 2002 | Applied Thermal Engineering2002，22，7： | 1 |
| 12 | Basic fibroblast growth factor is efficiently released from a cytolsolic storage site through plasma membrane disruptions of endothelial cells显示文摘 | Muthukrishnan L Warder E McNeil PL | 1991 | J Cell Physiol1991，148，1： | 1 |
| 13 | Estimation of tail-related risk measures for heteroscedastic financial time series:An extreme value approach显示文摘 | McNeil A J Frey R | 2000 | Journal of Empirical Finance2000，，7： | 1 |
| 14 | Jitter in ring oscillators 显示文摘 | MCNEIL J A | 1997 | IEEE JSSC1997，32，6： | 1 |
| 15 | Annual cancer statistics report raises key questions 显示文摘 | McNeil C | 2006 | J Natl Cancer Inst2006，98，22： | 1 |
| 16 | Postrumina protein supply and N retention of weaner sheep fed on a basal diet of lucerrne hay (Medicago sativa) with increasing levels of Quebracho tannin显示文摘 | KOMOLONG M K BARBER D M McNEIL D M | | Anim Fee0，，： | 1 |
| 17 | Fungal infections: a growing threat显示文摘 | Dixon DM McNeil MM Cohen ML | 1996 | Public Health Rep1996，111，3： | 1 |
| 18 | Atrial septostomy in the treatement of severe pulmonary arterial hypertension显示文摘 | Reichenberger F Pepke-Zaba J Mcneil K | 2003 | Thorax2003，58，： | 1 |
| 19 | Progression of HIV : follow-up of Edinburgh injecting drug user with narrow seroconversion intervals in 1983 - 1985 显示文摘 | Brettle R McNeil A Bums S | 1996 | AIDS1996，10，： | 1 |
| 20 | Continuous fractional crystallization显示文摘 | W D Bert J W Freemall D McNeil | 1968 | J Appl Chem1968，18，6： | 1 |
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