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| 1 | Helicobacter pylori arginase mutant colonizes arginase Ⅱ knockout mice显示文摘AIM: To investigate the role of host and bacterial arginases in the colonization of mice by Helicobacter pylori (H.pylori).METHODS: H.pylori produces a very powerful urease that hydrolyzes urea to carbon dioxide and ammonium,which neutralizes acid.Urease is absolutely essential to H.pylori pathogenesis;therefore,the urea substrate must be in ample supply for urease to work efficiently.The urea substrate is most likely provided by arginase activity,which hydrolyzes L-arginine to L-ornithine and urea.Previous work has demonstrated that H.pylori arginase is surprisingly not required for colonization of wild-type mice.Hence,another in vivo source of the critical urea substrate must exist.We hypothesized that the urea source was provided by host arginase Ⅱ,since this enzyme is expressed in the stomach,and H.pylori has previously been shown to induce the expression of murine gastric arginase Ⅱ.To test this hypothesis,wild-type and arginase (rocF) mutant H.pylori strain SS1 were inoculated into arginase Ⅱ knockout mice.RESULTS: Surprisingly,both the wild-type and rocF mutant bacteria still colonized arginase Ⅱ knockout mice.Moreover,feeding arginase Ⅱ knockout mice the host arginase inhibitor S-(2-boronoethyl)L-cysteine (BEC),while inhibiting > 50% of the host arginase Ⅰ?activity in several tissues,did not block the ability of the rocF mutant H.pylori to colonize.In contrast,BEC poorly inhibited H.pylori arginase activity.CONCLUSION: The in vivo source for the essential urea utilized by H.pylori urease is neither bacterial arginase nor host arginase Ⅱ;instead,either residual host arginase Ⅰ?or agmatinase is probably responsible. | Songhee H Kim Melanie L Langford Jean-Luc Boucher Traci L Testerman David J McGee | 2011 | World Journal of Gastroenterology2011，17，28： | 3 |
| 2 | Involvement of exodermal passage cells in mycorrhizal infection of some orchids显示文摘 | Esnault A L Masuhara G McGee R A | 1994 | Mycol Res1994，98，6： | 1 |
| 3 | Prevention of perinatal group B streptococcal disease--revised guidelines from CDC,2010显示文摘 | Verani JR McGee L SchragSJ | 2010 | MMWR Recomm Rep2010，59，10： | 1 |
| 4 | AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5显示文摘 | MCGEE S L VANDENDEREN B J HOWLETT K F | | 0，，04： | 1 |
| 5 | Exercise and myocyte enhan cer factor 2 regulation in human skeletal muscle 显示文摘 | MCGEE S L HARGREAVES M | 2004 | Diabetes2004，53，5： | 1 |
| 6 | Prevention of perinatal group B stretococcal disease-revised guidelines from CDC,2010显示文摘 | Verani JR McGee L Schrag S J | | 0，，10： | 1 |
| 7 | Metabolic adaptations to short-term high-intensity interval training: a little pain for a lot of gain? 显示文摘 | Gibala M J Mcgee S L | 2008 | Exerc Sport Sci Rev2008，36，2： | 1 |
| 8 | Prevention of perinatal group B streptococcal disease:revised guidelines from CDC,2010显示文摘 | Verani JR McGee L Schrag SJ | 2010 | MMWR Recomm Rep2010，59，10： | 1 |
| 9 | Live benthic diatoms from the upper continental slope: extending the limits of marine primary production显示文摘 | McGee D Laws R A Cahoon L B | 2008 | Marine Ecology-Progress Series2008，356，10： | 1 |
| 10 | Nomenclature of major anti- microbial-resistant clones of Streptococcus pneumoniae defined by the pneumoeoccal molecular epidemiology network显示文摘 | McGee L McDougal L Zhou J | 2001 | J Clin Microbiol2001，39，7： | 1 |
| 11 | Prevention of perinatal group B strep- tococcal disease: revised guidelines from CDC, 2010 显示文摘 | Verani JR McGee L Schrag SJ | 2010 | Morbidity and Mortality Weekly Report2010，59，10： | 1 |
| 12 | Prevention of perinatal group B streptococcal disease-revised guidelines from CDC, 2010显示文摘 | VeraniJR McGee L Schrag SJ | 2010 | MMWR Recomm Rep2010，59，1： | 1 |
| 13 | Prevention of Perinatal group B streptococcal disease revised guidelines from CDC ,2010 显示文摘 | Verani JR Mcgee L Schrag SJ | 2010 | MMWR Recomm Rep2010，59，10： | 1 |
| 14 | Metabolic adaptations to short-term high-intensity interval training: a little pain for a lot of gain? 显示文摘 | Gibala M J Mcgee S L | 2008 | Exercise &Sport Sciences Reviews2008，36，2： | 1 |
| 15 | Prevention of perinatal group B streptococcal disease-revised guidelines from CDC,2010显示文摘 | VERANI JR MCGEE L SCHRAG SJ | 2010 | MMWR Recomm Rep2010，59，10： | 1 |
| 16 | Calcareous nannofossil biostratigraphic dating of a ferromanganese crust from Schumann Seamount显示文摘 | Cowen J P DeCarlo E H and McGee D L | 1993 | Marine Geology1993，115，： | 1 |
| 17 | Prevention of perinatal group B streptococcal revised disease-guidelines from CDC 显示文摘 | Verani JR Mcgee L Schrag SJ | 2010 | MMWR Recomm Rep2010，59，： | 1 |
| 18 | Short stature and risk of mortality and cardiovascular disease, negative findings from the NHANES I epidemiologic follow-up study显示文摘 | LIAO Y MCGEE D L CAO G | 1996 | J Am Coll Cardiol1996，27，： | 1 |
| 19 | Epidemiologic features of isolated syncope: The Framingham study显示文摘 | Savage DD Corwin L McGee DL | 1985 | Stroke1985，16，： | 1 |
| 20 | Exercise and Skeletal Muscle Glucose Transporter 4 Expression:Molecular Mechanisms显示文摘 | McGee S L Hargreaves M | 2006 | Clin Exp Pharmacol Physiol2006，33，4： | 1 |
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