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| 1 | Sequential slip transfer of mixed-character dislocations across Σ3 coherent twin boundary in FCC metals: a concurrent atomistic-continuum study显示文摘Sequential slip transfer across grain boundaries(GB)has an important role in size-dependent propagation of plastic deformation in polycrystalline metals.For example,the Hall–Petch effect,which states that a smaller average grain size results in a higher yield stress,can be rationalised in terms of dislocation pile-ups against GBs.In spite of extensive studies in modelling individual phases and grains using atomistic simulations,well-accepted criteria of slip transfer across GBs are still lacking,as well as models of predicting irreversible GB structure evolution.Slip transfer is inherently multiscale since both the atomic structure of the boundary and the long-range fields of the dislocation pile-up come into play.In this work,concurrent atomistic-continuum simulations are performed to study sequential slip transfer of a series of curved dislocations from a given pile-up onΣ3 coherent twin boundary(CTB)in Cu and Al,with dominant leading screw character at the site of interaction.A Frank-Read source is employed to nucleate dislocations continuously.It is found that subject to a shear stress of 1.2 GPa,screw dislocations transfer into the twinned grain in Cu,but glide on the twin boundary plane in Al.Moreover,four dislocation/CTB interaction modes are identified in Al,which are affected by(1)applied shear stress,(2)dislocation line length,and(3)dislocation line curvature.Our results elucidate the discrepancies between atomistic simulations and experimental observations of dislocation-GB reactions and highlight the importance of directly modeling sequential dislocation slip transfer reactions using fully 3D models. | Shuozhi Xu Liming Xiong Youping Chen David L McDowell | 2016 | npj Computational Materials2016，，1： | 4 |
| 2 | Physiological levels of ATP negatively regulate proteasome function显示文摘由 ubiquitin-proteasome 系统的细胞内部的蛋白质降级是 ATP 依赖者,和最佳的 ATP 集中激活 proteasome 在 vitro 的功能是 ~ 100 渭 M。细胞内部的 ATP 层次在在这个范围以内的水平通常在低 millimolar 范围,而是 ATP 被显示在 vitro 禁止 proteasome peptidase 活动。这里,我们报导支持在生理的层次的细胞内部的 ATP 双向地调整的一个假设的新证据 26S proteasome 在房间的解朊的功能。首先,我们证实 ATP 在 vitro 在 26S proteasome 上施加了双向规定,与最佳的 ATP 集中(在 50 和 100 渭 M 之间) 刺激 proteasome 像糜蛋白酶的活动。第二,我们发现操作细胞内部的 ATP 层次也在有教养的房间在 proteasome 特定的蛋白质底层的层次导致了双向变化。最后,测量增加提高的细胞内部的 ATP,当减少的细胞内部的 ATP 稀释了导致房间死亡的 proteasome 抑制的能力时。这些数据强烈建议在生理的集中范围以内的内长的 ATP 能在 proteasome 活动施加否定影响,允许房间到很快,在应力下面的 ATP 减小上的 upregulate proteasome 活动调节。 | Hongbiao Huang Xiaoyan Zhang Shujue Li Ningning Liu Wen Elan Emily McDowell Ping Zhou Canguo Zhao Haiping Guo Change Zhang Changshan Yang Guangmei Wen Xiaoxian Dong Li Lu Ningfang Ma Weihua Dong Q Ping Dou Xuejun Wang Jinbao Liu | 2010 | Cell Research2010，20，12： | 4 |
| 3 | 解偶联蛋白与动物的能量代谢显示文摘动物需要能量来维持生命活动,所需的能量主要来源于食物里的碳水化合物、脂肪和蛋白质。即使在体重平衡(非生产、生长状态)动物仍需要能量来维持体重、体温恒定及肌肉的基本活动。最新发现的线粒体内膜转运蛋白质,具有调节能量代谢的作用,它们的活动增加了动物的基础代谢率,这类蛋白质被称为解偶联蛋白(Uncoup ling Prote ins,UCPs)。UCPs作为质子通道驱散氧化呼吸时形成的H+梯度,降低了线粒体膜电位差ΔμH+,从而增加呼吸产热,阻止ATP的形成。目前已至少发现有5种UCPs(UCP1,UCP2,UCP3,UCP4和UCP5),这个家族的蛋白质已经在人类、哺乳动物、禽类、鱼、真菌、甚至在植物不同组织的线粒体内膜上被发现。 | 刘丽 田建云 李琦华 贾俊静 余红心 Mark Jois Graham H McDowell | 2006 | 云南农业大学学报2006，21，4： | 4 |
| 4 | 循环荷载下柔性路面路基变形的动力耦合分析(英文)显示文摘首先简要综述了循环荷载下路基变形的研究现状。然后 ,基于饱和土体的动力耦合分析理论 ,研究了平面应变条件下的柔性路面路基变形的数值分析模型和方法 ,并建立了一个简单的粘弹性动力计算模型来预测路基在循环荷载下的动力反应。该模型可以全面考虑路基材料的剪切模量、阻尼比、孔隙水压力以及永久变形。最后 ,以一个柔性路面为例 ,应用本文方法在循环荷载下的路基变形发展进行了分析。 | 黄雨 Stephen F Brown Glenn R Mcdowell | 2001 | 岩土工程学报2001，23，6： | 3 |
| 5 | Safe acupuncture and dry needling during pregnancy:New Zealand physiotherapists' opinion and practice显示文摘Objective: Acupuncture guidelines have advised caution when treating women during pregnancy,because historical ‘‘forbidden' acupuncture points are believed to stimulate miscarriage or early labor.Despite recent research demonstrating that acupuncture is a useful and safe treatment tool for pregnancy-related low-back pain(LBP) and pelvic girdle pain(PGP), it is postulated that fear of miscarriage and subsequent blame by association, restricts its provision. More recently, an increase in dry needling(DN) courses for physiotherapists has potentiated the rapid growth in DN practice in New Zealand(NZ). Many dry needlers do not consider DN to be a form of acupuncture; it is unknown if they have similar safety concerns.Methods: NZ registered physiotherapists practicing acupuncture and/or DN were invited to participate in an electronic survey to examine their practice and level of understanding in regard to safe needling during pregnancy.Results: Of 124 respondents, only 60(48%) would needle pregnant women, with a further 66% of those still expressing safety concerns. NZ physiotherapists practicing DN only, were more likely to needle areas related to ‘‘forbidden' points in all trimesters. However, overall, NZ physiotherapists were less likely to needle ‘‘forbidden' points than their UK peers.Conclusion: Conflicting literature and a ‘‘fear of blame' influences NZ physiotherapists' decisions to offer needling(both acupuncture and DN) during pregnancy. Further training in this field is recommended to ensure safe practice and adequate provision of acupuncture treatment options for pregnant women suffering musculoskeletal pain, such as LBP and PGP. Further research, particularly into DN, for women during pregnancy, is warranted. | Jillian Marie McDowell Susan Heather Kohut Debra Betts | 2019 | Journal of Integrative Medicine2019，17，1： | 3 |
| 6 | 第25章 水文学100年进步显示文摘本章聚焦过去100年水文学进步。这一时期出现了从实用工程水文向水文科学基础研究的显著转变,包括了对地球系统科学的贡献。本章前3节回顾理论、观测和水文预报进展。在此基础上,讨论了全球水文、陆地-大气相互作用和耦合、生态水文学和水管理等主题,同时对出现的挑战和未来方向给出建议总结。尽管评述力争全面,但对于美国气象学会(AMS)文集的读者来说,本章还是在地表水文学和水文气象阐述更全面些。 | 克里斯塔·彼得斯-利达德 FAISAL HOSSAIN L.RUBYLEUNG NATE MCDOWELL MATTHEW RODELL FRANCISCO J.TAPIADOR F.JOE TURK ANDREW WOOD 贾朋群(编译) 李婧华(编译) | 2019 | 气象科技进展2019，9，S01： | 3 |
| 7 | 基于三维离散元黏弹性模型的沥青砂单轴压缩数值模拟显示文摘通过建立三维离散元模型对沥青砂单轴压缩试验进行了一系列的数值模拟。沥青砂是由近似大小的圆细砂颗粒和沥青混合而成,是一种理想化的沥青混合料。首先在三维离散元模型中对沥青砂的三维空间结构进行了数字重构,然后引入Burger’s模型模拟沥青的黏弹性质,同时建立以时间和温度为函数的黏结破坏模型模拟沥青砂在单轴压缩过程中的应力-应变曲线,尤其是在应变软化阶段的力学表现。研究结果表明,建立的三维离散元模型对沥青砂在单轴压缩试验中各阶段的应力与应变特性都能进行较好地数值模拟,在细观层面上为进一步分析和预测沥青材料开裂破坏产生和发展的演变过程提供了新的研究手段。 | 吴军伟 白彦峰 Andrew Collop Glenn McDowell | 2012 | 公路2012，57，3： | 3 |
| 8 | 从PDF到PDF/X——在可靠性、灵活性和使用的复杂性之间寻找恰当的平衡显示文摘 | David McDowell 马智勇 | 2003 | 印刷质量与标准化2003，，2： | 2 |
| 9 | An automated biological nitrification toxicity test显示文摘 | Stensel H D McDowell C S Ritter E D | 1976 | Journal Water Pollution Control Federation1976，48，： | 2 |
| 10 | Problem of amputations in patients with newly diagnosed diabetes mellitus显示文摘 | New JP McDowell D Burns E | 1998 | Diabet Med1998，15，9： | 1 |
| 11 | Cementation for femoral head necrosis:a preliminary clinic study显示文摘 | Wood ML McDowell CM Kelley SS | 2003 | Clinical Orthopaeics and Reaited Research2003，412，： | 1 |
| 12 | Immunization against somatotropin release inhibiting factor increases milk yield in ewes 显示文摘 | Sinclair S E Wynn P C and McDowell G H | 1990 | Aust J Agric Res1990，41，： | 1 |
| 13 | Vestibular dysfunction in Parkinson's disease显示文摘 | Reichert WH Doolittle J Mcdowell FH | 1982 | Neurology1982，32，10： | 1 |
| 14 | The effect of antecedent moisture conditions on sediment and phosphorus loss during over-land flow: Mahantango Creek catchment, Pennsylvanian, USA 显示文摘 | McDowell R W Sharpley A N | 2002 | Hydrological Processes2002，16，： | 1 |
| 15 | Micromeehanics of creep of granular materials 显示文摘 | MCDOWELL G R | 2003 | Geotechnique2003，53，10： | 1 |
| 16 | Discrete Element Model-ling of Soil Particle Fracture显示文摘 | Mcdowell G R Harireche O | 2002 | Géotechnique2002，52，2： | 1 |
| 17 | Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults 显示文摘 | Bellamy MF McDowell IF Ramsey MW | 1998 | Circulation1998，98，： | 1 |
| 18 | Plasticity in plolycrystalline fretting fatigue contacts 显示文摘 | Goh C H McDowell D L Neu R W | 2006 | J Mech Phys Solids2006，54，： | 1 |
| 19 | Phosphorus loss from land to water:integrating agricultural and environmental management 显示文摘 | A N Sharpley R W McDowell and P J A Kleinman | 2001 | Plant and Soil2001，237，2： | 1 |
| 20 | Effects of micro- structure variability on intrinsic fatigue resistance of nickel-base superalloys-a computational micromechan ics approach显示文摘 | Kumar R Wang A Mcdowell D | 2006 | International Journal of Fracture2006，137，： | 1 |
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