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| 1 | Impact of alcohol on hepatitis C virus replication and interferon signaling显示文摘Hepatitis C virus (HCV) is one of the main etiological factors responsible for liver disease worldwide. It has been estimated that there are over 170 million people infected with HCV worldwide. Of these infected individuals, approximately 75% will go on to develop a life long necroinflammatory liver disease, which over decades, can result in serious complications, such as cirrhosis and hepatocellular carcinoma. Currently there is no effective vaccine and whilst antiviral therapies have been improved, they are still only effective in approximately 50% of individuals. HCV infection stands as a major cause of global morbidity and suffering, and places a signifi cant burden on health systems. The second highest cause of liver disease in the western world is alcoholic liver disease. Frequently, HCV infected individuals consume alcohol, and the combined effect of HCV and alcohol consumption is deleterious for both liver disease and response to treatment. This review discusses the impact of alcohol metabolism on HCV replication and the negative impact on interferon (IFN)-α treatment, with a particular focus on how alcohol and HCV act synergistically to increase oxidative stress, ultimately leading to exacerbated liver disease and a reduction in the effi cacy of IFN-α treatment. A better understanding of the complicated mechanisms at play in hepatocytes infected with HCV and metabo- lizing alcohol will hopefully provide better treatment options for chronic hepatitis C individuals that consume alcohol. | Erin M McCartney Michael R Beard | 2010 | World Journal of Gastroenterology2010，16，11： | 5 |
| 2 | Magnetic microstructure of magnetotactic bacteria by electron holography显示文摘 | Dunin R E McCartney M R Frankel R B | 1998 | Science1998，282，： | 1 |
| 3 | Isolation and characterization of human colonic bacteria able to hydrolyse chlorogenic acid 显示文摘 | Couteau D McCartney A L Gibson G R | 2001 | J Appl Microbiol2001，90，： | 1 |
| 4 | Neurological complications after regional anesthesia:contemporary estimates of risk显示文摘 | Brull R Mccartney CJ Chan VW | 2007 | Anesth Analg2007，104，4： | 1 |
| 5 | Methods for integrat- ed air sampling and DNA analysis for detection of airborne fun- gal spores 显示文摘 | Williams R H Ward E McCartney H A | 2001 | Applied and Environmental Microbiology2001，67，6： | 1 |
| 6 | Prebiotic effects: metabolic and health benefits显示文摘 | Roberfroid M Gibson G R Hoyles L McCartney A L Rastall R Rowland I Wolvers D Watztl B Szajewska H Stahl B Guarner F Respondek F Whelan K Coxam V Davieco M Laotoing L Wittrant Y Delzenne N Cani P Neyrinek A Meheust A | 2010 | British Journal of Nutrition2010，104，2： | 1 |
| 7 | Neurological complications after regional anesthesia:contemporary estimates of risk显示文摘 | Brull R Mccartney CJ Chan VW | 2007 | Anesth Analg2007，104，4： | 1 |
| 8 | The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome显示文摘 | Blank S K McCartney C R Marshall J C | 2006 | Hum Reprod Update2006，12，4： | 1 |
| 9 | Advances in PTC thermistor technology 显示文摘 | McCartney J H Casselton R E W Morter C M | 1991 | Br Ceram Proc1991，50，： | 1 |
| 10 | Neuroendocrine effects of androgens in adult polycystic ovary syndrome and female puberty显示文摘 | Blank S K McCartney C R Helm K D et a1 | 2007 | Semin Reprod Med2007，25，5： | 1 |
| 11 | Decision analysis of dis-cordant thyroid nodule biopsy guideline criteria 显示文摘 | MCCARTNEY C R STUKENBORG G J | 2008 | J ClinEndocrinol Metab2008，93，8： | 1 |
| 12 | Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila 显示文摘 | McCartney B M Price M H Webb R L | 2006 | Development2006，133，12： | 1 |
| 13 | An in vitro study of the probiotic potential of a bile-salt-hydrolyzing Lactobacillus fermentum strain,and determination of its cholesterol-lowering properties显示文摘 | PEREIRA D I A McCARTNEY A L GIBSON G R | | 0，，： | 1 |
| 14 | An in vitro study ofthe probiotic potential of a bile - salt - hydrolyzing Lactobacillus fermentum strain, and determination of its cholesterol - lowering properties显示文摘 | Pereira D I A McCartney A L Gibmn G R | 2003 | Appl Environ Microbiol2003，69，47： | 1 |
| 15 | Microstruc- tural characterization of CO2 laser welds in the A1 - Li based alloy 8090 显示文摘 | Whitaker I R Mccartney D G Calder N | 1993 | Journal of Materials Science1993，28，20： | 1 |
| 16 | An in vitro study of the probiotic potential of a Bile-Salt-Hydrolyzing lactobacillus fermentum strain, and determination of its cholesterol-lowering properties 显示文摘 | Pereira D I A McCartney A L Gibson G R | 2003 | Applied and Environmental Microbiology2003，69，8： | 1 |
| 17 | Effects of a strobilurin-based spray programme on disease control, green leaf area, yield and development of fungicide-resistance in Mycosphaerella graminicola in Northern Ireland 显示文摘 | MCCARTNEY C MERCER P C COOKE L R | 2007 | Crop Protection2007，26，8： | 1 |
| 18 | Displacement Considerations for a Ductile Propagating Fracture in Line Pipe显示文摘 | Shoemaker A K McCartney R F | 1974 | Journal of Engineering Materials and Technology1974，，96： | 1 |
| 19 | Neurological complications after regional anesthesia : contemporary estimates of risk 显示文摘 | Brull R McCartney C J Chan VW | 2007 | Anesth Analg2007，104，4： | 1 |
| 20 | The microstructure of CO2 laser welds in an Al Fe V Si alloy显示文摘 | Whitaker I R McCartney D G | 1995 | Materials Science and Engineering1995，196，12： | 1 |
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