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| 1 | Impact of alcohol on hepatitis C virus replication and interferon signaling显示文摘Hepatitis C virus (HCV) is one of the main etiological factors responsible for liver disease worldwide. It has been estimated that there are over 170 million people infected with HCV worldwide. Of these infected individuals, approximately 75% will go on to develop a life long necroinflammatory liver disease, which over decades, can result in serious complications, such as cirrhosis and hepatocellular carcinoma. Currently there is no effective vaccine and whilst antiviral therapies have been improved, they are still only effective in approximately 50% of individuals. HCV infection stands as a major cause of global morbidity and suffering, and places a signifi cant burden on health systems. The second highest cause of liver disease in the western world is alcoholic liver disease. Frequently, HCV infected individuals consume alcohol, and the combined effect of HCV and alcohol consumption is deleterious for both liver disease and response to treatment. This review discusses the impact of alcohol metabolism on HCV replication and the negative impact on interferon (IFN)-α treatment, with a particular focus on how alcohol and HCV act synergistically to increase oxidative stress, ultimately leading to exacerbated liver disease and a reduction in the effi cacy of IFN-α treatment. A better understanding of the complicated mechanisms at play in hepatocytes infected with HCV and metabo- lizing alcohol will hopefully provide better treatment options for chronic hepatitis C individuals that consume alcohol. | Erin M McCartney Michael R Beard | 2010 | World Journal of Gastroenterology2010，16，11： | 5 |
| 2 | Magnetic microstructure of magnetotactic bacteria by electron holography显示文摘 | Dunin R E McCartney M R Frankel R B | 1998 | Science1998，282，： | 1 |
| 3 | Prebiotic effects: metabolic and health benefits显示文摘 | Roberfroid M Gibson G R Hoyles L McCartney A L Rastall R Rowland I Wolvers D Watztl B Szajewska H Stahl B Guarner F Respondek F Whelan K Coxam V Davieco M Laotoing L Wittrant Y Delzenne N Cani P Neyrinek A Meheust A | 2010 | British Journal of Nutrition2010，104，2： | 1 |
| 4 | Advances in PTC thermistor technology 显示文摘 | McCartney J H Casselton R E W Morter C M | 1991 | Br Ceram Proc1991，50，： | 1 |
| 5 | Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila 显示文摘 | McCartney B M Price M H Webb R L | 2006 | Development2006，133，12： | 1 |
| 6 | A technique for the prevention of pneumothorax in pulmonary aspiration biopsy显示文摘 | McCartney R Tait D Stilson M | 1974 | Am J Reontgentol Radium Ther Nucl Med1974，120，： | 1 |
| 7 | Lipid and acid compositional differences between eggs of wild and captive - breeding alligators Alligator mississipiensis, an association with re- duced hatchability 显示文摘 | NOBLE R C MCCARTNEY R FERGUSON M W J | 1993 | J Zool Land1993，230，： | 1 |
| 8 | Obesity and the pubertal transition in girls and boys 显示文摘 | BURT-SOLORZANO C M MCCARTNEY C R | 2010 | Reproduction2010，140，3： | 1 |
| 9 | Synthesis,character- ization and modeling of high quality ferromagnetic Cr-doped AIN thin films 显示文摘 | Stephen Y W Liu H X Lin G Singh R K Budd L Schilfgaarde m V McCartney M R Smith D J Newman N | 2004 | Appl Phys Lett2004，85，16： | 1 |
| 10 | Off-axis electron holography of patterned mag- netic nanostructures 显示文摘 | DUNIN-BORKOWSKI R E MCCARTNEY M R KARDYNAL B | 2000 | J Microsc2000，200，3： | 1 |
| 11 | Effect of shape on magnetic response for slotted Co nanorings 显示文摘 | Agaiwal N Smith D J Mccartney M R | 2007 | J Appl Phys2007，102，2： | 1 |
| 12 | Crystal habits and magnetic microstructures of magnetosomes in coccoid magnetotactic bacteria显示文摘 | Lins U McCartney M R Farina M | 2006 | Anais da Academia Bras ileira de Ci ncias2006，78，： | 1 |
| 13 | Magnetic domain configurations in spark-eroded ferromagnetic shape memory Ni-Mn-Ga particles显示文摘 | SOLOMON V C MCCARTNEY M R SMITH D J TANG Y J BERKOWITZ A E O'HANDLEY R C | 2005 | Appl Phys Lett2005，86，19： | 1 |
| 14 | Crystal habits and magnetic microstructures of magnetosomes in coccoid magnetotactic bacteria显示文摘 | Lins U McCartney M R Farina M | | 0，，： | 1 |
| 15 | Hypothalamic regulation of cyclic ovulation: Evidence that the increase igonadotropin-releasing hormone pulse frequency during the follicula phase reflects the gradual loss of the restraining effects of progesterone显示文摘 | McCartney C R Gingrich M B Hu Y | 2004 | Clin Endocrinol Metab2004，47，87： | 1 |
| 16 | Transequatorial flow of Antarctic Bottom Water in the western Atlantic Ocean:Abyssal gcostrophy at the equator显示文摘 | MCCARTNEY M S CURRY R A | 1993 | Journal of Physical Oceanography1993，23，： | 1 |
| 17 | Production and characterization of single-crystal FeCo nanowires inside carbon nanotubes 显示文摘 | Elias A L Rodriguez-Manzo J A McCartney M R | 2005 | Nano Letters2005，5，3： | 1 |
| 18 | Comparison of intensity distributions in tomograms from BF TEM,ADF STEM,HAADF STEM,and calculated tilt series显示文摘 | Friedrich H McCartney M R Buseck P R | 2005 | Ultramicroscopy2005，106，1： | 1 |
| 19 | A prospective, randomized, double-blind comparison of bupivacaine and lidocaine for maxillary infiltrations 显示文摘 | Gross R McCartney M Reader A | 2007 | J Endod2007，33，9： | 1 |
| 20 | Production and characterization of single-crystal FeCo nanowires inside carbon nanotubes显示文摘 | ELIAS A L Rodriguez-Manzo J A McCartney M R | 2005 | Nano Lett2005，5，3： | 1 |
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