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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Overpressures from non-detonating baffle-accelerated turbulent flames in tubes显示文摘 | DUNN-RANKIN D and MCCANN M A | 2000 | Combustion and Flame2000，120，： | 1 |
| 3 | Stimulatory and inhibitory effects of purified hypothalamic extracts on growth hormone release from rat pituitary in vitro显示文摘 | Krulich L Dhariwal A P McCann S M | 1968 | Endocrinology1968，83，4： | 1 |
| 4 | The relationship between estimated glomerular filtration rate and thyroid function: an observational study显示文摘 | Woodward A McCann S Al-Jubouri M | 2008 | Ann Clin Biochem2008，45，5： | 1 |
| 5 | Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of TNF-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis 显示文摘 | McCann F E Palfreeman A C Andrews M | 2010 | Arthritis Res Ther2010，12，3： | 1 |
| 6 | Role of leptin in hypothalamic-pituitary function 显示文摘 | Kimura M Walczewska A Karanth S McCann SM | 1997 | Proc Natl Acad Sci USA1997，94，3： | 1 |
| 7 | Predictors of cardiac rehabilitation participation in older coronary patients显示文摘 | Ades P A Waldmann M L McCann W J | | 0，，05： | 1 |
| 8 | Experimental verifications of numerical predictions for the hydrodynamic performance of horizontal axis marine current turbines显示文摘 | BAHAJ A S BATTEN W M J MCCANN G | 2007 | Renewable Energy2007，32，15： | 1 |
| 9 | Aerobicexercise, but not flexibility/resistance exercise, reduces serumIL-18 CRP and IL-6 independent of beta-blockers * BMI and psy-chosocial factors in older adults显示文摘 | KOHUT M L MCCANN D A RUSSELL D W | 2006 | Brain Behav Immun2006，20，3： | 1 |
| 10 | Assessment of zygomatico-orbital complex fractures using ultrasonography显示文摘 | McCANN P J BROCKLEBANK L M AYOUB A F | 2000 | Br J Oral Maxillofac Surg2000，38，5： | 1 |
| 11 | Overpressures from nondetonating, baffle accelerated turbulent flames in tubes 显示文摘 | Dunn Rankin D Mccann M A | 2000 | Combustion and Flame2000，120，： | 1 |
| 12 | Copper(Ⅱ) Complexes of Salicylic Acid Combining Superoxide Dismutase Mimetic Properties with DNA Binding and Cleaving Capabilities Display Promising Chemotherapeutic Potential with Fast Acting in Vitro Cytotoxicity Against Cisplatin Sensitive and Resistant Cancer Cell Lines显示文摘 | O′Connor M Kellett A McCann M | 2012 | J Med Chem2012，55，5： | 1 |
| 13 | Rotational vscontinuous stoching of beef cows and calves on mixed endophte-free tall fescue-berm udagrass pasture 显示文摘 | HOVELAND C S MCCANN M A HILL N S | 1997 | J Prod Agric1997，10，2： | 1 |
| 14 | Experimental verification of numerical predictions for the hydrodynamic performance of horizontal axis marina current turbines显示文摘 | Bahaj A S Batten W M J McCann G | 2007 | Renewable Energy2007，32，15： | 1 |
| 15 | Talin2 is Induced During Striated Muscle Differentiation and is Targeted to Stable Adhesion Complexes in Mature Muscle 显示文摘 | Senetar M A Moncman C L McCann R O | 2007 | Cell Motil Cytoskel2007，64，3： | 1 |
| 16 | Hypothalamic control of gonadotropin secretion by LHRH, FSHRF, NO, cytokines, and leptin显示文摘 | McCann S Kimura M Walczewska A et aJ | 1998 | Domest Anim fndocrinol1998，15，： | 1 |
| 17 | Exergy analysis of ammonia based solar thermochemical power systems显示文摘 | Lovegrove K Luzzi A Mccann M | 1999 | Solar Energy1999，，66： | 1 |
| 18 | The correlation of bispectral index with endtidal sevoflurane concentration and haemodynamic parameters in preschoolers显示文摘 | McCann M E Baxsik J Davidson A | 2002 | Paediatr Anaesth2002，12，： | 1 |
| 19 | Gene duplication and functional divergence during evolution of the cytoskeletal linker protein talin 显示文摘 | Senetar M A McCann R O | 2005 | Gene2005，362，： | 1 |
| 20 | Complications of definitive open reduction and internal fixation of Pilon fractures of the distal tibia 显示文摘 | McCann P A Jackson M Mitchell S T | 2011 | Int Orthop2011，35，3： | 1 |
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