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| 1 | FDG-PET/CT response evaluation during EGFR-TKI treatment in patients with NSCLC显示文摘Over recent years,[18F]-fluorodeoxyglucose positron emission tomography acquired together with low dose computed tomography(FDG-PET/CT)has proven its role as a staging modality in patients with non-small cell lung cancer(NSCLC).The purpose of this review was to present the evidence to use FDG-PET/CT for response evaluation in patients with NSCLC,treated with epidermal growth factor receptor(EGFR)-tyrosine kinase inhibitors(TKI).All published articles from 1November 2003 to 1 November 2013 reporting on 18FFDG-PET response evaluation during EGFR-TKI treatment in patients with NSCLC were collected.In total 7studies,including data of 210 patients were eligible for analyses.Our report shows that FDG-PET/CT responseduring EGFR-TKI therapy has potential in targeted treatment for NSCLC.FDG-PET/CT response is associated with clinical and radiologic response and with survival.Furthermore FDG-PET/CT response monitoring can be performed as early as 1-2 wk after initiation of EGFR-TKI treatment.Patients with substantial decrease of metabolic activity during EGFR-TKI treatment will probably benefit from continued treatment.If metabolic response does not occur within the first weeks of EGFR-TKI treatment,patients may be spared(further)unnecessary toxicity of ineffective treatment.Refining FDG-PET response criteria may help the clinician to decide on continuation or discontinuation of targeted treatment. | Matthijs H van Gool Tjeerd S Aukema Koen J Hartemink Renato A Valdés Olmos Houke M Klomp Harm van Tinteren | 2014 | World Journal of Radiology2014，6，7： | 8 |
| 2 | Four-year follow-up of endoscopic gastroplication for the treatment of gastroesophageal reflux disease显示文摘AIM:To evaluate the long-term effect of Endocinch treatment for gastroesophageal reflux disease(GERD).METHODS:After unblinding and crossover,50 patients(32 males,18 females; mean age 46 years) with pH-proven chronic GERD were recruited from an initial randomized,placebo-controlled,single-center study,and included in the present prospective open-label follow-up study.Initially,three gastroplications using the Endocinch device were placed under deep sedation in a standardized manner.Optional retreatment was offered in the first year with 1 or 2 extra gastroplications.At baseline,3 mo after(re) treatment and yearly proton pump inhibitor(PPI) use,GERD symptoms,quality of life(QoL) scores,adverse events and treatment failures(defined as:patients using > 50% of their baseline PPI dose or receiving alternative antireflux therapy) were assessed.Intention-to-treat analysis was performed.RESULTS:Median follow-up was 48 mo [interquartile range(IQR):38-52].Three patients were lost to follow-up.In 44% of patients retreatment was done after a median of 4 mo(IQR:3-8).No serious adverse events occurred.At the end of follow-up,symptom scores and4 out of 6 QoL subscales were improved(all P < 0.01compared to baseline).However,80% of patients required PPIs for their GERD symptoms.Ultimately,64% of patients were classified as treatment failures.In 60% a post-procedural endoscopy was carried out,of which in 16% reflux esophagitis was diagnosed.CONCLUSION:In the 4-year follow-up period,the subset of GERD patients that benefit from endoscopic gastroplication kept declining gradually,nearly half opted for retreatment and 80% required PPIs eventually. | Matthijs P Schwartz J Rieneke C Schreinemakers André J P M Smout | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，4： | 4 |
| 3 | Best Practice Guidelines for Molecular Analysis in Spinal Muscular Atrophy显示文摘 | Scheffer H Cobben J M Matthijs G | 2001 | European Journal of Human Genetics2001，9，7： | 1 |
| 4 | Uri- nary Kidney biomarkers for early detection of nephrotoxicity in clinical drug development 显示文摘 | LEONINE VAN MEER MATTHIJS M JACOBUS B | 2013 | Brit J Clin Pharm2013，77，6： | 1 |
| 5 | Haptoglob indi- rectly affects T cells and suppresses T helper cell type cytokine re- lease 显示文摘 | Arredouani M Matthijs P Van Hoeyveld E | 2003 | Immunology2003，108，2： | 1 |
| 6 | Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release显示文摘 | Arredouani M Matthijs P Van Hoeyveld E | 2003 | Immunology2003，108，2： | 1 |
| 7 | The role of phagocytic cells in enhanced susceptibility of broilers to coli- bacillosis after infectious bronchitis virus infection 显示文摘 | Ariaans M P Matthijs M G van Haarlem D | 2008 | Veteri-nary immunology and immunopathology2008，123，3： | 1 |
| 8 | Detecting the phosphate status of phytoplankton by enzyme-labelled fluorescence and flow cytometry显示文摘 | Dignum M Hoogveld H Matthijs H C P | | 0，，： | 1 |
| 9 | Ability of Massachusetts-type infectious bronchitis virus to increase cotibacillosis susceptibility in commercial broilers:a comparison between vaccine and virulent field virus显示文摘 | MATTHIJS M G VAN ECK J H LANDMAN W J | 2003 | Avian Pathol2003，32，5： | 1 |
| 10 | Uniformity of rotavirus strain nomenclature proposed by the Rotavirus classification working group(RCWG)显示文摘 | Matthij nssens J Ciarlet M Mc Donald SM | 2011 | Arch Viro2011，156，8： | 1 |
| 11 | Human uncoupling protein-3 and obesity: an update显示文摘 | Matthijs KCH Marco M Patriek S | 2003 | Obes Res2003，11，： | 1 |
| 12 | Chiral Separation Strate-gy in Polar Organic Solvent Chromatography and PerformanceComparison with Normal-Phase Liquid and Supercritical-FluidChromatography显示文摘 | Matthijs N Maftouh M Heyde YV | 2006 | J Sep Sci2006，29，10： | 1 |
| 13 | Inhibition of lipolysis in bovine adipose tissue by buturate and 13 hydroxybutyrate显示文摘 | Stef H M M Matthijs L C Simon G V B | 1974 | FEBS Lett1974，47，1： | 1 |
| 14 | Note on relationship between leaf soluble carbohydrate and chlorophyll concertration in maize during leaf senescence显示文摘 | Irena Rajcan Lianne M D Matthijs T R | 1999 | Field Crops Research1999，63，： | 1 |
| 15 | Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release显示文摘 | ARREDOUANI M MATTHIJS P VAN HOEYVELD E | 2003 | Immunology2003，108，： | 1 |
| 16 | Emergency hemipelvectomy as a result of uncontrolled infection after total hip arthroplaty plasty显示文摘 | Matthijs R Krijnen M D Paul IJ M | 2004 | The Journal of Arthroplasty Vol2004，19，： | 1 |
| 17 | Detectingthe phosphate status of phytoplankton by enzyme-labelledfluorescence and flow cytometry显示文摘 | Dignum M Hoogveld H Matthijs H C P | 2004 | FEMS Microbiologi-cal Ecology2004，48，： | 1 |
| 18 | Application of light-emitting diodes in bioreactors:Flashing light effects and energy economy in algal culture(Chlorella pyrenoidosa)显示文摘 | Matthijs H C Balke H Van Hes U M | 1996 | Biotechnology and Bioengineering1996，50，1： | 1 |
| 19 | Ability of Massachusetts-type Infectious bronchitis virus to increase colibacillosis susceptibility in commerciaI broilers:a comparison between vaccine and virulent field virus显示文摘 | Matthijs M G van Eck J H Landman W J | 2003 | Avian Pathol2003，32，5： | 1 |
| 20 | Growth and survival of the mycoparasite Coniothyrium minitans on lettuce leaves in contact with soil in the presence or absence of Sclerotinia sclerotiorum显示文摘 | Matthijs Gerlagh Marianne Kruse Helen M Van de Geijn | 1994 | European Journal of Plant Pathology1994，100，： | 1 |
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