|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Four-year follow-up of endoscopic gastroplication for the treatment of gastroesophageal reflux disease显示文摘AIM:To evaluate the long-term effect of Endocinch treatment for gastroesophageal reflux disease(GERD).METHODS:After unblinding and crossover,50 patients(32 males,18 females; mean age 46 years) with pH-proven chronic GERD were recruited from an initial randomized,placebo-controlled,single-center study,and included in the present prospective open-label follow-up study.Initially,three gastroplications using the Endocinch device were placed under deep sedation in a standardized manner.Optional retreatment was offered in the first year with 1 or 2 extra gastroplications.At baseline,3 mo after(re) treatment and yearly proton pump inhibitor(PPI) use,GERD symptoms,quality of life(QoL) scores,adverse events and treatment failures(defined as:patients using > 50% of their baseline PPI dose or receiving alternative antireflux therapy) were assessed.Intention-to-treat analysis was performed.RESULTS:Median follow-up was 48 mo [interquartile range(IQR):38-52].Three patients were lost to follow-up.In 44% of patients retreatment was done after a median of 4 mo(IQR:3-8).No serious adverse events occurred.At the end of follow-up,symptom scores and4 out of 6 QoL subscales were improved(all P < 0.01compared to baseline).However,80% of patients required PPIs for their GERD symptoms.Ultimately,64% of patients were classified as treatment failures.In 60% a post-procedural endoscopy was carried out,of which in 16% reflux esophagitis was diagnosed.CONCLUSION:In the 4-year follow-up period,the subset of GERD patients that benefit from endoscopic gastroplication kept declining gradually,nearly half opted for retreatment and 80% required PPIs eventually. | Matthijs P Schwartz J Rieneke C Schreinemakers André J P M Smout | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，4： | 4 |
| 2 | C-reactive protein levels during a relapse of Crohn’s disease are associated with the clinical course of the disease显示文摘AIM: To explore if C-reactive protein (CRP) levels might serve as a prognostic factor with respect to the clinical course of Crohn's disease and might be useful for classification.METHODS: In this retrospective cohort study we enrolled 94 patients from the inflammatory bowel disease (IBD) database of the University Medical Centre Utrecht. CRP levels during relapse were correlated with the number of relapses per year. Severity of relapses was based on endoscopic reports and prednisone use. Furthermore, patients were categorized in a low or high CRP group based on their CRP response during relapse and demographic and clinical features were compared.RESULTS: Overall, a positive correlation between CRP levels, number of relapses, and severity of relapse was found (respectively rs = 0.31, P < 0.01 and rs = 0.50, P < 0.001). Employing a cut-off level of 15 mg/L, the index CRP level was found to discriminate patients with respect to the number of relapses per year, as well as for severity of relapses (respectively 0.25 ± 0.16 vs 0.36 ± 0.24, P < 0.05 and 4.4 ± 1.2 vs 3.2 ± 1.1 on a 10-point visual analogue scale, P < 0.001 for the high CRP and low CRP groups respectively). In addition, the high CRP group showed more cumulative days of prednisone use per year (107 ± 95 vs 58 ± 48, P < 0.05), as well as a better response to infliximab (93 % vs 33 %, P = 0.06).CONCLUSION: A higher CRP level during relapse seems to be associated with a more severe clinical course of disease. | Chantal L Koelewijn Matthijs P Schwartz Melvin Samsom Bas Oldenburg | 2008 | World Journal of Gastroenterology2008，14，1： | 4 |
| 3 | A deletion polymorphism in the human alph a-2-m acroglobulin(A2M)gene显示文摘 | Matthijs G Marynen P | 1991 | Nucleic Acids Res1991，19，18： | 1 |
| 4 | Genomic, genetic and structural analysis of pyoverdine mediated iron acquisition in the plant growth-promoting bacterium Pseudomonas fluorescens SBW25显示文摘 | Moon C D Rainey P B Matthijs S | 2008 | BMC Microbiology2008，8，： | 1 |
| 5 | The pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment显示文摘 | Diggle S P Matthijs S Wright V J | 2007 | Chemistry & Biology2007，14，1： | 1 |
| 6 | Exposure of the cyanobacterium Synechocystis PCC6803to salt stress in-duces concerted changes in respiration and photosynthesis显示文摘 | Jean R Matthijs H P Onana B | 1993 | Plant Cell Physiology1993，34，： | 1 |
| 7 | Haptoglob indi- rectly affects T cells and suppresses T helper cell type cytokine re- lease 显示文摘 | Arredouani M Matthijs P Van Hoeyveld E | 2003 | Immunology2003，108，2： | 1 |
| 8 | A deletion polymorphism in the human alpha-2-macroglobulin (A2M)gene显示文摘 | Matthijs G Marynen P | 1991 | Nucleic Acids Res1991，19，18： | 1 |
| 9 | HapX-mediated iron homeostasis is essential forrhizosphere competence and virulence of the soilbornepathogen Fusarium oxysporum显示文摘 | López-Berges MS Capilla J Turrà D Schafferer L Matthijs S J?chl C Cornelis P Guarro J Haas H PietroAD | 2012 | Plant Cell2012，24，38： | 1 |
| 10 | Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release显示文摘 | Arredouani M Matthijs P Van Hoeyveld E | 2003 | Immunology2003，108，2： | 1 |
| 11 | The role of phagocytic cells in enhanced susceptibility of broilers to coli- bacillosis after infectious bronchitis virus infection 显示文摘 | Ariaans M P Matthijs M G van Haarlem D | 2008 | Veteri-nary immunology and immunopathology2008，123，3： | 1 |
| 12 | Detecting the phosphate status of phytoplankton by enzyme-labelled fluorescence and flow cytometry显示文摘 | Dignum M Hoogveld H Matthijs H C P | | 0，，： | 1 |
| 13 | The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment 显示文摘 | Diggle S P Matthijs S Wright V J | 2007 | Chem Biol2007，14，1： | 1 |
| 14 | Exposure of the Cyanobacterium Synechocystis PCC 6803 to salt stress induces concerted changes in respiration and photosynthesis显示文摘 | Matthijs H C P Onana B | 1993 | Plant cell Physical1993，34，： | 1 |
| 15 | Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release显示文摘 | ARREDOUANI M MATTHIJS P VAN HOEYVELD E | 2003 | Immunology2003，108，： | 1 |
| 16 | Description-driven community detection 显示文摘 | Simon P Franeesco B Matthijs V L | 2014 | ACM Transation on Intelligent Systems Technology2014，5，2： | 1 |
| 17 | Detectingthe phosphate status of phytoplankton by enzyme-labelledfluorescence and flow cytometry显示文摘 | Dignum M Hoogveld H Matthijs H C P | 2004 | FEMS Microbiologi-cal Ecology2004，48，： | 1 |
| 18 | Exposure of the cyanobacterium Synechocystis PCC6803 to salt induces concerted changes in respiration and photosynthesis显示文摘 | Jeanjean R Matthijs H C P Onana B | 1993 | Plant Cell Physiol1993，，34： | 1 |
| 19 | Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release显示文摘 | Addredouani M Matthijs P Van Hoeyveld E | 2003 | Immunology2003，108，2： | 1 |
| 20 | Diversity of siderophore-mediated iron uptake system in fluorescent Pseudomonads:not only pyoverdines 显示文摘 | CORNELIS P MATTHIJS S | 2002 | Enviromental Microbiology2002，4，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员