|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9显示文摘RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors. | Anat Kohn Timothy P Rutkowski Zhaoyang Liu Anthony J Mirando Michael J Zuscik Regis J O'Keefe Matthew J Hilton | 2015 | Bone Research2015，3，3： | 8 |
| 2 | The Nature and Biosynthesis of the Carotenoids of Different Color Varieties of Capsicum annuum显示文摘 | B H Davies S Matthew J T O Kirk | 1970 | Phytochemistry1970，，9： | 1 |
| 3 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 4 | Examining the relation between ethical focus and fi-nancial performance in family firms:an exploratory study显示文摘 | O BOYLE E H MATTHEW W R POLLACK J M | | 0，，04： | 1 |
| 5 | Effects of chromium propionate on growth, carcass traits, and pork quality of growing -finishing pigs 显示文摘 | Matthews J O Guzik A C LeMieux F M | 2006 | Journal Animal Science2006，，84： | 1 |
| 6 | How green is my river? A new paradigm of eutrophication in rivers显示文摘 | John H Matthew O Miehael J | 2006 | Science of the Total Environment2006，365，： | 1 |
| 7 | 显示文摘 | Matthews R O | 1979 | J Organoment Chem1979，175，： | 1 |
| 8 | Cancer/testis antigens:an expanding family of targets for cancer immunotherapy显示文摘 | Matthew J Scanlan Ali O Gure A chim A Jungbluth | 2002 | Immunological Review s2002，188，： | 1 |
| 9 | Effects of hetaine , pen space, and slaughter handling method on growthper formance, carcass traits, and pork quality of finishing barrows显示文摘 | Matthews J O Southern L L Bidner T D | 2001 | J Anim Sci2001，79，： | 1 |
| 10 | Transcriptional changes underlying the secretory activation phase of mammary gland development显示文摘 | MATTHEW J N SAMANTHA R O GARDEN M G | 2005 | Mol Endocrinol2005，19，7： | 1 |
| 11 | A tryptophan amphiphilic tetramerization domaincontai-ning acetylcholinesterase from the bovine lungworm,Dictyocaulus viviparous显示文摘 | Matthews J B Lazari O Davidson A J | 2006 | Parasitol2006，133，： | 1 |
| 12 | Ethylene trimerisation and tetramerisation catalysts with polar-substituted diphosphinoamine ligands显示文摘 | Matthew J O Kevin B Annette B | 2005 | Chem Commun2005，，5： | 1 |
| 13 | Nucleotide sequence and analysis and comparison of the structural genes for Shiga-like toxin i and Shiga-like toxin Ⅱ encoded by bacteriophages from Escherichia coli 933显示文摘 | MATTHEW P J ROGER J H ALISON D O | 1987 | FEMS Microbiology Letters1987，44，10： | 1 |
| 14 | Effect of chromium propionate and metabolizable energy on growth, carcass traits, and pork quality of growing-finishing pig显示文摘 | Matthews J O Higbie A D Southern L L | 2003 | J Anim Sci2003，81，： | 1 |
| 15 | Identification of phases in zinc alloy powders using electron backscatter diffraction显示文摘 | Martin G Perez Edward A Kenik Matthew J O'Keefe F Scott Miller Benedict Johnson | 2006 | Mater Sci Eng A2006，424，： | 1 |
| 16 | Homeostasis Model Assessment: Insulin Resistance and Beta-cell Function from Fasting Plasma Glucose and Insulin Concentrations in Man显示文摘 | Matthews O R Honker J R Rudenski A S | 1985 | Diabetologgia1985，28，7： | 1 |
| 17 | Dietary tryptophan ef- fects on plasma and salivary cortisol and meat quality in pigs 显示文摘 | Guzik A C Matthews J O Kerr B J | 2006 | J Anim Sci2006，84，8： | 1 |
| 18 | Holocene glacier fluctuations of Flatebreen and winter-precipitation changes in the Jostedalsbreen region, western Norway, based on glaciolacustrine sediment records 显示文摘 | Nesje A Matthews J A Dahl S O | 2001 | The Holocene2001，11，： | 1 |
| 19 | Mass fractionation processes of transition metal isotopes显示文摘 | Zhu X K Guo Y Williams R J P O'Nions R K Matthews A Belshaw N S Canters G W de Waal E C Weser U Burgess B K Salvato B | 2002 | Earth Planet Sci Lett2002，200，12： | 1 |
| 20 | Effects of chromium propionate on growth,carcass traits,and pork quality of growing-finishing pigs显示文摘 | MATTHEWS J O GUZIK A C LEMIEUX F M | 2005 | Journal of Animal Science2005，83，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员