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| 1 | Portal vein thrombosis in liver cirrhosis显示文摘Portal vein thrombosis(PVT) is considered to be a frequent complication of liver cirrhosis. However, unlike PVT in patients without cirrhosis, very few data are available on the natural history and management of PVT in cirrhosis, despite its association with potentially life-threatening conditions, such as gastroesophageal bleeding and acute intestinal ischemia. Moreover, no consensus regarding PVT in cirrhosis exists. Suggested causes of PVT in cirrhosis include reduced portal blood flow velocity, multiple congenital or acquired thrombophilic factors, inherited or acquired conditions, and derangement of liver architecture. However, the understanding of PVT in cirrhosis is incomplete. In addition, information on the management of PVT in cirrhosis is inadequate. The aims of this review are to:(1) assemble data on the physiopathological mechanism, clinical findings, diagnosis and management of PVT in cirrhosis;(2) describe the principal factors most frequently involved in PVT development; and(3) summarize the recent knowledge concerning diagnostic and therapeutic procedures. | Nao Kinjo Hirofumi Kawanaka Tomohiko Akahoshi Yoshi-hiro Matsumoto Masahiro Kamori Yoshihiro Nagao Naotaka Hashimoto Hideo Uehara Morimasa Tomikawa Ken Shirabe Yoshihiko Maehara | 2014 | World Journal of Hepatology2014，6，2： | 38 |
| 2 | Anti-inflammatory activity of probiotic Bifidobacterium: Enhancement of IL-10 production in peripheral blood mononuclear cells from ulcerative colitis patients and inhibition of IL-8 secretion in HT-29 cells显示文摘AIM: To determine the anti-inflammatory activity of probiotic Bifidobacteria in Bifidobacteria-fermented milk (BFM) which is effective against active ulcerative colitis (UC) and exacerbations of UC, and to explore the immunoregulatory mechanisms. METHODS: Peripheral blood mononuclear cells (PBMNC) from UC patients or HT-29 cells were co-cultured with heat-killed probiotic bacteria or culture supernatant of Bifidobacterium breve strain Yakult (BbrY) or Bifidobacterium bifidum strain Yakult (BbiY) to estimate the amount of IL-10 or IL-8 secreted. RESULTS: Both strains of probiotic Bifidobacteria contained in the BFM induced IL-10 production in PBMNC from UC patients, though BbrY was more effective than BbiY. Conditioned medium (CM) and DNA of both strains inhibited IL-8 secretion in HT-29 cells stimulated with TNF-α, whereas no such effect was observed with heat- killed bacteria. The inhibitory effect of CM derived from BbiY was greater than that of CM derived from BbrY. DNAs of the two strains had a comparable inhibitory activity against the secretion of IL-8. CM of BbiY induced a repression of IL-8 gene expression with a higher expression of IκB-ζ mRNA 4 h after culture of HT-29 cells compared to that in the absence of CM.CONCLUSION: Probiotic Bifidobacterium strains in BFM enhance IL-10 production in PBMNC and inhibit IL-8 secretion in intestinal epithelial cells, suggesting that BFM has anti-inflammatory effects against ulcerative colitis. | Akemi Imaoka Tatsuichiro Shima Kimitoshi Kato Shigeaki Mizuno Toshiki Uehara Satoshi Matsumoto Hiromi Setoyama Taeko Hara Yoshinori Umesaki | 2008 | World Journal of Gastroenterology2008，14，16： | 37 |
| 3 | Holocene vegetational and climatic variation in westerly-dominated areas of Central Asia inferred from the Sayram Lake in northern Xinjiang,China显示文摘Changes in the vegetation and climate of the westerly-dominated areas in Central Asia during the Holocene were interpreted using pollen-assemblages and charcoal data from a 300-cm-long sediment core of the Sayram Lake,northern Xinjiang.Accele-rator Mass Spectrometry(AMS) radiocarbon dating methods were applied to bulk organic matter of the samples.Artemisia spp./Chenopodiaceae ratios and results from principal component analysis were used to infer that the lake basin was dominated by desert vegetation before ca.9.6 cal.ka BP,which suggests a warm and dry climate in the early Holocene.Desert steppe/steppe expanded during 9.6-5.5 cal.ka BP,indicating a remarkable increase both in the precipitation and temperature during the mid-Holocene.Desert vegetation dominated between 6.5 and 5.5 cal.ka BP,marking an extreme warmer and drier interval.The steppe/meadow steppe recovered,and temperatures decreased from 5.5 cal.ka BP in the late Holocene,as indicated by the increased abundance of Artemisia and the development of meadows.Holocene temperatures and moisture variations in the Sayram Lake areas were similar to those of adjacent areas.This consistency implies that solar radiation was the main driving factor for regional temperature changes,and that the effect of temperature variations was significant on regional changes in humidity.The evolution of climate and environment in the Sayram Lake areas,which were characterized as dry in the early Holocene and relatively humid in the middle-late Holocene,are clearly different from those in monsoonal areas.Dry conditions in the early Holocene in the Sayram Lake areas were closely related to decreased water vapor advection.These conditions were a result of reduced westerly wind speeds and less evaporation upstream,which in turn were caused by seasonal changes in solar radiation superimposed by strong evaporation following warming and drying local climate. | JIANG QingFeng JI JunFeng SHEN Ji Ryo MATSUMOTO TONG GuoBang QIAN Peng REN XueMei YAN DeZhi | 2013 | Science China Earth Sciences2013，56，3： | 32 |
| 4 | 赛里木湖孢粉记录的亚洲内陆西风区全新世植被与气候变化显示文摘通过对西风区新疆赛里木湖沉积岩芯的精确定年和孢粉、炭屑分析,重建了该地区全新世以来的植被和气候环境演化历史.结果表明,-9.6cal.kaBP前的早全新世,研究区以荒漠植被为主,A/C比值和第一主成分样品得分所指示的有效湿度明显偏低,第二主成分样品得分所指示的气温回升,气候干旱.9.6~5.5cal.kaBP的中全新世湖区为典型的荒漠草原/草原植被,区域有效湿度明显增加,气温较高,为温暖时期.其中6.5~5.5cal.kaBP期间,研究区植被由荒漠草原/草原迅速转变为荒漠,有效湿度明显降低,同时温度升至最高,可能是一次千年尺度的高温干旱事件.5.5cal.kaBP以来的中-晚全新世,研究区呈现出典型的草原/草甸景观,有效湿度相对较高,温度大幅降低,气候温凉湿润,相对较为适宜.赛里木湖孢粉、炭屑记录的温度和湿度变化与区域其他湖泊记录对比的一致性表明,太阳辐射是造成区域温度变化的主要驱动因素,同时温度变化影响了区域的有效湿度变化.该地区早全新世气候干旱,中.晚全新世气候相对湿润的气候环境演化特征与季风影响区有着明显的差异.早全新世干旱是中纬度西风减弱和上风向蒸发减少的环流背景下局地温度高蒸发强烈的结果. | 蒋庆丰 季峻峰 沈吉 Matsumoto RYO 童国榜 钱鹏 任雪梅 闫德智 | 2013 | 中国科学:地球科学2013，43，2： | 33 |
| 5 | Apoptosis and non-alcoholic fatty liver diseases显示文摘The number of patients with nonalcoholic fatty liver diseases(NAFLD) including nonalcoholic steatohepatitis(NASH), has been increasing. NASH causes cirrhosis and hepatocellular carcinoma(HCC) and is one of the most serious health problems in the world. The mechanism through which NASH progresses is still largely unknown. Activation of caspases, Bcl-2 family proteins, and c-Jun N-terminal kinase-induced hepatocyte apoptosis plays a role in the activation of NAFLD/NASH. Apoptotic hepatocytes stimulate immune cells and hepatic stellate cells toward the progression of fibrosis in the liver through the production of inflammasomes and cytokines. Abnormalities in glucose and lipid metabolism as well as microbiota accelerate these processes. The production of reactive oxygen species, oxidative stress, and endoplasmic reticulum stress is also involved. Cell death, including apoptosis, seems very important in the progression of NAFLD and NASH. Recently, inhibitors of apoptosis have been developed as drugs for the treatment of NASH and may prevent cirrhosis and HCC. Increased hepatocyte apoptosis may distinguish NASH from NAFLD, and the improvement of apoptosis could play a role in controlling the development of NASH. In this review, the association between apoptosis and NAFLD/NASH are discussed. This review could provide their knowledge, which plays a role in seeing the patients with NAFLD/NASH in daily clinical practice. | Tatsuo Kanda Shunichi Matsuoka Motomi Yamazaki Toshikatsu Shibata Kazushige Nirei Hiroshi Takahashi Tomohiro Kaneko Mariko Fujisawa Teruhisa Higuchi Hitomi Nakamura Naoki Matsumoto Hiroaki Yamagami Masahiro Ogawa Hiroo Imazu Kazumichi Kuroda Mitsuhiko Moriyama | 2018 | World Journal of Gastroenterology2018，24，25： | 32 |
| 6 | NUMERICAL ANALYSIS OF THE INFLUENCE OF THE TIP CLEARANCE FLOWS ON THE UNSTEADY CAVITATING FLOWS IN A THREE- D IMENSIONAL INDUCER显示文摘To clarify the influences of the tip clearance flows on the unsteady cavitating flow, the three-dimensional unsteady cavitating flows through both the two-dimensional cascades and the three-dimensional inducer with and without tip clearance are performed numerically. The governing equations for the compressible fluid flow with the DES turbulence model are employed with the assumption of the isentropic process of liquid phase. The evolution of cavities is represented as the source/sink of vapor phase. The basic equations in the curve linear coordinate are solved by the finite difference method. As the results of the three-dimensional cavitating flows through the two-dimensional cascades, the tip clearance flows from the pressure side to the suction side of the blade produces the tip vortex cavitation, which affects the sheet cavitation on the leading edge of the next blade and enhances the blockage effect near the casing than the flows without tip clearance. On the other hand, in the case of the three-dimensional inducer, the large backflow cavitation is observed around the inlet of the inducer, where the cavities are developed on the casing by the tip clearance flows. The large pressure gradient between the non-cavitating pressure side and the cavitating suction side enhances the tip clearance flows. The calculation considering the tip clearance reproduces the developed cavitation region similar to that of experimental visualizations. Additionally, the backflow cavitation rotates with the speed slower than the rotation speed of the inducer. Then, the rotation of backflow cavitation causes the periodic fluctuation of the outlet pressure greater than that of the inlet pressure. | OKITA K. UGAJIN H. MATSUMOTO Y. | 2009 | Journal of Hydrodynamics2009，21，1： | 30 |
| 7 | A high-resolution climatic change since the Late Glacial Age inferred from multi-proxy of sediments in Qinghai Lake显示文摘Based on multi-proxy analysis of pollen, carbonate, TOC, TN and δ13C of organic matters, a high-resolution climatic evolution of Qinghai Lake since the Late Glacial Age is recon-structed. The results indicate that the boundary between the Last Glacial Maximum and the Late Glacial Age is at about 18.2 cal.ka BP. The warm and wet period, which began at about 15.4 cal.ka BP, culminated at 7.4 cal.ka BP and came to its end at about 4.5 cal.ka BP. After that, the climate gradually became cold and dry. The multi-proxy analysis indicates that the climate fluc-tuated greatly during the transitional period from the Late glacial Age to the Holocene, and this is in good accordance with that reflected by deep sea cores of North Atlantic, ice cores of Greenland, lake sediments in Europe, loess sequences and Guliya ice core in China. The cli-matic evolutional characteristic of the Qinghai Lake since the Late Glacial Age shows that the driving force of the East-Asia Monsoon correlates with solar radiation on the ten-thousand-year scale. | Ryo Matsumoto | 2005 | Science China Earth Sciences2005，48，6： | 27 |
| 8 | Lake sediment records on climate change and human activities since the Holocene in Erhai catchment, Yunnan Province, China显示文摘According to high-resolution analyses on multi-proxy of sediment core from the Er- hai Lake, Yunnan Province, the sequence of climatic and environmental change since the Holo- cene has been reconstructed based on accurate dating. The results show that climate had tran- sited from cold-wet to warm-wet during ca. 12950-8399 aBP in this area, and the transition happened in ca. 10329 aBP. Due to the enhancing southwest Asian monsoon and increasing precipitation, the lake-level of the Erhai Lake began to rise after ca. 10329 a BP. Climate in the catchment was warm and wet during the mid-Holocene, and the warmest stage appeared in ca. 8399-6371 a BP. The lake-level descended in the mid-Holocene because of the decrease of effective moisture in the basin. Human activities appeared in ca. 6371 a BP, and the initial man- ner mainly focused on deforestation. Up to ca. 2139 a BP, due to the amount of immigration into this area, the cultivation was developed widely, which was followed by mining (coal mine). | R. Matsumoto | 2005 | Science China Earth Sciences2005，48，3： | 22 |
| 9 | Seasonal Transition Features of Large-Scale Moisture Transport in the Asian-Australian Monsoon Region显示文摘用为时期的 NCEP/NCAR 分析数据 1957 2001,季节的转变在亚洲澳大利亚人的季风区域大规模垂直地综合的潮湿运输(VIMT ) 展示的 climatological 在这篇论文被调查。到夏天的从冬季的 VIMT 的季节的转变的基本特征是夏日的建立“大潮湿河”模式(说出 GMR 模式)并且它的东方扩大,与发生在“一些关键时期”的一系列 climatological 事件联系了,它在中间的5月在中间的三月,在在迟了的4月的斯里兰卡附近的低 VIMT 旋涡的活动,和华南海夏季风的发作在印度支那半岛上包括著名南方的 VIMT 的出现,在其它之中。在到冬季的从夏天的转变期间,然而,特征被建立主要展出在东方位于热带区域的 VIMT 带,由发生在“关键时期”的一些事件伴随了。当在季节的变化过程期间从西的 VIMT 的南方的迁居看了时,进一步的分析揭示印第安人和东方亚洲季风区域之间的大差别,根据哪个亚洲季风区域能容易沿着印度支那半岛的西方的方面被划分成二部分,它可以也表示在二个区域之间的不同形成机制。 | 何金海 孙丞虎 刘芸芸 Jun MATSUMOTO 李维京 | 2007 | Advances in Atmospheric Sciences2007，24，1： | 22 |
| 10 | IMPROVEMENT OF BUBBLE MODEL FOR CAVITATING FLOW SIMULATIONS显示文摘In the present research, a bubble dynamics based model for cavitating flow simulations is extended to higher void fraction region for wider range of applications. The present bubble model is based on the so-called Rayleigh-Plesset equation that calculates a temporal bubble radius with the surrounding liquid pressure and is considered to be valid in an area below a certain void fraction. The solution algorithm is modified so that the Rayleigh-Plesset equation is no more solved once the bubble radius (or void fraction) reaches at a certain value till the liquid pressure recovers above the vapor pressure in order to overcome this problem. This procedure is expected to stabilize the numerical calculation. The results of simple two-dimensional flow field are presented compared with the existing bubble model. | TAMURA Y. MATSUMOTO Y. | 2009 | Journal of Hydrodynamics2009，21，1： | 23 |
| 11 | 内蒙古岱海古盐度定量复原初探显示文摘通过分析湖泊表层沉积物中活体介形类(Limnocythere cf. inopinata)壳体的Sr, Ca 比值以及湖水的Sr2+, Ca2+比值, 获取岱海介形类壳体的Sr 分配系数Kd (Sr). 利用湖水Sr2+/Ca2+值与盐度的相关关系, 建立岱海湖水盐度与水介质离子比函数方程. 结合岱海沉积钻孔中同种介形类壳体的Sr, Ca比值, 定量恢复湖水的古盐度. | 沈 吉 王苏民 R. Matsumoto 朱育新 | 2000 | 科学通报2000，45，17： | 23 |
| 12 | Efficacy of mosapride citrate with polyethylene glycol solution for colonoscopy preparation显示文摘AIM:To evaluate the efficacy and safety of adjunctive mosapride citrate for bowel preparation before colonoscopy. METHODS:We conducted a randomized,double-blind, placebo-controlled study with mosapride in addition to polyethylene glycol(PEG)-electrolyte solution.Of 250 patients undergoing colonoscopy,124 were randomized to receive 2 L PEG plus 15 mg of mosapride citrate (mosapride group),and 126 received 2 L PEG plus placebo(placebo group).Patients completed a questionnaire reporting the acceptability and tolerability of the bowel preparation process.The efficacy of bowel preparation was assessed by colonoscopists using a 5-point scale based on Aronchick's criteria.The primary end point was optimal bowel preparation rates(scores of excellent/good/fair vs poor/inadequate). RESULTS:A total of 249 patients were included in the analysis.In the mosapride group,optimal bowel preparation rates were significantly higher in the left colon compared with the placebo group(78.2%vs 65.6%,P<0.05),but not in the right colon(76.5%vs 66.4%,P=0.08).After excluding patients with severe constipation,there was a significant difference in bowel preparation in both the left and right colon(82.4%vs 66.7%,80.8%vs 67.5%,P<0.05,P<0.01).The incidence of adverse events was similar in both groups. Among the subgroup who had previous colonoscopy experience,a significantly higher number of patients in the mosapride group felt that the current preparation was easier compared with patients in the placebo group(34/72 patients vs 24/74 patients,P<0.05). CONCLUSION:Mosapride citrate may be an effective and safe adjunct to PEG-electrolyte solution that leads to improved quality of bowel preparation,especially in patients without severe constipation. | Masahiro Tajika Yasumasa Niwa Vikram Bhatia Hiroki Kawai Shinya Kondo Akira Sawaki Nobumasa Mizuno Kazuo Hara Susumu Hijioka Kazuya Matsumoto Yuji Kobayashi Akira Saeki Asana Akabane Koji Komori Kenji Yamao | 2012 | World Journal of Gastroenterology2012，18，20： | 21 |
| 13 | Diagnostic and therapeutic single-operator cholangiopancreatoscopy in biliopancreatic diseases:Prospective multicenter study in Japan显示文摘AIM: To assess the utility and safety of single-operator cholangiopancreatoscopy(SOCPS) using the Spy Glass system in widespread clinical application for biliary and pancreatic diseases.METHODS: This study was a prospective case series conducted in 20 referral centers in Japan. There were 148 patients who underwent SOCPS; 124 for biliary diseases and 24 for pancreatic diseases. The attempted interventions were SOCPS examination, SOCPS-directed tissue sampling, and therapy for stone removal, among others. The main outcomes were related to the procedure success rate in terms of visualizing the target lesions, SOCPS-directed adequate tissue sampling, and complete stone removal. RESULTS: A total of 148 patients were enrolled for the diagnosis of indeterminate biliary and pancreatic lesions or treatment of biliary and pancreatic disease. The overall procedure success rate of visualizing the target lesions was 91.2%(135/148). The overall procedural success rates of visualizing the target lesions of diagnostic SOCPS in the bile duct and pancreatic duct were 95.5%(84/89) and 88.2%(15/17), respectively. Diagnosis: the overall adequate tissue for histologic examination was secured in 81.4% of the 86 patients who underwent biopsy under SOCPS(bile duct, 60/75, 80.0%; pancreatic duct, 10/11, 90.9%). The accuracy of histologic diagnosis using SOCPS-directed biopsies in indeterminate bile duct lesions was 70.7%(53/75). In the pancreatic duct, the accuracy of SOCPS visual impression of intraductal papillary mucinous neoplasm was 87.5%(14/16). Stone therapy: complete biliary and pancreatic stone clearance combined with SOCPS-directed stone therapy using electrohydraulic lithotripsy or laser lithotripsy was achieved in 74.2%(23/31) and 42.9%(3/7) of the patients, respectively. Others: SOCPS using the Spy Glass system was used in cannulation of the cystic duct in two patients and for passing across the obstructed self-expandable metallic stent for a malignant biliary stricture in two patients. All procedures were successful in both SOCPS-guided therapies. The incidence of procedure-related adverse events was 5.4%(8/148). CONCLUSION: SOCPS with direct visualization and biopsy for diagnosis and SOCPS-directed therapy for biliary and pancreatic diseases can be safely performed with a high success rate. | Toshio Kurihara Ichiro Yasuda Hiroyuki Isayama Toshio Tsuyuguchi Taketo Yamaguchi Ken Kawabe Yoshinobu Okabe Keiji Hanada Tsuyoshi Hayashi Takao Ohtsuka Syuhei Oana Hiroshi Kawakami Yoshinori Igarashi Kazuya Matsumoto Kiichi Tamada Shomei Ryozawa Hiroki Kawashima Yutaka Okamoto Iruru Maetani Hiroyuki Inoue Takao Itoi | 2016 | World Journal of Gastroenterology2016，22，5： | 20 |
| 14 | Clinicopathological features of alpha-fetoprotein producing early gastric cancer with enteroblastic differentiation显示文摘AIM To investigate clinicopathological features of early stage gastric cancer with enteroblastic differentiation(GCED).METHODS We retrospectively investigated data on 6 cases of early stage GCED and 186 cases of early stage conventional gastric cancer(CGC: well or moderately differentiated adenocarcinoma) who underwent endoscopic submucosal dissection or endoscopic mucosal resection from September 2011 to February 2015 in our hospital.GCED was defined as a tumor having a primitive intestine-like structure composed of cuboidal or columnar cells with clear cytoplasm and immunohistochemical positivity for either alpha-fetoprotein, Glypican 3 or SALL4. The following were compared between GCED and CGC: age, gender, location and size of tumor, macroscopic type, ulceration, depth of invasion, lymphatic and venous invasion, positive horizontal and vertical margin, curative resection rate.RESULTS Six cases(5 males, 1 female; mean age 75.7 years; 6 lesions) of early gastric cancer with a GCED component and 186 cases(139 males, 47 females; mean age 72.7 years; 209 lesions) of early stage CGC were investigated. Mean tumor diameters were similar but rates of submucosal invasion, lymphatic invasion, venous invasion, and non-curative resection were higher in GCED than CGC(66.6% vs 11.4%, 33.3% vs 2.3%, 66.6% vs 0.4%, 83.3% vs 11% respectively, P < 0.01). Deep submucosal invasion was not revealed endoscopically or by preoperative biopsy. Histologically, in GCED the superficial mucosal layer was covered with a CGC component. The GCED component tended to exist in the deeper part of the mucosa to the submucosa by lymphatic and/or venous invasion, without severe stromal reaction. In addition, Glypican 3 was the most sensitive marker for GCED(positivity, 83.3%), immunohistochemically.CONCLUSION Even in the early stage GCED has high malignant potential, and preoperative diagnosis is considered difficult. Endoscopists and pathologists should know the clinicopathological features of this highly malignant type of cancer. | Kohei Matsumoto Hiroya Ueyama Kenshi Matsumoto Yoichi Akazawa Hiroyuki Komori Tsutomu Takeda Takashi Murakami Daisuke Asaoka Mariko Hojo Natsumi Tomita Akihito Nagahara Yoshiaki Kajiyama Takashi Yao Sumio Watanabe | 2016 | World Journal of Gastroenterology2016，22，36： | 20 |
| 15 | 可可西里库赛湖揭示的青藏高原北部近4000年来的干湿变化显示文摘通过青藏高原北部可可西里库赛湖KS-2006孔(深637cm)沉积岩芯总有机碳、总氮含量及沉积物粒度变化的研究,恢复了该地区近4000年来的干湿变化历史.结果表明,该地区近4000年来经历了显著的干湿变化,干旱时段出现在3900-3590cal aBP、3320-2630cal aBP、1720-1420cal aBP及1100-840cal aBP期间;湿润时段出现在3590-3320cal aBP、2630-1720cal aBP、1420-1100cal aBP以及840cal aBP之后小冰期有效降水升高的相对湿润时期.区域对比分析表明库赛湖地区近4000年来的干湿变化受亚洲季风影响;同时,该地区存在明显的中世纪暖期及小冰期的三次降温事件记录. | 王永波 刘兴起 羊向东 张恩楼 Ryo Matsumoto | 2008 | 湖泊科学2008，20，5： | 20 |
| 16 | Clinical investigation of 41 patients with ischemic colitis accompanied by ulcer显示文摘AIM: To investigate the relationship among the presence of ulcer lesions, underlying disease, and clinical course in patients with ischemic colitis. METHODS: The subjects were 41 patients (10 male and 31 female; mean age 70 years) with ischemic colitis who were admitted to and received treatment in our hospital from 2000 to 2006. We compared their characteristics and analyzed the mean lengths of admission and fast- ing for 9 patients with ulcer lesions (ulcer group) and 32 without (non-ulcer group). RESULTS: The groups with presence and absence of ulcer differed significantly only in white blood cell (WBC) count. Lengths of fasting and admission were 7.9 d and 17.9 d for the ulcer group and 4.4 d and 10.7 d for the non-ulcer group, respectively, and significantly longer in the ulcer group (P = 0.0057 and 0.0001). There was no correlation between presence of ulcer and presence of underlying diseases. CONCLUSION: Lengths of fasting and admission were significantly longer in patients with ischemic colitis with ulcer than for those without ulcer. | Satohiro Matsumoto Kenichiro Tsuji Satoshi Shirahama | 2007 | World Journal of Gastroenterology2007，13，8： | 18 |
| 17 | Selection of appropriate endoscopic therapies for duodenal tumors: An open-label study, single-center experience显示文摘AIM:To determine an appropriate compartmentalization of endoscopic submucosal dissection(ESD)or endoscopic mucosal resection(EMR)for duodenal tumors.METHODS:Forty-six duodenal lesions(excluding papillary lesions)from 44 patients with duodenal tumors treated endoscopically between 2005 and 2013 were divided into the ESD and EMR groups for retrospective comparison and analysis.RESULTS:The mean age was 65±9 years(35-79years).There were 24 lesions from men and 22 from women.The lesions consisted of 6 early cancers,31adenomas and 9 neuroendocrine tumors.Lesion location was the duodenal bulb in 15 cases and the descending part of the duodenum in 31 cases.The most common macroscopic morphology was elevated type in 21 cases(45.6%).Mean tumor diameter was 11.9±9.7 mm(3-60 mm).Treatment procedure was ESD(15 cases)vs EMR(31 cases).The examined parameters in the ESD vs EMR groups were as follows:mean tumor diameter,12.9±14.3 mm(3-60 mm)vs 11.4 ±6.7 mm(4-25 mm);en bloc resection rate,86.7%vs 83.9%;complete resection rate,86.7%vs 74.2%;procedure time,86.5±63.1 min(15-217 min)vs 13.2±17.0 min(2-89 min)(P<0.0001);intraprocedural perforation,3 cases vs none(P=0.0300);delayed perforation,none in either group;postprocedural bleeding,1 case vs none;mean postoperative length of hospitalization,8.2±2.9 d(5-16 d)vs 6.1±2.0 d(2-12 d)(P=0.0067);recurrence,none vs 1 case(occurring at 7 mo postoperatively).CONCLUSION:ESD was associated with a longer procedure time and a higher incidence of intraprocedural perforation;EMR was associated with a lower rate of complete resection. | Satohiro Matsumoto Yukio Yoshida | 2014 | World Journal of Gastroenterology2014，20，26： | 17 |
| 18 | A combination treatment of entecavir and early-phase corticosteroid in severe exacerbation of chronic hepatitis B显示文摘Of patients with severe exacerbation of chronic hepatitis B accompanied by jaundice and coagulopathy,20%-30%have a fatal outcome.In this report,we describe 2 cases of severe exacerbation of chronic hepatitis B with jaundice and coagulopathy who were successfully treated with a combination of entecavir and corticosteroid.In both cases,rapid reductions in serum hepatitis B virus(HBV)-DNA levels were observed,and corticosteroid was stopped after serum HBV-DNA levels became undetectable.Entecavir treatment was continued.Generally,entecavir treatment reduced serum HBV-DNA levels rapidly,although the improvement in liver function was delayed by a few weeks.During this time lag,liver cell injury continued and the disease progressed.Corticosteroid suppressed the excessive host immune response and was useful for stopping progressive deterioration.A combination of entecavir and early-phase corticosteroid may be a useful treatment in severe exacerbation of chronic hepatitis B. | Kazuyuki Matsumoto Yasuhiro Miyake Hirokazu Miyatake Masahiro Takahara Takayuki Imada Satoru Yagi Tatsuya Toyokawa Morihito Nakatsu Masaharu Ando Mamoru Hirohata | 2009 | World Journal of Gastroenterology2009，15，13： | 16 |
| 19 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 20 | 气相色谱-串联质谱检测蔬菜中氟吡菌酰胺及其代谢物残留显示文摘采用气相色谱-串联质谱(GC-MS/MS)技术建立了同时检测7种类型蔬菜中氟吡菌酰胺及其代谢物残留的分析方法。样品采用乙腈提取,无水硫酸镁和氯化钠盐析后,经分散固相萃取(PSA)净化,GC-MS/MS检测。结果表明:在0.01、0.1和1 mg/kg 3个添加水平下,氟吡菌酰胺及其代谢物2-(三氟甲基)苯甲酰胺(BZM)的平均回收率在80%-108%之间,相对标准偏差(RSD)在1.5%-8.4%之间。氟吡菌酰胺及其代谢物在7种蔬菜中的检出限(LOD)(S/N=3)分别为2.17-3.13μg/kg和1.22-2.04μg/kg,两者的定量限(LOQ)均为0.01 mg/kg。该方法操作简便、稳定和快速,可以满足大部分蔬菜中氟吡菌酰胺及其代谢物的定性与定量分析要求。 | 李文卓 钱圆 MATSUMOTO Haruna 刘晓玉 秦丽 王蒙岑 朱国念 | 2016 | 农药学学报2016，18，6： | 14 |
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