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| 1 | Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients显示文摘The introduction of tacrolimus in clinical practice has improved patient survival after organ transplant.However,despite the long use of tacrolimus in clinical practice,the best way to use this agent is still a matter of intense debate.The start of the genomic era has generated new research areas,such as pharmacogenetics,which studies the variability of drug response in relation to the genetic factors involved in the processes responsible for the pharmacokinetics and/or the action mechanism of a drug in the body.This variability seems to be correlated with the presence of genetic polymorphisms.Genotyping is an attractive option especially for the initiation of the dosing of tacrolimus;also,unlike phenotypic tests,the genotype is a stable characteristic that needs to be determined only once for any given gene.However,prospective clinical studies must show that genotype determination before transplantation allows for better use of a given drug and improves the safety and clinical efficacy of that medication.At present,research has been able to reliably show that the CYP3A5 genotype,but not the CYP3A4 or ABCB1 ones,can modify the pharmacokinetics of tacrolimus.However,it has not been possible to incontrovertibly show that the corresponding changes in the pharmacokinetic profile are linked with different patient outcomes regarding tacrolimus efficacy and toxicity.For these reasons,pharmacogenetics and individualized medicine remain a fascinating area for further study and may ultimately become the face of future medical practice and drug dosing. | Alessio Provenzani Andrew Santeusanio Erin Mathis Monica Notarbartolo Manuela Labbozzetta Paola Poma Ambra Provenzani Carlo Polidori Giovanni Vizzini Piera Polidori Natale D'Alessandro | 2013 | World Journal of Gastroenterology2013，19，48： | 15 |
| 2 | Hematological changes during androgen deprivation therapy显示文摘雄激素剥夺治疗(ADT ) 与不利效果的过多被联系了,与多重繁殖、体的纸巾的雄激素相关性一致。一如此的纸巾是 hemopoietic 系统,并且 ADT 的最可预言的后果之一是贫血症的开发。尽管 ADT 引起的贫血症是很少严重, ADT 经常与增加的危险性被给脆弱的、老人到贫血症由于多重另外的原因。联系 ADT 的贫血症可以贡献疲劳并且减少在如此的人的生活(QoL ) 的质量,尽管这要求进一步的学习。当贫血症是在有前列腺癌症的人的死亡的一个独立风险因素时,联系 ADT 的贫血症的治疗是否改变临床上重要的结果,或治疗是否影响死亡,不被知道。导致 ADT 的贫血症的现象的了解应该在正常红血球的 normochromic 贫血症的温和情况中避免不必要的病情的检查。然而,对更多的严重贫血症的评价和治疗可以被要求。这应该在一个单个基础上被决定。与红血球生成上的 ADT 的描述得好的行动相对照,它另外的 hemopoietic 系上的效果是更少很好阐明。当现出症状之前的潜的研究在成熟为雄激素发现了角色并且区分了 neutrophils,淋巴细胞和血小板的功能时,为有收到 ADT 的前列腺癌症的人的这些调查结果的含意要求进一步的研究。 | Mathis Grossmann Jeffrey D Zajac | 2012 | Asian Journal of Andrology2012，14，2： | 9 |
| 3 | A case of Maffucci syndrome显示文摘 | Mathys L Jenzer A Della Santa D | 2010 | Chir Main2010，29，1： | 1 |
| 4 | A mechanism for divalent cation regulation of beta 3-integrins显示文摘 | Smith J W Piotrowicz R E Mathis D | 1994 | J Bio Chem1994，269，： | 1 |
| 5 | Simultaneous quantitation of histamine and its major metabolite 1-methylhistamine in brain dialysates by using precolumn derivatization prior to HILICMS/MS analysis 显示文摘 | Bourgogne E Mathy FX Boucat D | 2012 | Anal Bioanal Chem2012，402，1： | 1 |
| 6 | A decade of Aire显示文摘 | MATHIS D BENOIST C | 2007 | Nature2007，7，： | 1 |
| 7 | Number of T reg ceils that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells显示文摘 | van Santen H M Benoist C Mathis D | 2004 | J Exp Med2004，200，： | 1 |
| 8 | The AKT- roTOR axis regulates de novo differentiation of CD4^+ Foxp3^+ cells 显示文摘 | Haxhinasto S Mathis D Benoist C | 2008 | J Exp Med2008，205，3： | 1 |
| 9 | Online determination of fluconazole in blood and dermal rat microdialysates by microbore high-performance liquid chromatography 显示文摘 | Mathy F X Vroman B Ntivunwa D | 2003 | J Chromatogr B: Anal Technol Biomed Life Sci2003，787，2： | 1 |
| 10 | The Intemet: A Global Telecommunications Solution 显示文摘 | MATHY L EDWARDS C HUTCHISON D | 2000 | IEEE Network2000，14，4： | 1 |
| 11 | Effect of augumentation on the mechanics of vertebral wedge fractures显示文摘 | Wilson D Myers ER Mathis JM | 2000 | Spine ( Phila Pa 1976 )2000，25，2： | 1 |
| 12 | Microwave processing of WC-Co composites and ferroic titanates 显示文摘 | CHENG J P AGRAWAL D K KOMAMENI S MATHIS M ROY R | 1997 | Materials Research Innovations1997，1，1： | 1 |
| 13 | Top chemistry + top technology = PET staple fiber with optimum processability显示文摘 | Mathis R Gross D | 1998 | Chemistry Fibers Intermation1998，，12： | 1 |
| 14 | Fluconazole distribution in rat dermis following intravenous and topical application: a microdialysis study显示文摘 | Mathy FX Ntivunwa D Verbeeck RK | 2005 | JPharm Sci2005，94，4： | 1 |
| 15 | A defective 1115 allele underlies the deficiency in natural killer cell activity in nono- bese diabetic mice显示文摘 | SUWANAI H WILCOX M A MATHIS D | 2010 | Proc Natl Acad Sci U S A2010，107，20： | 1 |
| 16 | Implementation of a real-time human movement classifier using a triaxial accelerometer for ambulatory monitoring显示文摘 | Karantonis D M Narayanan M R Mathie M | 2006 | IEEE Trans Inf Technol Biomed2006，10，1： | 1 |
| 17 | Impleme- ntation of a real-time human movement classifier using a 3- axial accelerometer for ambulatory monitoring显示文摘 | D M Karantonis M R Narayanan M Mathie etal | 2006 | IEEE Tran- sactions on Information Technology in Biomedicine2006，10，1： | 1 |
| 18 | Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells显示文摘 | van Santen H M Benoist C Mathis D | 2004 | J Exp Med2004，200，10： | 1 |
| 19 | Foxp3+ regulatory T cells:dif-ferentiation,specification,subphenotypes显示文摘 | Fenerer M Mill JA Mathis D | 2009 | Nat Jmmunol2009，10，7： | 1 |
| 20 | beta-Cell death during progression to diabetes显示文摘 | MATHIS D VENCE L BENOIST C | 2001 | Nature2001，414，6865： | 1 |
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