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| 1 | Toxic tau: structural origins of tau aggregation in Alzheimer’s disease显示文摘Alzheimer’s disease is characterized by the extracellular accumulation of the amyloidβin the form of amyloid plaques and the intracellular deposition of the microtubule-associated protein tau in the form of neurofibrillary tangles.Most of the Alzheimer’s drugs targeting amyloidβhave been failed in clinical trials.Particularly,tau pathology connects greatly in the pathogenesis of Alzheimer’s disease.Tau protein enhances the stabilization of microtubules that leads to the appropriate function of the neuron.Changes in the quantity or the conformation of tau protein could affect its function as a microtubules stabilizer and some of the processes wherein it is involved.The molecular mechanisms leading to the accumulation of tau are principally signified by numerous posttranslational modifications that change its conformation and structural state.Therefore,aberrant phosphorylation,as well as truncation of tau protein,has come into focus as significant mechanisms that make tau protein in a pathological entity.Furthermore,the shape-shifting nature of tau advocates to comprehend the progression of Alzheimer’s disease precisely.In this review,we emphasize the recent studies about the toxic and shape-shifting nature of tau in the pathogenesis of Alzheimer’s disease. | Abdullah Al Mamun Md.Sahab Uddin Bijo Mathew Ghulam Md Ashraf | 2020 | Neural Regeneration Research2020，15，8： | 21 |
| 2 | Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure显示文摘 | Mathews DH Disney MD Childs JL | 2004 | Proc Natl Acad Sci USA2004，101，19： | 1 |
| 3 | Comparison of creep rupture behaviour oftype 316L(N) austenitic stainless steel joints welded by TIG andactivated TIG welding processes显示文摘 | SAKTHIVEL T VASUDEVAN M LAHA K PARAMESWARAN P CHANDRAVATHI K S MATHEW MD BHADURI A K | 2011 | Materials Science andEngineering A2011，528，2223： | 1 |
| 4 | Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure 显示文摘 | Mathews DH Disney MD Childs JL | 2004 | Proc Natl Acad Sci USA2004，101，19： | 1 |
| 5 | Diffusion-weighted imaging of white matter abnormalities in patients with phenylketonuria显示文摘 | Phillips MD McGraw P Lowe MJ Mathews VP Hainline BE | 2001 | AJNR Am J Neuroradiol2001，22，8： | 1 |
| 6 | Intraoperative radiofrequency linear catheter ablation of accessory pathways in children with ebstein's anomaly undergoing tricuspid annuloplasty显示文摘 | Robert H Pass MD Mathew R | 2002 | American Journal of Cardiology2002，90，7： | 1 |
| 7 | Activation of the transcription factor, nuclear factor kappa-B, during the estrous cycle and early pregnancy in the pig显示文摘 | Ross JW Ashworth MD Mathew D | 2010 | Reprod Biol Endocrinol2010，8，： | 1 |
| 8 | Radiofrequency ablation of 231 unresectable hepatic tumors: Indications, limitations, and complications显示文摘 | Thomas F. Wood MD D. Michael Rose MD Mathew Chung MD David P. Allegra MD Leland J. Foshag MD Anton J. Bilchik MD PhD | 2000 | Annals of Surgical Oncology2000，，8： | 1 |
| 9 | Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure显示文摘 | Mathews DH Disney MD Childs JL | 2004 | Proc Natl Acad Sci USA2004，101，19： | 1 |
| 10 | Risks in offshore IT outsourcing:A service provider perspective显示文摘 | Aundhe MD Mathew S K | | 0，，06： | 1 |
| 11 | Hospital Treatment of Patients With Ischemic Stroke or Transient Ischemic Attack U- sing the ' Get With The Guidelines' Program 显示文摘 | Kenneth A LaBresh MD Mathew J | 2008 | Arch Intern Med2008，168，4： | 1 |
| 12 | Cost-Effectiveness of Positron Emission Tomography in Breast Cancer显示文摘 | J. Scott Sloka MD Peter D. Hollett Maria Mathews | 2005 | Molecular Imaging and Biology2005，，5： | 1 |
| 13 | Activation of the tran- scription factor, nuclear factor kappa -B, during the estrous cycle and early pregnancy in the pig显示文摘 | Ross JW Ashworth MD Mathew D | 2010 | Reprod Biol Endocrinol2010，8，： | 1 |
| 14 | Acquired Fanconi’s syndrome associated with tenofovir therapy显示文摘 | George Mathew MD Stephen J. Knaus MD | 2006 | Journal of General Internal Medicine2006，，11： | 1 |
| 15 | Effects of theheavy usage of kava on physicalhealth:summary of a pilot survey in an aboriginal community显示文摘 | Mathews JD Riley MD Fejo L | 1998 | Med JAust1998，148，11： | 1 |
| 16 | Elimination of preoperative mechanical bowel preparation in patients un- dergoing cystectomy and urinary diversion显示文摘 | Mathew C Raynor MD Garjae Lavien MD | 2013 | Urologic On- cology2013，31，： | 1 |
| 17 | Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure显示文摘 | Mathews DH Disney MD Childs JL | 2004 | Proc Natl Acad Sci USA2004，101，19： | 1 |
| 18 | Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure显示文摘 | Disney MD Childs JL | 2004 | Proc Natl Acad Sci USA2004，101，19： | 1 |
| 19 | 美国心脏超声协会/美国心血管麻醉医师协会对围手术期超声心动图检查持续质量改进的建议和指南显示文摘美国心脏超声协会(American Society of Echocardiography,ASE)始成立于1975年,长期以来一直鼓励对超声心动图检查质量的评估。为此,已发表了一些超声心动图检查的指南,并不断进行修订。1995年,ASE发表了一系列专门用于超声心动图持续质量改进(Continuous Quality Improvement,CQI)的建议。超声心动图检查的临床广泛应用以及超声技术、检查方法和图像判读的复杂性是进行CQI项目的原因之一。本文旨在阐述美国心脏超声协会与美国心血管麻醉医师协会针对围手术期超声心动图检查CQI项目所发表的建议和指南。在ASE已发表的有关CQI项目文章的基础上,本文将涉及如下内容:1)提出围手术期开展CQI的理由,2)确定围手术期超声心动图检查的项目内容,3)提出与围手术期超声心动图检查有关的CQI原则,4)评估CQI项目在围手术期的有效性。本文所提出的建议和操作指南适用于任何围手术期间的超声心动图检查,包括手术前、手术中和手术后。任何具有Ⅲ级水平超声心动图检查的单位可独立实施CQI项目。 | Joseph P. Mathew, MD, FASE Kathryn Glas, MD, FASE Christopher A. Troianos, MD Pamela Sears-Rogan, MD, FASE Robert Savage, MD Jack Shanewise, MD, FASE Solomon Aronson, MD, FASE Joseph Kisslo, MD, FASE Stanton Shernan, MD, FASE 丛涌滋(译) 王多友(校) | 2008 | 麻醉与镇痛2008，4，1： | 0 |
| 20 | 关于手术中知晓的危险因素、发生原因及后遗症的文献综述显示文摘背景手术中知晓是一种不常见的临床现象,仅通过一项研究的病例数量不足以证明和评估其危险因素、发生原西及后遗症。对已发表在科学期刊上的大量病例报告进行综合分析可有效表明术中知晓的状况。方法通过检索国家图书馆医学PubMed数据库,检索词为“知晓”和“麻醉”,检索起止时间为1950年至2005年8月,同时手工检索了上述报告及其他与知晓相关的参考文献。为进行比较,本文设置了2个外科对照组:Sebel等研究中的无知晓患者和1996年国家门诊外科调查中接受全身麻醉的患者,同时采用了全国卫生统计中心的数据对体重和体重指数进行比较。结果271例出现手术中知晓的患者与19504例无知晓患者进行比较,发现知晓患者中大多为女性(P〈0.05)、青年(P〈0.001),手术种类为心脏或产科手术(P〈0.0001)。麻醉恢复室中报告的知晓发生仅占总数的35%。知晓患者使用的麻醉药剂量较小(P〈0.0001),手术中常出现发作性心跳加速及血压升高(P〈0.0001),手术后主诉知晓(52%,P〈0.0001)、睡眠障碍、对未来麻醉的恐惧感及手术中制动、无助及虚弱感、听到噪音和语音等有关(P〈0.041—0.0003)。22%的患者出现迟发型精神症状。结论本综述提示,麻醉过浅和既往知晓史是发生手术中知晓的危险因素,氧化亚氮或肥胖都不会增加其发生率。其中麻醉过浅是最常见的原因。某些预防性操作或许可以减少其发生。 | Mohamed M. Ghoneim, MD Robert I. Block, PhD Mary Haffarnan, CRNA Maya J. Mathews, CRNA 刘梦琳(译) 王祥瑞(校) | 2011 | 麻醉与镇痛2011，7，4： | 0 |
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