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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Porcine circovirus type 2 (PCV2) Cap and Rep proteins are involved in the development of cell-mediated immunity upon PCV2 infection显示文摘 | Maria Fort Marina Sibila Miquel Nofrarías Eva Pérez-Martín Alex Olvera Enric Mateu Joaquim Segalés | 2010 | Veterinary Immunology and Immunopathology2010，，3： | 2 |
| 3 | Recognition of ox-alate by a copper(11)polyaza macrobicyclic complex显示文摘 | Mateus P Delgado R Brandao P | 2011 | Chem Eur /2011，17，25： | 1 |
| 4 | Grape and wine polyphenolic composition of red Vitis vinifera varieties concerning vineyard altitude 显示文摘 | Mateus N Proenca S Ribeiro P | 2001 | Cienc Teenol Aliment2001，3，2： | 1 |
| 5 | Value of frational flow reserve in the management of patients with moderate coronary stenosis 显示文摘 | Dias CC Mateus P Bettencourt N | 2004 | Rev Port Cardil2004，23，11： | 1 |
| 6 | Removal of organic contaminants from soils by an electrokinetic process:the case of atrazine显示文摘 | RIBEIRO A B RODRIGUEZ-MAROTO J M MATEUS E P | 2005 | Chemosphere2005，59，： | 1 |
| 7 | Relation- ship between endotoxin and prostaglandin(PGE2 and PGFM) concent rations and ovarian function in dairy cows with puerperal endometritis显示文摘 | Mateus L Lopes da Costa L Diniz P | 2003 | Anim Reprod Sci2003，76，34： | 1 |
| 8 | Transmission loss allocation through equivalent bilateral exchanges and economical analysis显示文摘 | MATEUS J C FRANCO P C | 2005 | IEEE Trans on Power Systems2005，20，4： | 1 |
| 9 | Biomarkers of exposure and effect as indicators of the interference of selenomethionine on methylmercury toxicity 显示文摘 | DOS SANTOS A P MATEUS M L CARVALHO C M | 2007 | Toxicol Lett2007，169，2： | 1 |
| 10 | Security analyses and improvement of arbitrated quantum signaturewith an untrusted arbitrator 显示文摘 | ZOU Xiangfu QIU Daowen MATEUS P | 2013 | Int J Theor Phys2013，52，9： | 1 |
| 11 | De novo urological neoplasms in kidney transplantpatinnets: experience in 1751 patients显示文摘 | Di Capua Sacoto C Lujan Marco S Bahilo Mateu P etal | 2010 | Actas UrolEsp2010，34，1： | 1 |
| 12 | Interempping soybean and palisade grass for enhanced land use efficiency and revenue in a no till system显示文摘 | CRUSCIOL C A C NASCENTE A S MATEUS G P | 2014 | European Journal of Agronomy2014，，58： | 1 |
| 13 | Probabilistic situation calculus 显示文摘 | Mateus P Pacheco A Pinto J Sernadas A Sernadas C | 2001 | Annals of Mathematics and Artificial Intelligence2001，32，14： | 1 |
| 14 | Nanohydroxyapatite Microspheres as Delivery System for Antibiotics:Release Kinetics,Antimicrobial Activity,and Interaction with Osteoblasts显示文摘 | Ferraz M P Mateus A Y Sousa J C | 2007 | Wiley InterScience2007，81，4： | 1 |
| 15 | Neuroretinal dysfunction with intact blood-retinal barrier and absent vasculopathy in type 1 diabetes 显示文摘 | Reis A Mateus C Melo P | 2014 | Diabetes2014，63，11： | 1 |
| 16 | Selective generation of different dendritic cell precursors from CD34 + cells by interleukin-6 and interleukin-3显示文摘 | Encabo A Solves P Mateu E | 2004 | Stem Cells2004，22，5： | 1 |
| 17 | Nonaqueous capillary electrophoresis for the analysis of selected tropane alkaloids in a plant extract 显示文摘 | Cherkaoui S Mateus L Christen P | 1999 | Chromatographia1999，49，： | 1 |
| 18 | Removal of Organic Contaminants from Soils by an Electrokinetic Process: the Case of Atrazine Experimental and Modeling 显示文摘 | Ribeiro A B Rodriguez-Maroto J M Mateus E P | 2005 | Chemosphere2005，59，9： | 1 |
| 19 | Grape and wine polyphenolic composition of red Vitis vinifer L varieties concerning vineyard altitude显示文摘 | Mateus N Proenca S Ribeiro P | 2001 | Cincia e Tecnologia de Alimentos2001，3，2： | 1 |
| 20 | Value of frational flow reserve in the management of patients with moderate coronary stenosis 显示文摘 | Dias CC Mateus P Bettencourt N | 2004 | Rev Port Cardil2004，23，14： | 1 |
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