|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | New therapeutic options opened by the molecular classification of gastric cancer显示文摘Gastric cancer(GC) is one of the most lethal and aggressive cancers, being the third cause of cancer related death worldwide. Even with radical gastrectomy and the latest generation of molecular chemotherapeutics, the numbers of recurrence and mortality remains high. This is due to its biological heterogeneity based on the interaction between multiple factors, from genomic to environmental factors, diet or infections with various pathogens. Therefore, understanding the molecular characteristics at a genomic level is critical to develop new treatment strategies. Recent advances in GC molecular classification provide the unique opportunity to improve GC therapy by exploiting the biomarkers and developing novel targeted therapy specific to each subtype. This article highlights the molecular characteristics of each subtype of gastric cancer that could be considered in shaping a therapeutic decision, and also presents the completed and ongoing clinical trials addressed to those targets. The implementation of the novel molecular classification system will allow a preliminary patient selection for clinical trials, a mandatory issue if it is desired to test the efficacy of a certain inhibitor to the given target. This will represent a substantial advance as well as a powerful tool for targeted therapy. Nevertheless, translating the scientific results into new personalized treatment opportunities is needed in order to improve clinical care, the survival and quality of life of patients with GC. | Mihaela Chivu-Economescu Lilia Matei Laura G Necula Denisa L Dragu Coralia Bleotu Carmen C Diaconu | 2018 | World Journal of Gastroenterology2018，24，18： | 14 |
| 2 | Web pages,a viable solution for the development of the agritourism in Romania 显示文摘 | Pop I Stanca L Matei F | 2008 | Horticulture2008，65，2： | 1 |
| 3 | A view of cloud computing显示文摘 | MICHAEL A ARMANDO F REAN Q ANTHONY D J RANDY K ANDY K GUNHO L DAVID P ARIEL R ION S MATEI Z | 2010 | Communications of the ACM2010，53，4： | 1 |
| 4 | PDGF BB induces VEGF secretion in ovarian cancer显示文摘 | Matei D Kelich S Cao L | 2007 | Cancer Biol Ther2007，6，12： | 1 |
| 5 | PDGF BB induces VEGF secretion in ovarian cancer显示文摘 | Matei D Kelich S Cao L | 2007 | Cancer Biol Ther2007，6，12： | 1 |
| 6 | Growth and characterization of a-axis textured ZnO thin films 显示文摘 | NISTOR L C GHICA C MATEI D | 2005 | J Cryst Growth2005，277，14： | 1 |
| 7 | Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V) beta(3) and alpha (V) beta(5) integrins and promotes cell motility显示文摘 | Gillan L Matei D Fishman DA | | 0，，18： | 1 |
| 8 | Autoscrine activation of PDGFRalpha promotes the progression of ovarian cancer显示文摘 | Matei D Emerson R E Lai Y C L | 2006 | Oncogene2006，25，14： | 1 |
| 9 | Interspecific differences in hypoxia-induced gill remodeling in carp显示文摘 | Dhillon R S Yao L L Matey V | 2013 | Physiological and Biochemical Zoology2013，86，6： | 1 |
| 10 | The platelet derived growth factor recept or alpha is destabilized by geldanamycins in cancer cells 显示文摘 | Matei D Satpathy M Cao L | 2007 | J Biolog Chem2007，282，1： | 1 |
| 11 | Iris image segmentation and sub-optimal images 显示文摘 | Matey J R Broussard R Kennell L | 2010 | Image and Vision Computing (S0262-8856)2010，28，： | 1 |
| 12 | Periostin secreted by epithelial ovar- ian carcinoma is a ligand for aVb3 and aVb5 integrins and promotes cell motility 显示文摘 | Gillan L Matei D Fishman DA | 2002 | Cancer Res2002，62，： | 1 |
| 13 | PDGF BB induces VEGF secretion in ovarian cancer 显示文摘 | Matei D Kelich S Cao L | 2007 | Cancer Biol Ther2007，6，12： | 1 |
| 14 | Iris image segmentation and sub-optimal images 显示文摘 | MATEY J BROUSSARD R KENNELL L | 2010 | Image and Vision Computing2010，28，2： | 1 |
| 15 | Synergistic effect of a granulocyte-macrophage colony-stimulating factor-transduced tumor vaccine and systemic interleukin-2 in the treatment of murine colorectal cancer hepatic metastasis 显示文摘 | Jian A Slansky J E Matey L C | 2003 | Ann Surg Oncol2003，10，7： | 1 |
| 16 | PDGF BB induces VEGF seeretion in ovarian cancer 显示文摘 | Matei D Kelieh S Cao L | 2007 | Cancer Biol Ther2007，6，12： | 1 |
| 17 | Soluble thrombomodulin as a predictor of incident coronary heart disease and symptomless carotid artery atherosclerosis in ARIC study:a case-cohort study显示文摘 | Salomaa V Matei C Aleksic N Sansores-Garcia L Folsom AR Juneja H | 1999 | Lancet1999，353，9166： | 1 |
| 18 | Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility显示文摘 | Gillan L Matei D Fishman DA | 2002 | Cancer Res2002，62，18： | 1 |
| 19 | PDGF BB induces VEGF secretion in ovarian cancer显示文摘 | Matei D Kelich S Cao L | 2007 | Cancer Biol Ther2007，6，12： | 1 |
| 20 | Soluble thrombomodulin as a predictor of incident coronary heart disease and symptomless carotid artery atherosclerosis in the Atherosclerosis Risk in Communities (ARIC) Study:A case-cohort study显示文摘 | Salomaa V Matei C Aleksic N Sansores-Garcia L Folsom AR Juneja H | 1999 | Lancet1999，353，9166： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员