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| 1 | Recent advances in gastric cancer early diagnosis显示文摘Gastric cancer(GC) remains an important cause of cancer death worldwide with a high mortality rate due to the fact that the majority of GC cases are diagnosed at an advanced stage when the prognosis is poor and the treatment options are limited. Unfortunately, the existing circulating biomarkers for GC diagnosis and prognosis display low sensitivity and specificity and the GC diagnosis is based only on the invasive procedures such as upper digestive endoscopy. There is a huge need for less invasive or non-invasive tests but also highly specific biomarkers in case of GC. Body fluids such as peripheral blood, urine or saliva,stomach wash/gastric juice could be a source of specific biomarkers, providing important data for screening and diagnosis in GC. This review summarized the recently discovered circulating molecules such as microRNAs, long non-coding RNAs, circular RNAs, which hold the promise to develop new strategies for early diagnosis of GC. | Laura Necula Lilia Matei Denisa Dragu Ana I Neagu Cristina Mambet Saviana Nedeianu Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu | 2019 | World Journal of Gastroenterology2019，25，17： | 70 |
| 2 | New therapeutic options opened by the molecular classification of gastric cancer显示文摘Gastric cancer(GC) is one of the most lethal and aggressive cancers, being the third cause of cancer related death worldwide. Even with radical gastrectomy and the latest generation of molecular chemotherapeutics, the numbers of recurrence and mortality remains high. This is due to its biological heterogeneity based on the interaction between multiple factors, from genomic to environmental factors, diet or infections with various pathogens. Therefore, understanding the molecular characteristics at a genomic level is critical to develop new treatment strategies. Recent advances in GC molecular classification provide the unique opportunity to improve GC therapy by exploiting the biomarkers and developing novel targeted therapy specific to each subtype. This article highlights the molecular characteristics of each subtype of gastric cancer that could be considered in shaping a therapeutic decision, and also presents the completed and ongoing clinical trials addressed to those targets. The implementation of the novel molecular classification system will allow a preliminary patient selection for clinical trials, a mandatory issue if it is desired to test the efficacy of a certain inhibitor to the given target. This will represent a substantial advance as well as a powerful tool for targeted therapy. Nevertheless, translating the scientific results into new personalized treatment opportunities is needed in order to improve clinical care, the survival and quality of life of patients with GC. | Mihaela Chivu-Economescu Lilia Matei Laura G Necula Denisa L Dragu Coralia Bleotu Carmen C Diaconu | 2018 | World Journal of Gastroenterology2018，24，18： | 14 |
| 3 | Estimation of nonlinear errors-in-variables models for computer vision applications 显示文摘 | Matei B C Meer P | 2006 | IEEE Transactions on Pattern Analysis and Machine Intelligence2006，28，10： | 1 |
| 4 | Laser Photoacoustic Spectroscopy: Principles, Instrumentation, and Characterization 显示文摘 | Dumitras D C Dutu D C Matei C | 2007 | Journal of Optoelectronics and Advanced Materials2007，9，12： | 1 |
| 5 | Estimation of nonlinear errors- in-variables models for computer vision application显示文摘 | MATEI B C MEER P | 2006 | IEEE Transactions on Pattern Analysis and Machine Intelligence2006，28，10： | 1 |
| 6 | Soluble thrombomodulin as a predictor of incident coronary heart disease and symptomless carotid artery atherosclerosis in the Atherosclerosis Risk in Communities(ARIC) Study:a case-cohort study显示文摘 | Salomaa V Matei C Aleksic N | 1999 | Lancet1999，353，： | 1 |
| 7 | Minireview:epigenetic changes in ovarian cancer显示文摘 | Balch C Fang F Matei DE | 2009 | Endocrinology2009，150，9： | 1 |
| 8 | Evaluation of ammonia absorption coefficients by photoacoustic spectroscopy for detection of ammonia levels in human breath显示文摘 | DUMITRAS D C DUTU D C MATEI C | 2011 | Laser Physics2011，21，4： | 1 |
| 9 | Epigenetic resensitiza-tion to platinum in ovarian cancer显示文摘 | Matei D Fang F Shen C | 2012 | Cancer Res2012，72，： | 1 |
| 10 | Octreotide induced remission of a refractory small cell carcinoma of the endometrium显示文摘 | Verschraegen CF Matei C Loyer E | 1999 | Int J Gynecol Cancer1999，9，1： | 1 |
| 11 | Cardiomyocyte apoptosis in ischemia-reperfusion due to the exogenous oxidants at the time of reperfusion显示文摘 | Rosca A M Matei C Dragan E | 2012 | Cell Biol Int2012，36，12： | 1 |
| 12 | A phase II study of decit abine and carboplatin in recurrent platinum (Pt)-resistant ovatian cancer (OC) 显示文摘 | Matei D Shen C Fang F | 2011 | J Clin Oncol2011，，： | 1 |
| 13 | Soluble thrombomod-ulin as apredictor of incident coronary heart disease and symptom-less carotid artery atherosclerosis in the atherosclerosis risk in communities(ARIC)study:a case-cohort study显示文摘 | Salomaa V Matei C Aleksic N | 1999 | Lancet1999，353，9166： | 1 |
| 14 | Epigenetic resensitization to platinum in ovarian cancer显示文摘 | Matei D Fang F Shen C | 2012 | Cancer Res2012，72，9： | 1 |
| 15 | Photodynamic therapy in the treatment of basal cell carcinoma 显示文摘 | Matei C Tampa M Poteca TM | 2013 | J Med Life2013，，： | 1 |
| 16 | AMI-227-enhanced MR lym- phangography: usefulness for differentiating reactive from tumor-bear- ing lymph nodes显示文摘 | Vassallo P Matei C Heston WD | 1994 | Radiology1994，193，： | 1 |
| 17 | Pharmacokinetics and biodistribution of (86)Y-trastuzumab for (90)Y dosimetry in an ovarian carcinoma model: correlative MicroPET and MRI显示文摘 | Palm S Enmon RM Jr Matei C | 2003 | J Nucl Med2003，44，7： | 1 |
| 18 | Lanthanumbased perovskites obtained in molten nitrates or nitrites显示文摘 | MATEI C BERGER D MAROTE P | 2007 | Progress in Solid State Chemistry2007，35，24： | 1 |
| 19 | Metabolic signatures associated with a NAD synthesis inhibitor-induced tumor apoptosis identified by H-l-decoupled-P-31 magnetic resonance spectroscopy 显示文摘 | MURUGANANDHAM M ALFIERI A MATEI C | 2005 | Clin Cancer Res2005，11，9： | 1 |
| 20 | Murine S Factors for Liver, Spleen, and Kidney 显示文摘 | Kolbert K S Watson T Matei C | 2003 | Journal of Nuclear Medicine2003，44，5： | 1 |
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