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| 1 | 叶酸对胃癌和其他胃肠道癌发生的干预作用──临床试验七年随访显示文摘目的:评估叶酸和β-湖萝卜素对胃癌及其他胃肠道癌发生的干预作用。方法:在上海10所医院进行随机双盲安 慰剂对照的临床研究。216例萎缩性胃炎患者分4组:①叶酸组,20mg/日,每月肌肉注射维生素B12 1mg,次年减 为每周服药2日,3月肌肉注射1次;②天然β-胡萝卜素组,30 mg/日,次年减为每周服2日,共工年;③合成β-胡萝卜 素组,用法同天然组;④安慰剂对照组。每1~3年胃镜及活检,随访6~7年(1994~2001年)。结果:叶酸组未发生胃 肠肿瘤,天然及合成组各发现胃癌1例,对照组发生胃癌3例,结肠癌及食管癌各1例。以胃癌发生为终点,各干预组 单独与对照组相比,未达统计学显著差异,但合并干预组已接近显著(P=0.06);以胃肠道癌为终点,叶酸组显著低 于对照组(P=0046),β-胡萝卜素组趋向显著(P=0.07~0.08),合并干预组非常显著(P=0.004),胃肠道癌风险明 显降低[比数比(OR)为0.12,95%可信区间(CI)为0.03~0.51]。叶酸组胃粘膜炎症和萎缩逆转稳定(P=0.04),肠化 逆转接近显著(P=0.06)。异型增生于12个月时显著逆转(P=0.017)。 | 朱舜时 Joel Mason 施尧 胡运彪 李蓉蓉 汪敏 周怡和 金冠球 谢宇野 邬桂泉 夏德凰 钱珍华 宋海连 屠伯强 张丽冬 Robert Russell 萧树东 | 2002 | 胃肠病学2002，7，2： | 51 |
| 2 | 高精度光释光测年揭示的晚第四纪毛乌素和浑善达克沙地沙丘的固定与活化过程显示文摘利用光释光测年技术对毛乌素沙地和浑善达克沙地7个地点的沉积剖面进行了年代测试,结合地层特征,获得了最近60kaBP以来两个沙地沙丘固定与活化时间的年代学控制60kaBP以来毛乌素沙地的固定期分别为距今37.71ka、8.54ka、8.32ka、7.93ka、7.77ka、7.57ka、7.39ka和2.39ka以后;活化的时间分别为距今57.08ka、52.50ka、13.65ka、13.13ka、7.20ka前后、2.39ka以前和0.29ka以来。在10.97kaBP、10.04kaBP、9.81kaBP和8.67kaBP前后沙地处于气候干湿交替时期。全新世期间,浑善达克沙地在距今8.74~8.72ka、7.79ka前后,沙丘活化;5.69kaBP、4.25kaBP、2.75kaBP、1.53kaBP和0.71kaBP前后,沙丘处于相对固定阶段,0.15kaBP以来,沙丘处于半固定状态。晚第四纪气候千年至百年尺度的变化可能是两个沙地沙丘活化与固定的主导因素。 | 周亚利 鹿化煜 张家富 周力平 苗晓东 Mason J A | 2005 | 中国沙漠2005，25，3： | 49 |
| 3 | Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum显示文摘The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity. | LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG Han DONG LiNa ZHUO HaiXin YU KaiFeng MASON Joseph WANG XiaoYong CHEN YingYong LU Qi WU Bo DONG ZhiBao QU JianJun WANG XunMing GUO ZhengTang | 2013 | Chinese Science Bulletin2013，58，23： | 40 |
| 4 | 末次盛冰期和全新世大暖期毛乌素沙地的空间变化显示文摘沙漠/沙地边缘和内部的古风成沙层、砂质古土壤是重建晚第四纪以来地表变化的直接地质证据。位于我国北方半干旱区的毛乌素沙地,其地表过程对气候变化响应敏感。在对毛乌素沙地进行野外拉网式调查以及前人研究的基础上,我们在沙地南部和东部的沙漠-黄土过渡带发现了大量的埋藏古风成沙丘沉积,指示了干冷期沙漠扩张的最南、东界限;沙地内部广泛发育的砂质古土壤则表明在气候相对暖湿期地表植被生长,土壤发育,沙丘基本被固定。对14个典型风成沙/黄土/古土壤沉积剖面进行了光释光年代学样品的采集和测试,结合空间分析和他人研究结果,发现在末次盛冰期(约26~16ka),毛乌素沙地的流动沙丘向南、东扩张,扩张距离现代边界约30~50km,面积扩大至少约10000km^2,占现代沙地面积的25%;在全新世大暖期(约9~5ka),毛乌索沙地大部分被固定,发育了较厚的砂质古土壤。研究结果揭示了毛乌素沙地的地表过程对末次盛冰期和全新世大暖期气候变化的直接响应。 | 徐志伟 鹿化煜 弋双文 周亚利 Joseph A Mason 王晓勇 陈英勇 朱芳莹 张瀚之 翟秀敏 | 2013 | 第四纪研究2013，33，2： | 30 |
| 5 | 禽流感病毒血凝素疫苗在转基因马铃薯中的表达显示文摘利用转基因马铃薯表达禽流感病毒血凝素疫苗。将含有禽流感病毒血凝素序列的表达载体导入农杆菌 ,再感染马铃薯的幼茎外植体。转化植株的再生及温室栽培。Westernblot分析表明 ,83%的转化植株在其块茎组织中表达了重组血凝素 ,表达量占总蛋白量的 0 0 3%~ 0 0 4 % 。 | 宋长征 Hugh S Mason | 2001 | 生物技术2001，11，5： | 25 |
| 6 | Optically stimulated luminescence dating of aeolian sand in the Otindag dune field and Holocene climate change显示文摘The dune system in Otindag sand field of northern China is sensitive to climate change, where effective moisture and related vegetation cover play a controlling role for dune activity and stability. Therefore, aeolian deposits may be an archive of past environmental changes, possibly at the millennial scale, but previous studies on this topic have rarely been reported. In this study, thirty-five optically stimulated luminescence (OSL) ages of ten representative sand-paleosol profiles in Otindag sand field are ob-tained, and these ages provide a relatively complete and well-dated chronology for wet and dry varia-tions in Holocene. The results indicate that widespread dune mobilization occurred from 9.9 to 8.2 ka, suggesting a dry early Holocene climate. The dunes were mainly stabilized between 8.0 and 2.7 ka, implying a relatively wet climate, although there were short-term penetrations of dune activity during this wet period. After ~2.3 ka, the region became dry again, as inferred from widespread dune activity. The '8.2 ka' cold event and the Little Ice Age climatic deterioration are detected on the basis of the dune records and OSL ages. During the Medieval Warm Period and the Sui-Tang Warm Period (570-770 AD), climate in Otindag sand field was relatively humid and the vegetation was denser, and the sand dunes were stabilized again. These aeolian records may indicate climate changes at millennial time scale during Holocene, and these climatic changes may be the teleconnection to the climate changes elsewhere in the world. | Joseph MASON James SWINEHART Ronald GOBLE | 2008 | Science China Earth Sciences2008，51，6： | 18 |
| 7 | Proposal of an ultrasonographic classification for hepatic alveolar echinococcosis: Echinococcosis multilocularis Ulm classification-ultrasound显示文摘AIM: To establish an ultrasonographic classification based on a large sample of patients with confirmed hepatic alveolar echinococcosis(AE).METHODS: Clinical data and ultrasonography(US) findings of 185 patients(100 males; 85 females; mean age at diagnosis: 51.4 ± 17.6 years; mean age at time of US examination: 58.7 ± 18.2 years) were retrospectively reviewed with respect to the US morphology of hepatic AE lesions. The sonomorphological findings were grouped according to a five-part classification scheme.RESULTS: Application of the new classification resulted in the following distribution of sonomorphological patterns among the patients examined: hailstorm(54.1%); pseudocystic(13.5%); ossification(13.0%); hemangioma-like(8.1%); and metastasis-like(6.5%). Only 4.9% of lesions could not be assigned to a sonomorphological pattern.CONCLUSION: The sonomorphological classification proposed in the present study facilitates the diagnosis,interpretation and comparison of hepatic alveolar echinococcosis in routine practice and in the context of scientific studies. | Wolfgang Kratzer Beate Gruener Tanja EM Kaltenbach Sarina Ansari-Bitzenberger Peter Kern Michael Fuchs Richard A Mason Thomas FE Barth Mark M Haenle Andreas Hillenbrand Suemeyra Oeztuerk Tilmann Graeter | 2015 | World Journal of Gastroenterology2015，21，43： | 16 |
| 8 | Research progress and strategies for multifunctional rapeseed: A case study of China显示文摘Rapeseed(Brassicanapus),is an important source of edible oil,animal fodder,vegetables,condiments and biodiesel,and plays a significant role in securing edible oil production worldwide.However,in countries with comparatively low levels of agricultural mechanization,such as China,increasing costs of labor and agricultural inputs are decreasing rapeseed profitability,and hence the area of rapeseed under cultivation.If the value of rapeseed crops is not further increased,the rapeseed growing area will continue to decrease,potentially jeopardizing oil production.Therefore,full exploitation of the existing and potential value of rapeseed is desirable.Different rapeseed products are already utilized in different ways,with more applications currently underutilized.As well as oil extraction from the seeds,the shoot and leaves can be used as vegetables,the roots to absorb soil cadmium for pollution remediation,the flowers for sightseeing and as a source of nectar,the pollen for extracting flavonoids and useful amino acids,the seeds/seed meal for extracting isthiocyanates and other important sulforaphane compounds,the straw and seed meal for fodder,and immature whole plants for green manure.This review summarizes recent research on ways to explore the potential holistic value of rapeseed,by taking the example of multifunctionality of rapeseed in China. | FU Dong-hui JIANG Ling-yan Annaliese S Mason XIAO Mei-li ZHU Long-rong LI Li-zhi ZHOU Qing-hong SHEN Chang-jian HUANG Chun-hui | 2016 | Journal of Integrative Agriculture2016，15，8： | 15 |
| 9 | 青海湖地区冰消期以来气候变化的黄土记录显示文摘青海湖周围堆积着很多黄土和风沙沉积,这些风成沉积序列是过去气候变化的良好记录。相对于湖泊沉积,这些沉积物受到的研究较为薄弱。对青海湖南岸的黄土堆积进行了光释光年代学、磁化率、Fe/Mg值、粒度和有机质含量等气候替代性指标测量。在具有绝对年代标尺控制的基础上,结合气候替代性指标变化特征的分析,表明冰消期以来青海湖地区的古气候经历了多次的冷暖和干湿变化过程:14~9ka间气候前期相对冷干,后期转为凉干,其中可能在11ka左右存在一次暖湿事件;9~2.5ka间气候呈暖湿状态;2.5ka以后的地层扰动较大。黄土和湖泊沉积记录的环境变化过程具有可比性。 | 赵存法 鹿化煜 周亚利 弋双文 Joseph Mason | 2009 | 高校地质学报2009，15，1： | 14 |
| 10 | 便携式粉尘观测仪测定腾格里沙漠和毛乌素沙地PM_(10)释放通量显示文摘中国北方沙漠和沙地是亚洲粉尘释放的重要源区,定量估算这一地区的粉尘释放量有助于评估区域大气环境质量及其气候效应.目前,对中国北方粉尘释放量的估算主要是基于模拟结果,野外直接观测数据很少.利用一种新型的粉尘释放观测仪器——便携式粉尘观测仪(PI-SWERL),测量腾格里沙漠和毛乌素沙地若干典型地表(沙丘、干湖、灌丛沙丘、河流冲积物等)的粉尘释放通量,获得了不同地表潜在粉尘释放量的直接观测数据.结果表明,不同地表的PM10释放通量存在较大差异,但均随摩阻风速的增加而增加.在相同的摩阻风速U*=0.55 m/s条件下,灌丛沙丘的PM10通量最高(0.70~10.23 mg/(m2 s)),河流冲积物次之(0.12~4.97 mg/(m2 s)),干湖湖底、沙丘等地表的通量较小(〈0.5 mg/(m2 s)).对比试验表明,破碎结壳地表释放的PM10通量是未破碎结壳的几倍甚至几十倍;披覆松散沙粒结壳地面的PM10释放通量高出未披覆的1~2个数量级.对比前人研究结果,PI-SWERL可以较好地反映不同源区粉尘释放的差异,对定量评估区域乃至全球的粉尘释放量等具有重要意义. | 崔梦淳 鹿化煜 SWEENEY Mark MASON Joseph 冯晗 徐志伟 | 2015 | 科学通报2015，60，17： | 12 |
| 11 | 镉中毒解毒机理的研究——硒化合物的预防和治疗作用初探显示文摘对大鼠组织胞液(Cytosol)的体外试验结果表明:亚硒酸钠、硒酸钠及硒化钠以明显影响[^(109)Cd]标记的氯化镉在组织胞液中的分布。硒酸钠、亚硒酸钠有较强的封闭金属硫蛋白(MT)与镉结合部位、激活分子量较大的蛋白质,捕获胞液中[^(109)Cd]的作用,还可使已经和MT结合的[^(109)Cd]被剥离,随后,[^(109)Cd]转入分子量较大的蛋白质上;亚硒酸钠还可使[^(109)Cd]转入分子量为32000~35000的蛋白质上。硒化钠仅有较弱的剥离与MT结合的镉,使之转入分子量较大的蛋白质上,但几乎不能阻止镉与MT结合。镉与大、中分子量蛋白质结合力远较它与MT的结合力弱,因而以能有利于镉被排出体外。 | 王宗元 王捍东 史德浩 吴维芬 James Mason | 1993 | 畜牧兽医学报1993，24，4： | 12 |
| 12 | 天然β-胡萝卜素对胃癌前期病变的逆转作用显示文摘天然β-胡萝卜素对胃癌前期病变的逆转作用朱舜时,周怡和,夏德凰,金冠球,胡运彪,施尧,李蓉蓉,房静远,JoelMason,萧树东,江绍基萎缩性胃炎时粘膜萎缩、肠化和不典型增生是胃癌的癌前病变,逆转这些病变既是对萎缩性胄炎的治疗,也是对胃癌的预防。晚近... | 朱舜时 周怡和 夏德凰 金冠球 胡运彪 施尧 李蓉蓉 房静远 Joel Mason 萧树东 江绍基 | 1996 | 中华消化杂志1996，16，1： | 12 |
| 13 | 维生素逆转胃癌的癌前病变——初期临床干预试验显示文摘为探索逆转胃癌的癌前病变以预防其发病,本文观察叶酸加维生素B_(12)、合成β-胡萝卜素及天然β-胡萝卜素对56例中重度萎缩性胃炎牯膜病理和DNA甲基化水平的作用。结果:①叶酸加维生素B_(12)对胃牯膜萎缩和肠化的逆转率达77.7%,高于文献统计:②天然β-胡萝卜素显著逆转不典型增生(P=0.04),推测与其所含异构体有关;③血浆叶酸、隐黄素、α-胡萝卜素水平与胃癌癌前病变呈显著负相关:④α-胡萝卜素可使胃粘膜DNA甲基化水平显著提高(P<0.01~0.0001)。本文提示某些维生素可能通过提高胃粘膜细胞DNA甲基化水平,调节某些基因的活性,因而具有逆转胃癌癌前病变的作用。 | 朱舜时 胡运彪 施尧 李蓉蓉 房静远 顾伟齐 江绍基 周怡和 夏德凰 金冠球 Joel Mason 萧树东 | 1996 | 胃肠病学1996，1，2： | 11 |
| 14 | Proposal of a computed tomography classification for hepatic alveolar echinococcosis显示文摘AIM: To establish a computed tomography(CT)-morphological classification for hepatic alveolar echinococcosis was the aim of the study. METHODS: The CT morphology of hepatic lesions in 228 patients with confirmed alveolar echinococcosis(AE) drawn from the Echinococcus Databank of the University Hospital of Ulm was reviewed retrospectively. For this reason, CT datasets of combined positron emission tomography(PET)-CT examinations were evaluated. The diagnosis of AE was made in patientswith unequivocal seropositivity; positive histological findings following diagnostic puncture or partial resection of the liver; and/or findings typical for AE at either ultrasonography, CT, magnetic resonance imaging or PET-CT. The CT-morphological findings were grouped into the new classification scheme.RESULTS: Within the classification a lesion was dedicated to one out of five 'primary morphologies' as well as to one out of six 'patterns of calcification'. 'primary morphology' and 'pattern of calcification' are primarily focussed on separately from each other and combined, whereas the 'primary morphology' V is not further characterized by a 'pattern of calcification'. Based on the five primary morphologies, further descriptive sub-criteria were appended to types Ⅰ-Ⅲ. An analysis of the calcification pattern in relation to the primary morphology revealed the exclusive association of the central calcification with type Ⅳ primary morphology. Similarly, certain calcification patterns exhibited a clear predominance for other primary morphologies, which underscores the delimitation of the individual primary morphological types from each other. These relationships in terms of calcification patterns extend into the primary morphological sub-criteria, demonstrating the clear subordination of those criteria.CONCLUSION: The proposed CT-morphological classification(EMUC-CT) is intended to facilitate the recognition and interpretation of lesions in hepatic alveolar echinococcosis. This could help to interpret different clinical courses better and shall assist in the context of scientific studies to improve the comparability of CT findings. | Tilmann Graeter Wolfgang Kratzer Suemeyra Oeztuerk Mark Martin Haenle Richard Andrew Mason Andreas Hillenbrand Thomas Kull Thomas F Barth Peter Kern Beate Gruener | 2016 | World Journal of Gastroenterology2016，22，13： | 10 |
| 15 | 放疗与替莫唑胺联合治疗胶质母细胞瘤 | Stupp R. Mason W.P. Van Den Bent M.J. 黄卫东 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，9： | 8 |
| 16 | Endoscopic approach to malignant strictures at the hepatic hilum显示文摘Hilar tumors have proven to be a challenge to treat and manage because of their poor sensitivity to conventional therapies and our inability to prevent or to detect early tumor formation. Endoscopic stent drainage has been proposed as an alternative to biliary-enteric bypass surgery and percutaneous drainage to palliate malignant biliary obstruction. Prosthetic palliation of patients with malignant hilar stenoses poses particular difficulties, especially in advanced lesions (type n lesions or higher). The risk of cholangitis after contrast injection into the biliary tree in cases where incomplete drainage is achieved is well known. The success rate of plastic stent insertion is around 80% in patients with proximal tumors. Relief of symptoms can be achieved in nearly all patients successfully stented. | Giovanni D De Palma Stefania Masone Maria Rega Immacolata Simeoli Francesca Salvatori Saverio Siciliano Francesco Maione Valerio Girardi Marta Celiento Giovanni Persico | 2007 | World Journal of Gastroenterology2007，13，30： | 8 |
| 17 | Crescentic dune migration and stabilization: Implications for interpreting paleo-dune deposits as paleoenvironmental records显示文摘Paleo-dune deposits have been widely used as a proxy indicator of past dune activity, which is further used to reconstruct paleoclimates. However, recent studies have critically examined the reproducibility of dune chronologies and the complexity of paleo-dune deposits as paleoenvironmental records. This paper addresses questions on the paleoenvironmental implications of dune chronostratigraphies that have been raised by those reviews, in the specific case of crescentic dunes, using a case study from the Mu Us dune field, north-central China. The processes of turn-over and stabilization of relatively small crescentic dunes are first investigated by observational evidence. In combination with the analysis of a simplified sand preservation model and stratigraphic records, the effect of dune morphodynamics on sand preservation is demonstrated. It is especially evident that thick, nearly instantaneously deposited sand units record dune stabilization near the very end of a dune activity episode, while thin sand units may signal the preservation of sand deposited earlier in episodes of activity. Interpreting the distribution of luminescence ages that indicate sand deposition over time is not as simple as assumed in some previous work. Low frequency of sand ages could indicate an interval of either dune field stabilization or extensive dune activity but poor sand preservation. A peak of sand age frequency likely represents a shift in dune field activity towards stabilization, not a peak of active dune extent, especially if it partially overlaps with an independently identified interval of stabilization(e.g. one recorded by paleosols). The nature and magnitude of these biases in the distribution of sand ages over time are strongly affected by the magnitude of net sand accumulation, which is in turn related to sand supply, transport capacity and sand availability, and ultimately climate change. Relatively short dune stabilization and turn-over time(10~1 to 10~2 yrs) indicate that dune geomorphic processes can quickly respond to short-term disturbance, but the chronology of that response must be interpreted in light of how those processes influence age distributions. | XU Zhiwei Joseph A. MASON LU Huayu YI Shuangwen ZHOU Yali WU Jiang HAN Zhiyong | 2017 | Journal of Geographical Sciences2017，27，11： | 7 |
| 18 | Complications associated with prone positioning in elective spinal surgery显示文摘Complications associated with prone surgical positioning during elective spine surgery have the potential to cause serious patient morbidity.Although many ofthese complications remain uncommon,the range of possible morbidities is wide and includes multiple organ systems.Perioperative visual loss(POVL)is a well described,but uncommon complication that may occur due to ischemia to the optic nerve,retina,or cerebral cortex.Closed-angle glaucoma and amaurosis have been reported as additional etiologies for vision loss following spinal surgery.Peripheral nerve injuries,such as those caused by prolonged traction to the brachial plexus,are more commonly encountered postoperative events.Myocutaneous complications including pressure ulcers and compartment syndrome may also occur after prone positioning,albeit rarely.Other uncommon positioning complications such as tongue swelling resulting in airway compromise,femoral artery ischemia,and avascular necrosis of the femoral head have also been reported.Many of these are well-understood and largely avoidable through thoughtful attention to detail.Other complications,such as POVL,remain incompletely understood and thus more difficult to predict or prevent.Here,the current literature on the complications of prone positioning for spine surgery is reviewed to increase awareness of the spectrum of potential complications and to inform spine surgeons of strategies to minimize the risk of prone patient morbidity. | J Mason De Passe Mark A Palumbo Maahir Haque Craig P Eberson Alan H Daniels | 2015 | World Journal of Orthopedics2015，6，3： | 7 |
| 19 | 低社会经济地位与美国成年人早发冠状动脉粥样硬化性心脏病的关系显示文摘低社会经济地位(socioeconomic status,SES)的个体承担着不成比例的冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)负担。在美国低收入地区,CHD仍然是死亡的主要原因。该研究旨在评估美国低SES个体的过量CHD负担,以及传统风险因素和与低SES相关因素影响所占的比例。 | Hamad R Penko J Kazi DS Coxson P Guzman D Pengxiao C.Wei Mason A Wang EA Goldman L Fiscella K Bibbins-Domingo K 周卫(译) 刘莉(审校) | 2020 | 中华高血压杂志2020，28，7： | 7 |
| 20 | Hepatobiliary complications of alveolar echinococcosis: A long-term follow-up study显示文摘AIM:To determine the long-term hepatobiliary complications of alveolar echinococcosis(AE) and treatment options using interventional methods.METHODS:Included in the study were 35 patients with AE enrolled in the Echinococcus Multilocularis Data Bank of the University Hospital of Ulm.Patients underwent endoscopic intervention for treatment of hepatobiliary complications between 1979 and 2012.Patients' epidemiologic data, clinical symptoms, and indications for the intervention, the type of intervention and any additional procedures, hepatic laboratory parameters(pre- and post-intervention), medication and surgical treatment(pre- and post-intervention), as well as complications associated with the intervention and patients‘ subsequent clinical courses were analyzed.In order to compare patients with AE with and without history of intervention, data from an additional 322 patients with AE who had not experienced hepatobiliary complications and had not undergone endoscopic intervention were retrieved and analyzed.RESULTS:Included in the study were 22 male and 13 female patients whose average age at first diagnosis was 48.1 years and 52.7 years at the time of intervention.The average time elapsed between first diagnosis and onset of hepatobiliary complications was 3.7 years.The most common symptoms were jaundice, abdominal pains, and weight loss.Thenumber of interventions per patient ranged from one to ten.Endoscopic retrograde cholangiopancreatography(ERCP)was most frequently performed in combination with stent placement(82.9%),followed by percutaneous transhepatic cholangiodrainage(31.4%)and ERCP without stent placement(22.9%).In 14.3%of cases,magnetic resonance cholangiopancreatography was performed.A total of eight patients received a biliary stent.A comparison of biochemical hepatic function parameters at first diagnosis between patients who had or had not undergone intervention revealed that these were significantly elevated in six patients who had undergone intervention.Complications(cholangitis,pancreatitis)occurred in six patients during and in 12patients following the intervention.The average survival following onset of hepatobiliary complications was 8.8years.CONCLUSION:Hepatobiliary complications occur in about 10%of patients.A significant increase in hepatic transaminase concentrations facilitates the diagnosis.Interventional methods represent viable management options. | Tilmann Graeter Franziska Ehing Suemeyra Oeztuerk Richard Andrew Mason Mark Martin Haenle Wolfgang Kratzer Thomas Seufferlein Beate Gruener | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
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