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| 1 | A novel protein-repellent dental composite containing 2-methacryloyloxyethyl phosphorylcholine显示文摘Secondary caries due to biofilm acids is a primary cause of dental composite restoration failure.To date,there have been no reports of dental composites that can repel protein adsorption and inhibit bacteria attachment.The objectives of this study were to develop a protein-repellent dental composite by incorporating 2-methacryloyloxyethyl phosphorylcholine(MPC) and to investigate for the first time the effects of MPC mass fraction on protein adsorption,bacteria attachment,biofilm growth,and mechanical properties.Composites were synthesized with 0(control),0.75%,1.5%,2.25%,3%,4.5%and 6%of MPC by mass.A commercial composite was also tested as a control.Mechanical properties were measured in three-point flexure.Protein adsorption onto the composite was determined by the microbicinchoninic acid method.A human saliva microcosm biofilm model was used.Early attachment at 4 h,biofilm at 2 days,live/dead staining and colony-forming units(CFUs) of biofilms grown on the composites were investigated.Composites with MPC of up to 3%had mechanical properties similar to those without MPC and those of the commercial control,whereas 4.5%and 6%MPC decreased the mechanical properties(P<0.05).Increasing MPC from 0 to 3%reduced the protein adsorption on composites(P<0.05).The composite with 3%MPC had protein adsorption that was 1/12 that of the control(P<0.05).Oral bacteria early attachment and biofilm growth were also greatly reduced on the composite with 3%MPC,compared to the control(P<0.05).In conclusion,incorporation of MPC into composites at 3%greatly reduced protein adsorption,bacteria attachment and biofilm CFUs,without compromising mechanical properties.Protein-repellent composites could help to repel bacteria attachment and plaque build-up to reduce secondary caries.The protein-repellent method might be applicable to other dental materials. | Ning Zhang Chen Chen Mary AS Melo Yu-Xing Bai Lei Cheng Hockin HK Xu | 2015 | International Journal of Oral Science2015，7，2： | 8 |
| 2 | Science and technology for water purification in the coming decades显示文摘 | SHANNONL M A BOHN P W ELIMELECH M GEORGIADIS J G MARIAS B J MAYES A M | 2008 | Nature2008，452，3： | 1 |
| 3 | Study of wheat gluten plasticization with fatty acids 显示文摘 | Marion P Andre'as Redl Marie - He'le'ne M | 2003 | Polymer2003，，44： | 1 |
| 4 | Lack of association between intussusception and oral polio vaccine in Cuban children显示文摘 | Miguel A. Galindo Sardi?as Andrés Zambrano Cárdenas Gisele Coutin Marie Manuel Santin Pe?a Miriam Ali?o Santiago Marlen Valcárcel Sanchez C.P. Farrington | 2001 | European Journal of Epidemiology2001，，8： | 1 |
| 5 | Vildagliptin,a dipeptidyl peptidase-IV inhibitor,improves model-assessed beta-cel function in patients with type 2 diabetes显示文摘 | Mari A Sal as WM He YL | | 0，，08： | 1 |
| 6 | Identifying the educational needs and concerns of newly diagnosed patients with breast cander after surgey显示文摘 | Patrice AS Maryjo O Mary SF | 2007 | Clinical Journal of Oncology Nursing2007，12，2： | 1 |
| 7 | Different nuclearity silver( Ⅰ ) complexes with novel tetracyano pendantarmed hexaazamacrocyclic ligands显示文摘 | MARI'A DEL C F F BASTIDA R MACI'AS A | 2006 | Inorg Chem2006，45，： | 1 |
| 8 | Remodeling of the Microenvironment by Aggressive Melanoma Tumor Cells显示文摘 | Mary JCH Elisabeth AS Dawn AK | 2003 | Ann N Y Acad Sci2003，995，： | 1 |
| 9 | The Therapeutic benefit of repeat pereutaneous vertebroplasty at previously treated vertebral levels 显示文摘 | John RG Mary EJ Patricia AS | 2002 | AJNR2002，23，16： | 1 |
| 10 | Costs and utilization asso-ciated with pharmaceutical adherence in a diabetic popu-lation 显示文摘 | Kera LH Mary TM David AS | 2004 | Am J Manag Care2004，10，2： | 1 |
| 11 | Preliminary evidence of an Adolescent HIV/AIDS Peer Education Program 显示文摘 | GANGA M MARY AS TARA DL | 2008 | J Pediatr Nurs2008，23，5： | 1 |
| 12 | Remodeling of the Micro-environment by Aggressive Melanoma Tumor Cells显示文摘 | Mary JCH Elisabeth AS Dawn AK | 2003 | Ann NY Acad Sci2003，995，： | 1 |
| 13 | Optimisation of headspace solid-phase microextraction for the analysis of volatile phenols in wine显示文摘 | Meji as R C Mari n R N Moreno M de V G | 2002 | Journal of Chromatography A2002，995，12： | 1 |
| 14 | Optimization of Benzoxazinones as Natural Herbicidemodels by Lipophilicity Enhancement显示文摘 | MACI'AS F A MARI'N D OLIVEROS-BASTIDAS A | 2006 | J Agric Food Chem2006，54，： | 1 |
| 15 | Comparison of the clinical history of symptomatic isolated muscular calf vein thrombosis显示文摘 | JEAN PG MARIE AS CELINE G | 2010 | J Vasc Surg2010，52，4： | 1 |
| 16 | Inhibition of telomerase limits the growth of human cancer cells 显示文摘 | William CH Sheila AS Mary WB | 1999 | Nat Med1999，5，10： | 1 |
| 17 | Immunohistochemical detection of inducible nitric oxide synthase, nitryro- sine and manganese superoxide dismutase following hyperglycemic focal cerebral isehemia 显示文摘 | Ste - Marie I Hazell AS Bemeur C | 2001 | Brain Res2001，918，12： | 1 |
| 18 | Sensitivities of Four New Com-mereial HePatitis B Virus Surfaee Antige(HBsAG)Assays inDeteetion of HBsAg Mutant Forms显示文摘 | Ly TD Delmas AS Marie P | 2006 | J Clinical Microbiology2006，4，7： | 1 |
| 19 | Lateral epicondylitis : new evidence for work relatedness显示文摘 | Alexis D Ann Marie D Barbara AS | 2014 | J Bone Spine2014，82，1： | 1 |
| 20 | Assessing sources of support for diabetes self-care in urban and rural underserved communities显示文摘 | Benjamin AS Mary PG Mary Riley-Jacome | 2006 | Journal of Community Health2006，31，5： | 1 |
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