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| 1 | Double-balloon-enteroscopy-based endoscopic retrograde cholangiopancreatography in post-surgical patients显示文摘AIM: To evaluate double balloon enteroscopy (DBE) in post-surgical patients to perform endoscopic retrograde cholangiopancreatography (ERCP) and interventions. METHODS: In 37 post-surgical patients, a stepwise approach was performed to reach normal papilla or enteral anastomoses of the biliary tract/pancreas. When conventional endoscopy failed, DBE-based ERCP was performed and standard parameters for DBE, ERCP and interventions were recorded. RESULTS: Push-enteroscopy (overall, 16 procedures) reached enteral anastomoses only in six out of 37 post-surgical patients (16.2%). DBE achieved a high rate of luminal access to the biliary tract in 23 of the remaining 31 patients (74.1%) and to the pancreatic duct (three patients). Among all DBE-based ERCPs (86 procedures), 21/23 patients (91.3%) were successfully treated. Interventions included ostium incision or papillotomy in 6/23 (26%) and 7/23 patients (30.4%), respectively. Biliary endoprosthesis insertion and regular exchange was achieved in 17/23 (73.9%) and 7/23 patients (30.4%), respectively. Furthermore, bile duct stone extraction as well as ostium and papillary dilation were performed in 5/23 (21.7%) and 3/23 patients (13.0%), respectively. Complications during DBE-based procedures were bleeding (1.1%), perforation (2.3%) and pancreatitis (2.3%), and minor complications occurred in up to 19.1%. CONCLUSION: The appropriate use of DBE yields a high rate of luminal access to papilla or enteral anastomoses in more than two-thirds of post-surgical patients, allowing important successful endoscopic therapeutic interventions. | Martin Raithel Harald Dormann Andreas Naegel Frank Boxberger Eckhart G Hahn Markus F Neurath Juergen Maiss | 2011 | World Journal of Gastroenterology2011，17，18： | 9 |
| 2 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 3 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 4 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 5 | Distribution of beta-glucanases within the genus Bacillus 显示文摘 | Martin D F Priest F G Todd C | 1980 | Appl Environ Microbiol1980，40，6： | 1 |
| 6 | Effect of the dissolved oxygen on the bioproduction of glycerol and ethanol by Hansenula anomala growing under salt stress con- ditions显示文摘 | DJELAL H LARHER F MARTIN G | 2006 | Journal of biotechnongy2006，63，： | 1 |
| 7 | 显示文摘 | MARTIN P D JONES G R STRINGER F WILSON I D | 2003 | Analyst2003，128，： | 1 |
| 8 | Defini-tion of relapse risk and role of nonanthracycline drugsfor consolidation in patients with acute promyelocyticleukemia: A joint study of the PETHEMA andG1MEMA cooperative groups 显示文摘 | SANZ M A LO COCO F MARTIN G | 2000 | Blood2000，96，： | 1 |
| 9 | Will massive open online courses change how we teach? 显示文摘 | Martin F G | 2012 | Communications of the ACM2012，55，8： | 1 |
| 10 | Theoretical Comparison Between Different Configurations of Radial and Conventional Bogies 显示文摘 | GARCIA J F OLAIZOLA X MARTIN L M GIMENEZ J G | 2000 | Vehicle System Dynamics2000，，33： | 1 |
| 11 | Printed monopole antennas loaded With OCSRRs for PANs and WLAN显示文摘 | Herraiz-Martinez F J Zamora G Martin F | 2011 | IEEE Antennas and Wireless Propagation Letters2011，，10： | 1 |
| 12 | Interaction of Saccha-romyces boulardii with Salmonella enterica serovar typhimurium protects miceand modifies T84 cell response to the infection 显示文摘 | Martins F S Dalmasso G Arantes R M E | 2010 | Plos One2010，5，1： | 1 |
| 13 | Estimating Intraclass Correlation for Binary Data 显示文摘 | Martin S R Clarice G B and David F | 1999 | Bio- metrics1999，55，1： | 1 |
| 14 | Bosentan attenuates right ventricu- lar hypertrophy and fibrosis in normobaric hypoxia model of pulmonary hyperten- sion显示文摘 | Choudhary G Troncales F Martin D | 2011 | J Heart Lung Transplant2011，30，7： | 1 |
| 15 | An NB-LRR protein required for HR signalling mediated by both extra-and intracellular resistance proteins显示文摘 | Gabrils S H E J Vossen J H Ekengren S K Ooijen G Abd-El-Haliem A M Berg G Rainey D Y Martin G B Takken F L W Wit P J G M | 2007 | The Plant Journal2007，50，1： | 1 |
| 16 | Mutage- nicity and DNA adduct formation of PAH, nitro-PAH, and oxy- PAH fractions of atmospheric particulate matter from Sao Paulo, Brazil显示文摘 | UMBUZEIRO G ALEXANDRE F MARTINS M | 2008 | Murat Res2008，652，1： | 1 |
| 17 | Inhibitionof interleukin-1 beta-induced activation of MEK/ERKpathway and DNA binding of NF-kappa B and AP-1 : po-tential mechanism for Diacerein effects in osteoarthritis显示文摘 | Domagaia F Martin G Bogdanowicz P | 2006 | Biorheology2006，43，： | 1 |
| 18 | Optimal de- sign in vibration control of adaptive structures using a simula- ted annealing algorithm显示文摘 | Moita J M S Correia V M F Martins P G | 2006 | Composite Structures2006，75，1： | 1 |
| 19 | Effects of paradoxical sleep deprivation on blood parameters associated with cardiovascular risk in aged rats 显示文摘 | Andersen M L Martins P G F D'Almeida V | 2004 | Exp Gerontol2004，39，6： | 1 |
| 20 | Hypomorphism for RPGRIP1L, a cili-ary gene vicinal to the FTO locus,causes increased ad-iposity in mice 显示文摘 | STRATIGOPOULOS G MARTIN CARLI J F O ’DAY D R | 2014 | Cell Metabolism2014，19，5： | 1 |
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