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| 1 | Serum chromogranin-A in hepatocellular carcinoma: Diagnostic utility and limits显示文摘AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable.High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC).METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD)as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, nonparametric combination test and confidence interval analysis were used for statistical analysis.RESULTS: Serum CgA above normal values (100 ng/mL)were found in 83% of HCC patients, in 48% of LC patients,in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1 046), in LC (249±369), in CH (87±94), in CRF (1 390±1 401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18).HCC patients had higher CgA values (P<0.01) than LC,CH, and IBD patients but did not differ from those with CRF or CHF. The 95% CI for the mean (250-1 289 ng/mL)in HCC patients was selected as a CgA range and the lower value of such range was assumed as cut-off.Sensitivity and specificity of CgA, calculated in relation to the cut-off in patients with cirrhosis and HCC, were respectively 61% (CI 48-73%) and 82% (CI 75-88%).Serum α-FP values were >200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between α-FP and CgA in patients with HCC and in patients with cirrhosis.CONCLUSION: When HCC is suspected and α-FP is normal or <200 ng/mL, CgA serum values represent a complementary diagnostic tool, unless kidney or heart failure is present. | Aldo Spadaro Antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo Carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato Santi Turiano Oscar Ferraù Maria Antonietta Freni | 2005 | World Journal of Gastroenterology2005，11，13： | 4 |
| 2 | Anatomical and functional changes after dexamethasone implant and ranibizumab in diabetic macular edema: a retrospective cohort study显示文摘AIM: To investigate the efficacy and safety of ranibizumab(RZB group) and dexamethasone implant(DEX group) intravitreal treatments in patients with treatment-na?ve center involved diabetic macular edema(DME) by means of functional and morphological assessments.METHODS: This retrospective cohort study included 50 eyes of 50 patients with DME treated either with RBZ or DEX. Best-corrected visual acuity(BCVA) and microperimetry were evaluated at baseline and during a 6-month follow-up. In addition, central macular thickness(CMT) by means of structural optical coherence tomography(OCT) and retinal capillary plexus density and choriocapillary density by means of OCT angiography were assessed in all cases.RESULTS: Functional and morphological parameters significantly improved during the study period in both groups. BCVA improved significantly in both groups witha greater increase in the DEX group compared to the RBZ group(P=0.030). Microperimetry significantly differed during follow-up between the two treatments(P=0.031). In both groups CMT significantly decreased(P<0.001) without statistically significant differences between the two groups. A statistically significant increase of deep capillary plexus density was detected in both groups at 30 d after therapy. The retreatment rate was 0.70±0.10 and 0.65±0.10 in the RBZ group and 0.65±0.10 and 0.50±0.11 in DEX group at 120 and 180 d respectively. Two out of 25 patients in DEX group showed intraocular pressure increase requiring hypotonic eye drops.CONCLUSION: Both treatments are very effective for DME treatment during 6 mo of follow-up with a lower retreatment rate in DEX group. | Leonardo Mastropasqua Silvio Di Staso Rossella D’Aloisio Alessandra Mastropasqua Luca DiAntonio Alfonso Senatore Marco Ciancaglini Marta Di Nicola Giuseppe Di Martino DanieleTognetto Lisa Toto | 2019 | International Journal of Ophthalmology(English edition)2019，12，10： | 2 |
| 3 | Pentoxifylline 通过 TNF- 合成和 TGF-1 基因表示的下面规定改进肝新生显示文摘 AIM:To investigate the mechanism of pentoxifylline(PTX)improvement in liver regeneration.RESULTS:Rats were randomized into 4 groups:Control rats;Sham-sham-operation rats;Saline-70% hepatectomy plus saline solution;PTX-70%hepatectomy plus PTX.At 2 and 6 h after hepatectomy,aspartate aminotransferase,alanine aminotransferase,tumor necrosis factor(TNF)-α and interleukin-6(IL-6)serum and hepatic tissue levels were determined.Tumor growth factor(TGF)-β1 gene expression in liver tissue was evaluated 24 h after hepatectomy by quantitative reverse transcriptase polymerase chain reaction analysis.Proliferation was analyzed by mitotic index and proliferating cell nuclear antigen(PCNA)staining 48 h after hepatectomy.RESULTS:TNF-α and IL-6 serum levels increased at 2 and 6 h after hepatectomy.At 2 h after hepatectomy serum PTX was reduced but not hepatic levels of TNF-α and IL-6.A decrease in liver TGF-β1 gene expression and an increase in mitotic index and PCNA after hepatectomy were observed in the PTX treatment group in comparison to the saline group.CONCLUSION:PTX improves liver regeneration by a mechanism related to down regulation of TNF-α production and TGF-β1 gene expression. | Rodrigo Bronze Martino Ana Maria Mendona Coelho Márcia Saldanha Kubrusly Regina Leito Sandra Nassa Sampietre Marcel Cerqueira Cesar Machado Telesforo Bacchella Luiz Augusto Carneiro D’Albuquerque | 2012 | World Journal of Gastrointestinal Surgery2012，4，6： | 2 |
| 4 | Clinical resuhs of topical fluconazole for the treatment of filamentous fungal keratitis 显示文摘 | Sonego-Krone S Sanchez-Di D Martino D | 2006 | Graefes Arch Clin Exp Ophthalmol2006，244，7： | 1 |
| 5 | 查看详情显示文摘 | Saladino M L Caponetti E Martino D C Enzo S Ibba G | | 0，，2： | 1 |
| 6 | Therapeutic implications of colon cancer stem cells显示文摘 | FABRIAI E D I MARTINO S PELACCHI F | 2010 | World journal of gas- troenterology: WJG2010，16，31： | 1 |
| 7 | The relationship between group A streptococcal infections and Tourette syndrome: a study on a large service-based cohort 显示文摘 | Martino D Chiarotti F Buttiglione M | 2011 | Dev Med Child Neurol2011，53，10： | 1 |
| 8 | Peripheral depletion of NK cells and imbalance of the Treg/Thl7 axis in idiopathic pulmonary fibrosis patients显示文摘 | Galati D De Martino M Trotta A | 2014 | Cytokine2014，66，2： | 1 |
| 9 | Policy and technological constraints to implementation of greenhouse gas mitigation options in agricuhure 显示文摘 | Smith P Martino D Cai Z C | 2007 | Agriculture Ecosystem & Environment2007，118，： | 1 |
| 10 | 6β-Hydroxyipolamide, an iridoid glucoside from Stachytarpheta mutabilis 显示文摘 | Luca C D Guiso M Martino C | 1983 | Phytochemistry1983，22，5： | 1 |
| 11 | Greenhouse gas mitigation in agriculture 显示文摘 | Smith P Martino D Cai Z C | 2008 | Philosophical Transactions of the RoyalSociety2008，363，： | 1 |
| 12 | Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)显示文摘 | Payne D M Rossomando A J Martino P | 1991 | The EMBO Journal1991，10，4： | 1 |
| 13 | Serun and CSF levels of MCP - 1 and IP - 10 in multiple sclerosis patients with acute and stable disease and undergoing immunomodulatory therapies显示文摘 | Franeiotta D Martino G Zardini E | 2001 | J Neuroimmunol2001，115，： | 1 |
| 14 | Three-dimensional profiling with binary fringes using phase-shifting interferometry algorithms显示文摘 | Ayubi G A J Martino M D Alonso J R | 2011 | Applied Optics2011，50，2： | 1 |
| 15 | Disturbed diurnal rhythm al- ters gene expression and exacerbates cardiovascular disease with rescue by resynehronization显示文摘 | Martino T A Tata N Belsham D D | 2007 | Hypertension2007，49，5： | 1 |
| 16 | Laser microdissection and DNA typing of cells from single hair follicles显示文摘 | DI MARTINO D GIUFFRE G STAITI N | 2004 | Forensic sci Int2004，146，2： | 1 |
| 17 | Intraindividual compari- son of gadoxetate disodium-enhanced MR imaging and 64-section multidetector CT in the Detection of hepatocellular carcinoma in patients with cirrhosis显示文摘 | Di Martino M Marin D Guerrisi A | 2010 | Radiology2010，256，3： | 1 |
| 18 | Controlling integrin specificity and stem cell differentia tion in 2D and 3D environments through regulation of fibronc ctin domain stability 显示文摘 | MARTINO M M MOCHIZUKI M ROTHENFLUH D A | 2009 | Biomaterials2009，30，6： | 1 |
| 19 | Autoaggressive immune-mediated movement disorders显示文摘 | Martino D Giovannoni G | 2005 | Adv Neurol2005，96，5： | 1 |
| 20 | The entity of young onset primay cervical dystonia显示文摘 | Koukouni V Martino D Arabia | 2007 | Mov Disord2007，22，6： | 1 |
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