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| 1 | Metabolic syndrome and colorectal neoplasms:An ominous association显示文摘AIM:To evaluate the association of metabolic syndrome(MS) and colorectal cancer and adenomas in a Western country,where the incidence of MS is over 27%.METHODS:This was a prospective study between March 2013 and March 2014.MS was diagnosed according to the National Cholesterol Education ProgramATP III.Demographic characteristics,anthropometric measurements,metabolic risk factors,and colonoscopic pathologic findings were assessed in patients with MS(group 1) who underwent routine colonoscopy at our department.This data was compared with consecutive patients without metabolic syndrome(group 2),with no differences regarding sex and age.Patients with incomplete colonoscopy,family history,or past history of colorectal neoplasm were excluded.Informed consent was obtained and the ethics committee approved this study.Statistical analysis was performed using Student's t-test and χ2 test,with a P value ≤ 0.05 being considered statistically significant.RESULTS:Of 258 patients,129 had MS;51% males;mean-age 67.1 years(50-87).Among the MS group,94% had high blood pressure,91% had increased waist circumference,60% had diabetes,55% had low high-density lipoprotein cholesterol level,50% had increased triglyceride level,and 54% were obese [body mass index(BMI) 30 kg/m2].51% presented 4 criteria of MS.MS was associated with increased prevalence of adenomas(43% vs 25%,P = 0.004) and colorectal cancer(13% vs 5%,P = 0.027),compared with patients without MS.MS was also positively associated with multiple(≥ 3) adenomas(35% vs 9%,P = 0.024) and sessile adenomas(69% vs 53%,P = 0.05).No difference existed between location(P = 0.086),grade of dysplasia(P = 0.196),or size(P= 0.841) of adenomas.In addition,no difference was found between BMI(P = 0.078),smoking(P = 0.146),alcohol consumption(P = 0.231),and the presence of adenomas.CONCLUSION:MS is positively associated with adenomas and colorectal cancer.However,there is not enough information in western European countries to justify screening in patients with MS.To our knowledge,no previous study has evaluated this association in Portuguese patients. | Daniel Trabulo Suzane Ribeiro Cláudio Martins Cristina Teixeira Cláudia Cardoso Jo?o Mangualde Ricardo Freire élia Gamito Ana L Alves Fátima Augusto Ana P Oliveira Isabelle Cremers | 2015 | World Journal of Gastroenterology2015，21，17： | 5 |
| 2 | 烤烟,白肋烟和香料烟(Nicotiana tabacum)烟叶中镉浓度的调查显示文摘 | LLUGON-MOULIN N MARTIN F KRAUSS M R RAMEY P B ROSSIL 吴晓芸(译) 康婧(校) | 2006 | 中国烟草学报2006，12，6： | 3 |
| 3 | Organization and expression of genes involved in the biosynthesis of antibiotics and other secondary metabolites 显示文摘 | Martin J F Liras P | 1989 | Annu Rev Microbiol1989，43，： | 3 |
| 4 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 5 | Leak detection and calibration using transients and genetic algorithms显示文摘 | Vitkovsky J P Simpson A R Martin F L | 2000 | Journal Water Resource Planning and Management2000，126，4： | 1 |
| 6 | Chemical root pruing improves the root system morphology of coniferous seedlings显示文摘 | Burden A N Martin P A F | 1982 | Hort Sei ence1982，17，4： | 1 |
| 7 | 显示文摘 | MARTIN P D JONES G R STRINGER F WILSON I D | 2003 | Analyst2003，128，： | 1 |
| 8 | Three-Dimensional Modeling of Vertical-Horizontal Rolling Process显示文摘 | XIONG Shang-wu Rodrigues J M C Martins P A F | 2003 | Finite Elements in Analysis and Design2003，39，： | 1 |
| 9 | Revisiting the fundamental of single point incremental forming by means of mem- brane analysis显示文摘 | Silva M B Skjoedt M Martins P A F | 2008 | International Journal of Machine Toll & Manufacture2008，48，1： | 1 |
| 10 | Sulfuric activation of a brazilian manganese ore for heavy metals removal显示文摘 | RESENDE P C BARRADO F S MARTINS A H | 1999 | Hydrometallurgy1999，51，3： | 1 |
| 11 | Photolumi- neseenee from nanosize gold clusters 显示文摘 | Wilcoxon J P Martin J E Parsapour F | 1998 | J Chem Phys1998，108，17： | 1 |
| 12 | Living arrangements and social integration 显示文摘 | Alwin D F Converse P E Martin S S | 1985 | Journal of Marriage and the Family1985，47，2： | 1 |
| 13 | An NB-LRR protein required for HR signalling mediated by both extra-and intracellular resistance proteins显示文摘 | Gabrils S H E J Vossen J H Ekengren S K Ooijen G Abd-El-Haliem A M Berg G Rainey D Y Martin G B Takken F L W Wit P J G M | 2007 | The Plant Journal2007，50，1： | 1 |
| 14 | Inhibitionof interleukin-1 beta-induced activation of MEK/ERKpathway and DNA binding of NF-kappa B and AP-1 : po-tential mechanism for Diacerein effects in osteoarthritis显示文摘 | Domagaia F Martin G Bogdanowicz P | 2006 | Biorheology2006，43，： | 1 |
| 15 | Day-to-day stability in running economy and step length among well-trained male runners显示文摘 | Morgan D W Baldini F D Martin P E | | 0，，： | 1 |
| 16 | Optimal de- sign in vibration control of adaptive structures using a simula- ted annealing algorithm显示文摘 | Moita J M S Correia V M F Martins P G | 2006 | Composite Structures2006，75，1： | 1 |
| 17 | Pitting corrosion of welded joints of austenitic stainless steels studied by using an electrochemical minicell显示文摘 | GARCIA C MARTIN F TIEDRA P D | 2008 | Corro- sion Science2008，50，： | 1 |
| 18 | A first genoty ping assay of French cattle breeds based on a new al- lele of the extension gene encoding the melanocortin-1 receptor (MC1R) 显示文摘 | Rouzaud F Martin J Gallet P F | 2000 | Genet Sel Evol2000，32，5： | 1 |
| 19 | Effects of paradoxical sleep deprivation on blood parameters associated with cardiovascular risk in aged rats 显示文摘 | Andersen M L Martins P G F D'Almeida V | 2004 | Exp Gerontol2004，39，6： | 1 |
| 20 | Theory of single point incremental forming显示文摘 | MARTINS P A F BAY N | 2008 | CIRP annals-manufacturing technology2008，57，1： | 1 |
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