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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma显示文摘瞄准:在整个 Barretts 食管的前进调查 cyclooxygenase-2 (COX-2 ) 和上皮的生长因素受体(EGFR ) 的表示() 。方法:COX-2 和 EGFR 蛋白质表情被使用免疫检测组织化学的方法。详细 cytomorphological 改变的 A 是坚定的。COX-2 和 EGFR 表示的区域被使用计算机成像系统确定。结果:COX-2 和 EGFR 的表情与前进一起增加了从到食管腺癌(EAC ) 。积极关联在 COX-2 表示和 EGFR 表示之间被发现。结论:COX-2 和 EGFR 可能在逐步的前进从是合作的到 EAC,从而导致致癌作用。 | Yan Li John M Wo Mukunda B Ray Whitney Jones Ruifeng R Su Susan Ellis Robert C G Martin | 2006 | World Journal of Gastroenterology2006，12，6： | 14 |
| 3 | Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells显示文摘 | Arnold Isabelle C Dehzad Nina Reuter Sebastian Martin Helen Becher Burkhard Taube Christian Müller Anne | 2011 | Journal of Clinical Investigation2011，，8： | 4 |
| 4 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 5 | 12-epi-Heterone min; new sesterterpenes from the marine sponge Hyrtios erecta 显示文摘 | Bourgu K M Martin M T Debitus C | 1994 | Tetrahedron Lett1994，35，1： | 2 |
| 6 | Effects of resistance training on the lipid profile in obese women显示文摘 | Costa R R Lima Alberton C Tagliari M Martins Kruel L F | 2011 | Journal of Sports Medicine and Physical Fitness2011，，1： | 2 |
| 7 | Query Expansion with a Medical Ontology to Improve a Multimodal Information Retrieval System 显示文摘 | Diaz - Galiano M C Martin - Valdivia M T Urena - Lopez L A | 2009 | Computers in Biology and Medicine2009，39，4： | 1 |
| 8 | Pulmonary fibrosis correlates with outcome in the adult respiratory dis- tress syndrome显示文摘 | Martin C Papazian L Payan M J | 1995 | Chest1995，107，1： | 1 |
| 9 | Influence of soil and organic residue management on biomass and in a Eucalyptus globules Labill Plantation显示文摘 | Fabia A Martins M C Cerverira C | 2002 | Forest Ecology and Management2002，171，： | 1 |
| 10 | Effect of phosphtidyl cholide on the topical bioavailability of corticostoroids assessed by the human skin blanching assay显示文摘 | J acobs M Martin GP Mariott C | 1988 | J Pharm Parmacol1988，40，： | 1 |
| 11 | CuInSe2thin films grown by MOCVD: characterization, first devices 显示文摘 | Artaud M C Ouchen F Martin L | 1998 | Thin solid films1998，324，： | 1 |
| 12 | Effect of norepinephrine on the outcome of septic shock显示文摘 | Martin C Viviand X Leone M | 2000 | Crit Care Med2000，28，： | 1 |
| 13 | Three-Dimensional Modeling of Vertical-Horizontal Rolling Process显示文摘 | XIONG Shang-wu Rodrigues J M C Martins P A F | 2003 | Finite Elements in Analysis and Design2003，39，： | 1 |
| 14 | A comparison of methods used to determine bi mass on naturalized swards显示文摘 | MARTIN R C ASTATKIE T COOPER J M | 2005 | Journal of Agronomy and Crop Science2005，191，2： | 1 |
| 15 | Modeling charge transport in composite solar cells显示文摘 | Martin C M Burlakov V M | 2006 | Solar Energy Mater Solar Cells2006，90，： | 1 |
| 16 | 显示文摘 | Martin C Maignan A Hervieu M | 2001 | Phys Rev B2001，63，17： | 1 |
| 17 | Effect of norepinephrine on the outcome of septic shock 显示文摘 | Martin C Viviand X leone M | 2000 | Crit Care Med2000，28，8： | 1 |
| 18 | Restrictions to the adaptation of influenza A virus H5 hemagglutinin to the human host显示文摘 | Harvey R Martin A C Zambon M | 2004 | J Virol2004，78，1： | 1 |
| 19 | The synthesis of the starch granule 显示文摘 | Smith A M Denyer K Martin C | 1997 | Ann Rev Plant Physiol Plant Mol Biol1997，48，： | 1 |
| 20 | A mechanism of bread firming I, role of starch swelling显示文摘 | MARTIN M L ZELENZNAK K J HOSENEY R C | 1991 | Cereal Chem1991，68，5： | 1 |
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