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| 1 | Role of pentoxifylline in non-alcoholic fatty liver disease in high-fat diet-induced obesity in mice显示文摘AIM:To study pentoxifylline effects in liver and adipose tissue inflammation in obese mice induced by high-fat diet(HFD).METHODS: Male swiss mice(6-wk old) were fed a highfat diet(HFD; 60% kcal from fat) or AIN-93(control diet; 15% kcal from fat) for 12 wk and received pentoxifylline intraperitoneally(100 mg/kg per day) for the last 14 d. Glucose homeostasis was evaluated by measurements of basal glucose blood levels and insulin tolerance test two days before the end of the protocol. Final body weight was assessed. Epididymal adipose tissue was collected and weighted for adiposity evaluation. Liver and adipose tissue biopsies were homogenized in solubilization buffer and cytokines were measured in supernatant by enzyme immunoassay or multiplex kit, respectively. Hepatic histopathologic analyses were performed in sections of paraformaldehyde-fixed, paraffin-embedded liver specimens stained with hematoxylin-eosin by an independent pathologist. Steatosis(macrovesicular and microvesicular), ballooning degeneration and inflammation were histopathologically determined. Triglycerides measurements were performed after lipid extraction in liver tissue. RESULTS: Pentoxifylline treatment reduced microsteatosis and tumor necrosis factor(TNF)-α in liver(156.3 ± 17.2 and 62.6 ± 7.6 pg/mL of TNF-α for non-treated and treated obese mice, respectively; P < 0.05). Serum aspartate aminotransferase levels were also reduced(23.2 ± 6.9 and 12.1 ± 1.6 U/L for nontreated and treated obese mice, respectively; P < 0.05) but had no effect on glucose homeostasis. In obese adipose tissue, pentoxifylline reduced TNF-α(106.1 ± 17.6 and 51.1 ± 9.6 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) and interleukin-6(340.8 ± 51.3 and 166.6 ± 22.5 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) levels; however, leptin(8.1 ± 0.7 and 23.1 ± 2.9 ng/mL for non-treated and treated lean mice, respectively; P < 0.05) and plasminogen activator inhibitor-1(600.2 ± 32.3 and 1508.6 ± 210.4 pg/mL for non-treated and treated lean mice, respectively; P < 0.05) levels increased in lean adipose tissue. TNF-α level in the liver of lean mice also increased(29.6 ± 6.6 and 75.4 ± 12.6 pg/mL for non-treated and treated lean mice, respectively; P < 0.05) while triglycerides presented a tendency to reduction.CONCLUSION: Pentoxifylline was beneficial in obese mice improving liver and adipose tissue inflammation. Unexpectedly, pentoxifylline increased pro-inflammatory markers in the liver and adipose tissue of lean mice. | Simone Coghetto Acedo Cintia Rabelo e Paiva Caria érica Martins Ferreira Gotardo José Aires Pereira José Pedrazzoli Marcelo Lima Ribeiro Alessandra Gambero | 2015 | World Journal of Hepatology2015，7，24： | 2 |
| 2 | Rubber assisted compression beading of tubes 显示文摘 | Aires L M Martins P A F | 2014 | Procedia Cirp2014，18，： | 1 |
| 3 | Shell interpopulation variation and its origin in Pomacea canaliculata (Gastropoda:Ampullariidae) from Southern Pampas, Argentina 显示文摘 | Estebenet Air Martin PR | 2003 | J Moll Stud2003，69，： | 1 |
| 4 | No effect of age or gender on the pharmaeokinetics of rosuvastatin: a new HMG CoA reductase inhibitor显示文摘 | Martin PD Dane Air Nwose OM | 2002 | J Clin Pharmacol2002，42，10： | 1 |
| 5 | Competition of High- the Case of Madrid-Barce- lona显示文摘 | Roman C Espino R Martin J Speed Train with Air Transport: C | 2007 | Journal of Air Transport Management2007，13，5： | 1 |
| 6 | Effect of soil type and pH on adsorption, mobility and efficacy of imazaquin and imazethapyr显示文摘 | STOUGAARD RN SHEA PJ MARTIN AIR | 1990 | Weed- Science1990，38，： | 1 |
| 7 | Coccidae, Pseudococeidae, Ortheziidae, and Monophlebidae (Hemiptera: Coccoidea) of Esplfito Santo, Brazil显示文摘 | Mark Paul Culik David dos Santos Martins Jose Aires Ventura | 2007 | Biota2007，7，3： | 1 |
| 8 | Late Protective Effects of the Anticalmodulin Drug Fluphenazine on Carbon Tetrachloride-induced Liver Necrosis显示文摘Fluphenazine (FP) treatment (50mg/kg bw, ip in saline) 30 min before or 6 or 10 h after CCl4 administration (1 ml/kg ip in olive oil) significantly prevented the liver necrosis produced by the hepatotoxin at 24 h. FP had enhancing effects on the covalent binding of CCl4 reactive metabolites to cellular constituents and on CCl4 induced lipid peroaldation.FP lowered bOdy temperature of the CCl4-poisoned animals during the 24 h observation period. The obtained results are compatible but do not prove the hypothesis that calmodulin (CaM) had participation in late occurring events preceding necrosis. FP lowering action on body temperature, however, might also play a role in the effects of this drug on the onset of CCl4 induced liver necrosis. FP levels in liver tissue as determined by gas chromatography-mass spectrometry evidenced the presence of the drug in amounts suffi cient to inhibit CaM and that suggests that not all preventive effects of FP are due to its indirect actions on the central nervous system via decreased body | E. C. DE FERREYRA A. S. BERNACCHI M. F. SAN MARTIN G. D. CASTRO AND J. A. CASTRO (Centro de Investigaciones Toxicologicas (CEITOX)-CITEFA/CONICET,Zufriategui 4380, (1603) Villa Martelli, Buenos Aires, Angentina) | 1995 | Biomedical and Environmental Sciences1995，8，3： | 0 |
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