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| 1 | Reelin induces EphB activation显示文摘进功能的 neuronal 网络的新生的神经原的集成在 neuronal 进程和与另外的神经原的 synaptic 接触的形成的发展中的大脑,生长和树枝状要求房间的移植到他们的最后的位置。在协调区别事件的这个复杂序列的信号之中的一个中央播放器是分泌 glycoprotein Reelin,它也调制 synaptic 粘性,学习并且在成年大脑的记忆形成。到 ApoER2 和 VLDL 受体的 Reelin 有约束力, LDL 受体家庭的二个成员,开始包含细胞内部的细胞质的适配器蛋白质 Disabled-1 的酷氨酸 phosphorylation 的发信号的串联,它指向 neuronal 细胞骨架并且最终控制在整个发展中的大脑放神经原。然而, Reelin 信号与另外的调停受体的发信号串联交往调整大脑开发和粘性的不同方面,是可能的。EphB 酷氨酸 kinases 经由通过 ephrin B transmembrane 蛋白质的双向发信号调整房间粘附和排斥依赖者过程。这里,我们证明 Reelin 绑在 EphB transmembrane 蛋白质的细胞外的领域,导致受体聚类和向前在神经原发信号的 EphB 的激活,独立于“古典”的 Reelin 受体, ApoER2 和 VLDLR。因此,鼠标缺乏 EphB1 和 EphB2 显示 CA3 海马趾的金字塔形的神经原的一个放的缺点,类似于那在 Reelin 缺乏的鼠标,和这房间迁居,缺点取决于 EphB 蛋白质的 kinase 活动。一起,我们的数据为在向前发信号的 Reelin 和 EphB 之间的信号集成提供生物化学、功能的证据。 | Elisabeth Bouche Mario I Romero-Ortega Mark Henkemeyer Timothy Catchpole Jost Leemhuis Michael Frotscher Petra May Joachim Herz Hans H Bock | 2013 | Cell Research2013，23，4： | 5 |
| 2 | INMA-Sabadell队列中孕期双酚A及邻苯二甲酸酯暴露与胎儿发育的超声测量(续完)显示文摘暴露于ΣMWPm与任何胎儿大小或胎儿发育结局(见补充材料,表8)及所评估的出生结局(表2及补充材料表S7)都没有显著相关性。代谢物MnBP与12-20孕周HC增长降低有显著相关性(-4.88%;95%CI:-8.36,-1.36),且与EFW增长减低也有显著相关性(-4.32%;95%CI:-8.33,-0.27)(图3及补充材料表S8)。 | Maribel Casas Damaskini Valvi Ana Ballesteros-Gomez Mireia Gascon Mariana F.Fernández Raquel Garcia-Esteban Carmen I?iguez David Martínez Mario Murcia Nuria Monfort Noelia Luque Soledad Rubio Rosa Ventura Jordi Sunyer Martine Vrijheid 袁亚群(翻译) 金泰廙(审校) | 2016 | 环境与职业医学2016，33，9： | 3 |
| 3 | 胰腺手术:演变及目前的个体化方案显示文摘胰腺癌的手术切除是患者延长生命的唯一机会,但胰腺手术目前仍然是一种技术上的挑战,并伴有术后并发症的风险,尤其是胰瘘。现在胰瘘发生的危险因素已被人们熟知,通过预防性用药及技术上的干预有可能阻止胰瘘的发生。随着术后护理的进步及影像学手段的干预,大多数常见的并发症可以保守治疗。这篇综述也试图对胰腺术后最佳管理方式所存在的争议进行阐述。 | Mario Zovak Dubravka Muzina Mi Goran Glavi 冯铁诚 李新营 | 2015 | 中国普通外科杂志2015，24，3： | 3 |
| 4 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 5 | The aging burden of hospitalization for heart failure in Chinese populations:evidence from the Macao Heart Failure Study显示文摘Objective To assess the aging burden of hospitalization for heart failure in Chinese populations in Macao.Methods The Macao Heart Failure Study consists of patients hospitalized with a diagnosis of acute heart failure(AHF)at Centro Hospitalar Conde de São Januário(the only public hospital that provides medical care for the approximately 600,000 residents of Macao)from January 2014 to December 2016.First,we investigated the relationship between socioeconomic development and epidemiological characteristics of HF in Macao.Then we assessed the patients’clinical features and outcomes according to the age groups.Results A total of 967 patients were included in the final analysis.The median age at admission was 82 years old.The advanced age at the admission of HF in Macao was significantly associated with a high-income level and the aging population structure.Marked heterogeneity existed in the epidemiological characteristics,clinical features,utilization of evidence-based therapies,short-and long-term outcomes,and prognostic utility of clinical variables among the different age groups.Conclusion Rapid economic development and significantly aging populations have produced a profound impact on the epidemiological characteristics of HF in Chinese populations.Acute decompensated heart failure(ADHF)is predominantly a disease of the elderly in Macao,and a significant heterogeneity exists in the clinical features,managements,and outcomes among different age groups.Age-based risk stratification models and multidisciplinary HF teams are urgently needed to improve the management and outcomes of hospitalized heart failure(HHF)patients. | Zhi-Nan LU Mario Evora Edmundo Lao Man Ieng Pun Weng Hong Pun Monica Pon Kong Chu Pui I Ieong Toi-Meng Mok Yong-Jian WU | 2020 | Journal of Geriatric Cardiology2020，17，9： | 2 |
| 6 | Ring sideroblasts and sider- oblastic anemias 显示文摘 | MARIO C ROSANGELA I | 2011 | Haematologica2011，96，6： | 1 |
| 7 | A sliding mode missile pitch autopilot synthesis for high angle of attack maneuvering显示文摘 | Mario I | 1998 | IEEE Transactions on Control Systems Technology1998，6，3： | 1 |
| 8 | Strategic environmental assessment of plans and programs: A methodology for estimating effects on biodiversity显示文摘 | MARIo D JUAN C I DOLORES H | 2001 | Environmental Management2001，28，2： | 1 |
| 9 | An integrated pricing model for defaultable loans and bonds显示文摘 | Mario Onorato Edward I Airman | 2005 | European Journal of Operational Research2005，163，： | 1 |
| 10 | Autonomous formation flight 显示文摘 | FABRIZIO G LORENZO P MARIO I | 2000 | IEEE Control Systems Magazine2000，25，12： | 1 |
| 11 | Dynamic and control issues of formation flight 显示文摘 | FABRIZIO G MARIO I MARCELLO N | 2005 | Aerospace Science and Technology2005，36，9： | 1 |
| 12 | Image processing using the PCNN time matrix as a selective filter显示文摘 | Mario I Chacon M Alijandro Z S | 2003 | IEEE2003，1，： | 1 |
| 13 | Accuracy of high-resolution MRI with lumen distention in rectal cancer staging and circumferential margin involvement prediction 显示文摘 | Elsa I Sara DR Mario F | 2014 | Korean J Radiol2014，15，1： | 1 |
| 14 | Evidence of a chytrid fungus infection involved in the decline of the common midwife toad (Alytes obstetricans) in protected areas of central Spain显示文摘 | JaimeB Iigo Mart I nez-Solano Mario Garc I a-Par 1 s | 2001 | Biological Conservation2001，97，3： | 1 |
| 15 | Two acylated monoterpene glucosides from Paeonia peregina显示文摘 | Ivanka N K Mario F S Daniela I T | 1998 | Phytochemistry1998，48，3： | 1 |
| 16 | Comparison of angiographic and clinical outcomes of coronary stenting of chronic total occlusions versus subtotal occlusions显示文摘 | Moussa I Di Mario C Moses J | 1998 | Am J Cardiol1998，81，： | 1 |
| 17 | A sliding mode missile pitch autopilot synthesis for high angle of attack maneuvering显示文摘 | T Ajay I Mario | 1998 | IEEE Transactions on Control Systems Technology1998，，3： | 1 |
| 18 | Subacute stent thrombosis in the era of intravascular ultrasound-guided coronary stenting without anticoagulation:frequency,predictors and clinical outcome显示文摘 | Si Mario C Reimers B | 1997 | J Am Coll Cardiol1997，29，1： | 1 |
| 19 | The Impact of the Internet on R&D Efficiency:The-ory and Evidence显示文摘 | Mario I Kafouros | 2006 | Technovation2006，，82： | 1 |
| 20 | A sliding mode missile pitch autopilot synthesis for high angle of attack maneuvering显示文摘 | Ajay T Mario I | 1998 | IEEE Transactions on Control Systems Technology1998，6，3： | 1 |
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