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| 1 | Interleukin 10 prevents dendritic ceil accumulation and vaccination with granulocyte macrophage colony-stimulating factor gene modified tumor cells显示文摘A wide variety of human tumors express interleukin10 (IL-10) for reasons poorly understood. We haveanalysed the effect of spontaneous IL-10 expression by amouse tumor (J558L) on its immunparalysing effect.Because cross-priming' of T cells by host antigenpresenting cells for MHC class I restricted tumor antigensis a major pathway for induction of tumor immunity andthat is enhanced by granulocyte-macrophage colony-stimulating factor (GM-CSF), we expressed this cytokinein J558L cells. GM-CSF secreting cells were not | Gabriele Noffz Mariette Mohaupt Thomas Blankenstein | 1997 | 中国实验血液学杂志1997，5，3： | 7 |
| 2 | Surgery in Esophageal and Gastric Cancer Patients: What is the Role for Nutrition Support in your Daily Practice?显示文摘 | Christophe Mariette Marie-Laure Botton Guillaume Piessen | 2012 | Annals of Surgical Oncology2012，，7： | 5 |
| 3 | Relationships between mucinous gastric carcinoma, MUC2 expression and survival显示文摘瞄准:为了调查四的表示,在一系列胃的癌分泌了形成胶化的粘蛋白( MUC2 , MUC5AC , MUC5B 和 MUC6 ),分类 Lauren 的,素菜烩肉的,并且 Goseki 的分类,与到所有的特殊注意,不同部件(专业和未成年者)在肿瘤并且到介绍在临床的数据上面列在后面。方法:MUC2, MUC5AC, MUC5B 和 MUC6 的表示用免疫组织化学和原位杂交被调查。结果:在胃的癌的分泌形成胶化的粘蛋白的表示是特别地复杂的,各粘蛋白 being 没限制到平的任何组织病理学说的类型在一个给定的肿瘤认为所有部件(专业和未成年者) 是现在。在有粘液(Goseki II 或 IV ) 和高积极 MUC2 表示的一个更高的内容的病人有最糟的幸存。结论:在胃的癌症的粘蛋白基因表达式模式的复杂性可以在没在使用的词法分类系统认出的房间水平反映区别的一个精确状态。MUC2 的高表示不过与 WHO 分类的粘蛋白的子类型并且与 Goseki 一个特别肿瘤的主要部件识别的分类的组 II 被联系。粘液的数量和质量与幸存有关。 | Emmanuelle Leteurtre Farid Zerimech Guillaume Piessen Agnès Wacrenier Xavier Leroy Marie-Christine Copin Christophe Mariette Jean-Pierre Aubert Nicole Porchet Marie-Pierre Buisine | 2006 | World Journal of Gastroenterology2006，12，21： | 4 |
| 4 | Early local intracoronary platelet activation after drug-eluting stent placement显示文摘在冠的干预以后的背景早本地的血小板激活在尖锐 stent 血栓(著名计算机生产厂商) 的增加的风险识别病人。然而,早在跟随 drug-eluting stent ( DES )培植的冠的循环在血小板激活变化从来没是在 26 连续选任的马厩的未来的研究的 reported.Methods 咽峡炎病人,血小板激活被在 DES 或赤裸的金属 stent ( BMS )的培植前后测量可溶的 glycoprotein V ( sGPV )和 P-selectin ( CD62P )分析。所有病人是有 clopidogrel (300 mg 装载剂量) 和阿司匹林的 pretreated (75 mg 口头上地) 在过程前的日子。血样品从冠的口被拉并且 10 -对与更低的基线一致的损害 site.Results 远侧的 20 公里临床的风险, CD62P 和 sGPV 的层次在正常参考以内范围,两个在冠的口并且对在 CD62P 和 sGPV 的 procedure.The 层次没显著地改变的经皮的冠的干预(打印机控制语言)前的损害远侧( CD62P :(31.1 他们区域比率(1.13he 瘤是穿正常白人衣服的 evaluated.With creatinine | Ailiman Mahemuti Nicolas Meneveau Marie-France Seronde FrancoisSchiele Mariette Mercier Evelyne Racadotand Jean-Pierre Bassand | 2007 | Chinese Medical Journal2007，，22： | 3 |
| 5 | Assessment of oxidative stress in chronic pancreatitis patients显示文摘AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy. | Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert JA Wanten Jan BMJ Jansen Wilbert HM Peters Joost PH Drenth | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 6 | Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers显示文摘AIM:To investigate the polymorphic simple sequencerepeat in intron 1 of the epidermal growth factor receptorgene(EGFR)(CA-SSRⅠ),which is known to affect theefficiency of gene transcription as a putative target of themismatch repair(MMR)machinery in colorectal tumors.METHODS:The CA-SSRⅠgenotype was analyzed ina total of 86 primary colorectal tumors,selected upontheir microsatellite instability(MSI)status[42 with highfrequency MSI(MSI-H)and 44 microsatellite stable(MSS)]and their respective normal tissue.The effect of the CA-SSRⅠgenotype on the expression of the EGFR gene wasevaluated in 18 specimens using quantitative real-timereverse transcription PCR and immunohistochemistry.RESULTS:Mutations in CA-SSRⅠwere detected in 86%(36 of 42)of MSI-H colorectal tumors and 0%(0 of 44)ofMSS tumors,indicating the EGFR gene as a novel putativespecific target of the defective MMR system(P<0.001).Impaired expression of EGFR was detected in most ofthe colorectal tumors analyzed[6/12(50%)at the mRNAlevel and 15/18(83%)at the peptide level].However,noassociation was apparent between EGFR expression andCA-SSRⅠstatus in tumors or normal tissues.CONCLUSION:Our results suggest that CA-SSRⅠsequence does not contribute to the regulation of EGFRtranscription in colon,and should thus not be consideredas a promising predictive marker for response to EGFRinhibitors in patients with colorectal cancer. | Marie-Pierre Buisine Agnès Wacrenier Christophe Mariette Emmanuelle Leteurtre Fabienne Escande Sana Aissi Amandine Ketele Annette Leclercq Nicole Porchet Thécla Lesuffleur | 2008 | World Journal of Gastroenterology2008，14，7： | 3 |
| 7 | Therapeutic strategies in oesophageal carcinoma: role of surgery and other modalities显示文摘 | Christophe Mariette Guillaume Piessen Jean-Pierre Triboulet | 2007 | Lancet Oncology2007，，6： | 3 |
| 8 | Is the negative prognostic impact of signet ring cell histology maintained in early gastric adenocarcinoma?显示文摘 | Caroline Gronnier Mathieu Messager William B. Robb Timothée Thiebot Damien Louis Guillaume Luc Guillaume Piessen Christophe Mariette | 2013 | Surgery2013，，： | 2 |
| 9 | Interleukin 10:a new therapeutic target in systemic lupus erythematosus 显示文摘 | Emilie D Mariette X | 2001 | Joint Bone Spine2001，68，1： | 2 |
| 10 | Diagnosis and treatment of non-metastatic esophagogastric junction adenocarcinoma: What are the current options?显示文摘 | C. Gronnier G. Piessen C. Mariette | 2012 | Journal of Visceral Surgery2012，，1： | 2 |
| 11 | Prognostic value ofvertebral lesions detected by magnetic resonance imaging in pa-tients with stage I multiple myeloma 显示文摘 | Mariette X Zagdanski AM Guermazi A | 1999 | Br J Haematol1999，104，4： | 1 |
| 12 | Reconstruction after gastrectomy:which technique is best?显示文摘 | Piessen G Triboulet JP Mariette C | 2010 | J Visc Surg2010，147，5： | 1 |
| 13 | External pancreatic duct stent decreases pancreatic fistula rate after pancreaticeduode- nectomy: prospective multicenter randomized trial 显示文摘 | Pessanx P Sauvanet A Mariette C | 2011 | Ann Surg2011，253，5： | 1 |
| 14 | Evolution of Water proton Nuclear Magnetic Relaxation during Milk Coagulation and Syneresis:structure Implications显示文摘 | Tellier C Mariette F Guillement J P | 1993 | Journal of Agriculture and Food Chemistry1993，41，： | 1 |
| 15 | External pancreatic duct stent decreases pancreatic fistula rate after pancreaticoduodenectomy:prospective multicenter randomized trial显示文摘 | Pessaux P Sauvanet A Mariette C | 2011 | Ann Surg2011，253，5： | 1 |
| 16 | External pancreatic duct stent decreases pancreatic fistula rate after panereaticodu- odenectomy : prospective multicenter randomized trial 显示文摘 | Pessaux P Sauvanet A Mariette C | 2011 | Ann Surg2011，253，： | 1 |
| 17 | ~1H-Nuclear magnetic resonance relaxometric characterization of fat and water states in soft and hard cheese显示文摘 | CHALAND B MARIETTE F MARCHAL P | 2000 | Journal of Dairy Research2000，67，4： | 1 |
| 18 | 1H nuclear magnetic resonance relaxometric characterization of fat and water states in soft and hard cheese显示文摘 | Chaland B Mariette F Marchal P | 2000 | Journal of Dairy Research2000，67，4： | 1 |
| 19 | External pancreatic duct stent decreases pancreatic fistula rate after pancreaticoduodenectomy:prospective multicenter randomized trial显示文摘 | Pessaux P Sauvanet A Mariette C | 2011 | Ann Surg2011，253，5： | 1 |
| 20 | Surgery alone versus chemoradiotherapy followed by surgery for stage I and II esophageal cancer: final analysis of randomized controlled phase III trial FFCD 9901显示文摘 | Mariette C Dahan L Momex F | 2014 | Journal of Clinical Oncology2014，32，23： | 1 |
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