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| 1 | Molecular targeting agents associated with transarterial chemoembolization or radiofrequency ablation in hepatocarcinoma treatment显示文摘Hepatocellular carcinoma(HCC)is the fifth most common cause of cancer in the world.According to Barcelona Clinic Liver Cancer modified criteria,patients with early stage disease are candidate to radiofrequency ablation(RFA),while patients with intermediate stage HCC are usually treated by transarterial chemoembolization(TACE).TACE and RFA induce a transient devascularisation effect followed by strong neoangiogenic stimulus.In fact,after these procedures,it has been demonstrated an up-regulation of pro-angiogenic and growth factors such as vascular endothelial growth factor-A,which might contribute to accelerated progression in patients with incomplete response.Several studies have demonstrated that MAP-kinase and AKT pathways,in addition to neo-angiogenesis,have an important role in the development of HCC.In advanced HCC,anti-angiogenic therapy and tyrosine kinases inhibitors showed potential clinical benefit.Actually,a number of clinical studies are ongoing testing these agents in combination with TACE or RFA.In this paper,we have reviewed the most recent preclinical and clinical results of such trials. | Girolamo Ranieri Ilaria Marech Vito Lorusso Veronica Goffredo Angelo Paradiso Domenico Ribatti Cosmo Damiano Gadaleta | 2014 | World Journal of Gastroenterology2014，20，2： | 14 |
| 2 | GLOBAL SOLUTIONS FOR SOME OLDROYD MODELS OF NON-NEWTONIAN FLOWS显示文摘The authors consider here some Oldroyd models of non-Newtonian flows consisting of a strong coupling between incompressible Navier-Stokes equations and some transport equations. It is proved that there exist global weak solutions for general initial conditions. The existence proof relies upon showing the propagation in time of the compactness of solutions. | P. L. LIONS (CEREMADE-UMR C.N.R.S. 7534, Universite Paris 9-Dauphine, Place du Marechal de Lattre de Tassigny, 75775 Paris Cedex 16, France.) N. MASMOUDI (CEREMADE-UMR C.N.R.S. 7534, Universite Paris 9-Dauphine, Place du Marechal de Lattre de Tassign | 2000 | Chinese Annals of Mathematics,Series B2000，21，2： | 14 |
| 3 | Vascular endothelial growth factor and tryptase changes after chemoembolization in hepatocarcinoma patients显示文摘AIM: To evaluate vascular endothelial growth factor(VEGF) and tryptase in hepatocellular cancer(HCC)before and after trans-arterial chemoembolization(TACE).METHODS: VEGF and tryptase serum concentrations were assessed from 71 unresectable HCC patients before and after hepatic TACE performed by binding DC-Beads?to doxorubicin. VEGF levels were examined for each serum sample using the Quantikine Human VEGF-enzyme-linked immuno-absorbent assay(ELISA),whereas tryptase serum concentrations were assessed for each serum sample by means of fluoro-enzyme immunoassay(FEIA) using the Uni-CAP100 tool.Differences between serum VEGF and tryptase values before and after TACE were evaluated using Student t test. Person's correlation was used to assess the degree of association between the two variables.RESULTS: VEGF levels and serum tryptase in HCCpatients before TACE had a mean value and standard deviation(SD) of 114.31 ± 79.58 pg/mL and 8.13± 3.61 μg/L, respectively. The mean levels and SD of VEGF levels and serum tryptase in HCC patients after TACE were 238.14 ± 109.41 pg/mL and 4.02 ±3.03 μg/L. The changes between the mean values of concentration of VEGF and tryptase before treatment and after treatment was statistically significant(P <0.000231 and P < 0.00124, by Wilcoxon-Mann-Whitney respectively). A significant correlation between VEGF levels before and after TACE and between tryptase levels before and after TACE was demonstrated(r =0.68, P = 0.003; r = 0.84, P = 0.000 respectively).CONCLUSION: Our pilot results suggest that the higher serum VEGF levels and the lower tryptase levels following TACE may be potential biomarkers changing in response to therapy. | Girolamo Ranieri Michele Ammendola Ilaria Marech Annamaria Laterza Ines Abbate Caroline Oakley Angelo Vacca Rosario Sacco Cosmo Damiano Gadaleta | 2015 | World Journal of Gastroenterology2015，21，19： | 13 |
| 4 | RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response显示文摘复制蛋白质 A (RPA ) 建筑群是真核细胞的 DNA 新陈代谢的一个必要管理者。RPA 贪心地通过多重 oligonucleotide/oligosaccharide-binding 褶层绑在搁浅单人赛的 DNA (ssDNA ) 并且协调染色体维护因素的招募和交换调整 DNA 复制,再结合和修理。RPA-ssDNA 平台也组成激活主人 ATR kinase 在复制应力期间保护并且修理阻止或崩溃的复制叉的一个关键生理的信号。在最近的年里, RPA 建筑群响应 DNA 损坏作为一个关键目标和 translational 以后修正的一个重要管理者出现了,它为它的染色体保护者功能是批评的。RPA 复杂、更最近调整 RPA 的 ubiquitination 的 Phosphorylation 和 SUMOylation,都被显示了控制 DNA 损坏发信号的特定的方面并且由 modulating 修理在 RPA 和它的搭挡之间的相互作用。这里,我们通过共有原子价修正的一个精致的网络在染色体稳定性和它的规定的维护考察我们 RPA-ssDNA 平台的批评函数的当前的理解。 | Alexandre Marechal Lee Zou | 2015 | Cell Research2015，25，1： | 9 |
| 5 | Targeting mast cells in gastric cancer with special reference to bone metastases显示文摘Bone metastases from gastric cancer(GC) are considered a relatively uncommon finding; however, they are related to poorer prognosis. Both primary GC and its metastatic progression rely on angiogenesis. Several lines of evidence from GC patients strongly support the involvement of mast cells(MCs) positive to tryptase(MCPT) in primary gastric tumor angiogenesis. Recently,we analyzed infiltrating MCs and neovascularization in bone tissue metastases from primary GC patients, and observed a significant correlation between infiltrating MCPT and angiogenesis. Such a finding suggested the involvement of peritumoral MCPT by infiltrating surrounding tumor cells, and in bone metastasis angiogenesis from primary GC. Thus, an MCPT-stimulated angiogenic process could support the development of metastases in bone tissue. From this perspective, we aim to review the hypothetical involvement of tumorinfiltrating,peritumoral MCPT in angiogenesis-mediated GC cell growth in the bone microenvironment and in tumor-induced osteoclastic bone resorption. We also focus on the potential use of MCPT targeting agents,such as MCs tryptase inhibitors(gabexate mesylate,nafamostat mesylate) or c-KitR tyrosine kinase inhibitors(imatinib, masitinib), as possible new anti-angiogenic and anti-resorptive strategies for the treatment of GC patientsaffected by bone metastases. | Christian Leporini Michele Ammendola Ilaria Marech Giuseppe Sammarco Rosario Sacco Cosmo Damiano Gadaleta Caroline Oakley Emilio Russo Giovambattista De Sarro Girolamo Ranieri | 2015 | World Journal of Gastroenterology2015，21，37： | 5 |
| 6 | Possible biological and translational significance of mast cells density in colorectal cancer显示文摘Mast cells(MCs), located ubiquitously near blood vessels, are descended from CD34+ hematopoietic stem cells. Initially, although their role has been well defined in hypersensitivity reactions, the discovery of their sharing in both innate and adaptive immunity has allowed to redefine their crucial interplay on the regulatory function between inflammatory and tumor cells through the release of mediators granule-associated(mainly tryptase and vascular endothelial growth factor). In particular, in several animal and human malignancies it has been well demonstrated that activated c-Kit receptor(c-KitR) and tryptase(an agonist of the proteinase-activated receptor-2) take pivotal part in tumor angiogenesis after the MCs activation, contributing to tumor cells invasion and metastasis. In this review, we focused on crucial MCs density(MCD) role in colorectal cancer(CRC) development and progression angiogenesis-mediated; then, we will analyze the principal studies that have focused on MCD as possible prognostic factor. Finally, we will consider a possible role of MCD as novel therapeutic target mainly by c-KitR tyrosine kinase inhibitors(imatinib, masitinib) and tryptase inhibitors(gabexate and nafamostat mesylate) with the aim to prevent CRC progression. | Ilaria Marech Michele Ammendola Claudia Gadaleta Nicola Zizzo Caroline Oakley Cosmo Damiano Gadaleta Girolamo Ranieri | 2014 | World Journal of Gastroenterology2014，20，27： | 3 |
| 7 | Conductionmechanisms in some graphite-polymer composites:effects oftemperature and hydrostatic pressure显示文摘 | CELZARD A MCRAE E MARECHE J F | 1998 | Journal of AppliedPhysics1998，83，3： | 1 |
| 8 | A multibiomarkerapproach in juvenile turbot, Scophthalmus maximus, exposed tocontaminated sediments 显示文摘 | Kerambrun E Henry F Marechal A | 2012 | Ecotoxicology and Environmental Safety2012，80，： | 1 |
| 9 | Modelling of exfoliated graphite显示文摘 | GELZARD A MARECHE J F FURDIN G | 2005 | Progress in Materials Science2005，50，1： | 1 |
| 10 | The role of surface free energy in the early in vivo formation of dental plaque on human enamel and polymeric substrata显示文摘 | Weerkamp AH Quirynen M Marechal M | 1989 | Microb Ecol1989，2，1： | 1 |
| 11 | Heteroepitaxial nucleation of diamond by bias pretreatment in an dectron cyclotron resonance microwave chemical vapor deposition system显示文摘 | YAMASHITA S | 1996 | Thin Solid Films1996，，： | 1 |
| 12 | Towards pharmacological approach of Alzheimer disease based on the molecular biology of the amyloidal precursor protein(APP) 显示文摘 | Dresse A Marechal D Scuvee-Moreau J | 1994 | Life Science1994，55，1： | 1 |
| 13 | Energy in the Perspective of the Sustainable Development显示文摘 | Francois Marechal | 2005 | Resources Conservation and Recycling2005，，44： | 1 |
| 14 | Masti-tis impact on technological properties of milk and quality of milk products-a review显示文摘 | LE MARECHAL C THIERY R VAUTOR E | | 0，，3： | 1 |
| 15 | Conduction mechanisms in some graphite-polymer composites: effects of temperature and hydrostatic pressure显示文摘 | Celzard A Mcrae E Mareche J F | 1998 | Journal of Applied Physics1998，83，3： | 1 |
| 16 | Phosphate deprivation induces transfer of DGDG galactolipid from chloroplast to mito- ehondria显示文摘 | JOUHET J MARECHAL E BLOCK M A | 2004 | Journal of Cell Biology2004，167，5： | 1 |
| 17 | The anti-oxidant ebselen antagonizes the release of the apoptogenic factor cytoehrome c induced by Fe2 +/citrate in rat liver mitochondria 显示文摘 | BoireauA Marechal PM Meunier M | 2000 | Neurosci Lett2000，289，2： | 1 |
| 18 | Inactivation and partition of human immunodeficiency virus during Kistler and Nitschmann fractionation of human blood plasma显示文摘 | Marechal V Barre-Sinousi F | 1988 | Vox Sang1988，54，2： | 1 |
| 19 | Evolution of trypsinogen activation peptides显示文摘 | Chen J M Kukor Z Le Marechal C | 2003 | Mol Biol Evol2003，，20： | 1 |
| 20 | Glycerolipid transfer for the building of membranes in plant cells显示文摘 | Jouhet J Marechal E Block M A | 2007 | Prog Lipid Res2007，46，： | 1 |
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