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| 1 | Immune response to hepatitis B virus vaccine in celiac subjects at diagnosis显示文摘AIM To evaluate hepatitis B virus(HBV) vaccine response and correlation with human leukocyte antigens(HLA) and/or gluten intake in celiac patients at diagnosis.METHODS Fifty-one patients affected by celiac disease, diagnosed at the Department of Pediatrics of the University of Catania(Italy), were recruited. All patients were tested at admission for immunization against HBV, according to findings from analysis of quantitative HBV surface antibody(anti-HBs). The anti-HBs titer was measured by enzyme-linked immunosorbent assay. Following the international standards, subjects with antibody titer < 10 IU/L were defined as non-responders. The prevalence of responders and non-responders among celiac subjects and the distribution of immunization for age were examined. In addition, the prevalence of responders and non-responders was assessed for correlation to HLA and clinical features at diagnosis of celiac disease.RESULTS The entire study population was divided into three groups according to age: 24 patients aged between 0to 5.5 years(48.9%, group A); 16 aged between 5.5 and 9.5 years(30.61%, group B); 9 aged between 9.5 and 17 years(18.75%, group C). Comparison of the percentage of responders and non-responders between the youngest and the oldest age group showed no significant difference between the two groups(P > 0.05). With regard to the HLA haplotype, comparison of the distribution of vaccination response showed no statistically significant difference between the different genotypes(homozygosity for the HLADQ2 haplotype compared with HLADQ2/DQ8 heterozygosity or other haplotypes; P > 0.05). Moreover, distribution of the responders according to clinical features of celiac disease showed no statistically significant differences(P > 0.05).CONCLUSION This prospective study confirmed the lower percentage of response to HBV vaccine in celiac subjects. However, the underlying mechanism remains unclear and further studies are needed. | Martina Filippelli Maria Teresa Garozzo Antonino Capizzi Massimo Spina Sara Manti Lucia Tardino Carmelo Salpietro Salvatore Leonardi | 2016 | World Journal of Hepatology2016，8，26： | 5 |
| 2 | Self-perceptions and social–emotional classroom engagement following structured physical activity among preschoolers: A feasibility study显示文摘Background: The well-rounded development of the child, including physical, cognitive, emotional, and social health, may be the most efficient route to well-being and academic success. The primary goal was to investigate the feasibility of implementing a 12-week structured program of physical activity(PA) incorporating cognitive, social, and emotional elements in preschool. Additionally, this study, using a within-subject design,examined the acute effects of a PA session on classroom engagement and changes on perceived competence and peer acceptance from the first to the last week of the program.Methods: Twenty-seven preschoolers(mean age = 4.2 years) completed the Pictorial Scale of Perceived Competence and Social Acceptance for Young Children before and after a twice-weekly PA program. Unobtrusive classroom observations were conducted for verbal, social, and affective engagement during the first and last week of the program, both following a structured PA session(experimental day) and on a day without PA(control day). Treatment fidelity was monitored to ensure that the intervention was delivered as designed.Results: The children exhibited longer periods of verbal and social engagement during classroom periods that followed PA sessions than on non-PA days. Children also expressed more positive affect following PA sessions during the last week of the PA program. Despite high baseline scores,perceptions of general competence increased meaningfully(η2= 0.15, p = 0.05), driven by increase in perceptions of cognitive competence(η2= 0.15,p = 0.06).Conclusion: This study demonstrates the feasibility of providing structured PA program to preschoolers. Moreover, these initial findings suggest that purposely designed, structured PA may help advance the social–emotional engagement and perceived competence of preschool children. | Spyridoula Vazou Constantine Mantis Gayle Luze Jacqueline S.Krogh | 2017 | Journal of Sport and Health Science2017，6，2： | 5 |
| 3 | Gastroesophageal reflux and congenital gastrointestinal malformations显示文摘Although the outcome of newborns with surgical congenital diseases(e.g.,diaphragmatic hernia;esophageal atresia;omphalocele;gastroschisis) has improved rapidly with recent advances in perinatal intensive care and surgery,infant survivors often require intensive treatment after birth,have prolonged hospitalizations,and,after discharge,may have longterm sequelae including gastro-intestinal comorbidities,above all,gastroesophageal reflux(GER).This condition involves the involuntary retrograde passage of gastric contents into the esophagus,with or without regurgitation or vomiting.It is a well-recognized condition,typical of infants,with an incidence of 85%,which usually resolves after physiological maturation of the lower esophageal sphincter and lengthening of the intra-abdominal esophagus,in the first few months after birth.Although the exact cause of abnormal esophageal function in congenital defects is not clearly understood,it has been hypothesized that common(increased intra-abdominal pressure after closure of the abdominal defect) and/or specific(e.g.,motility disturbance of the upper gastrointestinal tract,damage of esophageal peristaltic pump) pathological mechanisms may play a role in the etiology of GER in patients with birth defects.Improvement of knowledge could positively impact the long-term prognosis of patients with surgical congenital diseases.The present manuscript provides a literature review focused on pathological and clinical characteristics of GER in patients who have undergone surgical treatment for congenital abdominal malformations. | Lucia Marseglia Sara Manti Gabriella D'Angelo Eloisa Gitto Carmelo Salpietro Antonio Centorrino Gianfranco Scalfari Giuseppe Santoro Pietro Impellizzeri Carmelo Romeo | 2015 | World Journal of Gastroenterology2015，21，28： | 3 |
| 4 | Role of the diet as a link between oxidative stress and liver diseases显示文摘Oxidative stress is caused by an imbalance between the production of reactive oxygen(free radicals) and the body's ability(antioxidant capacity) to readily detoxify the reactive intermediates or easily repair the resulting damage. An adequate diet, characterized by daily intake of foods associated with improvementsin the total antioxidant capacity of individuals and reduced incidence of diseases related to oxidation, can modulate the degree of oxidative stress. In fact, dietderived micronutrients may be direct antioxidants, or are components of antioxidant enzymes, leading to improvement of some indicators of hepatic function. However, although their increased dietary intake might be beneficial, literature data are still controversial. This review summarizes what is known about the effects of diet nutrients on oxidative stress, inflammation and liver function. Moreover, we have analyzed:(1) the main nutritional components involved in the production and/or removal of free radicals; and(2) the role of free radicals in the pathogenesis of several hepatic diseases and related comorbidities. | Teresa Arrigo Salvatore Leonardi Caterina Cuppari Sara Manti Angela Lanzafame Gabriella D'Angelo Eloisa Gitto Lucia Marseglia Carmelo Salpietro | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 5 | Histaminoid reac- tions associated with rocuronium 显示文摘 | Neal S M Manti P R Gadiyar V | 2000 | Br J Anaesth2000，84，1： | 1 |
| 6 | Oligosaccharide side chains on human secretory IgA serve as receptors for ricin 显示文摘 | Mantis N J Farrant SA Mehta S | 2004 | J Immunol2004，172，11： | 1 |
| 7 | Secretory Ig A's complex roles in immunity and mucosal homeostasis in the gut显示文摘 | N J Mantis N Rol B Corthesy | 2011 | Immunology2011，4，： | 1 |
| 8 | Serum interleukin 17, interleukin 23, and interleukin 10 values in children with atopic eczema/dermatitis syndrome(AEDS): association with clinical severity and phenotype显示文摘 | Leonardi S Cuppari C Manti S | 2015 | Allergy Asthma Proc2015，36，1： | 1 |
| 9 | Secretory IgA: arresting microbial pathogens at epithelial borders 显示文摘 | Mantis NJ Forbes SJ | 2010 | Immunol Invest2010，39，45： | 1 |
| 10 | Secretory Ig A:arresting microbial pathogens at epithelial borders显示文摘 | Mantis N J Forbes S J | 2010 | Immunol2010，39，： | 1 |
| 11 | Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut显示文摘 | Mantis NJ Rol N Corth6sy B | 2011 | Mucosal Immu- nol2011，4，6： | 1 |
| 12 | Effects of caponiza- tion on growth performance,carcass composition and meat quality of males of a layer line 显示文摘 | Symeon G K Mantis F Bizelis l | 2012 | Animal2012，6，12： | 1 |
| 13 | Secretory IgA: arresting microbial pathogens at epithelial borders显示文摘 | MANTIS N J FORBES S J | 2010 | Immunol Invest2010，39，45： | 1 |
| 14 | Selective adherence of IgA to murine Peyer's patch M cells: evidence for a novel IgA receptor显示文摘 | Mantis NJ Cheung MC Chintalacharuvu KR | 2002 | J Immunol2002，169，4： | 1 |
| 15 | The viral sigma1 protein and glycoconjugates containing alpha2-3-linked sialic acid are involved in type 1 reovirus adherence to M cell apical surfaces显示文摘 | Helander A Silvey KJ Mantis NJ | 2003 | J Virol2003，77，14： | 1 |
| 16 | The composi- tion and function of M cell apical membranes:implications for microbial pathogenesis显示文摘 | NEUTRA M R MANTIS N J FREY A | 1999 | Semin Immunol1999，11，3： | 1 |
| 17 | Secretory IgA's complex roles in immu- nity and mucosal homeostasis in the gut显示文摘 | Mantis N J Rol N Corthesy B | 2011 | Mucosal Immunology2011，4，6： | 1 |
| 18 | Oxidative stress in obesity : A critical component in human diseases 显示文摘 | Marseglia L Manti S D'Angelo G | 2014 | Int J Mol Sei2014，16，1： | 1 |
| 19 | PM10-bound polycyclic aromatic hydrocarbons (PAHs) in the Greater Area of Athens, Greece 显示文摘 | Mantis J Chaloulakou A Samara C | 2005 | Chemosphere2005，59，5： | 1 |
| 20 | Oligosaccharide side chains on human secretory IgA serve as receptors for ricin 显示文摘 | Mantis NJ Farrant SA Mehta S | 2004 | Immunol2004，172，： | 1 |
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