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| 1 | Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease显示文摘BACKGROUND In non-alcoholic fatty liver disease(NAFLD), a high-fat or high-fructose diet increases intestinal permeability and promotes derangement of the gut-liver axis.We hypothesize that, diet could be able to modulate intestinal permeability in patients with NAFLD.AIM To detect diet-induced modification of intestinal permeability in patients with NAFLD undergoing a Mediterranean diet or a low-fat diet.METHODS The current study was a dietary intervention for non-diabetic, patients with biopsy-verified NAFLD and increased transaminases. A crossover design was employed: participants underwent 16 weeks of Mediterranean diet, 16 wk of free wash-out, and 16 weeks of low-fat diet. Both diets were hypocaloric and no consumption of supplements was allowed. All patients were followed bimonthly by a dietitian. Evaluations of clinical and metabolic parameters were completed at baseline and at the end of each dietary period. Intestinal permeability was assessed by chromium-51 ethylene diamine tetraacetate excretion testing(51 CrEDTA).RESULTS Twenty Caucasian patients, 90% male, median age 43 years, body mass index(BMI) 30.9, with biopsy-verified NAFLD were enrolled. At the end of 16 weeks of a Mediterranean diet, a significant reduction in mean body weight(-5.3 ± 4.1 kg,P = 0.003), mean waist circumference(-7.9 ± 4.9 cm, P = 0.001), and mean transaminase levels [alanine aminotransferase(ALT)-28.3 ± 11.9 IU/L, P =0.0001; aspartate aminotransferase(AST)-6.4 ± 56.3 IU/L, P = 0.01] were observed. These benefits were maintained after 16 wk of wash-out and also after16 wk of low-fat diet, without further improvements. Fourteen of the 20 patients had intestinal permeability alteration at baseline(mean percentage retention of51 Cr-EDTA = 5.4%), but no significant changes in intestinal permeability were observed at the end of the 16 wk of the Mediterranean diet or 16 wk of the low-fat diet.CONCLUSION Mediterranean diet is an effective strategy for treating overweight, visceral obesity and serum transaminase in patients with NAFLD. If the Mediterranean diet can improve intestinal permeability in patients with NAFLD, it deserves further investigation. | Marco Biolato Fiorella Manca Giuseppe Marrone Consuelo Cefalo Simona Racco Giacinto A Miggiano Venanzio Valenza Antonio Gasbarrini Luca Miele Antonio Grieco | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 2 | The reuse of abandoned Acquaresi mine voids for storage of the Masua flotation tailings显示文摘Often in abandoned mine sites are present both underground voids produced by mining and the tailings of treatment plant.An interesting solution for the rehabilitation of the sites would be to place the tailings of the process in the underground mining voids,thus obtaining the reclamation of surface areas and the stabilization of abandoned voids to prevent the dangerous phenomena of subsidence.However,these operations require inert waste,which must not be source of pollution,and the choice of a water/solid optimum to ensure good conditions of pumpability. | Pier Paolo Manca Paolo Desogus Giampaolo Orru | 2014 | International Journal of Coal Science & Technology2014，1，2： | 2 |
| 3 | Enteroscopy in children and adults with inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD)includes Crohn’s disease(CD),ulcerative colitis and unclassified entities.CD commonly involves the terminal ileum and colon but at the time of diagnosis it can be confined to the small bowel(SB)in about 30%of the patients,especially in the young ones.Management of isolated SB-CD can be challenging and objective evaluation of the SB mucosa is essential in differentiating CD from other enteropathies to achieve therapeutic decisions and to plan the follow-up.The introduction of cross-sectional imaging techniques and capsule endoscopy(CE)have significantly expanded the ability to diagnose SB diseases providing a non-invasive test for the visualization of the entire SB mucosa.The main CE limitations are the low specificity,the lack of therapeutic capabilities and the impossibility to take biopsies.Device assisted enteroscopy(DAE)enables histological confirmation when traditional endoscopy,capsule endoscopy and cross-sectional imaging are inconclusive and also allows therapeutic interventions such as balloon stricture dilation,intralesional steroid injection,capsule retrieval and more recently stent insertion.In the current review we will discuss technical aspect,indications and safety profile of DAE in children and adults with IBD. | Giovanni Di Nardo Gianluca Esposito Chiara Ziparo Federica Micheli Luigi Masoni Maria Pia Villa PasqualeParisi Maria Beatrice Manca Flavia Baccini Vito Domenico Corleto | 2020 | World Journal of Gastroenterology2020，26，39： | 2 |
| 4 | Characterization of mesenchymal stromal cells derived from full-term umbilical cord blood显示文摘 | Mf Manca I Zwart J Beo R Palasingham L-S Jen R Navarrete J Girdlestone Cv Navarrete | 2008 | Cytotherapy2008，，1： | 2 |
| 5 | Role of the advanced glycation end products receptor in Crohn's disease inflammation显示文摘AIM:To investigate the level of mucosal expression and the involvement of the receptor for the advanced glycation end products(RAGE)in delayed apoptosis and tumor necrosis factor(TNF)-αproduction in Crohn’s disease(CD).METHODS:Surgical and endoscopic specimens from both inflamed and non-inflamed areas of the ileum and/or colon were collected from 20 and 14 adult CD patients,respectively,and used for the assessment of RAGE expression by means of immunohistochemistry and western blotting analysis.Normal tissues from 21 control subjects were used for comparison.The same polyclonal anti-human RAGE antibody(R and D System)was used in all experimental conditions.RAGE staining was quantized by a score including both the amount of positive cells and intensity of immunoreactivity;cellular pattern was also described.The effects of RAGE blocking on apoptotic rate and TNF-αproduction were investigated on immune cells freshly isolated from CD mucosa and incubated both with and without the muramyl dipeptide used as antigenic stimulus.Statistical analysis was performed via the test for trend,with regression models to account for intra-patient correlations.A 2-sided P<0.05 was considered significant.RESULTS:In inflamed areas,RAGE expression in both the epithelial and lamina propria compartments was higher than control tissues(P=0.001 and 0.021,respectively),and a cluster of positive cells were usually found in proximity of ulcerative lesions.Similar results were obtained in the lamina propria compartment of non-inflamed areas(P=0.025).The pattern of staining was membranous and granular cytosolic at the epithelial level,while in the lamina propria it was diffuse cytosolic.When evaluating the amount of protein expression by immunoblotting,a significant increase of both surface area and band intensity(P<0.0001 for both)was observed in CD inflamed areas compared to control tissue,while in non-inflamed areas a significant increase was found only for band intensity(P<0.005).Moreover,a significantly lower expression in noninflamed areas in comparison with inflamed areas was found for both surface area and band intensity(P<0.0006 for both).Finally,RAGE blocking largely affects both the apoptotic rate of mucosal cells(towards an increase in both non-inflamed and inflamed areas of P<0.001 and<0.0001,respectively)and TNF-αsecretion(towards a decrease in both non-inflamed and inflamed areas of P<0.05 and<0.01,respectively),mainly in the presence of antigenic stimulation.CONCLUSION:RAGE is up-regulated in CD,especially in inflamed areas,and it appears to play a role in the mechanisms involved in chronic inflammation. | Rachele Ciccocioppo Alessandro Vanoli Catherine Klersy Venerina Imbesi Vincenzo Boccaccio Rachele Manca Elena Betti Giuseppina Cristina Cangemi Elena Strada Roberta Besio Antonio Rossi Colomba Falcone Sandro Ardizzone Paolo Fociani Piergiorgio Danelli Gino Roberto Corazza | 2013 | World Journal of Gastroenterology2013，19，45： | 2 |
| 6 | The treatment of stable and unstable proximal femoral fractures with a new trochanteric nail: results of a multicentre study with the Veronail显示文摘 | Franco Lavini L. Renzi-Brivio R. Aulisa F. Cherubino P. L. Seglio N. Galante W. Leonardi M. Manca | 2008 | Strategies in Trauma and Limb Reconstruction2008，，1： | 2 |
| 7 | Vascular remodeling and prothrombotic markers in subjects affected by familial combined hyperlipidemia and/or metabolic syndrome in primary prevention for cardiovascular disease 显示文摘 | Cicero AF Derosa G Manca M | 2007 | Endothelium2007，14，5： | 1 |
| 8 | Endoscopic laser ablation as palliative treatment of endobronchial, nonresectable, or recurrent lung cancer: Assessment of its impact on quality of life 显示文摘 | Mantovani G Astara G Manca G | 2000 | Clin Lung Cancer2000，1，4： | 1 |
| 9 | Effects of testosterone on differentiation and oxidative stress resistance in C1300 neuroblastoma cells显示文摘 | Chisu V Manca P Zedda M | 2006 | Neuro Endocrinol Lett2006，27，6： | 1 |
| 10 | Prevalence of irritable bowel syndrome in Italian rural and urban areas显示文摘 | Usai P Manca R Lai MA | 2010 | Eur J Intern Med2010，21，4： | 1 |
| 11 | Intention to usebike-sharing for holiday cycling : An application of the theory of plannedbehavior显示文摘 | KAPLAN S MANCA F NIELSEN T PRATO C G | 2015 | Tourism Management2015，47，4： | 1 |
| 12 | Urethroplasty in recurrent urethral diverticula in neurological patients: long-term results using a personal technique显示文摘 | Ronzoni G De Giovanni L Manca A | 2004 | BJU Int2004，94，： | 1 |
| 13 | Benefit of selective respiratory muscle training on exercise capacity in patients with chronic congestive heart failure显示文摘 | Mancini DM Henson D La Manca J | 1995 | Circulation1995，91，2： | 1 |
| 14 | Percutaneous vertebroplasty and bone cement leakage: clinical experience with a new high - viscosity bone cement and delivery system for vertebral augmentation in benign and malignant compression fractures显示文摘 | ANSELMETrI G C ZOARSKI G MANCA A | 2008 | Cardiovasc Intervent Radiol2008，31，5： | 1 |
| 15 | Percutaneous Vertebro-plasty in Osteoporotic Patients: An Institutional Experience of 1,634 Patients with Long-Term Follow-Up 显示文摘 | Anselmetti GC Manca A Hirsch J | 2011 | J Vasc Interv Radi-ol2011，22，12： | 1 |
| 16 | Characterization of mesenchymal stromal cells derived from full -term umbilical cord blood显示文摘 | Manca M F Zwart I Beo J | 2008 | Cytotherapy2008，10，1： | 1 |
| 17 | Characterization of mesenchymal stromal cells derived from full-term umbilical cord blood显示文摘 | Manca MF Zwert I Beo J | | 0，，01： | 1 |
| 18 | Mycobacterium tuberculosis CDC1551 induces a more vigorous host response in vivo and in vitro,but is not more virulent than other clinical isolates显示文摘 | Manca C Tsenova L Barry CE 3rd Bergtold A Freeman S Haslett PA Musser JM Freedman VH Kaplan G | 1999 | J Immunol1999，162，11： | 1 |
| 19 | Percutaneous vertebroplasty and bone cement leakage: clinical experience with a new high-viscosity bone cement and delivery system for vertebral augmentation in benign and malignant compression fractures显示文摘 | Anselmetti CK Zoarsld G Manca A | 2008 | Cardiovasc Intervent Radiol2008，3，5： | 1 |
| 20 | Cost effectiveness analysis of laparoscopic hysterectomy compared with standard hysterectomy: re- suits from a randomized trial显示文摘 | Sculpher M Manca A Abbott J | 2004 | BMJ2004，328，7432： | 1 |
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