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	题名	作者	年代	出处	被引量
1	Antibody engineering: facing new challenges in cancer therapy显示文摘Antibody-based therapeutics are beginning to realize the promise enclosed in their early denomination as “magic bullets”. Initial disappointment has turned into clinical and commercial success, and engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials. Recent structural and functional data have allowed the design of a new generation of therapeutic antibodies, with strategies ranging from complement-mediated and antibody-dependant cellular cytotoxicity enhancement to improved cytotoxic payloads using toxins, drugs,radionucleids and viral delivery. This review considers the structure of different types of recombinant antibodies, their mechanism of action and how their efficacy has been increased using a broad array of approaches. We will also focus on the additional benefits offered by the use of gene therapy methods for the in vivo production of therapeutic antibodies.	Laura S■NZ ■ngel M CUESTA Mana COMPTE Luis ■LVAREZ-VALLINA	2005	Acta Pharmacologica Sinica2005，26，6：	5
2	7-Substituted 2-phenyl-benzofurans as ERβ selective ligands显示文摘	COLLINI M D KAUFMAN D H MANAS E S	2004	Bioorg Med Chem Lett2004，14，19：	1
3	Bcl-xL promotes metastasis of breast cancer of cytokines resistance 显示文摘	FERNANDEZ Y ESPANA S MANAS S	2000	Cell Death Differ2000，7，4：	1
4	Mesaconitine- induced relaxation in rat aorta : involvement of Ca2 + influx and nitric - oxide synthase in the endothelium 显示文摘	MANA M SYUNJI H MASARU S	2002	European Journal of Pharmacology2002，436，：	1
5	Observation of carbon black agglomerate dispersion in simple shear flow显示文摘	Rwei S P Manas Z I	1990	Polym Eng Sci1990，30，12：	1
6	Deleterious role of IFNgamma in a toxic model of central nervous system demyelination 显示文摘	Mana P Linares D Fordham S	2006	Am J Pathol2006，168，5：	1
7	Hydrocarbon bioremedlation of a mineral-base contaminated waste from crude oil extraction by indigenous bacteria 显示文摘	Capelli Mana S	2001	International Biodeterioration & Biodegradation2001，，47：	1
8	Recovery of Sac- charomyces cerevisiae sublethally injured cells after Pulsed Electric Fields 显示文摘	Somolinos M Manas P Condon S	2008	International Journal of Food Microbi- ology2008，125，3：	1
9	Evaluation of a sporicidal peracetic acid/hydrogen peroxide-based daily disinfectant cleaner显示文摘	DESHPANDE A MANA T S C CADNUM J L	2014	Infection Control2014，35，11：	1
10	Optimal treatment for hepatocellular carcinoma in the cirrhotic liver显示文摘	White S A Manas D M Farid S G	2009	Ann R Coil Surg Engl2009，91，7：	1
11	Synthesis and characterization of diorganotin(Ⅳ)complexes of tetradentate Schiff bases crystal structure of n-Bu2Sn(Vanophen)显示文摘	Dilip K D Manas K S Mrina1 K D eta1	1999	Polyhedron1999，18，：	1
12	Dicopper( II ) Schiff base aminobenzoates with discrete molecular and 1D-chain polymeric structures 显示文摘	Arindam M Manas K S Munirathinam N	2004	Polyhedron2004，23，：	1
13	Effect of emulsion temperature on physical properties of palm oil -based margarine 显示文摘	MISKANDAR M S CHE MANA Y B YUSOFFB M S A	2002	J Am Oil Chem Soc2002，79，12：	1
14	Harmonic and intermodulation distortion indirect intensity modulated quantumcascade lases显示文摘	KELVIN S C Y MANAS K Haldar JEFFREY F W	2014	IEEE Journal of Lightwave Technology2014，32，20：	1
15	Assessment of determinants af- fecting the dual topology of hepadnaviral large envelope pro- teins显示文摘	Lamber C Mana S Prange R	2004	J Gen Virol2004，85，5：	1
16	Microbial Inactivation by Pulsed Electric Fields in a Batch Treatment Chamber:Effects of Some Electrical Parameters and Food Constituents显示文摘	MANAS P LAURA B S CHEFTEL C J	2001	Food Science & Emerging Technologies2001，2，：	1
17	Fluid flow analysis of magnetorheologieal abrasive flow finishing (MRAFF) process显示文摘	MANAS D JAIN V K GHOSHDASTIDAR P S	2008	International Journal of Machine Tools & Manufacture2008，48，：	1
18	Evaluation of a sporicidal peracetic acid/hydrogen peroxide-based daily disinfectant cleaner 显示文摘	Deshpande A Mana T S Cadnum J L	2014	lnfect Control Hosp Epidemiol2014，35，11：	1
19	Bcl-xL promotes metastasis of breast cancer of cytokines resistance显示文摘	Fernandez Y Espana S Manas S	2000	Cell Death Differ2000，7，4：	1
20	Understanding the selectivity of genistein for human estrogen receptor-β using X-ray crystallography and computational methods 显示文摘	Manas E S Xu Z B Unwalla R J	2004	Structure2004，12，12：	1

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